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Research Output

2016

The MIR-27a-calreticulin axis affects drug-induced immunogenic cell death in human colorectal cancer cells

Colangelo, T., Polcaro, G., Ziccardi, P., Muccillo, L., Galgani, M., Pucci, B., Milone, A., Budillon, A., Santopaolo, M., Sabatino, L. & Colantuoni, V., Feb 25 2016, In : Cell Death and Disease. 7, 2, e2108.

Research output: Contribution to journalArticle

The MIR-27a-calreticulin axis affects drug-induced immunogenic cell death in human colorectal cancer cells

Colangelo, T., Polcaro, G., Ziccardi, P., Muccillo, L., Galgani, M., Pucci, B., Rita Milone, M., Budillon, A., Santopaolo, M., Mazzoccoli, G., Matarese, G., Sabatino, L. & Colantuoni, V., Feb 25 2016, In : Cell Death and Disease. 7, 2, e2108.

Research output: Contribution to journalArticle

Valproic acid potentiates the anticancer activity of capecitabine in vitro and in vivo in breast cancer models via induction of thymidine phosphorylase expression

Terranova-Barberio, M., Roca, M. S., Zotti, A. I., Leone, A., Bruzzese, F., Vitagliano, C., Scognamiglio, G., Russo, D., D'Angelo, G., Franco, R., Budillon, A. & Di Gennaro, E., 2016, In : Oncotarget. 7, 7, p. 7715-7731 17 p.

Research output: Contribution to journalArticle

2015

Annexin A1 is involved in the acquisition and maintenance of a stem cell-like/aggressive phenotype in prostate cancer cells with acquired resistance to zoledronic acid

Bizzarro, V., Belvedere, R., Milone, M. R., Pucci, B., Lombardi, R., Bruzzese, F., Popolo, A., Parente, L., Budillon, A. & Petrella, A., 2015, In : Oncotarget. 6, 28, p. 25076-25092 17 p.

Research output: Contribution to journalArticle

A perspective on the current treatment strategies for locally advanced rectal cancer

Avallone, A., Aloj, L., Aprile, G., Rosati, G. & Budillon, A., Jun 19 2015, In : International Journal of Biochemistry and Cell Biology. 65, p. 192-196 5 p.

Research output: Contribution to journalArticle

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

Siravegna, G., Mussolin, B., Buscarino, M., Corti, G., Cassingena, A., Crisafulli, G., Ponzetti, A., Cremolini, C., Amatu, A., Lauricella, C., Lamba, S., Hobor, S., Avallone, A., Valtorta, E., Rospo, G., Medico, E., Motta, V., Antoniotti, C., Tatangelo, F., Bellosillo, B. & 12 others, Veronese, S., Budillon, A., Montagut, C., Racca, P., Marsoni, S., Falcone, A., Corcoran, R. B., Di Nicolantonio, F., Loupakis, F., Siena, S., Sartore-Bianchi, A. & Bardelli, A., Jun 1 2015, In : Nature Medicine. 21, 7, p. 795-801 7 p.

Research output: Contribution to journalArticle

Erratum: Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

Siravegna, G., Mussolin, B., Buscarino, M., Corti, G., Cassingena, A., Crisafulli, G., Ponzetti, A., Cremolini, C., Amatu, A., Lauricella, C., Lamba, S., Hobor, S., Avallone, A., Valtorta, E., Rospo, G., Medico, E., Motta, V., Antoniotti, C., Tatangelo, F., Bellosillo, B. & 12 others, Veronese, S., Budillon, A., Montagut, C., Racca, P., Marsoni, S., Falcone, A., Corcoran, R. B., Di Nicolantonio, F., Loupakis, F., Siena, S., Sartore-Bianchi, A. & Bardelli, A., Jul 7 2015, In : Nature Medicine. 21, 7, p. 827 1 p.

Research output: Contribution to journalArticle

Meet the editorial board

Budillon, A., Jan 1 2015, In : Recent Patents on Anti-Cancer Drug Discovery. 10, 1, p. 1 1 p.

Research output: Contribution to journalArticle

Pathophysiologically relevant in vitro tumor models for drug screening

Das, V., Bruzzese, F., Konečný, P., Iannelli, F., Budillon, A. & Hajdúch, M., Jul 9 2015, In : Drug Discovery Today. 20, 7, p. 848-855 8 p., 1610.

