• 965 Citations
  • 18 h-Index
20072018
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Research Output 2007 2018

  • 965 Citations
  • 18 h-Index
  • 36 Article
  • 3 Review article
  • 2 Comment/debate
2018
1 Citation (Scopus)

Correction: Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease (Scientific Reports DOI: 10.1038/s41598-017-05709-y)

Di Pardo, A., Amico, E., Basit, A., Armirotti, A., Joshi, P., Neely, M. D., Vuono, R., Castaldo, S., Digilio, A. F., Scalabrì, F., Pepe, G., Elifani, F., Madonna, M., Jeong, S. K., Park, B. M., D'Esposito, M., Bowman, A. B., Barker, R. A. & Maglione, V., Dec 1 2018, In : Scientific Reports. 8, 1, 8266.

Research output: Contribution to journalComment/debate

Huntington Disease
sphingosine 1-phosphate

New Therapeutic Drugs from Bioactive Natural Molecules: The Role of Gut Microbiota Metabolism in Neurodegenerative Diseases

Di Meo, F., Donato, S., Di Pardo, A., Maglione, V., Filosa, S. & Crispi, S., 2018, In : Current Drug Metabolism. 19, 6, p. 478-489 12 p.

Research output: Contribution to journalReview article

Neurodegenerative diseases
Metabolism
Neurodegenerative Diseases
Brain
Molecules
3 Citations (Scopus)

Positive Effects against UV-A Induced Damage and Oxidative Stress on an in Vitro Cell Model Using a Hyaluronic Acid Based Formulation Containing Amino Acids, Vitamins, and Minerals

Stellavato, A., Pirozzi, A. V. A., Donato, S., Scognamiglio, I., Reale, S., DI Pardo, A., Filosa, S., Vassallo, V., Bellia, G., De Rosa, M. & Schiraldi, C., Jun 26 2018, In : BioMed Research International. 2018, 8481243.

Research output: Contribution to journalArticle

Oxidative stress
Hyaluronic Acid
Vitamins
Minerals
Oxidative Stress

Sphingolipid Metabolism: A New Therapeutic Opportunity for Brain Degenerative Disorders

Di Pardo, A. & Maglione, V., Apr 17 2018, In : Frontiers in Neuroscience. 12, p. 249

Research output: Contribution to journalReview article

Sphingolipids
Brain Diseases
Neurodegenerative Diseases
Therapeutics
Clinical Trials
7 Citations (Scopus)

Stimulation of S1PR5 with A-971432, a selective agonist, preserves blood-brain barrier integrity and exerts therapeutic effect in an animal model of Huntington's disease

Di Pardo, A., Castaldo, S., Amico, E., Pepe, G., Marracino, F., Capocci, L., Giovannelli, A., Madonna, M., van Bergeijk, J., Buttari, F., van der Kam, E. & Maglione, V., Jul 15 2018, In : Human Molecular Genetics. 27, 14, p. 2490-2501 12 p.

Research output: Contribution to journalArticle

Huntington Disease
Therapeutic Uses
Blood-Brain Barrier
Lysosphingolipid Receptors
Animal Models
6 Citations (Scopus)

The S1P Axis: New Exciting Route for Treating Huntington's Disease

Di Pardo, A. & Maglione, V., May 1 2018, In : Trends in Pharmacological Sciences. 39, 5, p. 468-480 13 p.

Research output: Contribution to journalReview article

Huntington Disease
Brain
Brain Diseases
Drug Delivery Systems
Neurodegenerative Diseases
2017
2 Citations (Scopus)
Neurodegenerative diseases
Blood-Brain Barrier
Fluorescein
Intravenous Infusions
Neurodegenerative Diseases
15 Citations (Scopus)
5 Downloads (Pure)

Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease

Di Pardo, A., Amico, E., Basit, A., Armirotti, A., Joshi, P., Neely, D. M., Vuono, R., Castaldo, S., Digilio, A. F., Scalabrì, F., Pepe, G., Elifani, F., Madonna, M., Jeong, S. K., Park, B. M., D'Esposito, M., Bowman, A. B., Barker, R. A. & Maglione, V., Dec 1 2017, In : Scientific Reports. 7, 1, 5280.

Research output: Contribution to journalArticle

Open Access
File
Huntington Disease
Lipids
Lipid Metabolism
Neurodegenerative Diseases
Homeostasis
9 Citations (Scopus)

De novo synthesis of sphingolipids is defective in experimental models of Huntington's disease

Pardo, A. D., Basit, A., Armirotti, A., Amico, E., Castaldo, S., Pepe, G., Marracino, F., Buttari, F., Digilio, A. F. & Maglione, V., Dec 19 2017, In : Frontiers in Neuroscience. 11, DEC, 698.

