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Research Output

2007

A multidisciplinary approach is required to increase the quality of phase II/III clinical studies on biotherapies in oncology [2]

Ottaiano, A., Budillon, A., Normanno, N., Iaffaioli, V. R. & Caraglia, M., May 2007, In : Annals of Oncology. 18, 5, p. 960-961 2 p.

Research output: Contribution to journalArticle

Anticancer drugs and hyperthermia enhance cytotoxicity induced by polyamine enzymatic oxidation products

Marra, M., Agostinelli, E., Tempera, G., Lombardi, A., Meo, G., Budillon, A., Abbruzzese, A., Giuberti, G. & Caraglia, M., Aug 2007, In : Amino Acids. 33, 2, p. 273-281 9 p.

Research output: Contribution to journalArticle

Cetuximab is an active treatment of metastatic and chemorefractory thymoma

Palmieri, G., Marino, M., Salvatore, M., Budillon, A., Meo, G., Caraglia, M. & Montella, L., 2007, In : Frontiers in Bioscience. 12, 2, p. 757-761 5 p.

Research output: Contribution to journalArticle

Concomitant occurrence of facial cutaneous and parotid gland metastases from rectal cancer after preoperative chemoradiotherapy

Nasti, G., Facchini, G., Caraglia, M., Franco, R., Mura, A., Staiano, M., Budillon, A., Iaffaioli, R. V. & Ottaiano, A., Jun 2007, In : Onkologie. 30, 6, p. 324-326 3 p.

Research output: Contribution to journalArticle

C-Raf antagonizes apoptosis induced by IFN-α in human lung cancer cells by phosphorylation and increase of the intracellular content of elongation factor 1A

Lamberti, A., Longo, O., Marra, M., Tagliaferri, P., Bismuto, E., Fiengo, A., Viscomi, C., Budillon, A., Rapp, U. R., Wang, E., Venuta, S., Abbruzzese, A., Arcari, P. & Caraglia, M., May 2007, In : Cell Death and Differentiation. 14, 5, p. 952-962 11 p.

Research output: Contribution to journalArticle

Histone deacetylase inhibitors: A new wave of molecular targeted anticancer agents

Budillon, A., Di Gennaro, E., Bruzzese, F., Rocco, M., Manzo, G. & Caraglia, M., Jun 2007, In : Recent Patents on Anti-Cancer Drug Discovery. 2, 2, p. 119-134 16 p.

Research output: Contribution to journalArticle

Molecular rationales for signal transduction therapy and chemoprevention of BRCA1-related breast and ovarian tumours

Tagliaferri, P., Tassone, P., Pietragalla, A., Rotundo, M. S., Barbieri, V., Budillon, A., Caraglia, M., Costanzo, F. S. & Venuta, S., May 2007, In : Current Signal Transduction Therapy. 2, 2, p. 165-173 9 p.

Research output: Contribution to journalArticle

Phase II studies of anticancer chemotherapy: Indirect evidence of poor quality [7]

Ottaiano, A., Facchini, G., Nasti, G., Budillon, A. & Caraglia, M., Feb 2007, In : Annals of Oncology. 18, 2, p. 403 1 p.

Research output: Contribution to journalArticle

R115777 (Zarnestra®)/zoledronic acid (Zometa®) cooperation on inhibition of prostate cancer proliferation is paralleled by Erk/Akt inactivation and reduced Bcl-2 and bad phosphorylation

Caraglia, M., Marra, M., Leonetti, C., Meo, G., D'Alessandro, A. M., Baldi, A., Santini, D., Tonini, G., Bertieri, R., Zupi, G., Budillon, A. & Abbruzzese, A., May 2007, In : Journal of Cellular Physiology. 211, 2, p. 533-543 11 p.

Research output: Contribution to journalArticle

Small tumor of the medial breast presenting with a contralateral lymph node involvement detected on positron emission tomography scan [1]

Facchini, G., Caraglia, M., Nasti, G., Ottaiano, A., Franco, R., La Mura, A., Fulciniti, F., Libutti, M., Ruberto, M., Marra, M., Budillon, A. & Iaffaioli, R. V., Sep 2007, In : Annals of Oncology. 18, 9, p. 1579-1580 2 p.

