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Research Output

1998

Schedule-selective biochemical modulation of 5-fluorouracil in advanced colorectal cancer: A multicentric phase II study

Aschele, C., Guglielmi, A., Frassineti, G. L., Milandri, C., Amadori, D., Labianca, R., Vinci, M., Tixi, L., Caroti, C., Ciferri, E., Verdi, E., Rosso, R. & Sobrero, A., 1998, In : British Journal of Cancer. 77, 2, p. 341-346 6 p.

Research output: Contribution to journalArticle

1997

Fluorouracil in colorectal cancer - A tale of two drugs: Implications for biochemical modulation

Sobrero, A. F., Aschele, C. & Bertino, J. R., Jan 1997, In : Journal of Clinical Oncology. 15, 1, p. 368-381 14 p.

Research output: Contribution to journalArticle

Talking 'Tomudex': introduction.

Sobrero, A., Aug 1997, In : Anti-Cancer Drugs. 8 Suppl 2

Research output: Contribution to journalArticle

Talking 'Tomudex' Madrid, 19 April 1997. Introduction

Sobrero, A., 1997, In : Anti-Cancer Drugs. 8, SUPPL. 2

Research output: Contribution to journalArticle

The potential role of tomudex in the treatment of advanced colorectal cancer

Sobrero, A. F., Mar 1997, In : Tumori. 83, 2, p. 576-580 5 p.

Research output: Contribution to journalArticle

1996

Alternating bolus and continuous infusion 5-fluorouracil: A strategy to overcome resistance to this fluoropyrimidine in advanced colorectal cancer patients

Guglielmi, A., Aschele, C., Grossi, F., Tixi, L. & Sobrero, A., 1996, In : Cytotechnology. 19, 3, p. 215-219 5 p.

Research output: Contribution to journalArticle

1995

5-Fluorouracil plus 5-methyltetrahydrofolate in advanced pancreatic cancer

Bolli, E., Saccomanno, S., Mondini, G., Aschele, C., Guglielmi, A., Ligas, B., Connio, M., Mori, A., Rosso, R., Sobrero, A., Tixi, L. & Pugliese, V., Jul 1995, In : Cancer Chemotherapy and Pharmacology. 35, 4, p. 339-342 4 p.

Research output: Contribution to journalArticle

Adjuvant treatment of colorectal cancer in the elderly

Aschele, C., Guglielmi, A., Tixi, L. M., Bolli, E., Mori, A. M., Lionetto, R., Rosso, R. & Sobrero, A., 1995, In : Cancer Control. 2, 2 SUPPL., p. 36-38 3 p.

Research output: Contribution to journalArticle

How uniform are post-graduate training programs in medical oncology in the European Union?

Aschele, C., Sobrero, A., Lombardo, C. & Santi, L., 1995, In : Annals of Oncology. 6, 5, p. 441-443 3 p.

Research output: Contribution to journalArticle

In vitro synergism between 5-fluorouracil and natural β interferon in human colon carcinoma cells

Guglielmi, A., Aschele, C., Mori, A., Baldo, C., Russo, P., Debernardis, D., Valenti, M., Bruno, S., Taverna, M., Rosso, R. & Sobrero, A., 1995, In : Clinical Cancer Research. 1, 11, p. 1337-1344 8 p.

Research output: Contribution to journalArticle

Schedule-selective biochemical modulation of 5-fluorouracil: A phase II study in advanced colorectal cancer

Sobrero, A. F., Aschele, C., Guglielmi, A. P., Mori, A. M., Tixi, L. M., Bolli, E. A., Rosso, R., Mammoliti, S., Rollandi, G. A., Bertoglio, S., Bruzzi, P. & Bertino, J. R., 1995, In : Clinical Cancer Research. 1, 9, p. 955-960 6 p.

