• 4841 Citations
  • 42 h-Index
1991 …2019
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Research Output 1991 2019

  • 4841 Citations
  • 42 h-Index
  • 160 Article
  • 5 Review article
  • 1 Chapter
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Article
5 Citations (Scopus)

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

Elgendy, M., Cirò, M., Hosseini, A., Weiszmann, J., Mazzarella, L., Ferrari, E., Cazzoli, R., Curigliano, G., DeCensi, A., Bonanni, B., Budillon, A., Pelicci, P. G., Janssens, V., Ogris, M., Baccarini, M., Lanfrancone, L., Weckwerth, W., Foiani, M. & Minucci, S., May 13 2019, In : Cancer Cell. 35, 5, p. 798-815.e5

Research output: Contribution to journalArticle

Glycogen Synthase Kinase 3
Metformin
Hypoglycemia
Oxidative Phosphorylation
Growth

Histone deacetylase inhibitor ITF2357 (givinostat) reverts transformed phenotype and counteracts stemness in in vitro and in vivo models of human glioblastoma

Marampon, F., Leoni, F., Mancini, A., Pietrantoni, I., Codenotti, S., Letizia, F., Megiorni, F., Porro, G., Galbiati, E., Pozzi, P., Mascagni, P., Budillon, A., Maggio, R., Tombolini, V., Fanzani, A., Gravina, G. L. & Festuccia, C., Feb 2019, In : Journal of Cancer Research and Clinical Oncology. 145, 2, p. 393-409 17 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Glioblastoma
Phenotype
Histone Deacetylases
Differentiation Antigens
Open Access
Integrin alphaV
Prostatic Neoplasms
Integrins
Heterografts
Blister
Platinum
Non-Small Cell Lung Carcinoma
Proteomics
Cisplatin
Proteins

Perspectives in melanoma: Meeting report from the Melanoma Bridge (November 29th-1 December 1st, 2018, Naples, Italy)

Ascierto, P. A., Agarwala, S. S., Botti, G., Budillon, A., Davies, M. A., Dummer, R., Ernstoff, M., Ferrone, S., Formenti, S., Gajewski, T. F., Garbe, C., Hamid, O., Lo, R. S., Luke, J. J., Michielin, O., Palmieri, G., Zitvogel, L., Marincola, F. M., Masucci, G., Caracò, C. & 2 others, Thurin, M. & Puzanov, I., Jul 22 2019, In : Journal of Translational Medicine. 17, 1, 234.

Research output: Contribution to journalArticle

Open Access
Italy
Tumors
Melanoma
Biomarkers
Neoplasms

Reprogramming miRNAs global expression orchestrates development of drug resistance in BRAF mutated melanoma

Fattore, L., Ruggiero, C. F., Pisanu, M. E., Liguoro, D., Cerri, A., Costantini, S., Capone, F., Acunzo, M., Romano, G., Nigita, G., Mallardo, D., Ragone, C., Carriero, M. V., Budillon, A., Botti, G., Ascierto, P. A., Mancini, R. & Ciliberto, G., Jul 2019, In : Cell Death and Differentiation. 26, 7, p. 1267-1282 16 p.

Research output: Contribution to journalArticle

MicroRNAs
Drug Resistance
Melanoma
Recurrence
Mitogen-Activated Protein Kinase Kinases

Structure-function relationship of an Urokinase Receptor-derived peptide which inhibits the Formyl Peptide Receptor type 1 activity

Minopoli, M., Polo, A., Ragone, C., Ingangi, V., Ciliberto, G., Pessi, A., Sarno, S., Budillon, A., Costantini, S. & Carriero, M. V., Dec 1 2019, In : Scientific Reports. 9, 1, 12169.

