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2019
1 Citation (Scopus)

Counter-regulation of regulatory T cells by autoreactive CD8 + T cells in rheumatoid arthritis

Cammarata, I., Martire, C., Citro, A., Raimondo, D., Fruci, D., Melaiu, O., D'Oria, V., Carone, C., Peruzzi, G., Cerboni, C., Santoni, A., Sidney, J., Sette, A., Paroli, M., Caccavale, R., Milanetti, E., Riminucci, M., Timperi, E., Piconese, S., Manzo, A. & 5 others, Montecucco, C., Scrivo, R., Valesini, G., Cariani, E. & Barnaba, V., Jan 1 2019, In : Journal of Autoimmunity.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Rheumatoid Arthritis
T-Lymphocytes
Eragrostis
Tumor Necrosis Factor-alpha
Torticollis
Headache
Longitudinal Studies
Migraine Disorders
Age of Onset

Daily Consumption of Orange Juice from Citrus sinensis L. Osbeck cv. Cara Cara and cv. Bahia Differently Affects Gut Microbiota Profiling as Unveiled by an Integrated Meta-Omics Approach

Brasili, E., Hassimotto, N. M. A., Del Chierico, F., Marini, F., Quagliariello, A., Sciubba, F., Miccheli, A., Putignani, L. & Lajolo, F., Feb 6 2019, In : Journal of Agricultural and Food Chemistry. 67, 5, p. 1381-1391 11 p.

Research output: Contribution to journalArticle

formic acid
orange juice
Citrus sinensis
Metabolites
intestinal microorganisms
1 Citation (Scopus)

Death after hematopoietic stem cell transplantation: changes over calendar year time, infections and associated factors

for the Infectious Diseases Working Party EBMT, Jan 1 2019, (Accepted/In press) In : Bone Marrow Transplantation.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Transplantation
Transplants
Infection
Mortality
Cause of Death
Tracheostomy
Artificial Respiration
Noninvasive Ventilation
Language Development
Central Nervous System

Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy

Logiodice, F., Lombardelli, L., Kullolli, O., Haller, H., Maggi, E., Rukavina, D. & Piccinni, M-P., Jan 19 2019, In : International Journal of Molecular Sciences. 20, 2

Research output: Contribution to journalArticle

interleukins
T-cells
pregnancy
Interleukin-4
T-Lymphocytes

Deficiency and haploinsufficiency of histone macroH2A1.1 in mice recapitulate hematopoietic defects of human myelodysplastic syndrome

Bereshchenko, O., Lo Re, O., Nikulenkov, F., Flamini, S., Kotaskova, J., Mazza, T., Le Pannérer, M. M., Buschbeck, M., Giallongo, C., Palumbo, G., Li Volti, G., Pazienza, V., Cervinek, L., Riccardi, C., Krejci, L., Pospisilova, S., Stewart, A. F. & Vinciguerra, M., Aug 22 2019, In : Clinical Epigenetics. 11, 1, 121.

Research output: Contribution to journalArticle

Haploinsufficiency
Myelodysplastic Syndromes
Hematopoietic Stem Cells
Histones
Hematopoiesis
4 Citations (Scopus)

Deficient Natural Killer Cell NKp30-Mediated Function and Altered NCR3 Splice Variants in Hepatocellular Carcinoma

Mantovani, S., Oliviero, B., Lombardi, A., Varchetta, S., Mele, D., Sangiovanni, A., Rossi, G., Donadon, M., Torzilli, G., Soldani, C., Porta, C., Pedrazzoli, P., Chiellino, S., Santambrogio, R., Opocher, E., Maestri, M., Bernuzzi, S., Rossello, A., Clément, S., De Vito, C. & 3 others, Rubbia-Brandt, L., Negro, F. & Mondelli, M. U., Jan 1 2019, In : Hepatology.