Research output: Contribution to journalArticle

The two sides of 5-fluorouracil: Bolus and continuous infusion

Aschele, C., Guglielmi, A., Mori, A., Tixi, L., Bolli, E., Ciferri, E., Fazio, S., Municino, O. & Sobrero, A., 1995, In : Journal of Experimental and Clinical Cancer Research. 14, 2 SUPPL., p. 53-59 7 p.

Research output: Contribution to journalArticle

1994

Organ distribution of glutaraldehyde treated erythrocytes in patients with hepatic metastases

Tonetto, M., Bartolini, A., Sobrero, A., Guglielmi, A., Felletti, R., Gasparini, A., Benatti, U. & De Flora, A., 1994, In : Advances in the Biosciences. 92, p. 169-176 8 p.

Research output: Contribution to journalArticle

Phase II trial of 5-fluorouracil and the natural l isomer of folinic acid in the treatment of advanced colorectal carcinoma

Rosso, R., Mazzei, T., Sobrero, A., Mini, E., Cartei, G., Conte, P., Labianca, R., Cartei, F., Falcone, A., Pancera, G., Barsanti, G., Di Costanzo, F., Guglielmi, A., Bolli, E., Tixi, L., Aschele, C., Ribecco, A. & Periti, P., 1994, In : European Journal of Cancer. 30, 3, p. 338-343 6 p.

Research output: Contribution to journalArticle

1993

Activity of continuous-infusion 5-fluorouracil in patients with advanced colorectal cancer clinically resistant to bolus 5-fluorouracil

Mori, A., Bertoglio, S., Guglielmi, A., Aschele, C., Bolli, E., Tixi, L., Rosso, R. & Sobrero, A., Mar 1993, In : Cancer Chemotherapy and Pharmacology. 33, 2, p. 179-180 2 p.

Research output: Contribution to journalArticle

Dacarbazine and fotemustine in advanced colorectal cancer

Tixi, L., Bolli, E., Guglielmi, A., Mori, A., Aschele, C., Nobile, M. T., Rosso, R. & Sobrero, A., 1993, In : European Journal of Cancer. 29, 3, p. 476 1 p.

Research output: Contribution to journalArticle

Prospective randomised trial comparing fluorouracil versus doxifluridine for the treatment of advanced colorectal cancer

Bajetta, E., Colleoni, M., Rosso, R., Sobrero, A., Amadori, D., Comella, G., Marangolo, M., Scanni, A., Lorusso, V., Calabresi, F., Bonsignori, M., Crivellari, D., Pasquini, E., Bruzzi, P., Repetto, M. & Criscuolo, D., 1993, In : European Journal of Cancer. 29, 12, p. 1658-1663 6 p.

Research output: Contribution to journalArticle

Synergism and lack of cross-resistance between short-term and continuous exposure to fluorouracil in human colon adenocarcinoma cells

Sobrero, A. F., Aschele, C., Guglielmi, A. P., Mori, A. M., Melioli, G. G., Rosso, R. & Bertino, J. R., 1993, In : Journal of the National Cancer Institute. 85, 23, p. 1937-1944 8 p.

Research output: Contribution to journalArticle

1992

Phase II study of 5-fluorouracil plus leucovorin and interferon alpha 2b in advanced colorectal cancer

Sobrero, A., Nobile, M. T., Guglielmi, A., Mori, A., Aschele, C., Bolli, E., Tixi, L., Gallo, L., Parodi, G. C., Bruzzi, P., Brema, F. & Rosso, R., 1992, In : European Journal of Cancer. 28, 4-5, p. 850-852 3 p.

Research output: Contribution to journalArticle

Randomised comparison of weekly bolus 5-fluorouracil with or without leucovorin in metastatic colorectal carcinoma

Nobile, M. T., Rosso, R., Sertoli, M. R., Rubagotti, A., Vidili, M. G., Guglielmi, A., Venturini, M., Canobbio, L., Fassio, T., Gallo, L., Galligioni, E., Gallotti, P., Bruzzi, P. & Sobrero, A., 1992, In : European Journal of Cancer. 28, 11, p. 1823-1827 5 p.

