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2019

Identification of a Shared Microbiomic and Metabolomic Profile in Systemic Autoimmune Diseases

Bellocchi, C., Fernández-Ochoa, Á., Montanelli, G., Vigone, B., Santaniello, A., Quirantes-Piné, R., Borrás-Linares, I., Gerosa, M., Artusi, C., Gualtierotti, R., Segura-Carrettero, A., Alarcón-Riquelme, M. E. & Beretta, L., Aug 23 2019, In : Journal of Clinical Medicine. 8, 9, E1291.

Research output: Contribution to journalArticle

Iloprost use and medical management of systemic sclerosis-related vasculopathy in Italian tertiary referral centers: results from the PROSIT study

Negrini, S., Magnani, O., Matucci-Cerinic, M., Carignola, R., Data, V., Montabone, E., Santaniello, A., Adorni, G., Murdaca, G., Puppo, F., Indiveri, F., Della Rossa, A., D’Ascanio, A., Barsotti, S., Giuggioli, D., Ferri, C., Lumetti, F., Bosello, S. L., Canestrari, G., Bellando Randone, S. & 6 others, Bruni, C., Guiducci, S., Battaglia, E., De Andres, M. I., Russo, A. A. & Beretta, L., Jan 1 2019, In : Clinical and Experimental Medicine. 19, 3, p. 357-366

Research output: Contribution to journalArticle

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Patsopoulos, N. A., Baranzini, S. E., Santaniello, A., Shoostari, P., Cotsapas, C., Wong, G., Beecham, A. H., James, T., Replogle, J., Vlachos, I. S., McCabe, C., Pers, T. H., Brandes, A., White, C., Keenan, B., Cimpean, M., Winn, P., Panteliadis, I-P., Robbins, A., Andlauer, T. F. M. & 136 others, Zarzycki, O., Dubois, B., Goris, A., Søndergaard, H. B., Sellebjerg, F., Sorensen, P. S., Ullum, H., Thørner, L. W., Saarela, J., Cournu-Rebeix, I., Damotte, V., Fontaine, B., Guillot-Noel, L., Lathrop, M., Vukusic, S., Berthele, A., Pongratz, V., Buck, D., Gasperi, C., Graetz, C., Grummel, V., Hemmer, B., Hoshi, M., Knier, B., Korn, T., Lill, C. M., Luessi, F., Mühlau, M., Zipp, F., Dardiotis, E., Agliardi, C., Amoroso, A., Barizzone, N., Benedetti, M. D., Bernardinelli, L., Cavalla, P., Clarelli, F., Comi, G., Cusi, D., Esposito, F., Ferrè, L., Galimberti, D., Guaschino, C., Leone, M. A., Martinelli, V., Moiola, L., Salvetti, M., Sorosina, M., Vecchio, D., Zauli, A., Santoro, S., Mancini, N., Zuccalà, M., Mescheriakova, J., Van Duijn, C., Bos, S. D., Celius, E. G., Spurkland, A., Comabella, M., Montalban, X., Alfredsson, L., Bomfim, I. L., Gomez-Cabrero, D., Hillert, J., Jagodic, M., Lindén, M., Piehl, F., Jelčić, I., Martin, R., Sospedra, M., Baker, A., Ban, M., Hawkins, C., Hysi, P., Kalra, S., Karpe, F., Khadake, J., Lachance, G., Molyneux, P., Neville, M., Thorpe, J., Bradshaw, E., Caillier, S. J., Calabresi, P., Cree, B. A. C., Cross, A., Davis, M., De Bakker, P. W. I., Delgado, S., Dembele, M., Edwards, K., Fitzgerald, K., Frohlich, I. Y., Gourraud, P-A., Haines, J. L., Hakonarson, H., Kimbrough, D., Isobe, N., Konidari, I., Lathi, E., Lee, M. H., Li, T., An, D., Zimmer, A., Madireddy, L., Manrique, C. P., Mitrovic, M., Olah, M., Patrick, E., Pericak-Vance, M. A., Piccio, L., Schaefer, C., Weiner, H., Lage, K., Compston, A., Hafler, D., Harbo, H. F., Hauser, S. L., Stewart, G., D’Alfonso, S., Hadjigeorgiou, G., Taylor, B., Barcellos, L. F., Booth, D., Hintzen, R., Kockum, I., Martinelli-Boneschi, F., McCauley, J. L., Oksenberg, J. R., Oturai, A., Sawcer, S., Ivinson, A. J., Olsson, T., De Jager, P. L., Consortium, I. M. S. G. & ANZgene IIBDGC, WTCCC., 2019, In : Science. 365, 6460