Research output: Contribution to journalArticle

Natural Killer Cells
Hepatocellular Carcinoma
Ligands
Natural Cytotoxicity Triggering Receptor 3
Tumor-Infiltrating Lymphocytes
Hereditary Spastic Paraplegia
Mutation
Brain
Magnetic Resonance Imaging
Phenotype
Hereditary Spastic Paraplegia
Mutation
Brain
Magnetic Resonance Imaging
Phenotype

Delineation of MidXq28-duplication syndrome distal to MECP2 and proximal to RAB39B genes

Sinibaldi, L., Parisi, V., Lanciotti, S., Fontana, P., Kuechler, A., Baujat, G., Torres, B., Koetting, J., Splendiani, A., Postorivo, D., Beygo, J., Garaci, F. G., Malan, V., Lüdecke, H-J., Guida, V., Krumbiegel, M., Lonardo, F., Novelli, A., Albrecht, B., Perria, C. & 6 others, Scarano, G., Spielmann, M., Nardone, A. M., Battaglia, A., Brancati, F. & Bernardini, L., 2019, In : Clinical Genetics.

Research output: Contribution to journalArticle

Delineation of MidXq28-Duplication Syndrome Distal to MECP2 and Proximal to RAB39B genes

Sinibaldi, L., Parisi, V., Lanciotti, S., Fontana, P., Kuechler, A., Baujat, G., Torres, B., Koetting, J., Splendiani, A., Postorivo, D., Beygo, J., Garaci, F. G., Malan, V., Hermann-Josef-Lüdecke, Guida, V., Krumbiegel, M., Lonardo, F., Novelli, A., Albrecht, B., Perria, C. & 6 others, Scarano, G., Spielmann, M., Nardone, A., Battaglia, A., Brancati, F. & Bernardini, L., May 15 2019, In : Clinical Genetics.

Research output: Contribution to journalArticle

Genomic Segmental Duplications
Microcephaly
Brain
Intellectual Disability
Nervous System

Dendritic cell recognition by group 3 innate lymphoid cells through DNAX accessory molecule 1 triggers proinflammatory reciprocal cell activation

Campana, S., Di Carlo, E., De Pasquale, C., Barberi, C., Oliveri, D., Migliore, G. S., Cannavò, S. P., Galletti, B., Pende, D., Carrega, P. & Ferlazzo, G., Oct 2019, In : Journal of Allergy and Clinical Immunology. 144, 4, p. 1118-1122.e6

Research output: Contribution to journalArticle

De Novo Missense Variants in FBXW11 Cause Diverse Developmental Phenotypes Including Brain, Eye, and Digit Anomalies

Holt, R. J., Young, R. M., Crespo, B., Ceroni, F., Curry, C. J., Bellacchio, E., Bax, D. A., Ciolfi, A., Simon, M., Fagerberg, C. R., van Binsbergen, E., De Luca, A., Memo, L., Dobyns, W. B., Mohammed, A. A., Clokie, S. J. H., Zazo Seco, C., Jiang, Y. H., Sørensen, K. P., Andersen, H. & 14 others, Sullivan, J., Powis, Z., Chassevent, A., Smith-Hicks, C., Petrovski, S., Antoniadi, T., Shashi, V., Gelb, B. D., Wilson, S. W., Gerrelli, D., Tartaglia, M., Chassaing, N., Calvas, P. & Ragge, N. K., Sep 5 2019, In : American Journal of Human Genetics. 105, 3, p. 640-657 18 p.

Research output: Contribution to journalArticle

Open Access
Phenotype
Jaw
Brain
Zebrafish
SKP Cullin F-Box Protein Ligases
Dimerization
Transcriptional Activation
Developmental Disabilities
Energy Transfer
Brain

Deregulation of TLR4 signaling pathway characterizes Bicuspid Aortic valve syndrome

Balistreri, C. R., Marullo, A. G. M., Madonna, M., Cavarretta, E., Allegra, A., Cesarini, V., Iaccarino, A., Schiavon, S., Peruzzi, M., Greco, E., Sciarretta, S., Pisano, C., Ruvolo, G., Torella, M. & Frati, G., Jul 30 2019, In : Scientific Reports. 9, 1, p. 11028

Research output: Contribution to journalArticle

Aneurysm
Aorta
Aortic Valve
Tricuspid Valve
Aortic Diseases

Detection of iron deficiency in children with Down syndrome

Hart, S. J., Zimmerman, K., Linardic, C. M., Cannon, S., Pastore, A., Patsiogiannis, V., Rossi, P., Santoro, S. L., Skotko, B. G., Torres, A., Valentini, D., Vellody, K., Worley, G. & Kishnani, P. S., Aug 16 2019, In : Genetics in Medicine.

