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Research Output

8-Chloroadenosine 3',5'-monophosphate as a novel modulator of multidrug resistance

Yokozaki, H., Budillon, A., Clair, T., Kelley, K., Cowan, K. H., Rohlff, C., Glazer, R. I. & Cho-Chung, Y. S., 1993, In : International Journal of Oncology. 3, 3, p. 423-430 8 p.

Research output: Contribution to journalArticle

8-Cl-cAMP antagonizes mitogen-activated protein kinase activation and cell growth stimulation induced by epidermal growth factor

Budillon, A., Di Gennaro, E., Caraglia, M., Barbarulo, D., Abbruzzese, A. & Tagliaferri, P., 1999, In : British Journal of Cancer. 81, 7, p. 1134-1141 8 p.

Research output: Contribution to journalArticle

Acetylation of proteins as novel target for antitumor therapy: Review article

Di Gennaro, E., Bruzzese, F., Caraglia, M., Abruzzese, A. & Budillon, A., Jul 2004, In : Amino Acids. 26, 4, p. 435-441 7 p.

Research output: Contribution to journalArticle

Acquired resistance to zoledronic acid and the parallel acquisition of an aggressive phenotype are mediated by p38-MAP kinase activation in prostate cancer cells

Milone, M. R., Pucci, B., Bruzzese, F., Carbone, C., Piro, G., Costantini, S., Capone, F., Leone, A., Di Gennaro, E., Caraglia, M. & Budillon, A., May 2013, In : Cell Death and Disease. 4, 5, e641.

Research output: Contribution to journalArticle

Adenylate cyclase/cAMP pathway downmodulation counteracts apoptosis induced by IFN-α in human epidermoid cancer cells

Naviglio, S., Spina, A., Marra, M., Sorrentino, A., Chiosi, E., Romano, M., Improta, S., Budillon, A., Illiano, G., Abbruzzese, A. & Caraglia, M., Feb 2007, In : Journal of Interferon and Cytokine Research. 27, 2, p. 129-136 8 p.

Research output: Contribution to journalArticle

A high percentage of BRAFV600E alleles in papillary thyroid carcinoma predicts a poorer outcome

Guerra, A., Fugazzola, L., Marotta, V., Cirillo, M., Rossi, S., Cirello, V., Forno, I., Moccia, T., Budillon, A. & Vitale, M., Jul 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 7, p. 2333-2340 8 p.

Research output: Contribution to journalArticle

Alpha-interferon and its effects on signalling pathways within cells

Caraglia, M., Vitale, G., Marra, M., Budillon, A., Tagliaferri, P. & Abbruzzese, A., Dec 2004, In : Current Protein and Peptide Science. 5, 6, p. 475-485 11 p.

Research output: Contribution to journalArticle

A multidisciplinary approach is required to increase the quality of phase II/III clinical studies on biotherapies in oncology [2]

Ottaiano, A., Budillon, A., Normanno, N., Iaffaioli, V. R. & Caraglia, M., May 2007, In : Annals of Oncology. 18, 5, p. 960-961 2 p.

Research output: Contribution to journalArticle

An antisense oligodeoxynucleotide that depletes RIα subunit of cyclic AMP-dependent protein kinase induces growth inhibition in human cancer cells

Yokozaki, H., Budillon, A., Tortora, G., Meissner, S., Beaucage, S. L., Miki, K. & Cho-Chung, Y. S., Feb 15 1993, In : Cancer Research. 53, 4, p. 868-872 5 p.

Research output: Contribution to journalArticle

An interaction network approach to study the correlation between endocrine disrupting chemicals and breast cancer

Polo, A., Nittoli, C., Crispo, A., Langastro, T., Severino, L., Cocco, S., De Laurentiis, M., Ciliberto, G., Montella, M., Budillon, A. & Costantini, S., Jan 1 2017, In : Molecular BioSystems. 13, 12, p. 2687-2696 10 p.

Research output: Contribution to journalArticle

Annexin A1 is involved in the acquisition and maintenance of a stem cell-like/aggressive phenotype in prostate cancer cells with acquired resistance to zoledronic acid

Bizzarro, V., Belvedere, R., Milone, M. R., Pucci, B., Lombardi, R., Bruzzese, F., Popolo, A., Parente, L., Budillon, A. & Petrella, A., 2015, In : Oncotarget. 6, 28, p. 25076-25092 17 p.

Research output: Contribution to journalArticle

Anticancer drugs and hyperthermia enhance cytotoxicity induced by polyamine enzymatic oxidation products

Marra, M., Agostinelli, E., Tempera, G., Lombardi, A., Meo, G., Budillon, A., Abbruzzese, A., Giuberti, G. & Caraglia, M., Aug 2007, In : Amino Acids. 33, 2, p. 273-281 9 p.

