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Research Output

2020

Fibrinogen αC-regions are not directly involved in fibrin polymerization as evidenced by a “Double-Detroit” recombinant fibrinogen mutant and knobs-mimic peptides

Duval, C., Profumo, A., Aprile, A., Salis, A., Millo, E., Damonte, G., Sandrin-Gauer, J., Ariëns, R. A. S. & Rocco, M., Jan 1 2020, (Accepted/In press) In : Journal of Thrombosis and Haemostasis.

Research output: Contribution to journalArticle

Open Access
2019

Fibrin Gels Entrapment of a Poly-Cyclodextrin Nanocarrier as a Doxorubicin Delivery System in an Orthotopic Model of Neuroblastoma: Evaluation of In Vitro Activity and In Vivo Toxicity

Viale, M., Vecchio, G., Monticone, M., Bertone, V., Giglio, V., Maric, I., Cilli, M., Bocchini, V., Profumo, A., Ponzoni, M., Emionite, L. & Rocco, M., Aug 1 2019, In : Pharmaceutical Research. 36, 8, 115.

Research output: Contribution to journalArticle

Protection of trabecular meshwork cells by eyedrops containing high concentration of polyphenols.

Sacca, S. C., Pulliero, A., La Maestra, S., Geretto, M., Profumo, A., Ilderbayev, O., Rosano, C. & Izzotti, A., 2019, In : New Frontiers in Ophtalmology. 5, p. 1-7 7 p.

Research output: Contribution to journalArticle

2018

A novel calix[4]pyrrole derivative as a potential anticancer agent that forms genotoxic adducts with DNA

Geretto, M., Ponassi, M., Casale, M., Pulliero, A., Cafeo, G., Malagreca, F., Profumo, A., Balza, E., Bersimbaev, R., Kohnke, F. H., Rosano, C. & Izzotti, A., Dec 1 2018, In : Scientific Reports. 8, 1, 11075.

Research output: Contribution to journalArticle

ATR kinase inhibitors NVP-BEZ235 and AZD6738 effectively penetrate the brain after systemic administration

Fròsina, G., Profumo, A., Marubbi, D., Marcello, D., Ravetti, J. L. & Daga, A., Apr 23 2018, In : Radiation Oncology. 13, 1, 76.

Research output: Contribution to journalArticle

Characterization of drug release from fibrin gels loaded with different pharmaceutical and experimental doxorubicin formulations

Viale, M., Monticone, M., Maric, I., Giglio, V., Profumo, A., Aprile, A., Cilli, M., Abelmoschi, M. L. & Rocco, M., Aug 1 2018, In : Pharmacological Reports. 70, 4, p. 760-765 6 p.

Research output: Contribution to journalArticle

Drug delivery systems for chemotherapeutics through selected polysaccharidic vehicles

Merli, D., Profumo, A., Quadrelli, P., Arciola, C. R. & Visai, L., 2018, In : Current Organic Chemistry. 22, 12, p. 1157-1192 36 p.

Research output: Contribution to journalArticle

Faithful animal modelling of human glioma by using primary initiating cells and its implications for radiosensitization therapy

Frosina, G., Ravetti, J. L., Corvò, R., Fella, M., Garrè, M. L., Levrero, F., Marcello, D., Marubbi, D., Morana, G., Mussap, M., Neumaier, C. E., Profumo, A., Raso, A., Rosa, F., Vagge, S., Vecchio, D., Verrico, A., Zona, G. & Daga, A., Dec 1 2018, In : Scientific Reports. 8, 1, 14191.

Research output: Contribution to journalArticle

Faithful animal modelling of human glioma by using primary initiating cells and its implications for radiosensitization therapy [ARRIVE 1]

Frosina, G., Ravetti, J. L., Corvò, R., Fella, M., Garrè, M. L., Levrero, F., Marcello, D., Marubbi, D., Morana, G., Mussap, M., Neumaier, C. E., Profumo, A., Raso, A., Rosa, F., Vagge, S., Vecchio, D., Verrico, A., Zona, G. & Daga, A., 2018, In : Scientific Reports. 8, 1

Research output: Contribution to journalArticle

Pre-Processing MALDI/TOF Mass Spectra by Using Geena 2

Romano, P., Profumo, A. & Facchiano, A., Jan 1 2018, (Accepted/In press) In : Current Protocols in Bioinformatics. e59.

Research output: Contribution to journalArticle

2017

Small molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cells

Banelli, B., Daga, A., Forlani, A., Allemanni, G., Marubbi, D., Pistillo, M. P., Profumo, A. & Romani, M., 2017, In : Oncotarget. 8, 21, p. 34896-34910 15 p.

