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Research Output

2020

Large extracellular vesicles: Size matters in tumor progression

Ciardiello, C., Migliorino, R., Leone, A. & Budillon, A., Feb 2020, In : Cytokine and Growth Factor Reviews. 51, p. 69-74 6 p.

Research output: Contribution to journalReview article

Open Access

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

Elgendy, M., Cirò, M., Hosseini, A., Weiszmann, J., Mazzarella, L., Ferrari, E., Cazzoli, R., Curigliano, G., DeCensi, A., Bonanni, B., Budillon, A., Pelicci, P. G., Janssens, V., Ogris, M., Baccarini, M., Lanfrancone, L., Weckwerth, W., Foiani, M. & Minucci, S., 2019, In : Cancer Cell. 35, 5, p. 798

Research output: Contribution to journalArticle

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

Elgendy, M., Cirò, M., Hosseini, A., Weiszmann, J., Mazzarella, L., Ferrari, E., Cazzoli, R., Curigliano, G., DeCensi, A., Bonanni, B., Budillon, A., Pelicci, P. G., Janssens, V., Ogris, M., Baccarini, M., Lanfrancone, L., Weckwerth, W., Foiani, M. & Minucci, S., May 13 2019, In : Cancer Cell. 35, 5, p. 798-815.e5

Research output: Contribution to journalArticle

Histone deacetylase inhibitor ITF2357 (givinostat) reverts transformed phenotype and counteracts stemness in in vitro and in vivo models of human glioblastoma

Marampon, F., Leoni, F., Mancini, A., Pietrantoni, I., Codenotti, S., Letizia, F., Megiorni, F., Porro, G., Galbiati, E., Pozzi, P., Mascagni, P., Budillon, A., Maggio, R., Tombolini, V., Fanzani, A., Gravina, G. L. & Festuccia, C., Feb 2019, In : Journal of Cancer Research and Clinical Oncology. 145, 2, p. 393-409 17 p.

Research output: Contribution to journalArticle

Identification and Targeting of Stem Cell-Activated Pathways in Cancer Therapy

Budillon, A., Curley, S., Fusco, R. & Mancini, R., Jan 1 2019, In : Stem Cells International. 2019, 8549020.

Research output: Contribution to journalEditorial

Open Access

Large oncosomes overexpressing integrin alpha-V promote prostate cancer adhesion and invasion via AKT activation

Ciardiello, C., Leone, A., Lanuti, P., Roca, M. S., Moccia, T., Minciacchi, V. R., Minopoli, M., Gigantino, V., De Cecio, R., Rippa, M., Petti, L., Capone, F., Vitagliano, C., Milone, M. R., Pucci, B., Lombardi, R., Iannelli, F., Di Gennaro, E., Bruzzese, F., Marchisio, M. & 3 others, Carriero, M. V., Di Vizio, D. & Budillon, A., Jan 1 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 317.

Research output: Contribution to journalArticle

Open Access

Novel pathways involved in cisplatin resistance identified by a proteomics approach in non-small-cell lung cancer cells

Milone, M. R., Lombardi, R., Roca, M. S., Bruzzese, F., Addi, L., Pucci, B. & Budillon, A., Jun 2019, In : Journal of Cellular Physiology. 234, 6, p. 9077-9092 16 p.

Research output: Contribution to journalArticle

Perspectives in melanoma: Meeting report from the Melanoma Bridge (November 29th-1 December 1st, 2018, Naples, Italy)

Ascierto, P. A., Agarwala, S. S., Botti, G., Budillon, A., Davies, M. A., Dummer, R., Ernstoff, M., Ferrone, S., Formenti, S., Gajewski, T. F., Garbe, C., Hamid, O., Lo, R. S., Luke, J. J., Michielin, O., Palmieri, G., Zitvogel, L., Marincola, F. M., Masucci, G., Caracò, C. & 2 others, Thurin, M. & Puzanov, I., Jul 22 2019, In : Journal of Translational Medicine. 17, 1, 234.

Research output: Contribution to journalArticle

Open Access

Reprogramming miRNAs global expression orchestrates development of drug resistance in BRAF mutated melanoma

Fattore, L., Ruggiero, C. F., Pisanu, M. E., Liguoro, D., Cerri, A., Costantini, S., Capone, F., Acunzo, M., Romano, G., Nigita, G., Mallardo, D., Ragone, C., Carriero, M. V., Budillon, A., Botti, G., Ascierto, P. A., Mancini, R. & Ciliberto, G., Jul 2019, In : Cell Death and Differentiation. 26, 7, p. 1267-1282 16 p.

Research output: Contribution to journalArticle

Structural analysis of human SEPHS2 protein, a selenocysteine machinery component, over-expressed in triple negative breast cancer

Nunziata, C., Polo, A., Sorice, A., Capone, F., Accardo, M., Guerriero, E., Marino, F. Z., Orditura, M., Budillon, A. & Costantini, S., Dec 1 2019, In : Scientific Reports. 9, 1, 16131.