Research output: Contribution to journalArticle

Proteomic analysis of zoledronic-acid resistant prostate cancer cells unveils novel pathways characterizing an invasive phenotype

Milone, M. R., Pucci, B., Bifulco, K., Iannelli, F., Lombardi, R., Ciardiello, C., Bruzzese, F., Carriero, M. V. & Budillon, A., 2015, In : Oncotarget. 6, 7, p. 5324-5341 18 p.

Research output: Contribution to journalArticle

Synthesis and Evaluation of the Antiproliferative Properties of a Tethered Tubercidin-Platinum(II) Complex

D'Errico, S., Oliviero, G., Borbone, N., Di Gennaro, E., Zotti, A. I., Budillon, A., Cerullo, V., Nici, F., Mayol, L., Piccialli, V. & Piccialli, G., Dec 1 2015, In : European Journal of Organic Chemistry. 2015, 34, p. 7550-7556 7 p.

Research output: Contribution to journalArticle

Exposure to perfluoroalkyl substances and sperm DNA global methylation in arctic and European populations

Leter, G., Consales, C., Eleuteri, P., Uccelli, R., Specht, I. O., Toft, G., Moccia, T., Budillon, A., Jönsson, B. A. G., Lindh, C. H., Giwercman, A., Pedersen, H. S., Ludwicki, J. K., Zviezdai, V., Heederik, D., Bonde, J. P. E. & Spanò, M., 2014, In : Environmental and Molecular Mutagenesis. 55, 7, p. 591-600 10 p.

Research output: Contribution to journalArticle

Indices of methylation in sperm DNA from fertile men differ between distinct geographical regions

Consales, C., Leter, G., Bonde, J. P. E., Toft, G., Eleuteri, P., Moccia, T., Budillon, A., Jönsson, B. A. G., Giwercman, A., Pedersen, H. S., Ludwicki, J. K., Zviezdai, V., Heederik, D. & Spanò, M., 2014, In : Human Reproduction. 29, 9, p. 2065-2072 8 p.

Research output: Contribution to journalArticle

Local and systemic protumorigenic effects of cancer-associatedfibroblast- derived GDF15

Bruzzese, F., Hägglöf, C., Leone, A., Sjöberg, E., Roca, M. S., Kiflemariam, S., Sjöblom, T., Hammarsten, P., Egevad, L., Bergh, A., Östman, A., Budillon, A. & Augsten, M., Jul 1 2014, In : Cancer Research. 74, 13, p. 3408-3417 10 p.

Research output: Contribution to journalArticle

Pharmacological targeting of p53 through RITA is an effective antitumoral strategy for malignant pleural mesothelioma

Di Marzo, D., Forte, I. M., Indovina, P., Di Gennaro, E., Rizzo, V., Giorgi, F., Mattioli, E., Iannuzzi, C. A., Budillon, A., Giordano, A. & Pentimalli, F., Feb 15 2014, In : Cell Cycle. 13, 4, p. 652-665 14 p.

Research output: Contribution to journalArticle

2013

Acquired resistance to zoledronic acid and the parallel acquisition of an aggressive phenotype are mediated by p38-MAP kinase activation in prostate cancer cells

Milone, M. R., Pucci, B., Bruzzese, F., Carbone, C., Piro, G., Costantini, S., Capone, F., Leone, A., Di Gennaro, E., Caraglia, M. & Budillon, A., May 2013, In : Cell Death and Disease. 4, 5, e641.

Research output: Contribution to journalArticle

Panobinostat synergizes with zoledronic acid in prostate cancer and multiple myeloma models by increasing ROS and modulating mevalonate and p38-MAPK pathways

Bruzzese, F., Pucci, B., Milone, M. R., Ciardiello, C., Franco, R., Chianese, M. I., Rocco, M., Di Gennaro, E., Leone, A., Luciano, A., Arra, C., Santini, D., Caraglia, M. & Budillon, A., Oct 2013, In : Cell Death and Disease. 4, 10, e878.

Research output: Contribution to journalArticle

Tissue transglutaminase: A new target to reverse cancer drug resistance

Budillon, A., Carbone, C. & Di Gennaro, E., Jan 2013, In : Amino Acids. 44, 1, p. 63-72 10 p.