Research output: Contribution to journalArticle

Standard indication of immunotherapy for the treatnent of cancer

Boli, E., Tina, L., Wbri, A., Gugielmi, A., Awhele, C., Wviru, E. & Sobrero, A., 1992, In : Pharmacological Research. 26, SUPPL. 2, p. 100-101 2 p.

Research output: Contribution to journalArticle

Use of glutaraldehyde treated autologous human erythrocytes for hepatic targeting of doxorubicin

Tonetti, M., Zocchi, E., Guida, L., Polvani, C., Benatti, U., Biassoni, P., Romei, F., Guglielmi, A., Aschele, C., Sobrero, A. & De Flora, A., 1992, Advances in Experimental Medicine and Biology. Vol. 326. p. 307-317 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1991

La resistenza cellulare in oncologia. Prospettive terapeutiche.

Translated title of the contribution: Cell resistance in oncology. Therapeutic prospectsRosso, R., Guglielmi, A., Aschele, C., Mori, A., Tixi, L., Bolli, E. & Sobrero, A., Jan 1991, In : Giornale Italiano di Chemioterapia. 38, 1-3, p. 95-97 3 p.

Research output: Contribution to journalArticle

Liver targeting of autologous erythrocytes loaded with doxorubicin

Tonetti, M., Polvani, C., Zocchi, E., Guida, L., Benatti, U., Biassoni, P., Romei, F., Guglielmi, A., Aschele, C., Sobrero, A. & De Flora, A., 1991, In : European Journal of Cancer and Clinical Oncology. 27, 7, p. 947-948 2 p.

Research output: Contribution to journalArticle

Radiation treatment plus CCNU plus the radiosensitizer Lonidamine in malignant gliomas operated

Guglielmi, A., Bruzzone, E., Gentile, S. L., Barra, S., Mori, A., Bacigalupo, A., Rosso, R., Vitale, V., Giaretti, W., Frosina, G., Arena, G., Rossi, O., Abbondandolo, A. & Sobrero, A., 1991, In : Anticancer Research. 11, 5, p. 1779-1782 4 p.

Research output: Contribution to journalArticle

Rapid development of resistance to antifolates in vitro: Possible clinical implication

Sobrero, A., Aschele, C., Rosso, R., Nicolin, A. & Bertino, J. R., 1991, In : Journal of the National Cancer Institute. 83, 1, p. 24-28 5 p.

Research output: Contribution to journalArticle

1990

Comparison of in vitro drug sensitivity by inhibition of tritium release from [5-3H]-2'-deoxyuridine and a clonogenic assay

Aschele, C., Romanini, A., Nicolin, A., Rosso, R. & Sobrero, A., 1990, In : Anticancer Research. 10, 3, p. 759-764 6 p.

Research output: Contribution to journalArticle

Current strategies to reduce cisplatin toxicity

Sobrero, A., Guglielmi, A., Aschele, C. & Rosso, R., 1990, In : Journal of Chemotherapy. 2, 1, p. 3-7 5 p.

Research output: Contribution to journalArticle

Determinants of sensitivity and resistance to fluoropyrimidines

Aschele, C., Guglielmi, A., Maioli, D., Sobrero, A., Rosso, R. & Nicolin, A., 1990, In : Pharmacological Research. 22, SUPPL. 3, p. 1-2 2 p.

Research output: Contribution to journalArticle

Improved therapeutic index of cisplatin by procaine hydrochloride

Esposito, M., Fulco, R. A., Collecchi, P., Zicca, A., Cadoni, A., Merlo, F., Rosso, R. & Sobrero, A., 1990, In : Journal of the National Cancer Institute. 82, 8, p. 677-684 8 p.

Research output: Contribution to journalArticle

Resistance to 5-fluorouracil and 5-fluoro-2'-deoxyuridine mechanisms and clinical implications.