Research output: Contribution to journalArticle

2018

Microbial and metabolic multi-omic correlations in systemic sclerosis patients

Bellocchi, C., Fernández-Ochoa, Á., Montanelli, G., Vigone, B., Santaniello, A., Milani, C., Quirantes-Piné, R., Borrás-Linares, I., Ventura, M., Segura-Carrettero, A., Alarcón-Riquelme, M. E. & Beretta, L., 2018, In : Annals of the New York Academy of Sciences. 1421, 1, p. 97-109

Research output: Contribution to journalArticle

2017

An MIF promoter polymorphism is associated with susceptibility to pulmonary arterial hypertension in diffuse cutaneous systemic sclerosis

Bossini-Castillo, L., Campillo-Davo, D., Lopez-Isac, E., Carmona, F. D., Simeon, C. P., Carreira, P., Callejas-Rubio, J. L., Castellvi, I., Fernandez-Nebro, A., Rodriguez-Rodriguez, L., Rubio-Rivas, M., Garcia-Hernandez, F. J., Madronero, A. B., Beretta, L., Santaniello, A., Lunardi, C., Airo, P., Hoffmann-Vold, A. M., Kreuter, A., Riemekasten, G. & 11 others, Witte, T., Hunzelmann, N., Vonk, M. C., Voskuyl, A. E., De Vries-Bouwstra, J., Shiels, P., Herrick, A., Worthington, J., Radstake, T. R. D. J., Martin, J. & Spanish Scleroderma Group, Oct 1 2017, In : Journal of Rheumatology. 44, 10, p. 1453-1457 5 p.

Research output: Contribution to journalArticle

Drusen-like Deposits in Young Adults Diagnosed With Systemic Lupus Erythematosus

Invernizzi, A., dell'Arti, L., Leone, G., Galimberti, D., Garoli, E., Moroni, G., Santaniello, A., Agarwal, A. & Viola, F., Mar 1 2017, In : American Journal of Ophthalmology. 175, p. 68-76 9 p.

Research output: Contribution to journalArticle

2016

Brief Report: IRF4 Newly Identified as a Common Susceptibility Locus for Systemic Sclerosis and Rheumatoid Arthritis in a Cross-Disease Meta-Analysis of Genome-Wide Association Studies

López-Isac, E., Martín, J. E., Assassi, S., Simeón, C. P., Carreira, P., Ortego-Centeno, N., Freire, M., Beltrán, E., Narváez, J., Alegre-Sancho, J. J., Fernández-Gutiérrez, B., Balsa, A., Ortiz, A. M., González-Gay, M. A., Beretta, L., Santaniello, A., Bellocchi, C., Lunardi, C., Moroncini, G., Gabrielli, A. & 31 others, Witte, T., Hunzelmann, N., Distler, J. H. W., Riekemasten, G., van der Helm-van Mil, A. H., de Vries-Bouwstra, J., Magro-Checa, C., Voskuyl, A. E., Vonk, M. C., Molberg, Ø., Merriman, T., Hesselstrand, R., Nordin, A., Padyukov, L., Herrick, A., Eyre, S., Koeleman, B. P. C., Denton, C. P., Fonseca, C., Radstake, T. R. D. J., Worthington, J., Mayes, M. D., Martín, J., Ríos, R., Callejas, J. L., Hitos, J. A. V., Portales, R. G., Camps, M. T., Fernández-Nebro, A., González-Escribano, M. F. & the Spanish Scleroderma Group, Sep 1 2016, In : Arthritis and Rheumatology. 68, 9, p. 2338-2344 7 p.