Research output: Contribution to journalArticle

Open Access

Structure-function relationship of an Urokinase Receptor-derived peptide which inhibits the Formyl Peptide Receptor type 1 activity

Minopoli, M., Polo, A., Ragone, C., Ingangi, V., Ciliberto, G., Pessi, A., Sarno, S., Budillon, A., Costantini, S. & Carriero, M. V., Dec 1 2019, In : Scientific Reports. 9, 1, 12169.

Research output: Contribution to journalArticle

Open Access

Structure-function relationship of an Urokinase Receptor-derived peptide which inhibits the Formyl Peptide Receptor type 1 activity

Minopoli, M., Polo, A., Ragone, C., Ingangi, V., Ciliberto, G., Pessi, A., Sarno, S., Budillon, A., Costantini, S. & Carriero, M. V., Dec 1 2019, In : Sci. Rep.. 9, 1, p. 1-14 14 p., 12169.

Research output: Contribution to journalArticle

2018

A standardized flow cytometry network study for the assessment of circulating endothelial cell physiological ranges

Lanuti, P., Simeone, P., Rotta, G., Almici, C., Avvisati, G., Azzaro, R., Bologna, G., Budillon, A., Di Cerbo, M., Di Gennaro, E., Di Martino, M. L., Diodato, A., Doretto, P., Ercolino, E., Falda, A., Gregorj, C., Leone, A., Losa, F., Malara, N., Marini, M. & 18 others, Mastroroberto, P., Mollace, V., Morelli, M., Muggianu, E., Musolino, G., Neva, A., Pierdomenico, L., Pinna, S., Piovani, G., Roca, M. S., Russo, D., Scotti, L., Tirindelli, M. C., Venturella, R., Vitagliano, C., Zullo, F., Marchisio, M. & Miscia, S., Dec 1 2018, In : Scientific Reports. 8, 1, 5823.

Research output: Contribution to journalArticle

Effects of α-zearalenol on the metabolome of two breast cancer cell lines by 1H-NMR approach

Nittoli, A. C., Costantini, S., Sorice, A., Capone, F., Ciarcia, R., Marzocco, S., Budillon, A. & Severino, L., Mar 1 2018, In : Metabolomics. 14, 3, 33.

Research output: Contribution to journalArticle

Evaluation of Aflatoxin M1 Effects on the Metabolomic and Cytokinomic Profiling of a Hepatoblastoma Cell Line

Marchese, S., Sorice, A., Ariano, A., Florio, S., Budillon, A., Costantini, S. & Severino, L., Oct 28 2018, In : Toxins. 10, 11

Research output: Contribution to journalArticle

Identifying a panel of genes/proteins/miRNAs modulated by arsenicals in bladder, prostate, kidney cancers

Polo, A., Marchese, S., De Petro, G., Montella, M., Ciliberto, G., Budillon, A. & Costantini, S., Dec 1 2018, In : Scientific Reports. 8, 1, 10395.

Research output: Contribution to journalArticle

Targeting Mevalonate Pathway in Cancer Treatment: Repurposing of Statins

Iannelli, F., Lombardi, R., Milone, M. R., Pucci, B., De Rienzo, S., Budillon, A. & Bruzzese, F., 2018, In : Recent Patents on Anti-Cancer Drug Discovery. 13, 2, p. 184-200 17 p.

Research output: Contribution to journalArticle

The effect of light exposure at night (LAN) on carcinogenesis via decreased nocturnal melatonin synthesis

Giudice, A., Crispo, A., Grimaldi, M., Polo, A., Bimonte, S., Capunzo, M., Amore, A., Arena, G. D., Cerino, P., Budillon, A., Botti, G., Costantini, S. & Montella, M., Jan 1 2018, In : Molecules. 23, 6, 1308.

Research output: Contribution to journalReview article

The Effect of Light Exposure at Night (LAN) on Carcinogenesis via Decreased Nocturnal Melatonin Synthesis

Giudice, A., Crispo, A., Grimaldi, M., Polo, A., Bimonte, S., Capunzo, M., Amore, A., D'Arena, G., Cerino, P., Budillon, A., Botti, G., Costantini, S. & Montella, M., May 29 2018, In : Molecules. 23, 6

Research output: Contribution to journalReview article

Toxigenic effects of two benthic diatoms upon grazing activity of the sea urchin: Morphological, metabolomic and de novo transcriptomic analysis

Ruocco, N., Costantini, S., Zupo, V., Lauritano, C., Caramiello, D., Ianora, A., Budillon, A., Romano, G., Nuzzo, G., D'Ippolito, G., Fontana, A. & Costantini, M., Dec 1 2018, In : Scientific Reports. 8, 1, 5622.