Research output: Contribution to journalArticle

Erythrocyte Indices
Down Syndrome
Iron-Deficiency Anemias
Iron
Ferritins

Determination of pentraxin 3 levels in cerebrospinal fluid during central nervous system infections

Zatta, M., Di Bella, S., Bottazzi, B., Rossi, F., D’Agaro, P., Segat, L., Fabbiani, M., Mantovani, A. & Luzzati, R., Jan 1 2019, (Accepted/In press) In : European Journal of Clinical Microbiology and Infectious Diseases.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Development and initial validation of the MS score for diagnosis of macrophage activation syndrome in systemic juvenile idiopathic arthritis

Pediatric Rheumatology international Trials Organization, the Childhood arthritis &Rheumatology Research alliance, the Pediatric Rheumatology Collaborative study Group and the Histiocyte society, Jan 1 2019, In : Annals of the Rheumatic Diseases. 78, 10, p. 1357-1362 6 p.

Research output: Contribution to journalArticle

Macrophage Activation Syndrome
Juvenile Arthritis
Macrophages
Chemical activation
Neurology
2 Citations (Scopus)

Development and validation of a composite disease activity score for measurement of muscle and skin involvement in juvenile dermatomyositis

the Pediatric Rheumatology International Trials Organization (PRINTO), Jul 1 2019, In : Rheumatology (United Kingdom). 58, 7, p. 1196-1205 10 p.

Research output: Contribution to journalArticle

Muscles
Skin
amsonic acid
Parents
Physicians

Development of adaptive immune effector therapies in solid tumors

Comoli, P., Chabannon, C., Koehl, U., Lanza, F., Urbano-Ispizua, A., Hudecek, M., Ruggeri, A., Secondino, S., Bonini, C. & Pedrazzoli, P., Aug 21 2019, In : Annals of oncology : official journal of the European Society for Medical Oncology.

Research output: Contribution to journalArticle

Neoplasms
Therapeutics
T-Lymphocytes
Tumor Microenvironment
Hematologic Neoplasms

Development of adaptive immune effector therapies in solid tumors: Annals of oncology : official journal of the European Society for Medical Oncology

Comoli, P., Chabannon, C., Koehl, U., Lanza, F., Urbano-Ispizua, A., Hudecek, M., Ruggeri, A., Secondino, S., Bonini, C. & Pedrazzoli, P., 2019, In : Ann. Oncol.. 30, 11, p. 1740-1750 11 p.

Research output: Contribution to journalArticle

Development of adaptive immune effector therapies in solid tumors: Annals of oncology : official journal of the European Society for Medical Oncology

Comoli, P., Chabannon, C., Koehl, U., Lanza, F., Urbano-Ispizua, A., Hudecek, M., Ruggeri, A., Secondino, S., Bonini, C. & Pedrazzoli, P., 2019, In : Ann. Oncol.. 30, 11, p. 1740-1750 11 p.

Research output: Contribution to journalArticle

Development of a Dynamic Oriented Rehabilitative Integrated System (DORIS) and Preliminary Tests

Summa, S., Gori, R., Freda, L., Castelli, E. & Petrarca, M., Aug 2 2019, In : Sensors (Basel, Switzerland). 19, 15

Research output: Contribution to journalArticle

Robotics
Electromyography
Gait
Internet
Cell Movement

Development of a Novel Risk Prediction Model for Sudden Cardiac Death in Childhood Hypertrophic Cardiomyopathy (HCM Risk-Kids)

Norrish, G., Ding, T., Field, E., Ziólkowska, L., Olivotto, I., Limongelli, G., Anastasakis, A., Weintraub, R., Biagini, E., Ragni, L., Prendiville, T., Duignan, S., McLeod, K., Ilina, M., Fernández, A., Bökenkamp, R., Baban, A., Kubuš, P., Daubeney, P. E. F., Sarquella-Brugada, G. & 29 others, Cesar, S., Marrone, C., Bhole, V., Medrano, C., Uzun, O., Brown, E., Gran, F., Castro, F. J., Stuart, G., Vignati, G., Barriales-Villa, R., Guereta, L. G., Adwani, S., Linter, K., Bharucha, T., Garcia-Pavia, P., Rasmussen, T. B., Calcagnino, M. M., Jones, C. B., De Wilde, H., Toru-Kubo, J., Felice, T., Mogensen, J., Mathur, S., Reinhardt, Z., O'Mahony, C., Elliott, P. M., Omar, R. Z. & Kaski, J. P., Aug 14 2019, In : JAMA Cardiology.