Research output: Contribution to journalArticle

Sphingolipids
Huntington Disease
Theoretical Models
Corpus Striatum
Disease Susceptibility
9 Citations (Scopus)

Disease-modifying effects of ganglioside GM1 in Huntington's disease models

Alpaugh, M., Galleguillos, D., Forero, J., Morales, L. C., Lackey, S. W., Kar, P., Di Pardo, A., Holt, A., Kerr, B. J., Todd, K. G., Baker, G. B., Fouad, K. & Sipione, S., Nov 1 2017, In : EMBO Molecular Medicine. 9, 11, p. 1537-1557 21 p.

Research output: Contribution to journalArticle

G(M1) Ganglioside
Huntington Disease
Gangliosides
Psychiatry
Mutant Proteins
1 Citation (Scopus)

Glyco-sphingo biology: A novel perspective for potential new treatments in huntington’s disease

Di Pardo, A. & Maglione, V., Sep 1 2017, In : Neural Regeneration Research. 12, 9, p. 1439-1440 2 p.

Research output: Contribution to journalComment/debate

13 Citations (Scopus)

Impairment of blood-brain barrier is an early event in R6/2 mouse model of Huntington Disease

Di Pardo, A., Amico, E., Scalabrì, F., Pepe, G., Castaldo, S., Elifani, F., Capocci, L., De Sanctis, C., Comerci, L., Pompeo, F., D'esposito, M., Filosa, S., Crispi, S. & Maglione, V., Jan 24 2017, In : Scientific Reports. 7, 41316.

Research output: Contribution to journalArticle

Huntington Disease
Blood-Brain Barrier
Tight Junctions
Brain Diseases
Neurodegenerative Diseases
1 Citation (Scopus)

Motor phenotype is not associated with vascular dysfunction in symptomatic Huntington's disease transgenic R6/2 (160 CAG) mice

Di Pardo, A., Carrizzo, A., Damato, A., Castaldo, S., Amico, E., Capocci, L., Ambrosio, M., Pompeo, F., De Sanctis, C., Spinelli, C. C., Puca, A. A., Remondelli, P., Maglione, V. & Vecchione, C., Feb 17 2017, In : Scientific Reports. 7, 42797.

Research output: Contribution to journalArticle

Huntington Disease
Blood Vessels
Phenotype
Myography
Pathology

Neuromedin U potentiates ADP- and epinephrine-induced human platelet activation

Grippi, C., Izzi, B., Gianfagna, F., Noro, F., Falcinelli, E., Di Pardo, A., Amico, E., Donati, M. B., de Gaetano, G., Iacoviello, L., Hoylaerts, M. F. & Cerletti, C., Nov 1 2017, In : Thrombosis Research. 159, p. 100-108 9 p.

Research output: Contribution to journalArticle

Platelet Activation
Adenosine Diphosphate
Epinephrine
Blood Platelets
Platelet Aggregation
5 Citations (Scopus)

Reduced bioavailable manganese causes striatal urea cycle pathology in Huntington's disease mouse model

Bichell, T. J. V., Wegrzynowicz, M., Tipps, K. G., Bradley, E. M., Uhouse, M. A., Bryan, M., Horning, K., Fisher, N., Dudek, K., Halbesma, T., Umashanker, P., Stubbs, A. D., Holt, H. K., Kwakye, G. F., Tidball, A. M., Colbran, R. J., Aschner, M., Neely, M. D., Di Pardo, A. D., Maglione, V. & 2 others, Osmand, A. & Bowman, A. B., Jun 1 2017, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1863, 6, p. 1596-1604 9 p.

Research output: Contribution to journalArticle

Corpus Striatum
Arginase
Huntington Disease
Manganese
Urea
2016
Corpus Callosum
Gangliosides
Huntington Disease
Animal Models
G(M1) Ganglioside

Terapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease

Luca, G., Bellezza, I., Arato, I., Di Pardo, A., Mancuso, F., Calvitti, M., Falabella, G., Bartoli, S., Maglione, V., Amico, E., Favellato, M., Basta, G., Bodo, M., Minelli, A., Calafiore, R., Frati, L. & Squitieri, F., Aug 1 2016, In : CNS Neuroscience and Therapeutics. 22, 8, p. 686-690 5 p.