Research output: Contribution to journalArticle

2012

A high percentage of BRAFV600E alleles in papillary thyroid carcinoma predicts a poorer outcome

Guerra, A., Fugazzola, L., Marotta, V., Cirillo, M., Rossi, S., Cirello, V., Forno, I., Moccia, T., Budillon, A. & Vitale, M., Jul 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 7, p. 2333-2340 8 p.

Research output: Contribution to journalArticle

Caveolin-1 overexpression is associated with simultaneous abnormal expression of the E-cadherin/α-β catenins complex and multiple erbb receptors and with lymph nodes metastasis in head and neck squamous cell carcinomas

Masuelli, L., Budillon, A., Marzocchella, L., Mrozek, M. A., Vitolo, D., Di Gennaro, E., Losito, S., Sale, P., Longo, F., Ionna, F., Lista, F., Muraro, R., Modesti, A. & Bei, R., Sep 2012, In : Journal of Cellular Physiology. 227, 9, p. 3344-3353 10 p.

Research output: Contribution to journalArticle

Pancreatic cancer: Between bench and bedside

Melisi, D. & Budillon, A., Jun 2012, In : Current Drug Targets. 13, 6, p. 729-730 2 p.

Research output: Contribution to journalArticle

The PPAR-γ agonist troglitazone antagonizes survival pathways induced by STAT-3 in recombinant interferon-β treated pancreatic cancer cells

Vitale, G., Zappavigna, S., Marra, M., Dicitore, A., Meschini, S., Condello, M., Arancia, G., Castiglioni, S., Maroni, P., Bendinelli, P., Piccoletti, R., Van Koetsveld, P. M., Cavagnini, F., Budillon, A., Abbruzzese, A., Hofland, L. J. & Caraglia, M., Jan 2012, In : Biotechnology Advances. 30, 1, p. 169-184 16 p.

Research output: Contribution to journalArticle

The primary occurrence of BRAFV600E is a rare clonal event in papillary thyroid carcinoma

Guerra, A., Sapio, M. R., Marotta, V., Campanile, E., Rossi, S., Forno, I., Fugazzola, L., Budillon, A., Moccia, T., Fenzi, G. & Vitale, M., Feb 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 2, p. 517-524 8 p.

Research output: Contribution to journalArticle

2011

Anti-VEGF treatment-resistant pancreatic cancers secrete proinflammatory factors that contribute to malignant progression by inducing an EMT cell phenotype

Carbone, C., Moccia, T., Zhu, C., Paradiso, G., Budillon, A., Chiao, P. J., Abbruzzese, J. L. & Melisi, D., Sep 1 2011, In : Clinical Cancer Research. 17, 17, p. 5822-5832 11 p.

Research output: Contribution to journalArticle

Modulation of pancreatic cancer chemoresistance by inhibition of TAK1

Melisi, D., Xia, Q., Paradiso, G., Ling, J., Moccia, T., Carbone, C., Budillon, A., Abbruzzese, J. L. & Chiao, P. J., Aug 3 2011, In : Journal of the National Cancer Institute. 103, 15, p. 1190-1204 15 p.

Research output: Contribution to journalArticle

Proteomic analysis identifies differentially expressed proteins after HDAC vorinostat and EGFR inhibitor gefitinib treatments in Hep-2 cancer cells

Bianchi, L., Bruzzese, F., Leone, A., Gagliardi, A., Puglia, M., Di Gennaro, E., Rocco, M., Gimigliano, A., Pucci, B., Armini, A., Bini, L. & Budillon, A., Sep 2011, In : Proteomics. 11, 18, p. 3725-3742 18 p.

Research output: Contribution to journalArticle

Synthesis of 1-naphtylpiperazine derivatives as serotoninergic ligands and their evaluation as antiproliferative agents

Fiorino, F., Magli, E., Perissutti, E., Severino, B., Frecentese, F., Esposito, A., De Angelis, F., Incisivo, G. M., Massarelli, P., Nencini, C., Di Gennaro, E., Budillon, A., Di Cintio, A., Santagada, V. & Caliendo, G., Jun 2011, In : European Journal of Medicinal Chemistry. 46, 6, p. 2206-2216 11 p.