Research output: Contribution to journalArticle

Hypertrophic Cardiomyopathy
Sudden Cardiac Death
Implantable Defibrillators
Ventricular Tachycardia
Validation Studies

Diagnosis of 'possible' mitochondrial disease: an existential crisis

Parikh, S., Karaa, A., Goldstein, A., Bertini, E. S., Chinnery, P. F., Christodoulou, J., Cohen, B. H., Davis, R. L., Falk, M. J., Fratter, C., Horvath, R., Koenig, M. K., Mancuso, M., McCormack, S., McCormick, E. M., McFarland, R., Nesbitt, V., Schiff, M., Steele, H., Stockler, S. & 5 others, Sue, C., Tarnopolsky, M., Thorburn, D. R., Vockley, J. & Rahman, S., Mar 2019, In : Journal of Medical Genetics. 56, 3, p. 123-130 8 p.

Research output: Contribution to journalArticle

Mitochondrial Diseases
Inborn Genetic Diseases
Patient Harm
Anxiety
Phenotype
Inflammatory Bowel Diseases
Bone Marrow
Transplants
Phenotype

Dialysis modalities for the management of pediatric acute kidney injury

de Galasso, L., Picca, S. & Guzzo, I., Mar 18 2019, In : Pediatric Nephrology.

Research output: Contribution to journalArticle

Acute Kidney Injury
Renal Replacement Therapy
Dialysis
Pediatrics
Hospitalized Child
5 Citations (Scopus)

Dietary cadmium and risk of breast cancer subtypes defined by hormone receptor status: A prospective cohort study

Grioni, S., Agnoli, C., Krogh, V., Pala, V., Rinaldi, S., Vinceti, M., Contiero, P., Vescovi, L., Malavolti, M. & Sieri, S., May 1 2019, In : International Journal of Cancer. 144, 9, p. 2153-2160 8 p.

Research output: Contribution to journalArticle

Cadmium
Cohort Studies
Hormones
Prospective Studies
Breast Neoplasms
Intra-Abdominal Fat
Feeding Behavior
Colorectal Neoplasms
Fatty Acids
Obesity
5 Citations (Scopus)

Dietary Vitamin E as a protective factor for Parkinson's disease: Clinical and experimental evidence

Schirinzi, T., Martella, G., Imbriani, P., Di Lazzaro, G., Franco, D., Colona, V. L., Alwardat, M., Salimei, P. S., Mercuri, N. B., Pierantozzi, M. & Pisani, A., Jan 1 2019, In : Frontiers in Neurology. 10, 148.

Research output: Contribution to journalArticle

Open Access
Parkinsonian Disorders
Vitamin E
Parkinson Disease
Neuronal Plasticity
Antioxidants

Different features of tumor-associated NK cells in patients with low-grade or high-grade peritoneal carcinomatosis

Pesce, S., Belgrano, V., Greppi, M., Carlomagno, S., Squillario, M., Barla, A., Chiesa, M. D., Di Domenico, S., Mavilio, D., Moretta, L., Candiani, S., Sivori, S., De Cian, F. & Marcenaro, E., Jan 1 2019, In : Frontiers in Immunology. 10, AUG, 1963.

Research output: Contribution to journalArticle

Open Access
Natural Killer Cells
Carcinoma
Ascitic Fluid
Neoplasms
Phenotype
1 Citation (Scopus)

Differential modulation of SIRT6 deacetylase and deacylase activities by lysine-based small molecules

Sociali, G., Liessi, N., Grozio, A., Caffa, I., Parenti, M. D., Ravera, S., Tasso, B., Benzi, A., Nencioni, A., Del Rio, A., Robina, I., Millo, E. & Bruzzone, S., Jan 1 2019, In : Molecular Diversity.