Research output: Contribution to journalArticle

Sertoli Cells
Huntington Disease
Intraperitoneal Injections
Swine
Corpus Striatum
6 Citations (Scopus)

Terapeutic Potential of Microencapsulated Sertoli Cells in Huntington Disease

Luca, G., Bellezza, I., Arato, I., Di Pardo, A., Mancuso, F., Calvitti, M., Falabella, G., Bartoli, S., Maglione, V., Amico, E., Favellato, M., Basta, G., Bodo, M., Minelli, A., Calafiore, R., Frati, L. & Squitieri, F., Aug 1 2016, In : CNS Neuroscience and Therapeutics. 22, 8, p. 686-690 5 p.

Research output: Contribution to journalArticle

Sertoli Cells
Huntington Disease
Intraperitoneal Injections
Swine
Corpus Striatum
2015
29 Citations (Scopus)
Huntington Disease
Neuroprotective Agents
Dopamine
pridopidine
Corpus Striatum
2014
47 Citations (Scopus)

FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of huntington disease

Di Pardo, A., Amico, E., Favellato, M., Castrataro, R., Fucile, S., Squitieri, F. & Maglione, V., 2014, In : Human Molecular Genetics. 23, 9, p. 2251-2265 15 p.

Research output: Contribution to journalArticle

Huntington Disease
Inborn Genetic Diseases
Brain
Neurodegenerative Diseases
Serine
19 Citations (Scopus)

MRI measures of corpus callosum iron and myelin in early Huntington's disease

Di Paola, M., Phillips, O. R., Sanchez-Castaneda, C., Di Pardo, A., Maglione, V., Caltagirone, C., Sabatini, U. & Squitieri, F., 2014, In : Human Brain Mapping. 35, 7, p. 3143-3151 9 p.

Research output: Contribution to journalArticle

Corpus Callosum
Huntington Disease
Myelin Sheath
Iron
Echo-Planar Imaging
16 Citations (Scopus)

Nitric oxide dysregulation in platelets from patients with advanced Huntington disease

Carrizzo, A., Di Pardo, A., Maglione, V., Damato, A., Amico, E., Formisano, L., Vecchione, C. & Squitieri, F., Feb 25 2014, In : PLoS One. 9, 2, e89745.

Research output: Contribution to journalArticle

Huntington Disease
Platelets
nitric oxide
Nitric Oxide
Blood Platelets
2013
9 Citations (Scopus)

Candidate glutamatergic and dopaminergic pathway gene variants do not influence Huntington's disease motor onset

Ramos, E. M., Latourelle, J. C., Gillis, T., Mysore, J. S., Squitieri, F., Di Pardo, A., Di Donato, S., Gellera, C., Hayden, M. R., Morrison, P. J., Nance, M., Ross, C. A., Margolis, R. L., Gomez-Tortosa, E., Ayuso, C., Suchowersky, O., Trent, R. J., McCusker, E., Novelletto, A., Frontali, M. & 17 others, Jones, R., Ashizawa, T., Frank, S., Saint-Hilaire, M. H., Hersch, S. M., Rosas, H. D., Lucente, D., Harrison, M. B., Zanko, A., Abramson, R. K., Marder, K., Gusella, J. F., Lee, J. M., Alonso, I., Sequeiros, J., Myers, R. H. & MacDonald, M. E., 2013, In : Neurogenetics. 14, 3-4, p. 173-179 7 p.

Research output: Contribution to journalArticle

Huntington Disease
Minisatellite Repeats
N-Methyl-D-Aspartate Receptors
Genes
Dopamine
6 Citations (Scopus)

Changes of peripheral TGF-β1 depend on monocytes-derived macrophages in Huntington disease

Di Pardo, A., Alberti, S., Maglione, V., Amico, E., Cortes, E. P., Elifani, F., Battaglia, G., Busceti, C. L., Nicoletti, F., Vonsattel, J. P. G. & Squitieri, F., Dec 13 2013, In : Molecular Brain. 6, 1, 55.

Research output: Contribution to journalArticle

Huntington Disease
Transforming Growth Factors
Macrophages
Aptitude
Nerve Growth Factors
36 Citations (Scopus)

Synergistic effects of BDNF and rehabilitative training on recovery after cervical spinal cord injury

Weishaupt, N., Li, S., Di Pardo, A., Sipione, S. & Fouad, K., Feb 15 2013, In : Behavioural Brain Research. 239, 1, p. 31-42 12 p.

Research output: Contribution to journalArticle

Pyramidal Tracts
Brain-Derived Neurotrophic Factor
Nerve Growth Factors
Spinal Cord Injuries
Neurotrophin 3
27 Citations (Scopus)

Tractography of the Corpus Callosum in Huntington's Disease

Phillips, O., Sanchez-Castaneda, C., Elifani, F., Maglione, V., Di Pardo, A., Caltagirone, C., Squitieri, F., Sabatini, U. & Di Paola, M., Sep 3 2013, In : PLoS One. 8, 9, e73280.