Research output: Contribution to journalArticle

Zoledronate can induce colorectal cancer microenvironment expressing BTN3A1 to stimulate effector γδ T cells with antitumor activity

Zocchi, M. R., Costa, D., Venè, R., Tosetti, F., Ferrari, N., Minghelli, S., Benelli, R., Scabini, S., Romairone, E., Catellani, S., Profumo, A. & Poggi, A., Mar 4 2017, In : OncoImmunology. 6, 3, e1278099.

Research output: Contribution to journalArticle

Zoledronate can induce colorectal cancer microenvironment expressing BTN3A1 to stimulate effector γδ T cells with antitumor activity

Zocchi, MR., Costa, D., Venè, R., Tosetti, F., Ferrari, N., Minghelli, S., Benelli, R., Scabini, S., Romairone, E., Catellani, S., Profumo, A. & Poggi, A., 2017, In : OncoImmunology. 6, 3, e1278099.

Research output: Contribution to journalArticle

2016

Geena 2, improved automated analysis of MALDI/TOF mass spectra

Romano, P., Profumo, A., Rocco, M., Mangerini, R., Ferri, F. & Facchiano, A., Mar 2 2016, In : BMC Bioinformatics. 17, 4, 61.

Research output: Contribution to journalArticle

2015

Fibrin gels loaded with cisplatin and cisplatin-hyaluronate complexes tested in a subcutaneous human melanoma model

Viale, M., Rossi, M., Russo, E., Cilli, M., Aprile, A., Profumo, A., Santi, P., Fenoglio, C., Cafaggi, S. & Rocco, M., Dec 1 2015, In : Investigational New Drugs. 33, 6, p. 1151-1161 11 p.

Research output: Contribution to journalArticle

Host-guest chemistry of a bis-calix[4]pyrrole derivative containing a trans/cis-switchable azobenzene unit with several aliphatic bis-carboxylates

Cafeo, G., Kohnke, F. H., Mezzatesta, G., Profumo, A., Rosano, C., Villari, A. & White, A. J. P., Mar 27 2015, In : Chemistry - A European Journal. 21, 14, p. 5323-5327 5 p.

Research output: Contribution to journalArticle

Matrix-assisted laser desorption/ionisation (MALDI) TOF analysis identifies serum angiotensin II concentrations as a strong predictor of all-cause and breast cancer (BCa)-specific mortality following breast surgery

Boccardo, F., Rubagotti, A., Nuzzo, P. V., Argellati, F., Savarino, G., Romano, P., Damonte, G., Rocco, M. & Profumo, A., Nov 15 2015, In : International Journal of Cancer. 137, 10, p. 2394-2402 9 p.

Research output: Contribution to journalArticle

Pharmacokinetics, pharmacodynamics and efficacy on pediatric tumors of the glioma radiosensitizer KU60019

Vecchio, D., Daga, A., Carra, E., Marubbi, D., Raso, A., Mascelli, S., Nozza, P., Garrè, M. L., Pitto, F., Ravetti, J. L., Vagge, S., Corvò, R., Profumo, A., Baio, G., Marcello, D. & Frosina, G., Mar 15 2015, In : International Journal of Cancer. 136, 6, p. 1445-1457 13 p.

Research output: Contribution to journalArticle

2014

A comprehensive mechanism of fibrin network formation involving early branching and delayed single- to double-strand transition from coupled time-resolved X-ray/Light-scattering detection

Rocco, M., Molteni, M., Ponassi, M., Giachi, G., Frediani, M., Koutsioubas, A., Profumo, A., Trevarin, D., Cardinali, B., Vachette, P., Ferri, F. & Pérez, J., Apr 9 2014, In : Journal of the American Chemical Society. 136, 14, p. 5376-5384 9 p.

Research output: Contribution to journalArticle

Host-guest chemistry of aromatic-amide-linked bis- and tris-calix[4] pyrroles with bis-carboxylates and citrate anion

Cafeo, G., Gattuso, G., Kohnke, F. H., Papanikolaou, G., Profumo, A. & Rosano, C., Feb 3 2014, In : Chemistry - A European Journal. 20, 6, p. 1658-1668 11 p.

Research output: Contribution to journalArticle

Trastuzumab quantification in serum: A new, rapid, robust ELISA assay based on a mimetic peptide that specifically recognizes trastuzumab

Cardinali, B., Lunardi, G., Millo, E., Armirotti, A., Damonte, G., Profumo, A., Gori, S., Iacono, G., Levaggi, A. & Del Mastro, L., 2014, In : Analytical and Bioanalytical Chemistry. 406, 18, p. 4557-4561 5 p.

Research output: Contribution to journalArticle

2013

Complement C3f serum levels may predict breast cancer risk in women with gross cystic disease of the breast

Profumo, A., Mangerini, R., Rubagotti, A., Romano, P., Damonte, G., Guglielmini, P., Facchiano, A., Ferri, F., Ricci, F., Rocco, M. & Boccardo, F., Jun 24 2013, In : Journal of Proteomics. 85, p. 44-52 9 p.