Research output: Contribution to journalArticle

lysine
Sirtuin 1
Modulators
Lysine
Modulation

Different responses of PC12 cells to different pro-nerve growth factor protein variants

Soligo, M., Albini, M., Bertoli, F. L., Marzano, V., Protto, V., Bracci-Laudiero, L., Minnone, G., De Benedetti, F., Chiaretti, A., Mantuano, E. & Manni, L., Jul 3 2019, In : Neurochemistry International. p. 104498

Research output: Contribution to journalArticle

Nerve Growth Factor
Nerve Growth Factor Receptors
Proteins
Nerve Growth Factor Receptor
Phosphotransferases

Disease activity and damage in juvenile idiopathic arthritis: Methotrexate era versus biologic era

Giancane, G., Muratore, V., Marzetti, V., Quilis, N., Benavente, B. S., Bagnasco, F., Alongi, A., Civino, A., Quartulli, L., Consolaro, A. & Ravelli, A., Jul 8 2019, In : Arthritis Research and Therapy. 21, 1, 168.

Research output: Contribution to journalArticle

Open Access
Juvenile Arthritis
Methotrexate
Arthritis
Joints
Phenotype

Dissecting Integrin Expression and Function on Memory B Cells in Mice and Humans in Autoimmunity

Camponeschi, A., Gerasimcik, N., Wang, Y., Fredriksson, T., Chen, D., Farroni, C., Thorarinsdottir, K., Sjökvist Ottsjö, L., Aranburu, A., Cardell, S., Carsetti, R., Gjertsson, I., Mårtensson, I-L. & Grimsholm, O., Mar 21 2019, In : Frontiers in Immunology. 10, p. 534

Research output: Contribution to journalArticle

Autoimmunity
Integrins
B-Lymphocytes
Lymphocyte Function-Associated Antigen-1
Integrin alpha4beta1

Dissecting the mechanisms of bone loss in Gorham-Stout disease

Rossi, M., Buonuomo, P. S., Battafarano, G., Conforti, A., Mariani, E., Algeri, M., Pelle, S., D'Agostini, M., Macchiaiolo, M., De Vito, R., Gonfiantini, M. V., Jenkner, A., Rana, I., Bartuli, A. & Del Fattore, A., Sep 13 2019, In : Bone. p. 115068

Research output: Contribution to journalArticle

Essential Osteolysis
Bone and Bones
Osteoclasts
Serum
Osteoblasts
Biomarkers
HIV
Blood Vessels
Inflammation
Cardiovascular Diseases
Biomarkers
HIV
Blood Vessels
Inflammation
Cardiovascular Diseases

Distinct HR expression patterns significantly affect the clinical behavior of metastatic HER2+ breast cancer and degree of benefit from novel anti-HER2 agents in the real world setting

Pizzuti, L., Krasniqi, E., Barchiesi, G., Della Giulia, M., Izzo, F., Sanguineti, G., Marchetti, P., Mazzotta, M., Giusti, R., Botticelli, A., Gamucci, T., Natoli, C., Grassadonia, A., Tinari, N., Iezzi, L., Tomao, S., Tomao, F., Tonini, G., Santini, D., Astone, A. & 30 others, Michelotti, A., De Angelis, C., Mentuccia, L., Vaccaro, A., Magnolfi, E., Gelibter, A., Magri, V., Cortesi, E., D'Onofrio, L., Cassano, A., Rossi, E., Cazzaniga, M., Moscetti, L., Omarini, C., Piacentini, F., Fabbri, M. A., Scinto, A. F., Corsi, D., Carbognin, L., Bria, E., La Verde, N., Garufi, C., Paris, I., Giotta, F., Lorusso, V., De Maria, R., Ciliberto, G., Sperduti, I., Barba, M. & Vici, P., Jan 1 2019, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

Open Access

DNA methylation, colon cancer and Mediterranean diet: results from the EPIC-Italy cohort

Fasanelli, F., Giraudo, M. T., Vineis, P., Fiano, V., Fiorito, G., Grasso, C., Polidoro, S., Trevisan, M., Grioni, S., Krogh, V., Mattiello, A., Panico, S., Giurdanella, M. C., Tumino, R., De Marco, L., Ricceri, F. & Sacerdote, C., Oct 3 2019, In : Epigenetics. 14, 10, p. 977-988 12 p.