Research output: Contribution to journalArticle

Antitumor therapeutic strategies based on the targeting of epidermal growth factor-induced survival pathways

Tagliaferri, P., Tassone, P., Blotta, S., Viscomi, C., Grillone, F., Budillon, A., Caraglia, M. & Venuta, S., May 2005, In : Current Drug Targets. 6, 3, p. 289-300 12 p.

Research output: Contribution to journalArticle

Anti-VEGF treatment-resistant pancreatic cancers secrete proinflammatory factors that contribute to malignant progression by inducing an EMT cell phenotype

Carbone, C., Moccia, T., Zhu, C., Paradiso, G., Budillon, A., Chiao, P. J., Abbruzzese, J. L. & Melisi, D., Sep 1 2011, In : Clinical Cancer Research. 17, 17, p. 5822-5832 11 p.

Research output: Contribution to journalArticle

A perspective on the current treatment strategies for locally advanced rectal cancer

Avallone, A., Aloj, L., Aprile, G., Rosati, G. & Budillon, A., Jun 19 2015, In : International Journal of Biochemistry and Cell Biology. 65, p. 192-196 5 p.

Research output: Contribution to journalArticle

A standardized flow cytometry network study for the assessment of circulating endothelial cell physiological ranges

Lanuti, P., Simeone, P., Rotta, G., Almici, C., Avvisati, G., Azzaro, R., Bologna, G., Budillon, A., Di Cerbo, M., Di Gennaro, E., Di Martino, M. L., Diodato, A., Doretto, P., Ercolino, E., Falda, A., Gregorj, C., Leone, A., Losa, F., Malara, N., Marini, M. & 18 others, Mastroroberto, P., Mollace, V., Morelli, M., Muggianu, E., Musolino, G., Neva, A., Pierdomenico, L., Pinna, S., Piovani, G., Roca, M. S., Russo, D., Scotti, L., Tirindelli, M. C., Venturella, R., Vitagliano, C., Zullo, F., Marchisio, M. & Miscia, S., Dec 1 2018, In : Scientific Reports. 8, 1, 5823.

Research output: Contribution to journalArticle

Biotin-targeted Pluronic® P123/F127 mixed micelles delivering niclosamide: A repositioning strategy to treat drug-resistant lung cancer cells

Russo, A., Pellosi, D. S., Pagliara, V., Milone, M. R., Pucci, B., Caetano, W., Hioka, N., Budillon, A., Ungaro, F., Russo, G. & Quaglia, F., Sep 10 2016, In : International Journal of Pharmaceutics. 511, 1, p. 127-139 13 p.

Research output: Contribution to journalArticle

cAMP-dependent protein kinase: role in normal and malignant growth

Cho-Chung, Y. S., Pepe, S., Clair, T., Budillon, A. O. & Nesterova, M., 1995, In : Critical Reviews in Oncology/Hematology. 21, 1-3, p. 33-61 29 p.

Research output: Contribution to journalArticle

Caveolin-1 overexpression is associated with simultaneous abnormal expression of the E-cadherin/α-β catenins complex and multiple erbb receptors and with lymph nodes metastasis in head and neck squamous cell carcinomas

Masuelli, L., Budillon, A., Marzocchella, L., Mrozek, M. A., Vitolo, D., Di Gennaro, E., Losito, S., Sale, P., Longo, F., Ionna, F., Lista, F., Muraro, R., Modesti, A. & Bei, R., Sep 2012, In : Journal of Cellular Physiology. 227, 9, p. 3344-3353 10 p.

Research output: Contribution to journalArticle

Cetuximab is an active treatment of metastatic and chemorefractory thymoma

Palmieri, G., Marino, M., Salvatore, M., Budillon, A., Meo, G., Caraglia, M. & Montella, L., 2007, In : Frontiers in Bioscience. 12, 2, p. 757-761 5 p.

Research output: Contribution to journalArticle

Changes in bone resorption and vascular endothelial growth factor after a single zoledronic acid infusion in cancer patients with bone metastases from solid tumours

Santini, D., Vincenzi, B., Hannon, R. A., Brown, J. E., Dicuonzo, G., Angeletti, S., La Cesa, A., Coleman, R. E., Tonini, G., Budillon, A., Caraglia, M. & Holen, I., May 2006, In : Oncology Reports. 15, 5, p. 1351-1357 7 p.

Research output: Contribution to journalArticle

Chemotherapy regimen GOLF induces apoptosis in colon cancer cells through multi-chaperone complex inactivation and increased Raf-1 ubiquitin-dependent degradation

Caraglia, M., Marra, M., Budillon, A., Meo, G., Ricciardiello, F., Bismuto, E., Brachelente, G., Francini, G., Giordano, A., Correale, P. & Abbruzzese, A., Oct 2005, In : Cancer Biology and Therapy. 4, 10, p. 1159-1167 9 p.

