• 4040 Citations
  • 30 h-Index
1979 …2019
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Research Output 1979 2019

  • 4040 Citations
  • 30 h-Index
  • 94 Article
  • 1 Review article
2019
Glycogen Storage Disease
Macrophages
Glycogen
Liver
Proteomics
Open Access
Liver Cell Adenoma
Glycogen Storage Disease
Magnetic resonance
Glycogen
Magnetic resonance imaging

Exosomal microRNAs from longitudinal liquid biopsies for the prediction of response to induction chemotherapy in high-risk neuroblastoma patients: A proof of concept SIOPEN study

Morini, M., Cangelosi, D., Segalerba, D., Marimpietri, D., Raggi, F., Castellano, A., Fruci, D., De Mora, J. F., Cañete, A., Yáñez, Y., Viprey, V., Corrias, M. V., Carlini, B., Pezzolo, A., Schleiermacher, G., Mazzocco, K., Ladenstein, R., Sementa, A. R., Conte, M., Garaventa, A. & 5 others, Burchill, S., Luksch, R., Bosco, M. C., Eva, A. & Varesio, L., Oct 2019, In : Cancers. 11, 10, 1476.

Research output: Contribution to journalArticle

Open Access
Induction Chemotherapy
MicroRNAs
Neuroblastoma
Biopsy
Exosomes

Secondary somatic mutations in g-protein-related pathways and mutation signatures in Uveal melanoma

Piaggio, F., Tozzo, V., Bernardi, C., Croce, M., Puzone, R., Viaggi, S., Patrone, S., Barla, A., Coviello, D., Jager, M. J., Van Der Velden, P. A., Zeschnigk, M., Cangelosi, D., Eva, A., Pfeffer, U. & Amaro, A., Nov 2019, In : Cancers. 11, 11, 1688.

Research output: Contribution to journalArticle

Mutation
GTP-Binding Protein alpha Subunits
Proteins
Focal Adhesion Kinase 1
Encyclopedias
2018
4 Citations (Scopus)

CHL1 gene acts as a tumor suppressor in human neuroblastoma

Ognibene, M., Pagnan, G., Marimpietri, D., Cangelosi, D., Cilli, M., Benedetti, M. C., Boldrini, R., Garaventa, A., Frassoni, F., Eva, A., Varesio, L., Pistoia, V. & Pezzolo, A., Jan 1 2018, In : Oncotarget. 9, 40, p. 25903-25921 19 p.

Research output: Contribution to journalArticle

Neuroblastoma
Genes
Neoplasms
Heterografts
Neuronal Cell Adhesion Molecules

Development and characterization of an inducible mouse model for glycogen storage disease type Ib

Raggi, F., Pissavino, A. L., Resaz, R., Segalerba, D., Puglisi, A., Vanni, C., Antonini, F., Del Zotto, G., Gamberucci, A., Marcolongo, P., Bosco, M. C., Grillo, F., Mastracci, L. & Eva, A., Nov 2018, In : Journal of Inherited Metabolic Disease. 41, 6, p. 1015-1025 11 p.

Research output: Contribution to journalArticle

Glycogen Storage Disease
Tamoxifen
glucose 6-phosphate(transporter)
Liver Cell Adenoma
Phenotype
6 Citations (Scopus)
Transcriptome
Natural Killer Cells
Cell Movement
Interleukin-18
Chemokine Receptors
Transcriptome
Natural Killer Cells
Cell Movement
Interleukin-18
Chemokine Receptors

Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration

Parodi, M., Raggi, F., Cangelosi, D., Manzini, C., Balsamo, M., Blengio, F., Eva, A., Varesio, L., Pietra, G., Moretta, L., Mingari, M. C., Vitale, M. & Bosco, M. C., 2018, In : Frontiers in Immunology. 9, p. 2358

Research output: Contribution to journalArticle

Transcriptome
Natural Killer Cells
Cell Movement
Interleukin-18
Chemokine Receptors
2017
1 Citation (Scopus)
pyruvate dehydrogenase (acetyl-transferring) kinase
procollagen-proline dioxygenase
Prolyl Hydroxylases
Hypoxia-Inducible Factor 1
Neuroblastoma
30 Citations (Scopus)