Research output: Contribution to journalArticle

Mediterranean Diet
DNA Methylation
Colonic Neoplasms
Italy
Neoplasms

Do children with autism spectrum disorders understand pantomimic events?

Adornetti, I., Ferretti, F., Chiera, A., Wacewicz, S., Zywiczynski, P., Deriu, V., Marini, A., Magni, R., Casula, L., Vicari, S. & Valeri, G., Jan 1 2019, In : Frontiers in Psychology. 10, JUN, 1382.

Research output: Contribution to journalArticle

Open Access
Video Recording
Gestures
Aptitude
Posture
Autism Spectrum Disorder

Do Children With Autism Spectrum Disorders Understand Pantomimic Events?

Adornetti, I., Ferretti, F., Chiera, A., Wacewicz, S., Żywiczyński, P., Deriu, V., Marini, A., Magni, R., Casula, L., Vicari, S. & Valeri, G., 2019, In : Frontiers in Psychology. 10, p. 1382

Research output: Contribution to journalArticle

Video Recording
Gestures
Aptitude
Posture
Autism Spectrum Disorder

Does gender affect the prognosis and risk of complications in patients with congenital heart disease in the modern era?

D'Alto, M., Budts, W., Diller, G. P., Mulder, B., Egidy Assenza, G., Oreto, L., Ciliberti, P., Bassareo, P. P., Gatzoulis, M. A. & Dimopoulos, K., May 4 2019, In : International Journal of Cardiology.

Research output: Contribution to journalArticle

Heart Diseases
Behavioral Genetics
Mortality
Sudden Cardiac Death
Body Size
Septic Shock
Endotoxins
Pediatrics
Cytokines
In Vitro Techniques

Drug-induced gingival hyperplasia: An in vitro study using amlodipine and human gingival fibroblasts

Lauritano, D., Martinelli, M., Baj, A., Beltramini, G., Candotto, V., Ruggiero, F. & Palmieri, A., Jan 1 2019, In : International Journal of Immunopathology and Pharmacology. 33, 2058738419827746.

Research output: Contribution to journalArticle

Open Access
Gingival Hyperplasia
Amlodipine
Fibroblasts
Gingival Overgrowth
Pharmaceutical Preparations

Drug retention rate and predictive factors of drug survival for interleukin-1 inhibitors in systemic juvenile idiopathic arthritis

Sota, J., Insalaco, A., Cimaz, R., Alessio, M., Cattalini, M., Gallizzi, R., Maggio, M. C., Lopalco, G., Torre, F. L., Fabiani, C., Pardeo, M., Olivieri, A. N., Sfriso, P., Salvarani, C., Gaggiano, C., Grosso, S., Bracaglia, C., De Benedetti, F., Rigante, D. & Cantarini, L., Jan 1 2019, In : Frontiers in Pharmacology. 9, JAN, 1526.

Research output: Contribution to journalArticle

Open Access
Juvenile Arthritis
Interleukin-1
Survival
Interleukin 1 Receptor Antagonist Protein
Pharmaceutical Preparations

Dual-source computed tomography coronary artery imaging in children

Secinaro, A., Curione, D., Mortensen, K. H., Santangelo, T. P., Ciancarella, P., Napolitano, C., Del Pasqua, A., Taylor, A. M. & Ciliberti, P., Aug 22 2019, In : Pediatric Radiology.

Research output: Contribution to journalArticle

Coronary Vessels
Tomography
Heart Diseases
Pediatrics
Transposition of Great Vessels

Durable remissions in TCF3-HLF positive acute lymphoblastic leukemia with blinatumomab and stem cell transplantation

Mouttet, B., Vinti, L., Ancliff, P., Bodmer, N., Brethon, B., Cario, G., Chen-Santel, C., Elitzur, S., Hazar, V., Kunz, J., Möricke, A., Stein, J., Vora, A., Yaman, Y., Schrappe, M., Sanak, S., Baruchel, A., Locatelli, F., von Stackelberg, A., Stanulla, M. & 1 others, Bourquin, J-P., Feb 14 2019, In : Haematologica.

Research output: Contribution to journalArticle