Research output: Contribution to journalArticle

Open Access
2018
4 Citations (Scopus)

A standardized flow cytometry network study for the assessment of circulating endothelial cell physiological ranges

Lanuti, P., Simeone, P., Rotta, G., Almici, C., Avvisati, G., Azzaro, R., Bologna, G., Budillon, A., Di Cerbo, M., Di Gennaro, E., Di Martino, M. L., Diodato, A., Doretto, P., Ercolino, E., Falda, A., Gregorj, C., Leone, A., Losa, F., Malara, N., Marini, M. & 18 others, Mastroroberto, P., Mollace, V., Morelli, M., Muggianu, E., Musolino, G., Neva, A., Pierdomenico, L., Pinna, S., Piovani, G., Roca, M. S., Russo, D., Scotti, L., Tirindelli, M. C., Venturella, R., Vitagliano, C., Zullo, F., Marchisio, M. & Miscia, S., Dec 1 2018, In : Scientific Reports. 8, 1, 5823.

Research output: Contribution to journalArticle

Flow Cytometry
Endothelial Cells
Cell Count
Population
Endothelium

Effects of α-zearalenol on the metabolome of two breast cancer cell lines by 1H-NMR approach

Nittoli, A. C., Costantini, S., Sorice, A., Capone, F., Ciarcia, R., Marzocco, S., Budillon, A. & Severino, L., Mar 1 2018, In : Metabolomics. 14, 3, 33.

Research output: Contribution to journalArticle

Metabolome
MCF-7 Cells
Metabolomics
Cells
Nuclear magnetic resonance
1 Citation (Scopus)

Evaluation of Aflatoxin M1 Effects on the Metabolomic and Cytokinomic Profiling of a Hepatoblastoma Cell Line

Marchese, S., Sorice, A., Ariano, A., Florio, S., Budillon, A., Costantini, S. & Severino, L., Oct 28 2018, In : Toxins. 10, 11

Research output: Contribution to journalArticle

Aflatoxin M1
Hepatoblastoma
Metabolomics
Hep G2 Cells
Cells
1 Citation (Scopus)

Identifying a panel of genes/proteins/miRNAs modulated by arsenicals in bladder, prostate, kidney cancers

Polo, A., Marchese, S., De Petro, G., Montella, M., Ciliberto, G., Budillon, A. & Costantini, S., Dec 1 2018, In : Scientific Reports. 8, 1, 10395.

Research output: Contribution to journalArticle

Arsenicals
Kidney Neoplasms
MicroRNAs
Prostatic Neoplasms
Urinary Bladder
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Mevalonic Acid
Neoplasms
Lipogenesis
Patents
4 Citations (Scopus)

Toxigenic effects of two benthic diatoms upon grazing activity of the sea urchin: Morphological, metabolomic and de novo transcriptomic analysis

Ruocco, N., Costantini, S., Zupo, V., Lauritano, C., Caramiello, D., Ianora, A., Budillon, A., Romano, G., Nuzzo, G., D'Ippolito, G., Fontana, A. & Costantini, M., Dec 1 2018, In : Scientific Reports. 8, 1, 5622.

Research output: Contribution to journalArticle

Bacillariophyceae
metabolomics
transcriptomics
Echinoidea
grazing
2017

An interaction network approach to study the correlation between endocrine disrupting chemicals and breast cancer

Polo, A., Nittoli, C., Crispo, A., Langastro, T., Severino, L., Cocco, S., De Laurentiis, M., Ciliberto, G., Montella, M., Budillon, A. & Costantini, S., Jan 1 2017, In : Molecular BioSystems. 13, 12, p. 2687-2696 10 p.

Research output: Contribution to journalArticle

Endocrine Disruptors
Breast Neoplasms
Mycotoxins
Protein Interaction Maps
Proteins
1 Citation (Scopus)

Conformational analysis of the human chemokine receptor CXCR3

Raucci, R., Polo, A., Budillon, A., Colonna, G. & Costantini, S., Dec 1 2017, In : Molecular Immunology. 92, p. 76-86 11 p.