Regulation of Human Macrophage M1-M2 Polarization Balance by Hypoxia and the Triggering Receptor Expressed on Myeloid Cells-1

Raggi, F., Pelassa, S., Pierobon, D., Penco, F., Gattorno, M., Novelli, F., Eva, A., Varesio, L., Giovarelli, M. & Bosco, M. C., 2017, In : Frontiers in Immunology. 8, p. 1097

Research output: Contribution to journalArticle

Myeloid Cells
Macrophages
Phenotype
Aptitude
Juvenile Arthritis
2016
10 Citations (Scopus)

Artificial neural network classifier predicts neuroblastoma patients' outcome

Cangelosi, D., Pelassa, S., Morini, M., Conte, M., Bosco, M. C., Eva, A., Sementa, A. R. & Varesio, L., Nov 8 2016, In : BMC Bioinformatics. 17, 347.

Research output: Contribution to journalArticle

Neuroblastoma
Artificial Neural Network
Tumors
Tumor
Classifiers
4 Citations (Scopus)

Regulation of Langerhans cell functions in a hypoxic environment

Pierobon, D., Raggi, F., Cambieri, I., Pelassa, S., Occhipinti, S., Cappello, P., Novelli, F., Musso, T., Eva, A., Castagnoli, C., Varesio, L., Giovarelli, M. & Bosco, M. C., Mar 10 2016, (Accepted/In press) In : Journal of Molecular Medicine. p. 1-13 13 p.

Research output: Contribution to journalArticle

Langerhans Cells
Hypertrophic Cicatrix
Wound Healing
Wounds and Injuries
T-Lymphocytes
2015
2 Citations (Scopus)

Dbl oncogene expression in MCF-10 a epithelial cells disrupts mammary acinar architecture, induces EMT and angiogenic factor secretion

Vanni, C., Ognibene, M., Finetti, F., Mancini, P., Cabodi, S., Segalerba, D., Torrisi, M. R., Donnini, S., Bosco, M. C., Varesio, L. & Eva, A., Feb 27 2015, In : Cell Cycle. 14, 9, p. 1426-1437 12 p.

Research output: Contribution to journalArticle

Angiogenesis Inducing Agents
Oncogenes
Breast
Epithelial Cells
Guanine Nucleotide Exchange Factors
2014
7 Citations (Scopus)

Development of hepatocellular adenomas and carcinomas in mice with liver-specific G6Pase-aα deficiency

Resaz, R., Vanni, C., Segalerba, D., Sementa, A. R., Mastracci, L., Grillo, F., Murgia, D., Bosco, M. C., Chou, J. Y., Barbieri, O., Varesio, L. & Eva, A., Sep 1 2014, In : DMM Disease Models and Mechanisms. 7, 9, p. 1083-1091 9 p.

Research output: Contribution to journalArticle

Glycogen Storage Disease Type I
Liver Cell Adenoma
Glucose-6-Phosphatase
Glycogen
Liver
3 Citations (Scopus)

Identification of a novel mouse Dbl proto-oncogene splice variant: Evidence that SEC14 domain is involved in GEF activity regulation

Ognibene, M., Vanni, C., Blengio, F., Segalerba, D., Mancini, P., De Marco, P., Torrisi, M. R., Bosco, M. C., Varesio, L. & Eva, A., Mar 10 2014, In : Gene. 537, 2, p. 220-229 10 p.

Research output: Contribution to journalArticle

Proto-Oncogenes
Exons
Rho Guanine Nucleotide Exchange Factors
Brain
Gonads
11 Citations (Scopus)
Regulator Genes
Vascular Endothelial Growth Factor A
Monocytes
Macrophages
Hypoxia-Inducible Factor 1
2013
17 Citations (Scopus)

Bradykinin-induced asthmatic fibroblast/myofibroblast activities via bradykinin B2 receptor and different MAPK pathways

Sabatini, F., Luppi, F., Petecchia, L., Stefano, A. D., Longo, A. M., Eva, A., Vanni, C., Hiemstra, P. S., Sterk, P. J., Sorbello, V., Fabbri, L. M., Rossi, G. A. & Ricciardolo, F. L. M., Jun 15 2013, In : European Journal of Pharmacology. 710, 1-3, p. 100-109 10 p.