Research output: Contribution to journalArticle

Fibrinogen species as resolved by HPLC-SAXS data processing within the UltraScan Solution Modeler (US-SOMO) enhanced SAS module

Brookes, E., Pérez, J., Cardinali, B., Profumo, A., Vachette, P. & Rocco, M., Dec 2013, In : Journal of Applied Crystallography. 46, 6, p. 1823-1833 11 p.

Research output: Contribution to journalArticle

Hydrodynamic characterization of recombinant human fibrinogen species

Raynal, B., Cardinali, B., Grimbergen, J., Profumo, A., Lord, S. T., England, P. & Rocco, M., Jul 2013, In : Thrombosis Research. 132, 1

Research output: Contribution to journalArticle

2012

Identification and structural characterization by LC-ESI-IONTRAP and LC-ESI-TOF of some metabolic conjugation products of homovanillic acid in urine of neuroblastoma patients

Scapolla, C., Cangemi, G., Barco, S., Barbagallo, L., Bugnone, D., Maffia, A., Melioli, G., Profumo, A., Benatti, U. & Damonte, G., Jul 2012, In : Journal of Mass Spectrometry. 47, 7, p. 816-824 9 p.

Research output: Contribution to journalArticle

2011

The application of atmospheric pressure matrix-assisted laser desorption/ionization to the analysis of long-term cryopreserved serum peptidome

Mangerini, R., Romano, P., Facchiano, A., Damonte, G., Muselli, M., Rocco, M., Boccardo, F. & Profumo, A., Oct 15 2011, In : Analytical Biochemistry. 417, 2, p. 174-181 8 p.

Research output: Contribution to journalArticle

2010

Hydrodynamic and mass spectrometry analysis of nearly-intact human fibrinogen, chicken fibrinogen, and of a substantially monodisperse human fibrinogen fragment X

Cardinali, B., Profumo, A., Aprile, A., Byron, O., Morris, G., Harding, S. E., Stafford, W. F. & Rocco, M., Jan 15 2010, In : Archives of Biochemistry and Biophysics. 493, 2, p. 157-168 12 p.

Research output: Contribution to journalArticle

2006

Identification of a new truncated form and deamidation products of fibrinopeptide B released by thrombin from human fibrinogen

Cardinali, B., Damonte, G., Melone, L., Salis, A., Tosetti, F., Rocco, M. & Profumo, A., Sep 2006, In : Thrombosis and Haemostasis. 96, 3, p. 302-308 7 p.

Research output: Contribution to journalArticle

2005

Separation of human fibrinopeptides by capillary zone electrophoresis

Profumo, A., Cardinali, B., Cuniberti, C. & Rocco, M., Feb 2005, In : Electrophoresis. 26, 3, p. 600-609 10 p.

Research output: Contribution to journalArticle

2003

Kinetics of Fibrinopeptide Release by Thrombin as a Function of CaCl 2 Concentration: Different Susceptibility of FPA and FPB and Evidence for a Fibrinogen Isoform-Specific Effect at Physiological Ca 2+ Concentration

Profumo, A., Turci, M., Damonte, G., Ferri, F., Magatti, D., Cardinali, B., Cuniberti, C. & Rocco, M., Oct 28 2003, In : Biochemistry. 42, 42, p. 12335-12348 14 p.

Research output: Contribution to journalArticle

2001

Early events in the polymerization of fibrin

Rocco, M., Bernocco, S., Turci, M., Profumo, A., Cuniberti, C. & Ferri, F., 2001, In : Annals of the New York Academy of Sciences. 936, p. 167-184 18 p.

Research output: Contribution to journalArticle

2000

Polymerization of rod-like macromolecular monomers studied by stopped- flow, multiangle light scattering: Set-up, data processing, and application to fibrin formation

Bernocco, S., Ferri, F., Profumo, A., Cuniberti, C. & Rocco, M., Jul 2000, In : Biophysical Journal. 79, 1, p. 561-583 23 p.

Research output: Contribution to journalArticle

1996

Micellar electrokinetic capillary chromatography of three natural vitamin A derivatives

Profumo, A., Profumo, V. & Vidali, G., Oct 1996, In : Electrophoresis. 17, 10, p. 1617-1621 5 p.

Research output: Contribution to journalArticle

1992

Post-transcriptional control of H3 histone variants synthesis

Ferrari, N., Pfeffer, U., Profumo, A. & Vidali, G., 1992, In : Biochemistry International. 28, 2, p. 239-248 10 p.

Research output: Contribution to journalArticle

1989

Core histone acetylation during lymphocyte activation

Profumo, A., Querzola, F. & Vidali, G., Jul 3 1989, In : FEBS Letters. 250, 2, p. 297-300 4 p.

Research output: Contribution to journalArticle