Sobrero, A., Aschele, C., Guglielmi, A., Nobile, M. T. & Rosso, R., Feb 1990, In : Journal of Chemotherapy. 2 Suppl 1, p. 12-16 5 p.

Research output: Contribution to journalArticle

1989

Biochemical determinants of the antineoplastic activity of fluorinated pyrimidines

Sobrero, A., Russello, O., Aschele, C., Bruzzo, C., Maioli, D., Gamba, E., Romanini, A., Nicolin, A. & Rosso, R., 1989, In : Italian Journal of Biochemistry. 38, 2, p. 152-154 3 p.

Research output: Contribution to journalArticle

Enhancement of trimetrexate cytotoxicity in vitro and in vivo by carboxypeptidase G2

Romanini, A., Sobrero, A. F., Chou, T. C., Sherwood, R. F. & Bertino, J. R., 1989, In : Cancer Research. 49, 21, p. 6019-6023 5 p.

Research output: Contribution to journalArticle

FATTIBILITA' DELLA TERAPIA ADIUVANTE INTRAPERITONEALE E SISTEMICA IN PAZIENTI OPERATI RADICALMENTE PER CARCINOMA DEL COLON

Translated title of the contribution: Feasibility study of intraperitoneal or sistemic adjuvant chemotherapy in patients with Duke's B and C colon cancerGori, A., Sobrero, A., Nobile, M. T., Vidili, M. G., Mori, A., Guglie lmi, A., Aschele, C., Sertoli, M. R., Percivale, P., Livorti, M., Berto glio, S., Torelli, P., Dogliotti, M., Anfossi, A., Gori, E., Brignole, E., Speciale, A., Rubagotti, A. & Gallo, L., 1989, In : Folia Oncologica. 12, 2, p. 118-121 4 p.

Research output: Contribution to journalArticle

Sequence-dependent enhancement of HCT-8 cell kill by trimetrexate and fluoropyrimidines: Implications for the mechanism of this interaction

Sobrero, A., Romanini, A., Russello, O., Nicolin, A., Rosso, R. & Bertino, J. R., 1989, In : European Journal of Cancer and Clinical Oncology. 25, 6, p. 977-982 6 p.

Research output: Contribution to journalArticle

SOMMINISTRAZIONE ALTERNA DI METOTREXATE E TRIMETREXATE: RIDUZIONE DEL GRADO DI RESISTENZA AGLI ANTIFOLATI IN VITRO

Translated title of the contribution: Alternating trimetrexate with methotrexate reduces the degree of resistance to antifolates in vitroAschele, C., Maioli, D., Gamba, E., Romanini, A., Vidili, M. G., Nob ile, M. T., Nicolin, A., Rosso, R. & Sobrero, A., 1989, In : Folia Oncologica. 12, 2, p. 95-100 6 p.

Research output: Contribution to journalArticle

Time-dependent interactions between 5-fluorouracil and mitomycin C on a human colon carcinoma cell line, HCT-8, in vitro

Russello, O., Romanini, A., Civalleri, D., Rosso, R., Nicolin, A. & Sobrero, A., 1989, In : European Journal of Cancer and Clinical Oncology. 25, 3, p. 571-572 2 p.

Research output: Contribution to journalArticle

TRATTAMENTO SEQUENZIALE CON METHOTREXATE 5-FLUOROURACILE + ACIDO FOLIN ICO IN PAZIENTI CON CARCINOMA DEL COLON RETTO RESISTENTI AL5-FLUOROURACILE

Translated title of the contribution: Sequential therapy with methotrexate and 5-fluorouracil in combination with folinic acid in advanced colorectal carcinomaVidili, M. G., Nobile, M. T., Aschele, C., Guglielmi Venturini, A. M., Sobrero, A. & Rosso, R., 1989, In : Folia Oncologica. 12, 3, p. 173-175 3 p.