Research output: Contribution to journalArticle

Bradykinin B2 Receptors
Myofibroblasts
Bradykinin
Mitogen-Activated Protein Kinases
Fibroblasts
30 Citations (Scopus)

Chronic hypoxia reprograms human immature dendritic cells by inducing a proinflammatory phenotype and TREM-1 expression

Pierobon, D., Bosco, M. C., Blengio, F., Raggi, F., Eva, A., Filippi, M., Musso, T., Novelli, F., Cappello, P., Varesio, L. & Giovarelli, M., Apr 2013, In : European Journal of Immunology. 43, 4, p. 949-966 18 p.

Research output: Contribution to journalArticle

Dendritic Cells
Up-Regulation
T-Lymphocytes
Phenotype
Pattern Recognition Receptors
12 Citations (Scopus)

Logic learning machine creates explicit and stable rules stratifying neuroblastoma patients

Cangelosi, D., Blengio, F., Versteeg, R., Eggert, A., Garaventa, A., Gambini, C., Conte, M., Eva, A., Muselli, M. & Varesio, L., Apr 22 2013, In : BMC Bioinformatics. 14, SUPPL7, S12.

Research output: Contribution to journalArticle

Neuroblastoma
Learning systems
Tumors
Tumor
Risk Factors
30 Citations (Scopus)

The hypoxic environment reprograms the cytokine/chemokine expression profile of human mature dendritic cells

Blengio, F., Raggi, F., Pierobon, D., Cappello, P., Eva, A., Giovarelli, M., Varesio, L. & Bosco, M. C., Jan 2013, In : Immunobiology. 218, 1, p. 76-89 14 p.

Research output: Contribution to journalArticle

Chemokines
Dendritic Cells
Cytokines
Monocytes
Inflammation
2012
12 Citations (Scopus)

Design of a multi-signature ensemble classifier predicting neuroblastoma patients' outcome

Cornero, A., Acquaviva, M., Fardin, P., Versteeg, R., Schramm, A., Eva, A., Bosco, M. C., Blengio, F., Barzaghi, S. & Varesio, L., Mar 28 2012, In : BMC Bioinformatics. 13, SUPPL.4, S13.

Research output: Contribution to journalArticle

Multisignature
Ensemble Classifier
Neuroblastoma
Classifiers
Signature
2011
3 Citations (Scopus)

High frequency of development of B cell lymphoproliferation and diffuse large B cell lymphoma in Dbl knock-in mice

Ognibene, M., Barbieri, O., Vanni, C., Mastracci, L., Astigiano, S., Emionite, L., Salani, B., Fedele, M., Resaz, R., Tenca, C., Fais, F., Sabatini, F., De Santanna, A., Altruda, F., Varesio, L., Hirsch, E. & Eva, A., May 2011, In : Journal of Molecular Medicine. 89, 5, p. 493-504 12 p.

Research output: Contribution to journalArticle

Lymphoma, Large B-Cell, Diffuse
B-Lymphocytes
Missense Mutation
Mutant Strains Mice
Phenotype
73 Citations (Scopus)

Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: Identification of TREM-1 as a novel hypoxic marker in vitro and in vivo

Bosco, M. C., Pierobon, D., Blengio, F., Raggi, F., Vanni, C., Gattorno, M., Eva, A., Novelli, F., Cappello, P., Giovarelli, M. & Varesio, L., Mar 3 2011, In : Blood. 117, 9, p. 2625-2639 15 p.

Research output: Contribution to journalArticle

Transcriptome
Gene expression
Dendritic Cells
Genes
Phosphorylation
4 Citations (Scopus)

The tumor suppressor hamartin enhances Dbl protein transforming activity through interaction with ezrin

Ognibene, M., Vanni, C., Segalerba, D., Mancini, P., Merello, E., Torrisi, M. R., Bosco, M. C., Varesio, L. & Eva, A., Aug 26 2011, In : Journal of Biological Chemistry. 286, 34, p. 29973-29983 11 p.