Research output: Contribution to journalArticle

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

Siravegna, G., Mussolin, B., Buscarino, M., Corti, G., Cassingena, A., Crisafulli, G., Ponzetti, A., Cremolini, C., Amatu, A., Lauricella, C., Lamba, S., Hobor, S., Avallone, A., Valtorta, E., Rospo, G., Medico, E., Motta, V., Antoniotti, C., Tatangelo, F., Bellosillo, B. & 12 others, Veronese, S., Budillon, A., Montagut, C., Racca, P., Marsoni, S., Falcone, A., Corcoran, R. B., Di Nicolantonio, F., Loupakis, F., Siena, S., Sartore-Bianchi, A. & Bardelli, A., Jun 1 2015, In : Nature Medicine. 21, 7, p. 795-801 7 p.

Research output: Contribution to journalArticle

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

Elgendy, M., Cirò, M., Hosseini, A., Weiszmann, J., Mazzarella, L., Ferrari, E., Cazzoli, R., Curigliano, G., DeCensi, A., Bonanni, B., Budillon, A., Pelicci, P. G., Janssens, V., Ogris, M., Baccarini, M., Lanfrancone, L., Weckwerth, W., Foiani, M. & Minucci, S., May 13 2019, In : Cancer Cell. 35, 5, p. 798-815.e5

Research output: Contribution to journalArticle

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

Elgendy, M., Cirò, M., Hosseini, A., Weiszmann, J., Mazzarella, L., Ferrari, E., Cazzoli, R., Curigliano, G., DeCensi, A., Bonanni, B., Budillon, A., Pelicci, P. G., Janssens, V., Ogris, M., Baccarini, M., Lanfrancone, L., Weckwerth, W., Foiani, M. & Minucci, S., 2019, In : Cancer Cell. 35, 5, p. 798

Research output: Contribution to journalArticle

Concomitant occurrence of facial cutaneous and parotid gland metastases from rectal cancer after preoperative chemoradiotherapy

Nasti, G., Facchini, G., Caraglia, M., Franco, R., Mura, A., Staiano, M., Budillon, A., Iaffaioli, R. V. & Ottaiano, A., Jun 2007, In : Onkologie. 30, 6, p. 324-326 3 p.

Research output: Contribution to journalArticle

Conformational analysis of the human chemokine receptor CXCR3

Raucci, R., Polo, A., Budillon, A., Colonna, G. & Costantini, S., Dec 1 2017, In : Molecular Immunology. 92, p. 76-86 11 p.

Research output: Contribution to journalArticle

C-Raf antagonizes apoptosis induced by IFN-α in human lung cancer cells by phosphorylation and increase of the intracellular content of elongation factor 1A

Lamberti, A., Longo, O., Marra, M., Tagliaferri, P., Bismuto, E., Fiengo, A., Viscomi, C., Budillon, A., Rapp, U. R., Wang, E., Venuta, S., Abbruzzese, A., Arcari, P. & Caraglia, M., May 2007, In : Cell Death and Differentiation. 14, 5, p. 952-962 11 p.

Research output: Contribution to journalArticle

Cryptic epitopes on α-fetoprotein induce spontaneous immune responses in hepatocellular carcinoma, liver cirrhosis, and chronic hepatitis patients

Bei, R., Budillon, A., Reale, M. G., Capuano, G., Pomponi, D., Budillon, G., Frati, L. & Muraro, R., Nov 1 1999, In : Cancer Research. 59, 21, p. 5471-5474 4 p.

Research output: Contribution to journalArticle

Cyr61 downmodulation potentiates the anticancer effects of zoledronic acid in androgen-independent prostate cancer cells

Marra, M., Santini, D., Meo, G., Vincenzi, B., Zappavigna, S., Baldi, A., Rosolowski, M., Tonini, G., Loeffler, M., Lupu, R., Addeo, S. R., Abbruzzese, A., Budillon, A. & Caraglia, M., Nov 1 2009, In : International Journal of Cancer. 125, 9, p. 2004-2013 10 p.

Research output: Contribution to journalArticle

Docetaxel induces p53-dependent apoptosis and synergizes with farnesyl transferase inhibitor R115777 in human epithelial cancer cells

Caraglia, M., Giuberti, G., Marra, M., Di Gennaro, E., Facchini, G., Caponigro, F., Iaffeioli, R. V., Budillon, A. & Abbruzzese, A., 2005, In : Frontiers in Bioscience. 10, SUPPL. 2, p. 2566-2575 10 p.