Research output: Contribution to journalArticle

Influence of TYK2 in systemic sclerosis susceptibility: A new locus in the IL-12 pathway

López-Isac, E., Campillo-Davo, D., Bossini-Castillo, L., Guerra, S. G., Assassi, S., Simeón, C. P., Carreira, P., Ortego-Centeno, N., de la Peña, P. G., Beretta, L., Santaniello, A., Bellocchi, C., Lunardi, C., Moroncini, G., Gabrielli, A., Riemekasten, G., Witte, T., Hunzelmann, N., Kreuter, A., Distler, J. H. W. & 53 others, Voskuyl, A. E., de Vries-Bouwstra, J., Herrick, A., Worthington, J., Denton, C. P., Fonseca, C., Radstake, T. R. D. J., Mayes, M. D., Martín, J., Ríos, R., Callejas, J. L., Hitos, J. A. V., Portales, R. G., Camps, M. T., Fernández-Nebro, A., González-Escribano, M. F., García-Hernández, F. J., Castillo, M. J., Aguirre, M. Á., Gómez-Gracia, I., Fernández-Gutiérrez, B., Rodríguez-Rodríguez, L., Vicente, E., Andreu, J. L., de Castro, M. F., López-Longo, F. J., Martínez, L., Fonollosa, V., Guillén, A., Castellví, I., Espinosa, G., Tolosa, C., Pros, A., Carballeira, M. R., Narváez, F. J., Rivas, M. R., Santamaría, V. O., Madroñero, A. B., González-Gay, M. Á., Díaz, B., Trapiella, L., Freire, M., Sousa, A., Egurbide, M. V., Mateo, P. F., Sáez-Comet, L., Díaz, F., Hernánde, V., Beltrán, E., Román-Ivorra, J. A., Grau, E., Sancho, J. J. A. & García, F. J. B., 2016, In : Annals of the Rheumatic Diseases. 75, 8, p. 1521-1526 6 p.

Research output: Contribution to journalArticle

Serum levels of vascular dysfunction markers reflect disease severity and stage in systemic sclerosis patients

Cossu, M., Andracco, R., Santaniello, A., Marchini, M., Severino, A., Caronni, M., Radstake, T. & Beretta, L., Jun 1 2016, In : Rheumatology. 55, 6, p. 1112-1116 5 p., kew017.

Research output: Contribution to journalArticle

The magnitude of cytokine production by stimulated CD56+ cells is associated with early stages of systemic sclerosis

Cossu, M., van Bon, L., Nierkens, S., Bellocchi, C., Santaniello, A., Dolstra, H., Beretta, L. & Radstake, T. R. D. J., 2016, In : Clinical Immunology. 173, p. 76-80 5 p.

Research output: Contribution to journalArticle

2015

Confirmation of CCR6 as a risk factor for anti-topoisomerase I antibodies in systemic sclerosis

Ochoa, E., Martin, J. E., Assassi, S., Beretta, L., Carreira, P., Guillén, A., Simeón, C. P., Koumakis, E., Dieude, P., Allanore, Y., García-Hernández, F. J., Espinosa, G., Castellví, I., Trapiella, J. L., Rodriguez, L., González-Gay, M., Egurbide, M. V., Sáez, L., Callejas-Rubio, J. L., Vargas-Hitos, J. A. & 53 others, Hunzelmann, N., Riemekasten, G., Witte, T., Distler, J. H. W., Kreuter, A., Lunardi, C., Santaniello, A., Tan, F. K., Shiels, P. G., Herrick, A., Worthington, J., Vonk, M. C., Koeleman, B. P., Radstake, T. R. D. J., Mayes, M. D., Martin, J., Ortego-Centeno, N., Ríos, R., Granada, C., Camps, M. T., Fernández-Nebro, A., Sánchez-Román, J., Castillo, M. J., Aguirre, M. Á., Gómez-Gracia, I., Fernández-Gutiérrez, B., Vicente, E., Andreu, J. L., De Castro, M. F., De la Peña, P. G., López-Longo, F. J., Martínez, L., Fonollosa, V., Tolosa, C., Pros, A., Carballeira, M. R., Narváez, F. J., Rivas, M. R., Santamaría, V. O., Madroñero, A. B., Díaz, B., Freire, M., Sousa, A., Mateo, P. F., Díaz, F., Hernández, V., Beltrán, E., Grau, E., Román-Ivorra, J. A., Alegre Sancho, J. J., Blanco García, F. J., Oreiro, N. & Spanish Scleroderma Group, S. G., 2015, In : Clinical and Experimental Rheumatology. 33, p. 31-35 5 p.