Research output: Contribution to journalArticle

Very high dose cis-platinum (450 mg/sq m) in an infant with rhabdomyosarcoma

Haupt, R., Perin, G., Dallorso, S., Garre, M. L. & Sobrero, A., 1989, In : Anticancer Research. 9, 2, p. 427-428 2 p.

Research output: Contribution to journalArticle

1988

A randomized trial of 5-fluorouracil alone versus 5-fluorouracil and high dose leucovorin in untreated advanced colorectal cancer patients.

Nobile, M. T., Canobbio, L., Sobrero, A., Galligioni, E., Vidili, M. G., Fassio, T., Lo Re, G., Rubagotti, A., Sertoli, M. R. & Rosso, R., 1988, In : Advances in Experimental Medicine and Biology. 244, p. 213-218 6 p.

Research output: Contribution to journalArticle

Randomized trial of 5-Fluorouracil alone or combined with high dose folinic aced in advanced colorectal cancer. Preliminary report

Vidili, M. G., Nobile, M. T., Canobbio, L., Fassio, T., Rubagotti, A., Galligoni, E., Gatto, L., Michelotti, A., Sertoli, M. R., Sobrero, A. & Rosso, R., 1988, In : Folia Oncologica. 11, 2, p. 188-191 4 p.

Research output: Contribution to journalArticle

Uptake and metabolism of 5,8-dideazaisofolic acid in human colon carcinoma cells

Sobrero, A. F., McGuire, J. J. & Bertino, J. R., Mar 15 1988, In : Biochemical Pharmacology. 37, 6, p. 997-1001 5 p.

Research output: Contribution to journalArticle

1987

Design and rationale for novel antifolates

Bertino, J. R., Sobrero, A., Mini, E., Moroson, B. A. & Cashmore, A., 1987, NCI Monographs. 5 ed. p. 87-91 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mechanism of action of 5,8-dideazaisofolic acid and other quinazoline antifols in human colon carcinoma cells

McGuire, J. J., Sobrero, A. F., Hynes, J. B. & Bertino, J. R., 1987, In : Cancer Research. 47, 22, p. 5975-5981 7 p.

Research output: Contribution to journalArticle

1986

Clinical aspects of drug resistance.

Sobrero, A. & Bertino, J. R., 1986, In : Cancer Surveys. 5, 1, p. 93-107 15 p.

Research output: Contribution to journalArticle

1985

Defective facilitated diffusion of nucleosides, a primary mechanism of resistance to 5-fluoro-2'-deoxyuridine in the HCT-8 human carcinoma line

Sobrero, A. F., Moir, R. D., Bertino, J. R. & Handschumacher, R. E., 1985, In : Cancer Research. 45, 7, p. 3155-3160 6 p.

Research output: Contribution to journalArticle

Differential efficacy of trimetrexate (2,4-diamino-6-methyl-(3,4,5-trimethoxyanilino)methyl) quinazoline, JB-11, TMQ) and methotrexate (MTX) on human colon carcinoma and human leukemia cells in vitro

Mini, E., Sobrero, A., Moroson, B. A. & Bertino, J. R., 1985, Proceedings of the American Association for Cancer Research. Vol. VOL. 26.

Research output: Chapter in Book/Report/Conference proceedingChapter

Highly selective drug combination for human colon cancer cells resistant in vitro to 5-fluoro-2'-deoxyuridine

Sobrero, A. F., Handschumacher, R. E. & Bertino, J. R., 1985, In : Cancer Research. 45, 7, p. 3161-3163 3 p.

Research output: Contribution to journalArticle

Methotrexate resistant cells at targets for selective chemotherapy

Bertino, J. R., Mini, E., Sobrero, A., Moroson, B. A., Love, T., Jastreboff, M., Carmen, M., Srimatkandada, S. & Dube, S., 1985, In : Advances in Enzyme Regulation. 24, C, p. 3-11 9 p.

Research output: Contribution to journalArticle