Research output: Contribution to journalArticle

Urotensin II receptor predicts the clinical outcome of prostate cancer patients and is involved in the regulation of motility of prostate adenocarcinoma cells

Grieco, P., Franco, R., Bozzuto, G., Toccacieli, L., Sgambato, A., Marra, M., Zappavigna, S., Migaldi, M., Rossi, G., Striano, S., Marra, L., Gallo, L., Cittadini, A., Botti, G., Novellino, E., Molinari, A., Budillon, A. & Caraglia, M., Jan 2011, In : Journal of Cellular Biochemistry. 112, 1, p. 341-353 13 p.

Research output: Contribution to journalArticle

2010

Metronomic administration of zoledronic acid and taxotere combination in castration resistant prostate cancer patients. Phase I ZANTE trial

Facchini, G., Caraglia, M., Morabito, A., Marra, M., Piccirillo, M. C., Bochicchio, A. M., Striano, S., Marra, L., Nasti, G., Ferrari, E., Leopardo, D., Vitale, G., Gentilini, D., Tortoriello, A., Catalano, A., Budillon, A., Perrone, F. & Iaffaioli, R. V., Sep 15 2010, In : Cancer Biology and Therapy. 10, 6, p. 543-548 6 p.

Research output: Contribution to journalArticle

Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase

Di Gennaro, E., Piro, G., Chianese, M. I., Franco, R., Cintio, A. D., Moccia, T., Luciano, A., De Ruggiero, I., Bruzzese, F., Avallone, A., Arra, C. & Budillon, A., Nov 23 2010, In : British Journal of Cancer. 103, 11, p. 1680-1691 12 p.

Research output: Contribution to journalArticle

2009

Cyr61 downmodulation potentiates the anticancer effects of zoledronic acid in androgen-independent prostate cancer cells

Marra, M., Santini, D., Meo, G., Vincenzi, B., Zappavigna, S., Baldi, A., Rosolowski, M., Tonini, G., Loeffler, M., Lupu, R., Addeo, S. R., Abbruzzese, A., Budillon, A. & Caraglia, M., Nov 1 2009, In : International Journal of Cancer. 125, 9, p. 2004-2013 10 p.

Research output: Contribution to journalArticle

2008

Molecular and preclinical models enhancing anti-tumour activity of zoledronic acid

Marra, M., Santini, D., Tonini, G., Meo, G., Zappavigna, S., Facchini, G., Morabito, A., Abbruzzese, A., Cartenì, G., Budillon, A. & Caraglia, M., Oct 2008, In : European Journal of Cancer, Supplement. 6, 14, p. 79-85 7 p.

Research output: Contribution to journalArticle

The farnesyltransferase inhibitor R115777 (ZARNESTRA®) enhances the pro-apoptotic activity of interferon-α through the inhibition of multiple survival pathways (International Journal of Cancer (2007) 121, (2317-2330))

Caraglia, M., Marra, M., Viscomi, C., D'Alessandro, A. M., Budillon, A., Meo, G., Arra, C., Barbieri, A., Rapp, U. R., Baldi, A., Tassone, P., Venuta, S., Abbruzzese, A. & Tagliaferri, P., Apr 15 2008, In : International Journal of Cancer. 122, 8, p. 1922 1 p.

Research output: Contribution to journalArticle

The multidrug transporter P-glycoprotein: A mediator of melanoma invasion?

Colone, M., Calcabrini, A., Toccacieli, L., Bozzuto, G., Stringaro, A., Gentile, M., Cianfriglia, M., Ciervo, A., Caraglia, M., Budillon, A., Meo, G., Arancia, G. & Molinari, A., Apr 2008, In : Journal of Investigative Dermatology. 128, 4, p. 957-971 15 p.

Research output: Contribution to journalArticle

2007

Adenylate cyclase/cAMP pathway downmodulation counteracts apoptosis induced by IFN-α in human epidermoid cancer cells

Naviglio, S., Spina, A., Marra, M., Sorrentino, A., Chiosi, E., Romano, M., Improta, S., Budillon, A., Illiano, G., Abbruzzese, A. & Caraglia, M., Feb 2007, In : Journal of Interferon and Cytokine Research. 27, 2, p. 129-136 8 p.

Research output: Contribution to journalArticle