Research output: Contribution to journalArticle

Regional implantation of autologous adipose tissue-derived cells induces a prompt healing of long-lasting indolent digital ulcers in patients with systemic sclerosis

Papa, N. D., Di Luca, G., Sambataro, D., Zaccara, E., Maglione, W., Gabrielli, A., Fraticelli, P., Moroncini, G., Beretta, L., Santaniello, A., Sambataro, G., Ferraresi, R. & Vitali, C., 2015, In : Cell Transplantation. 24, 11, p. 2297-2305 9 p.

Research output: Contribution to journalArticle

Reply to J. Magalon et al

Del Papa, N., Di Luca, G., Sambataro, D., Zaccara, E., Maglione, W., Gabrielli, A., Fraticelli, P., Moroncini, G., Beretta, L., Santaniello, A., Sambataro, G., Ferraresi, R. & Vitali, C., 2015, In : Cell Transplantation. 24, 12, p. 2669-2670 2 p.

Research output: Contribution to journalArticle

Role of class II human leucocyte antigens in the progression from early to definite systemic sclerosis

Vigone, B., Santaniello, A., Marchini, M., Montanelli, G., Caronni, M., Severino, A. & Beretta, L., Apr 1 2015, In : Rheumatology. 54, 4, p. 707-711 5 p.

Research output: Contribution to journalArticle

2014

A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility

López-Isac, E., Bossini-Castillo, L., Simeon, C. P., Egurbide, M. V., Alegre-Sancho, J. J., Callejas, J. L., Roman-Ivorra, J. A., Freire, M., Beretta, L., Santaniello, A., Airó, P., Lunardi, C., Hunzelmann, N., Riemekasten, G., Witte, T., Kreuter, A., Distler, J. H. W., Schuerwegh, A. J., Vonk, M. C., Voskuyl, A. E. & 53 others, Shiels, P. G., van Laar, J. M., Fonseca, C., Denton, C., Herrick, A., Worthington, J., Assassi, S., Koeleman, B. P., Mayes, M. D., Radstake, T. R. D. J., Martin, J., Ortego-Centeno, N., Ríos, R., Navarrete, N., Portales, R. G., Camps, M. T., Fernández-Nebro, A., González-Escribano, M. F., Sánchez-Román, J., García-Hernández, F. J., Castillo, M. J., Aguirre, M. Á., Gómez-Gracia, I., Carreira, P., Fernández-Gutiérrez, B., Rodríguez-Rodríguez, L., Vicente, E., Andreu, J. L., de Castro, M. F., de la Peña, P. G., López-Longo, F. J., Martinez, L., Fonollosa, V., Simeón, C. P., Espinosa, G., Castellví, I., Tolosa, C., Pros, A., Carballeira, M. R., Narváez, F. J., Rivas, M. R., Santamarí, V. O., González-Gay, M. Á., Díaz, B., Trapiella, L., Sousa, A., Mateo, P. F., Sáez-Comet, L., Díaz, F., Hernández, V., Beltrán, E., Blanco García, F. J. & Oreiro, N., Jan 9 2014, In : Arthritis Research and Therapy. 16, 1, R6.