Research output: Contribution to journalArticle

Tumors
Neoplasms
Proteins
Rho Guanine Nucleotide Exchange Factors
tuberous sclerosis complex 1 protein
5 Citations (Scopus)

Treatment of newborn G6pc -/- mice with bone marrow-derived myelomonocytes induces liver repair

Resaz, R., Emionite, L., Vanni, C., Astigiano, S., Puppo, M., Lavieri, R., Segalerba, D., Pezzolo, A., Bosco, M. C., Oberto, A., Eva, C., Chou, J. Y., Varesio, L., Barbieri, O. & Eva, A., Dec 2011, In : Journal of Hepatology. 55, 6, p. 1263-1271 9 p.

Research output: Contribution to journalArticle

Bone Marrow
Liver
Knockout Mice
Hepatocytes
Glucose-6-Phosphatase
2010
55 Citations (Scopus)

A biology-driven approach identifies the hypoxia gene signature as a predictor of the outcome of neuroblastoma patients

Fardin, P., Barla, A., Mosci, S., Rosasco, L., Verri, A., Versteeg, R., Caron, H. N., Molenaar, J. J., Øra, I., Eva, A., Puppo, M. & Varesio, L., Jul 12 2010, In : Molecular Cancer. 9, 185.

Research output: Contribution to journalArticle

Neuroblastoma
Genes
Neoplasms
Gene Expression
Tumor Microenvironment
12 Citations (Scopus)

Mechanisms of bradykinin-induced contraction in human fetal lung fibroblasts

Petecchia, L., Sabatini, F., Usai, C., Carnevali, S., Ognibene, M., Vanni, C., Eva, A., Fabbri, L. M., Rossi, G. A. & Ricciardolo, F. L. M., Sep 2010, In : European Respiratory Journal. 36, 3, p. 655-664 10 p.

Research output: Contribution to journalArticle

Bradykinin
Actins
Fibroblasts
Smooth Muscle
Lung
38 Citations (Scopus)

p130Cas is an essential transducer element in ErbB2 transformation

Cabodi, S., Tinnirello, A., Bisaro, B., Tornillo, G., Camacho-Leal, M. D. P., Forni, G., Cojoca, R., Iezzi, M., Amici, A., Montani, M., Eva, A., Di Stefano, P., Muthuswamy, S. K., Tarone, G., Turco, E. & Defilippi, P., 2010, In : FASEB Journal. 24, 10, p. 3796-3808 13 p.

Research output: Contribution to journalArticle

Transducers
Tumors
Breast Neoplasms
Chemical activation
Cells
2009
2 Citations (Scopus)

Induction of epithelial mesenchimal transition and vasculogenesis in the lenses of Dbl oncogene transgenic mice

Fardin, P., Ognibene, M., Vanni, C., De Santanna, A., Varesio, L. & Eva, A., Sep 16 2009, In : PLoS One. 4, 9, e7058.

Research output: Contribution to journalArticle

oncogenes
Lens
Oncogenes
Transgenic Mice
Lenses
2008
51 Citations (Scopus)

Human dendritic cells differentiated in hypoxia down-modulate antigen uptake and change their chemokine expression profile

Elia, A. R., Cappello, P., Puppo, M., Fraone, T., Vanni, C., Eva, A., Musso, T., Novelli, F., Varesio, L. & Giovarelli, M., Dec 1 2008, In : Journal of Leukocyte Biology. 84, 6, p. 1472-1482 11 p.

Research output: Contribution to journalArticle

Chemokines
Dendritic Cells
Antigens
Monocytes
Hypoxia
57 Citations (Scopus)

Transcriptome of hypoxic immature dendritic cells: Modulation of chemokine/receptor expression

Ricciardi, A., Elia, A. R., Cappello, P., Puppo, M., Vanni, C., Fardin, P., Eva, A., Munroe, D., Wu, X., Giovarelli, M. & Varesio, L., Feb 1 2008, In : Molecular Cancer Research. 6, 2, p. 175-185 11 p.

Research output: Contribution to journalArticle

Chemokine Receptors
Transcriptome
Dendritic Cells
Chemokines
Cell Movement
2007
11 Citations (Scopus)

Gα13 regulation of proto-Dbl signaling

Vanni, C., Mancini, P., Ottaviano, C., Ognibene, M., Parodi, A., Merello, E., Russo, C., Varesio, L., Zheng, Y., Torrisi, M. R. & Eva, A., Aug 15 2007, In : Cell Cycle. 6, 16, p. 2058-2070 13 p.