Research output: Contribution to journalArticle

Somatostatin analogues, a series of tissue transglutaminase inducers, as a new tool for therapy of mesenchimal tumors of the gastrointestinal tract

Palmieri, G., Montella, L., Aiello, C., Barbieri, F., Di Vizio, D., Schulz, S., Beninati, S., Budillon, A., Caraglia, M., Insabato, L. & Florio, T., Apr 2007, In : Amino Acids. 32, 3, p. 395-400 6 p.

Research output: Contribution to journalArticle

Synergistic antitumour effect of raltitrexed and 5-fluorouracil plus folinic acid combination in human cancer cells

Avallone, A., Di Gennaro, E., Bruzzese, F., Laus, G., Delrio, P., Caraglia, M., Pepe, S., Comella, P. & Budillon, A., Aug 2007, In : Anti-Cancer Drugs. 18, 7, p. 781-791 11 p.

Research output: Contribution to journalArticle

Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine

Donadelli, M., Costanzo, C., Beghelli, S., Scupoli, M. T., Dandrea, M., Bonora, A., Piacentini, P., Budillon, A., Caraglia, M., Scarpa, A. & Palmieri, M., Jul 2007, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1773, 7, p. 1095-1106 12 p.

Research output: Contribution to journalArticle

The clinical response on bone metastasis from breast and lung cancer during treatment with zoledronic acid is inversely correlated to skeletal related events (SRE)

Facchini, G., Caraglia, M., Santini, D., Nasti, G., Ottaiano, A., Striano, S., Maiolino, P., Ruberto, M., Fiore, F., Tonini, G., Budillon, A., Iaffaioli, R. V. & Zeppetella, G. L., Sep 2007, In : Journal of Experimental and Clinical Cancer Research. 26, 3, p. 307-312 6 p.

Research output: Contribution to journalArticle

The farnesyltransferase inhibitor R115777 (ZARNESTRA®) enhances the pro-apoptotic activity of interferon-α through the inhibition of multiple survival pathways

Caraglia, M., Marra, M., Viscomi, C., D'Alessandro, A. M., Budillon, A., Meo, G., Arra, C., Barbieri, A., Rapp, U. R., Baldi, A., Tassone, P., Venuta, S., Abbruzzese, A. & Tagliaferri, P., Nov 15 2007, In : International Journal of Cancer. 121, 10, p. 2317-2330 14 p.

Research output: Contribution to journalArticle

The immunomodulatory protein SV-IV protects serum-deprived cells against apoptosis but not against G0/G1 arrest: Possible implications for the survival of implanting embryo

Morelli, F., Peluso, G., Petillo, O., Giannattasio, A., Filosa, S., Motta, C. M., Tammaro, S., Zatterale, A., Calzone, R., Budillon, A., Cartenì, M., De Maria, S., Costanza, M. R., Nigro, A., Petrazzuolo, M., Buommino, E., Rizzo, M., Capasso, G., Baiano, S., Moscatiello, F. & 7 others, Ravagnan, G., Fuggetta, M. P., Tajana, G., Stiuso, P., Metafora, B. M., Metafora, V. & Metafora, S., Sep 2007, In : Journal of Cellular Physiology. 212, 3, p. 610-625 16 p.

Research output: Contribution to journalArticle

The ribosomal P0 protein induces a spontaneous immune response in patients with head and neck advanced stage carcinoma that is not dependent on its overexpression in carcinomas

Bei, R., Masuelli, L., Trono, P., Orvietani, P. L., Losito, S., Marzocchella, L., Vitolo, D., Albonici, L., Mrozek, M. A., Di Gennaro, E., Lista, F., Faggioni, G., Ionna, F., Binaglia, L., Manzari, V., Budillon, A. & Modesti, A., Dec 2007, In : International Journal of Oncology. 31, 6, p. 1301-1308 8 p.