Research output: Contribution to journalArticle

2017

An interaction network approach to study the correlation between endocrine disrupting chemicals and breast cancer

Polo, A., Nittoli, C., Crispo, A., Langastro, T., Severino, L., Cocco, S., De Laurentiis, M., Ciliberto, G., Montella, M., Budillon, A. & Costantini, S., Jan 1 2017, In : Molecular BioSystems. 13, 12, p. 2687-2696 10 p.

Research output: Contribution to journalArticle

Conformational analysis of the human chemokine receptor CXCR3

Raucci, R., Polo, A., Budillon, A., Colonna, G. & Costantini, S., Dec 1 2017, In : Molecular Immunology. 92, p. 76-86 11 p.

Research output: Contribution to journalArticle

Environment and bladder cancer: molecular analysis by interaction networks

Polo, A., Crispo, A., Cerino, P., Falzone, L., Candido, S., Giudice, A., De Petro, G., Ciliberto, G., Montella, M., Budillon, A. & Costantini, S., May 2017, In : Oncotarget.

Research output: Contribution to journalArticle

Evaluating the effects of an organic extract from the mediterranean sponge Geodia cydonium on human breast cancer cell lines

Costantini, S., Guerriero, E., Teta, R., Capone, F., Caso, A., Sorice, A., Romano, G., Ianora, A., Ruocco, N., Budillon, A., Costantino, V. & Costantini, M., Oct 1 2017, In : International Journal of Molecular Sciences. 18, 10, 2112.

Research output: Contribution to journalArticle

HDAC inhibition potentiates immunotherapy in triple negative breast cancer

Terranova-Barberio, M., Thomas, S., Ali, N., Pawlowska, N., Park, J., Krings, G., Rosenblum, M. D., Budillon, A. & Munster, P. N., Jan 1 2017, In : Oncotarget. 8, 69, p. 114156-114172 17 p.

Research output: Contribution to journalArticle

Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ

Noto, A., De Vitis, C., Pisanu, M. E., Roscilli, G., Ricci, G., Catizone, A., Sorrentino, G., Chianese, G., Taglialatela-Scafati, O., Trisciuoglio, D., Del Bufalo, D., Di Martile, M., Napoli, A., Ruco, L., Costantini, S., Jakopin, Z., Budillon, A., Melino, G., Del Sal, G., Ciliberto, G. & 1 others, Mancini, R., Aug 2017, In : Oncogene.

Research output: Contribution to journalArticle

Synthesis and Evaluation of the Antitumor Properties of a Small Collection of PtII Complexes with 7-Deazaadenosine as Scaffold

D'Errico, S., Borbone, N., Piccialli, V., Di Gennaro, E., Zotti, A., Budillon, A., Vitagliano, C., Piccialli, I. & Oliviero, G., Sep 8 2017, In : European Journal of Organic Chemistry. 2017, 33, p. 4935-4947 13 p.

Research output: Contribution to journalArticle

Synthesis of arylpiperazine derivatives as protease activated receptor 1 antagonists and their evaluation as antiproliferative agents

Zotti, A. I., Di Gennaro, E., Corvino, A., Frecentese, F., Magli, E., Perissutti, E., Cirino, G., Roviezzo, F., Terranova-Barberio, M., Iannelli, F., Caliendo, G., Santagada, V., Fiorino, F., Budillon, A. & Severino, B., 2017, In : Anti-Cancer Agents in Medicinal Chemistry. 17, 7, p. 973-981 9 p.

Research output: Contribution to journalArticle

Tissue transglutaminase (TG2) is involved in the resistance of cancer cells to the histone deacetylase (HDAC) inhibitor vorinostat

Carbone, C., Di Gennaro, E., Piro, G., Milone, M. R., Pucci, B., Caraglia, M. & Budillon, A., 2017, In : Amino Acids. p. 1-12 12 p.

Research output: Contribution to journalArticle

Biotin-targeted Pluronic® P123/F127 mixed micelles delivering niclosamide: A repositioning strategy to treat drug-resistant lung cancer cells

Russo, A., Pellosi, D. S., Pagliara, V., Milone, M. R., Pucci, B., Caetano, W., Hioka, N., Budillon, A., Ungaro, F., Russo, G. & Quaglia, F., Sep 10 2016, In : International Journal of Pharmaceutics. 511, 1, p. 127-139 13 p.

Research output: Contribution to journalArticle

Endothelial progenitor cells, defined by the simultaneous surface expression of VEGFR2 and CD133, are not detectable in healthy peripheral and cord blood

Lanuti, P., Rotta, G., Almici, C., Avvisati, G., Budillon, A., Doretto, P., Malara, N., Marini, M., Neva, A., Simeone, P., Di Gennaro, E., Leone, A., Falda, A., Tozzoli, R., Gregorj, C., Di Cerbo, M., Trunzo, V., Marchisio, M. & Miscia, S., Mar 1 2016, In : Cytometry Part A. 89, 3, p. 259-270 12 p.