Research output: Contribution to journalArticle

Corpus Callosum
Huntington Disease
image analysis
diffusivity
Diffusion tensor imaging
2012
79 Citations (Scopus)

Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice

Di Pardo, A., Maglione, V., Alpaugh, M., Horkey, M., Atwal, R. S., Sassone, J., Ciammola, A., Steffan, J. S., Fouad, K., Truant, R. & Sipione, S., Feb 28 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 9, p. 3528-3533 6 p.

Research output: Contribution to journalArticle

G(M1) Ganglioside
Huntington Disease
Phosphorylation
Intraventricular Infusions
Corpus Striatum
33 Citations (Scopus)

Liver specific inactivation of carboxylesterase 3/triacylglycerol hydrolase decreases blood lipids without causing severe steatosis in mice

Lian, J., Wei, E., Wang, S. P., Quiroga, A. D., Li, L., Pardo, A. D., van der Veen, J., Sipione, S., Mitchell, G. A. & Lehner, R., Dec 2012, In : Hepatology. 56, 6, p. 2154-2162 9 p.

Research output: Contribution to journalArticle

Carboxylesterase
Lipase
Lipids
Triglycerides
Liver
24 Citations (Scopus)

Population stratiWcation may bias analysis of PGC-1α as a modiWer of age at Huntington disease motor onset

Ramos, E. M., Latourelle, J. C., Lee, J. H., Gillis, T., Mysore, J. S., Squitieri, F., Di Pardo, A., Di Donato, S., Hayden, M. R., Morrison, P. J., Nance, M., Ross, C. A., Margolis, R. L., Gomez-Tortosa, E., Ayuso, C., Suchowersky, O., Trent, R. J., McCusker, E., Novelletto, A., Frontali, M. & 16 others, Jones, R., Ashizawa, T., Frank, S., Saint-Hilaire, M. H., Hersch, S. M., Rosas, H. D., Lucente, D., Harrison, M. B., Zanko, A., Marder, K., Gusella, J. F., Lee, J. M., Alonso, I., Sequeiros, J., Myers, R. H. & MacDonald, M. E., Dec 2012, In : Human Genetics. 131, 12, p. 1833-1840 8 p.

Research output: Contribution to journalArticle

Huntington Disease
Gene Frequency
Population
Single Nucleotide Polymorphism
Alleles
24 Citations (Scopus)

β-amyloid inhibits protein prenylation and induces cholesterol sequestration by impairing SREBP-2 cleavage

Mohamed, A., Saavedra, L., di Pardo, A., Sipione, S. & de Chaves, E. P., May 9 2012, In : Journal of Neuroscience. 32, 19, p. 6490-6500 11 p.

Research output: Contribution to journalArticle

Sterol Regulatory Element Binding Protein 2
Protein Prenylation
Amyloidogenic Proteins
Cholesterol
Alzheimer Disease
2010
63 Citations (Scopus)

Impaired ganglioside metabolism in Huntington's disease and neuroprotective role of GM1

Maglione, V., Marchi, P., Di Pardo, A., Lingrell, S., Horkey, M., Tidmarsh, E. & Sipione, S., Mar 17 2010, In : Journal of Neuroscience. 30, 11, p. 4072-4080 9 p.

Research output: Contribution to journalArticle

Gangliosides
Huntington Disease
G(M1) Ganglioside
Corpus Striatum
Disease Susceptibility
18 Citations (Scopus)

Mutant Huntingtin induces activation of the Bcl-2/adenovirus E1B 19-kDa interacting protein (BNip3)

Sassone, J., Colciago, C., Marchi, P., Ascardi, C., Alberti, L., Di Pardo, A., Zippel, R., Sipione, S., Silani, V. & Ciammola, A., Jan 2010, In : Cell Death and Disease. 1, 1, e7.

Research output: Contribution to journalArticle

Huntington Disease
Adenoviridae
Proteins
Dimerization
Muscle Cells

Resistin impairs insulin-evoked vasodilation (Diabetes (2008) 57 (577-583))

Gentile, M. T., Vecchione, C., Marino, G., Aretini, A., Di Pardo, A., Antenucci, G., Maffei, A., Cifelli, G., Iorio, L., Landolfi, A., Frati, G. & Lembo, G., Jan 2010, In : Diabetes. 59, 1, p. 319 1 p.