Research output: Contribution to journalArticle

2006

Changes in bone resorption and vascular endothelial growth factor after a single zoledronic acid infusion in cancer patients with bone metastases from solid tumours

Santini, D., Vincenzi, B., Hannon, R. A., Brown, J. E., Dicuonzo, G., Angeletti, S., La Cesa, A., Coleman, R. E., Tonini, G., Budillon, A., Caraglia, M. & Holen, I., May 2006, In : Oncology Reports. 15, 5, p. 1351-1357 7 p.

Research output: Contribution to journalArticle

EGF-R small inhibitors and anti-EGF-R antibodies: Advantages and limits of a new avenue in anticancer therapy

Caraglia, M., Marra, M., Meo, G., Addeo, R., Tagliaferri, P. & Budillon, A., 2006, In : Recent Patents on Anti-Cancer Drug Discovery. 1, 2, p. 209-222 14 p.

Research output: Contribution to journalArticle

Emerging anti-cancer molecular mechanisms of aminobisphosphonates

Caraglia, M., Santini, D., Marra, M., Vincenzi, B., Tonini, G. & Budillon, A., Mar 2006, In : Endocrine-Related Cancer. 13, 1, p. 7-26 20 p.

Research output: Contribution to journalArticle

Highlights from: 97th Annual Meeting of the American Association for Cancer Research

Ranganathan, A., Budillon, A. & Lara, P., May 2006, In : Clinical Lung Cancer. 7, 6, p. 373-377 5 p.

Research output: Contribution to journalArticle

Last generation of amino-bisphosphonates (N-BPs) and cancer angiogenesis: A new role for these drugs?

Santini, D., Schiavon, G., Angeletti, S., Vincenzi, B., Gasparro, S., Grilli, C., La Cesa, A., Virzí, V., Leoni, V., Budillon, A., Addeo, S. R., Caraglia, M., Dicuonzo, G. & Tonini, G., 2006, In : Recent Patents on Anti-Cancer Drug Discovery. 1, 3, p. 383-396 14 p.

Research output: Contribution to journalArticle

Mechanisms of disease: Preclinical reports of antineoplastic synergistic action of bisphosphonates

Santini, D., Caraglia, M., Vincenzi, B., Holen, I., Scarpa, S., Budillon, A. & Tonini, G., Jun 2006, In : Nature Clinical Practice Oncology. 3, 6, p. 325-338 14 p.

Research output: Contribution to journalArticle

Molecular dynamics simulation and automated docking of the pro-apoptotic Bax protein and its complex with a peptide designed from the Bax-binding domain of anti-apoptotic Ku70

Mancinelli, F., Caraglia, M., Budillon, A., Abbruzzese, A. & Bismuto, E., Sep 1 2006, In : Journal of Cellular Biochemistry. 99, 1, p. 305-318 14 p.

Research output: Contribution to journalArticle

Phase II study of temozolomide plus pegylated liposomal doxorubicin in the treatment of brain metastases from solid tumours.

Caraglia, M., Addeo, R., Costanzo, R., Montella, L., Faiola, V., Marra, M., Abbruzzese, A., Palmieri, G., Budillon, A., Grillone, F., Venuta, S., Tagliaferri, P. & Del Prete, S., Jan 2006, In : Cancer Chemotherapy and Pharmacology. 57, 1, p. 34-39 6 p.

Research output: Contribution to journalArticle

Targeting Raf-kinase: Molecular rationales and translational issues

Caraglia, M., Tassone, P., Marra, M., Budillon, A., Venuta, S. & Tagliaferri, P., Jun 2006, In : Annals of Oncology. 17, SUPPL. 7

Research output: Contribution to journalArticle

The farnesyl-transferase r115777 and the aminobisphosphonate zoledronic acid synergize on the apoptosis and on the growth inhibition of human cancer cells

Caraglia, M., Marra, M., Leonetti, C., Meo, G., Addeo, S. R., Bruzzese, F., Tagliaferri, P., Zupi, G., Abbruzzese, A. & Budillon, A., 2006, In : Haematologica Reports. 2, 3, p. 27-28 2 p.