Research output: Contribution to journalArticle

Identification of IL12RB1 as a Novel Systemic Sclerosis Susceptibility Locus

Lõpez-Isac, E., Bossini-Castillo, L., Guerra, S. G., Denton, C., Fonseca, C., Assassi, S., Zhou, X., Mayes, M. D., Simeõn, C. P., Ortego-Centeno, N., Castellví, I., Carreira, P., Gorlova, O., Beretta, L., Santaniello, A., Lunardi, C., Hesselstrand, R., Nordin, A., Riemekasten, G., Witte, T. & 10 others, Hunzelmann, N., Kreuter, A., Distler, J. H. W., Voskuyl, A. E., De Vries-Bouwstra, J., Koeleman, B. P., Herrick, A., Worthington, J., Radstake, T. R. D. J. & Martin, J., Dec 1 2014, In : Arthritis and Rheumatology. 66, 12, p. 3521-3523 3 p.

Research output: Contribution to journalArticle

Influence of the IL17A locus in giant cell arteritis susceptibility

Márquez, A., Hernández-Rodríguez, J., Cid, M. C., Solans, R., Castañeda, S., Fernández-Contreras, M. E., Ramentol, M., Morado, I. C., Narváez, J., Gómez-Vaquero, C., Martínez-Taboada, V. M., Ortego-Centeno, N., Sopeña, B., Monfort, J., García-Villanueva, M. J., Caminal-Montero, L., De Miguel, E., Blanco, R., Palm, O., Molberg, O. & 11 others, Latus, J., Braun, N., Moosig, F., Witte, T., Beretta, L., Santaniello, A., Pazzola, G., Boiardi, L., Salvarani, C., González-Gay, M. A. & Martín, J., 2014, In : Annals of the Rheumatic Diseases. 73, 9, p. 1742-1745 4 p.

Research output: Contribution to journalArticle

2013

Carbohydrate antigen 15.3 as a serum biomarker of interstitial lung disease in systemic sclerosis patients

Celeste, S., Santaniello, A., Caronni, M., Franchi, J., Severino, A., Scorza, R. & Beretta, L., Oct 2013, In : European Journal of Internal Medicine. 24, 7, p. 671-676 6 p.

Research output: Contribution to journalArticle

In vivo confocal evaluation of the ocular surface morpho-functional unit in dry eye

Villani, E., Magnani, F., Viola, F., Santaniello, A., Scorza, R., Nucci, P. & Ratiglia, R., Jun 2013, In : Optometry and Vision Science. 90, 6, p. 576-586 11 p.

Research output: Contribution to journalArticle

2012

Analysis of class II human leucocyte antigens in Italian and Spanish systemic sclerosis

Beretta, L., Rueda, B., Marchini, M., Santaniello, A., Simeón, C. P., Fonollosa, V., Caronni, M., Rios-fernandez, R., Carreira, P., Rodriguez-rodriguez, L., Moreno, A., López-nevot, M. A., Escalera, A., González-escribano, M. F., Martin, J. & Scorza, R., Jan 2012, In : Rheumatology. 51, 1, p. 52-59 8 p., ker335.

Research output: Contribution to journalArticle

Successful pregnancies but a higher risk of preterm births in patients with systemic sclerosis: An Italian multicenter study

Taraborelli, M., Ramoni, V., Brucato, A., Airò, P., Bajocchi, G., Bellisai, F., Biasi, D., Blagojevic, J., Canti, V., Caporali, R., Caramaschi, P., Chiarolanza, I., Codullo, V., Cozzi, F., Cuomo, G., Cutolo, M., De Santis, M., De Vita, S., Di Poi, E., Doria, A. & 43 others, Faggioli, P., Favaro, M., Ferraccioli, G., Ferri, C., Foti, R., Gerosa, A., Gerosa, M., Giacuzzo, S., Giani, L., Giuggioli, D., Imazio, M., Iudici, M., Iuliano, A., Leonardi, R., Limonta, M., Lojacono, A., Lubatti, C., Matucci-Cerinic, M., Mazzone, A., Meroni, M., Meroni, P. L., Mosca, M., Motta, M., Muscarà, M., Nava, S., Padovan, M., Pagani, G., Paolazzi, G., Peccatori, S., Ravagnani, V., Riccieri, V., Rosato, E., Rovere-Querini, P., Salsano, F., Santaniello, A., Scorza, R., Tani, C., Valentini, G., Valesini, G., Vanoli, M., Vigone, B., Zeni, S. & Tincani, A., Jun 2012, In : Arthritis and Rheumatism. 64, 6, p. 1970-1977 8 p.