Research output: Contribution to journalArticle

Enhancement of 5-FU sensitivity by the proapoptotic rpL3 gene in p53 null colon cancer cells through combined polymer nanoparticles

Russo, A., Maiolino, S., Pagliara, V., Ungaro, F., Tatangelo, F., Leone, A., Scalia, G., Budillon, A., Quaglia, F. & Russo, G., Nov 8 2016, In : Oncotarget. 7, 48, p. 79670-79687 18 p.

Research output: Contribution to journalArticle

Impact of subsequent therapies on outcome of the FIRE-3/AIO KRK0306 trial

Avallone, A. & Budillon, A., May 1 2016, In : Journal of Clinical Oncology. 34, 13, p. 1564 1 p.

Research output: Contribution to journalArticle

Potential anticancer effects of polyphenols from chestnut shell extracts: Modulation of cell growth, and cytokinomic and metabolomic profiles

Sorice, A., Siano, F., Capone, F., Guerriero, E., Picariello, G., Budillon, A., Ciliberto, G., Paolucci, M., Costantini, S. & Volpe, M. G., Oct 1 2016, In : Molecules. 21, 10, 1411.

Research output: Contribution to journalArticle

Potential Anticancer Effects of Polyphenols from Chestnut Shell Extracts: Modulation of Cell Growth, and Cytokinomic and Metabolomic Profiles

Sorice, A., Siano, F., Capone, F., Guerriero, E., Picariello, G., Budillon, A., Ciliberto, G., Paolucci, M., Costantini, S. & Volpe, M. G., Oct 21 2016, In : Molecules. 21, 10

Research output: Contribution to journalArticle

Proteomic characterization of peroxisome proliferator-activated receptor-γ (PPARγ) overexpressing or silenced colorectal cancer cells unveils a novel protein network associated with an aggressive phenotype

Milone, M. R., Pucci, B., Colangelo, T., Lombardi, R., Iannelli, F., Colantuoni, V., Sabatino, L. & Budillon, A., Oct 1 2016, In : Molecular Oncology. 10, 8, p. 9-18 10 p.

Research output: Contribution to journalArticle

Proteomic screening identifies calreticulin as a MIR-27a direct target repressing MHC class I cell surface exposure in colorectal cancer

Colangelo, T., Polcaro, G., Ziccardi, P., Pucci, B., Muccillo, L., Galgani, M., Fucci, A., Milone, M. R., Budillon, A., Santopaolo, M., Votino, C., Pancione, M., Binaschi, M., Bigioni, M., Maggi, C. A., Fassan, M., Laudanna, C., Sabatino, L. & Colantuoni, V., Feb 25 2016, In : Cell Death and Disease. 7, 2, e2120.

Research output: Contribution to journalArticle

Proteomic screening identifies calreticulin as a MIR-27a direct target repressing MHC class I cell surface exposure in colorectal cancer

Colangelo, T., Polcaro, G., Ziccardi, P., Pucci, B., Muccillo, L., Galgani, M., Fucci, A., Milone, M. R., Budillon, A., Santopaolo, M., Votino, C., Pancione, M., Piepoli, A., Mazzoccoli, G., Binaschi, M., Bigioni, M., Maggi, C. A., Fassan, M., Laudanna, C., Matarese, G. & 2 others, Sabatino, L. & Colantuoni, V., Feb 25 2016, In : Cell Death and Disease. 7, 2, e2120.

Research output: Contribution to journalArticle

Synergistic antitumor activity of histone deacetylase inhibitors and anti-ErbB3 antibody in NSCLC primary cultures via modulation of ErbB receptors expression

Ciardiello, C., Roca, M. S., Noto, A., Bruzzese, F., Moccia, T., Vitagliano, C., Di Gennaro, E., Ciliberto, G., Roscilli, G., Aurisicchio, L., Marra, E., Mancini, R., Budillon, A. & Leone, A., Apr 12 2016, In : Oncotarget. 7, 15, p. 19559-19574 16 p.

Research output: Contribution to journalArticle

The MIR-27a-calreticulin axis affects drug-induced immunogenic cell death in human colorectal cancer cells

Colangelo, T., Polcaro, G., Ziccardi, P., Muccillo, L., Galgani, M., Pucci, B., Rita Milone, M., Budillon, A., Santopaolo, M., Mazzoccoli, G., Matarese, G., Sabatino, L. & Colantuoni, V., Feb 25 2016, In : Cell Death and Disease. 7, 2, e2108.

Research output: Contribution to journalArticle