Research output: Contribution to journalArticle

Downregulation of mdr-1 expression by 8-Cl-cAMP in multidrug resistant MCF-7 human breast cancer cells

Scala, S., Budillon, A., Zhan, Z., Cho-Chung, Y. S., Jefferson, J., Tsokos, M. & Bates, S. E., 1995, In : Journal of Clinical Investigation. 96, 2, p. 1026-1034 9 p.

Research output: Contribution to journalArticle

Effects of α-zearalenol on the metabolome of two breast cancer cell lines by 1H-NMR approach

Nittoli, A. C., Costantini, S., Sorice, A., Capone, F., Ciarcia, R., Marzocco, S., Budillon, A. & Severino, L., Mar 1 2018, In : Metabolomics. 14, 3, 33.

Research output: Contribution to journalArticle

EGF activates an inducible survival response via the RAS-> Erk-1/2 pathway to counteract interferon-α-mediated apoptosis in epidermoid cancer cells

Caraglia, M., Tagliaferri, P., Marra, M., Giuberti, G., Budillon, A., Di Gennaro, E., Pepe, S., Vitale, G., Improta, S., Tassone, P., Venuta, S., Bianco, A. R. & Abbruzzese, A., Feb 1 2003, In : Cell Death and Differentiation. 10, 2, p. 218-229 12 p.

Research output: Contribution to journalArticle

EGF-R small inhibitors and anti-EGF-R antibodies: Advantages and limits of a new avenue in anticancer therapy

Caraglia, M., Marra, M., Meo, G., Addeo, R., Tagliaferri, P. & Budillon, A., 2006, In : Recent Patents on Anti-Cancer Drug Discovery. 1, 2, p. 209-222 14 p.

Research output: Contribution to journalArticle

Electromagnetic fields at mobile phone frequency induce apoptosis and inactivation of the multi-chaperone complex in human epidermoid cancer cells

Caraglia, M., Marra, M., Mancinelli, F., D'Ambrosio, G., Massa, R., Giordano, A., Budillon, A., Abbruzzese, A. & Bismuto, E., Aug 2005, In : Journal of Cellular Physiology. 204, 2, p. 539-548 10 p.

Research output: Contribution to journalArticle

Emerging anti-cancer molecular mechanisms of aminobisphosphonates

Caraglia, M., Santini, D., Marra, M., Vincenzi, B., Tonini, G. & Budillon, A., Mar 2006, In : Endocrine-Related Cancer. 13, 1, p. 7-26 20 p.

Research output: Contribution to journalArticle

Endothelial progenitor cells, defined by the simultaneous surface expression of VEGFR2 and CD133, are not detectable in healthy peripheral and cord blood

Lanuti, P., Rotta, G., Almici, C., Avvisati, G., Budillon, A., Doretto, P., Malara, N., Marini, M., Neva, A., Simeone, P., Di Gennaro, E., Leone, A., Falda, A., Tozzoli, R., Gregorj, C., Di Cerbo, M., Trunzo, V., Marchisio, M. & Miscia, S., Mar 1 2016, In : Cytometry Part A. 89, 3, p. 259-270 12 p.

Research output: Contribution to journalArticle

Enhancement of 5-FU sensitivity by the proapoptotic rpL3 gene in p53 null colon cancer cells through combined polymer nanoparticles

Russo, A., Maiolino, S., Pagliara, V., Ungaro, F., Tatangelo, F., Leone, A., Scalia, G., Budillon, A., Quaglia, F. & Russo, G., Nov 8 2016, In : Oncotarget. 7, 48, p. 79670-79687 18 p.

Research output: Contribution to journalArticle

Environment and bladder cancer: molecular analysis by interaction networks

Polo, A., Crispo, A., Cerino, P., Falzone, L., Candido, S., Giudice, A., De Petro, G., Ciliberto, G., Montella, M., Budillon, A. & Costantini, S., May 2017, In : Oncotarget.

Research output: Contribution to journalArticle

Erratum: Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

Siravegna, G., Mussolin, B., Buscarino, M., Corti, G., Cassingena, A., Crisafulli, G., Ponzetti, A., Cremolini, C., Amatu, A., Lauricella, C., Lamba, S., Hobor, S., Avallone, A., Valtorta, E., Rospo, G., Medico, E., Motta, V., Antoniotti, C., Tatangelo, F., Bellosillo, B. & 12 others, Veronese, S., Budillon, A., Montagut, C., Racca, P., Marsoni, S., Falcone, A., Corcoran, R. B., Di Nicolantonio, F., Loupakis, F., Siena, S., Sartore-Bianchi, A. & Bardelli, A., Jul 7 2015, In : Nature Medicine. 21, 7, p. 827 1 p.

Research output: Contribution to journalArticle