Research output: Contribution to journalArticle

Antitumor therapeutic strategies based on the targeting of epidermal growth factor-induced survival pathways

Tagliaferri, P., Tassone, P., Blotta, S., Viscomi, C., Grillone, F., Budillon, A., Caraglia, M. & Venuta, S., May 2005, In : Current Drug Targets. 6, 3, p. 289-300 12 p.

Research output: Contribution to journalArticle

Chemotherapy regimen GOLF induces apoptosis in colon cancer cells through multi-chaperone complex inactivation and increased Raf-1 ubiquitin-dependent degradation

Caraglia, M., Marra, M., Budillon, A., Meo, G., Ricciardiello, F., Bismuto, E., Brachelente, G., Francini, G., Giordano, A., Correale, P. & Abbruzzese, A., Oct 2005, In : Cancer Biology and Therapy. 4, 10, p. 1159-1167 9 p.

Research output: Contribution to journalArticle

Docetaxel induces p53-dependent apoptosis and synergizes with farnesyl transferase inhibitor R115777 in human epithelial cancer cells

Caraglia, M., Giuberti, G., Marra, M., Di Gennaro, E., Facchini, G., Caponigro, F., Iaffeioli, R. V., Budillon, A. & Abbruzzese, A., 2005, In : Frontiers in Bioscience. 10, SUPPL. 2, p. 2566-2575 10 p.

Research output: Contribution to journalArticle

Electromagnetic fields at mobile phone frequency induce apoptosis and inactivation of the multi-chaperone complex in human epidermoid cancer cells

Caraglia, M., Marra, M., Mancinelli, F., D'Ambrosio, G., Massa, R., Giordano, A., Budillon, A., Abbruzzese, A. & Bismuto, E., Aug 2005, In : Journal of Cellular Physiology. 204, 2, p. 539-548 10 p.

Research output: Contribution to journalArticle

Isoprenylation of intracellular proteins as a new target for the therapy of human neoplasms: Preclinical and clinical implications

Caraglia, M., Budillon, A., Tagliaferri, P., Marra, M., Abbruzzese, A. & Caponigro, F., May 2005, In : Current Drug Targets. 6, 3, p. 301-323 23 p.

Research output: Contribution to journalArticle

Multidisciplinary approach to locally advanced rectal cancer: results of a single institution trial.

Delrio, P., Avallone, A., Guida, C., Lastoria, S., Tatangelo, F., Cascini, G. M., Marone, P., Petrillo, A., Budillon, A., Di Marzo, M., Palaia, R., Albino, V., De Rosa, V. & Parisi, V., 2005, I supplementi di Tumori : official journal of Società italiana di cancerologia ... [et al.]. 3 ed. Vol. 4.

Research output: Chapter in Book/Report/Conference proceedingChapter

Multiple-target drugs: Inhibitors of heat shock protein 90 and of histone deacetylase

Budillon, A., Bruzzese, F., Di Gennaro, E. & Caraglia, M., May 2005, In : Current Drug Targets. 6, 3, p. 337-351 15 p.

Research output: Contribution to journalArticle

New pharmacokinetic and pharmacodynamic tools for interferon-alpha (IFN-α) treatment of human cancer

Tagliaferri, P., Caraglia, M., Budillon, A., Marra, M., Vitale, G., Viscomi, C., Masciari, S., Tassone, P., Abbruzzese, A. & Venuta, S., Jan 2005, In : Cancer Immunology, Immunotherapy. 54, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

2004

Acetylation of proteins as novel target for antitumor therapy: Review article

Di Gennaro, E., Bruzzese, F., Caraglia, M., Abruzzese, A. & Budillon, A., Jul 2004, In : Amino Acids. 26, 4, p. 435-441 7 p.

Research output: Contribution to journalArticle

Alpha-interferon and its effects on signalling pathways within cells

Caraglia, M., Vitale, G., Marra, M., Budillon, A., Tagliaferri, P. & Abbruzzese, A., Dec 2004, In : Current Protein and Peptide Science. 5, 6, p. 475-485 11 p.