Research output: Contribution to journalArticle

G12-G13 GTP-Binding Protein alpha Subunits
G-Protein-Coupled Receptors
Rho Guanine Nucleotide Exchange Factors
rho GTP-Binding Proteins
GTP Phosphohydrolases
20 Citations (Scopus)

Induction of macrophage glutamine: Fructose-6-phosphate amidotransferase expression by hypoxia and by picolinic acid

Manzari, B., Kudlow, J. E., Fardin, P., Merello, E., Ottaviano, C., Puppo, M., Eva, A. & Varesio, L., Jan 2007, In : International Journal of Immunopathology and Pharmacology. 20, 1, p. 47-58 12 p.

Research output: Contribution to journalArticle

Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)
Macrophages
Deferoxamine
Hexosamines
Hypoxia-Inducible Factor 1
38 Citations (Scopus)

Recruitment of Dbl by ezrin and dystroglycan drives membrane proximal Cdc42 activation and filopodia formation

Batchelor, C. L., Higginson, J. R., Chen, Y. J., Vanni, C., Eva, A. & Winder, S. J., Feb 1 2007, In : Cell Cycle. 6, 3, p. 353-363 11 p.

Research output: Contribution to journalArticle

Dystroglycans
Pseudopodia
Chemical activation
Membranes
ezrin
2006
1 Citation (Scopus)

Growth arrest-inducing genes are activated in Dbl-transformed mouse fibroblasts

Melani, R., Sallustio, F., Fardin, P., Vanni, C., Ognibene, M., Ottaviano, C., Melillo, G., Varesio, L. & Eva, A., 2006, In : Gene Expression. 13, 3, p. 155-165 11 p.

Research output: Contribution to journalArticle

Oncogenes
Fibroblasts
Growth
Genes
Guanine Nucleotide Exchange Factors
5 Citations (Scopus)

Inhibition of PI3K induces Rac activation and membrane ruffling in proto-Dbl expressing cells

Vanni, C., Visco, V., Mancini, P., Parodi, A., Ottaviano, C., Ognibene, M., Manazza, A. D., Retta, S. F., Varesio, L., Torrisi, M. R. & Eva, A., Nov 15 2006, In : Cell Cycle. 5, 22, p. 2657-2665 9 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Chemical activation
Membranes
Cell Movement
Guanine Nucleotide Exchange Factors
2005
15 Citations (Scopus)

Constitutively active Cdc42 mutant confers growth disadvantage in cell transformation

Vanni, C., Ottaviano, C., Guo, F., Puppo, M., Varesio, L., Zheng, Y. & Eva, A., Nov 2005, In : Cell Cycle. 4, 11, p. 1673-1680 8 p.

Research output: Contribution to journalArticle

Chemical activation
Cell proliferation
Growth
Guanosine Triphosphate
Cell Proliferation

Constitutively active Cdc42 mutant confers growth disadvantage in cell transformation.

Vanni, C., Ottaviano, C., Guo, F., Puppo, M., Varesio, L., Zheng, Y. & Eva, A., Nov 2005, In : Cell Cycle. 4, 11, p. 1675-1682 8 p.

Research output: Contribution to journalArticle

Growth
Guanosine Triphosphate
Cell Proliferation
ras Proteins
Cell Polarity
10 Citations (Scopus)

Newborn liver gene transfer by an HIV-2-based lentiviral vector

Salani, B., Damonte, P., Zingone, A., Barbieri, O., Chou, J. Y., D'Costa, J., Arya, S. K., Eva, A. & Varesio, L., May 2005, In : Gene Therapy. 12, 10, p. 803-814 12 p.

Research output: Contribution to journalArticle

HIV-2
Liver
Genes
Genetic Therapy
Viruses
2004
22 Citations (Scopus)

Phosphorylation-independent membrane relocalization of ezrin following association with Dbl in vivo

Vanni, C., Parodi, A., Mancini, P., Visco, V., Ottaviano, C., Torrisi, M. R. & Eva, A., May 20 2004, In : Oncogene. 23, 23, p. 4098-4106 9 p.