Research output: Contribution to journalArticle

2009
53 Citations (Scopus)

Pressure-induced vascular oxidative stress is mediated through activation of integrin-linked kinase 1/βPIX/Rac-1 pathway

Vecchione, C., Carnevale, D., Di Pardo, A., Gentile, M. T., Damato, A., Cocozza, G., Antenucci, G., Mascio, G., Bettarini, U., Landolfi, A., Iorio, L., Maffei, A. & Lembo, G., Nov 2009, In : Hypertension. 54, 5, p. 1028-1034 7 p.

Research output: Contribution to journalArticle

Blood Vessels
Oxidative Stress
Pressure
NADPH Oxidase
Carotid Arteries
62 Citations (Scopus)

Tumor necrosis factor-α mediates hemolysis-induced vasoconstriction and the cerebral vasospasm evoked by subarachnoid hemorrhage

Vecchione, C., Frati, A., Di Pardo, A., Cifelli, G., Carnevale, D., Gentile, M. T., Carangi, R., Landolfi, A., Carullo, P., Bettarini, U., Antenucci, G., Mascio, G., Busceti, C. L., Notte, A., Maffei, A., Cantore, G. P. & Lembo, G., Jul 1 2009, In : Hypertension. 54, 1, p. 150-156 7 p.

Research output: Contribution to journalArticle

Intracranial Vasospasm
Subarachnoid Hemorrhage
Hemolysis
Vasoconstriction
Tumor Necrosis Factor-alpha
77 Citations (Scopus)

β-Amyloid deposition in brain is enhanced in mouse models of arterial hypertension

Gentile, M. T., Poulet, R., Pardo, A. D., Cifelli, G., Maffei, A., Vecchione, C., Passarelli, F., Landolfi, A., Carullo, P. & Lembo, G., Feb 2009, In : Neurobiology of Aging. 30, 2, p. 222-228 7 p.

Research output: Contribution to journalArticle

Amyloid
Hypertension
Alzheimer Disease
Passive Immunization
Brain
2008
4 Citations (Scopus)

Enhanced expression of Harvey ras induced by serum deprivation in cultured astrocytes

Messina, S., Molinaro, G., Bruno, V., Battaglia, G., Spinsanti, P., Pardo, A. D., Nicoletti, F., Frati, L. & Porcellini, A., Jul 2008, In : Journal of Neurochemistry. 106, 2, p. 551-559 9 p.

Research output: Contribution to journalArticle

Astrocytes
Mitogen-Activated Protein Kinases
Serum
Reactive Oxygen Species
Chemical activation
50 Citations (Scopus)

Resistin impairs insulin-evoked vasodilation

Gentile, M. T., Vecchione, C., Marino, G., Aretini, A., Pardo, A. D., Antenucci, G., Maffei, A., Cifelli, G., Iorio, L., Landolfl, A., Frati, G. & Lembo, G., Mar 2008, In : Diabetes. 57, 3, p. 577-583 7 p.

Research output: Contribution to journalArticle

Resistin
Vasodilation
Insulin
Blood Vessels
Nitric Oxide Synthase Type III
2007
114 Citations (Scopus)

DNA damage, homology-directed repair, and DNA methylation.

Cuozzo, C., Porcellini, A., Angrisano, T., Morano, A., Lee, B., Di Pardo, A., Messina, S., Iuliano, R., Fusco, A., Santillo, M. R., Muller, M. T., Chiariotti, L., Gottesman, M. E. & Avvedimento, E. V., Jul 2007, In : PLoS Genetics. 3, 7

Research output: Contribution to journalArticle

methylation
DNA methylation
DNA Methylation
Green Fluorescent Proteins
homology
56 Citations (Scopus)

Nebivolol induces nitric oxide release in the heart through inducible nitric oxide synthase activation

Maffei, A., Di Pardo, A., Carangi, R., Carullo, P., Poulet, R., Gentile, M. T., Vecchione, C. & Lembo, G., Oct 2007, In : Hypertension. 50, 4, p. 652-656 5 p.

Research output: Contribution to journalArticle

Nebivolol
Nitric Oxide Synthase Type II
Nitric Oxide
Nitric Oxide Synthase
Adrenergic Receptors
41 Citations (Scopus)

The p85 regulatory subunit of PI3K mediates TSH-cAMP-PKA growth and survival signals

De Gregorio, G., Coppa, A., Cosentino, C., Ucci, S., Messina, S., Nicolussi, A., D'Inzeo, S., Di Pardo, A., Avvedimento, E. V. & Porcellini, A., Mar 29 2007, In : Oncogene. 26, 14, p. 2039-2047 9 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Thyrotropin
Cyclic AMP-Dependent Protein Kinases
Growth
Serine