Research output: Contribution to journalArticle

Expression of COX-2, mPGE-synthase1, MDR-1 (P-gp), and Bcl-xL: A molecular pathway of H pylori-related gastric carcinogenesis

Nardone, G., Rocco, A., Vaira, D., Staibano, S., Budillon, A., Tatangelo, F., Sciulli, M. G., Perna, F., Salvatore, G., Di Benedetto, M., De Rosa, G. & Patrignani, P., Mar 2004, In : Journal of Pathology. 202, 3, p. 305-312 8 p.

Research output: Contribution to journalArticle

Frequent overexpression of multiple ErbB receptors by head and neck squamous cell carcinoma contrasts with rare antibody immunity in patients

Bei, R., Budillon, A., Masuelli, L., Cereda, V., Vitolo, D., Di Gennaro, E., Ripavecchia, V., Palumbo, C., Ionna, F., Losito, S., Modesti, A., Kraus, M. H. & Muraro, R., Nov 2004, In : Journal of Pathology. 204, 3, p. 317-325 9 p.

Research output: Contribution to journalArticle

The farnesyl transferase inhibitor R115777 (Zarnestra®) synergistically enhances growth inhibition and apoptosis induced on epidermoid cancer cells by zoledronic acid (Zometa®) and pamidronate

Caraglia, M., D'Alessandro, A. M., Marra, M., Giuberti, G., Vitale, G., Viscomi, C., Colao, A., Del Prete, S., Tagliaferri, P., Tassone, P., Budillon, A., Venuta, S. & Abbruzzese, A., Sep 9 2004, In : Oncogene. 23, 41, p. 6900-6913 14 p.

Research output: Contribution to journalArticle

Translational and post-translational modifications of proteins as a new mechanism of action of Alpha-Interferon: Review article

Caraglia, M., Vitale, G., Marra, M., Del Prete, S., Lentini, A., Budillon, A., Beninati, S. & Abbruzzese, A., Jul 2004, In : Amino Acids. 26, 4, p. 409-417 9 p.

Research output: Contribution to journalArticle

2003

EGF activates an inducible survival response via the RAS-> Erk-1/2 pathway to counteract interferon-α-mediated apoptosis in epidermoid cancer cells

Caraglia, M., Tagliaferri, P., Marra, M., Giuberti, G., Budillon, A., Di Gennaro, E., Pepe, S., Vitale, G., Improta, S., Tassone, P., Venuta, S., Bianco, A. R. & Abbruzzese, A., Feb 1 2003, In : Cell Death and Differentiation. 10, 2, p. 218-229 12 p.

Research output: Contribution to journalArticle

Valutazione precoce con PET-FDG della efficacia del trattamento radiochemioterapico neoadiuvante nelle neoplasie del retto inferiore localmente avanzate.

Translated title of the contribution: Early evaluation using PET-FDG of the efficiency of neoadjuvant radiochemotherapy treatment in locally advanced neoplasia of the lower rectumDelrio, P., Lastoria, S., Avallone, A., Ravo, V., Guida, C., Cremona, F., Izzo, F., Palaia, R., Ruffolo, F., Puppio, B., Guidetti, G. M., Cascini, G. L., Casaretti, R., Tatangelo, F., Marone, P., Rossi, G. B., Budillon, A., Petrillo, A., De Rosa, V., Comella, G. & 4 others, Morrica, B., Tempesta, A., Botti, G. & Parisi, V., Jul 2003, In : Tumori. 89, 4 Suppl, p. 50-53 4 p.

Research output: Contribution to journalArticle

2001

Raltitrexed/5-fluorouracil-based combination chemotherapy regimens in anticancer therapy

Caponigro, F., Avallone, A., Budillon, A., Comella, P. & Comella, G., 2001, In : Anti-Cancer Drugs. 12, 6, p. 489-497 9 p.

Research output: Contribution to journalArticle

The role of eukaryotic initiation factor 5A in the control of cell proliferation and apoptosis

Caraglia, M., Marra, M., Giuberti, G., D'Alessandro, A. M., Budillon, A., Del Prete, S., Lentini, A., Beninati, S. & Abbruzzese, A., 2001, In : Amino Acids. 20, 2, p. 91-104 14 p.

Research output: Contribution to journalArticle