Research output: Contribution to journalArticle

Phosphorylation
Membranes
Proteins
Cell Membrane
Rho Guanine Nucleotide Exchange Factors
2002
26 Citations (Scopus)

Defective dendrite elongation but normal fertility in mice lacking the rho-like GTPase activator Dbl

Hirsch, E., Pozzato, M., Vercelli, A., Barberis, L., Azzolino, O., Russo, C., Vanni, C., Silengo, L., Eva, A. & Altruda, F., 2002, In : Molecular and Cellular Biology. 22, 9, p. 3140-3148 9 p.

Research output: Contribution to journalArticle

GTP Phosphohydrolase Activators
rho GTP-Binding Proteins
Dendrites
Fertility
Gametogenesis
30 Citations (Scopus)

Regulation of proto-Dbl by intracellular membrane targeting and protein stability

Vanni, C., Mancini, P., Gao, Y., Ottaviano, C., Guo, F., Salani, B., Torrisi, M. R., Zheng, Y. & Eva, A., May 31 2002, In : Journal of Biological Chemistry. 277, 22, p. 19745-19753 9 p.

Research output: Contribution to journalArticle

Intracellular Membranes
Protein Stability
Guanine Nucleotide Exchange Factors
Membrane Proteins
Membranes
47 Citations (Scopus)

The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading

Degani, S., Balzac, F., Brancaccio, M., Guazzone, S., Retta, S. F., Silengo, L., Eva, A. & Tarone, G., Jan 21 2002, In : Journal of Cell Biology. 156, 2, p. 377-387 11 p.

Research output: Contribution to journalArticle

rho GTP-Binding Proteins
Integrins
GTP Phosphohydrolases
Cell-Matrix Junctions
Intrinsic Factor
2001
67 Citations (Scopus)

Autoinhibition mechanism of proto-Dbl

Bi, F., Debreceni, B., Zhu, K., Salani, B., Eva, A. & Zheng, Y., 2001, In : Molecular and Cellular Biology. 21, 5, p. 1463-1474 12 p.

Research output: Contribution to journalArticle

Guanine Nucleotide Exchange Factors
Rho Guanine Nucleotide Exchange Factors
rho GTP-Binding Proteins
Stress Fibers
Sequence Homology
63 Citations (Scopus)

Modulation of Oncogenic DBL Activity by Phosphoinositol Phosphate Binding to Pleckstrin Homology Domain

Russo, C., Gao, Y., Mancini, P., Vanni, C., Porotto, M., Falasca, M., Torrisi, M. R., Zheng, Y. & Eva, A., Jun 1 2001, In : Journal of Biological Chemistry. 276, 22, p. 19524-19531 8 p.

Research output: Contribution to journalArticle

Guanine Nucleotide Exchange Factors
Phosphates
Modulation
Cell membranes
Phosphatidylinositols

Ricerca di base e terapie innovative

Translated title of the contribution: Basic research and innovative therapiesEva, A., Bosco, M. C. & Varesio, L., 2001, In : Gaslini. 33, 3, p. 268-280 13 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Utilizzo di microarray di DNA per analizzare l'espressione genica

Translated title of the contribution: Expression profiling using cDNA microarraysMelani, R., Eva, A. & Varesio, L., 2001, In : Gaslini. 33, 1, p. 105-112 8 p.

Research output: Contribution to journalArticle

Oligonucleotide Array Sequence Analysis
Genes
Gene Expression
Gene Expression Profiling
Biomarkers
2000
21 Citations (Scopus)

Distinct involvement of Cdc42 and RhoA GTPases in actin organization and cell shape in untransformed and Dbl oncogene transformed NIH3T3 cells

Olivo, C., Vanni, C., Mancini, P., Silengo, L., Torrisi, M. R., Tarone, G., Defilippi, P. & Eva, A., Mar 9 2000, In : Oncogene. 19, 11, p. 1428-1436 9 p.

Research output: Contribution to journalArticle

Cell Shape
GTP Phosphohydrolases
Oncogenes
Actins
Stress Fibers