Research output: Contribution to journalArticle

2011

Efficacy of aminaftone in a rat model of monocrotaline-induced pulmonary hypertension

Zambelli, V., Santaniello, A., Fumagalli, F., Masson, S., Scorza, R., Beretta, L. & Latini, R., Sep 30 2011, In : European Journal of Pharmacology. 667, 1-3, p. 287-291 5 p.

Research output: Contribution to journalArticle

2010

A 3-factor epistatic model predicts digital ulcers in Italian scleroderma patients

Beretta, L., Santaniello, A., Mayo, M., Cappiello, F., Marchini, M. & Scorza, R., Aug 2010, In : European Journal of Internal Medicine. 21, 4, p. 347-353 7 p.

Research output: Contribution to journalArticle

Development of a five-year mortality model in systemic sclerosis patients by different analytical approaches

Beretta, L., Santaniello, A., Cappiello, F., Chawla, N. V., Vonk, M. C., Carreira, P. E., Allanore, Y., Popa-Diaconu, D. A., Cossu, M., Bertolotti, F., Ferraccioli, G., Mazzone, A. & Scorza, R., 2010, In : Clinical and Experimental Rheumatology. 28, 2 SUPPL. 58

Research output: Contribution to journalArticle

Survival dimensionality reduction (SDR): Development and clinical application of an innovative approach to detect epistasis in presence of right-censored data

Beretta, L., Santaniello, A., van Riel, P. L. C. M., Coenen, M. J. H. & Scorza, R., Aug 6 2010, In : BMC Bioinformatics. 11, 416.

Research output: Contribution to journalArticle

2008

Aminaftone, a Derivative of 4-Aminobenzoic Acid, Downregulates Endothelin-1 Production in ECV304 Cells: An in Vitro Study

Scorza, R., Santaniello, A., Salazar, G., Lenna, S., Colombo, G., Turcatti, F. & Beretta, L., 2008, In : Drugs in R and D. 9, 4, p. 251-257 7 p.

Research output: Contribution to journalArticle

Effects of aminaftone 75 mg TID on soluble adhesion molecules: A 12-week, randomized, open-label pilot study in patients with systemic sclerosis

Scorza, R., Santaniello, A., Salazar, G., Lenna, S., Della Bella, S., Antonioli, R., Toussoun, K. & Beretta, L., May 2008, In : Clinical Therapeutics. 30, 5, p. 924-929 6 p.

Research output: Contribution to journalArticle

2007

HLA-B35 Influences the Apoptosis Rate in Human Peripheral Blood Mononucleated Cells and HLA-Transfected Cells

Salazar, G., Colombo, G., Lenna, S., Antonioli, R., Beretta, L., Santaniello, A. & Scorza, R., Mar 2007, In : Human Immunology. 68, 3, p. 181-191 11 p.

Research output: Contribution to journalArticle

No evidence for a role of the proximal IL-6 G/C -174 single nucleotide polymorphism in Italian patients with systemic sclerosis [1]

Beretta, L., Santaniello, A., Cappiello, F., Barili, M. & Scorza, R., Jul 2007, In : Journal of Cellular and Molecular Medicine. 11, 4, p. 896-898 3 p.

Research output: Contribution to journalArticle

2006

HLA-B35 upregulates the production of endothelin-1 in HLA-transfected cells: A possible pathogenetic role in pulmonary hypertension

Santaniello, A., Salazar, G., Lenna, S., Antonioli, R., Colombo, G., Beretta, L. & Scorza, R., Sep 2006, In : Tissue Antigens. 68, 3, p. 239-244 6 p.

Research output: Contribution to journalArticle