Research output: Contribution to journalArticle

Chemokine Receptors
Ligands
Lipid Bilayers
Molecular Dynamics Simulation
Neoplasms
11 Citations (Scopus)

Environment and bladder cancer: molecular analysis by interaction networks

Polo, A., Crispo, A., Cerino, P., Falzone, L., Candido, S., Giudice, A., De Petro, G., Ciliberto, G., Montella, M., Budillon, A. & Costantini, S., May 2017, In : Oncotarget.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Arsenic
Arsenicals
Environmental Pollutants
Data Mining
3 Citations (Scopus)

Evaluating the effects of an organic extract from the mediterranean sponge Geodia cydonium on human breast cancer cell lines

Costantini, S., Guerriero, E., Teta, R., Capone, F., Caso, A., Sorice, A., Romano, G., Ianora, A., Ruocco, N., Budillon, A., Costantino, V. & Costantini, M., Oct 1 2017, In : International Journal of Molecular Sciences. 18, 10, 2112.

Research output: Contribution to journalArticle

Geodia
Rosaceae
Metabolomics
Porifera
cultured cells
20 Citations (Scopus)

HDAC inhibition potentiates immunotherapy in triple negative breast cancer

Terranova-Barberio, M., Thomas, S., Ali, N., Pawlowska, N., Park, J., Krings, G., Rosenblum, M. D., Budillon, A. & Munster, P. N., Jan 1 2017, In : Oncotarget. 8, 69, p. 114156-114172 17 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Immunotherapy
Histone Deacetylase Inhibitors
Breast Neoplasms
Epigenomics
32 Citations (Scopus)

Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ

Noto, A., De Vitis, C., Pisanu, M. E., Roscilli, G., Ricci, G., Catizone, A., Sorrentino, G., Chianese, G., Taglialatela-Scafati, O., Trisciuoglio, D., Del Bufalo, D., Di Martile, M., Napoli, A., Ruco, L., Costantini, S., Jakopin, Z., Budillon, A., Melino, G., Del Sal, G., Ciliberto, G. & 1 others, Mancini, R., Aug 2017, In : Oncogene.

Research output: Contribution to journalArticle

Stearoyl-CoA Desaturase
Lung Neoplasms
Catenins
Proteins
Neoplastic Stem Cells
4 Citations (Scopus)
Valproic Acid
Colorectal Neoplasms
Radiotherapy
Rectal Neoplasms
DNA Damage
2 Citations (Scopus)

Synthesis and Evaluation of the Antitumor Properties of a Small Collection of PtII Complexes with 7-Deazaadenosine as Scaffold

D'Errico, S., Borbone, N., Piccialli, V., Di Gennaro, E., Zotti, A., Budillon, A., Vitagliano, C., Piccialli, I. & Oliviero, G., Sep 8 2017, In : European Journal of Organic Chemistry. 2017, 33, p. 4935-4947 13 p.

Research output: Contribution to journalArticle

Tubercidin
Scaffolds
purines
acids
evaluation

Synthesis of arylpiperazine derivatives as protease activated receptor 1 antagonists and their evaluation as antiproliferative agents

Zotti, A. I., Di Gennaro, E., Corvino, A., Frecentese, F., Magli, E., Perissutti, E., Cirino, G., Roviezzo, F., Terranova-Barberio, M., Iannelli, F., Caliendo, G., Santagada, V., Fiorino, F., Budillon, A. & Severino, B., 2017, In : Anti-Cancer Agents in Medicinal Chemistry. 17, 7, p. 973-981 9 p.

Research output: Contribution to journalArticle

PAR-1 Receptor
Thrombin Receptors
Cell Line
Growth
Inhibitory Concentration 50
1 Citation (Scopus)
Histone Deacetylase Inhibitors
Cells
Neoplasms
Multifunctional Enzymes
transglutaminase 2
27 Citations (Scopus)

Biotin-targeted Pluronic® P123/F127 mixed micelles delivering niclosamide: A repositioning strategy to treat drug-resistant lung cancer cells

Russo, A., Pellosi, D. S., Pagliara, V., Milone, M. R., Pucci, B., Caetano, W., Hioka, N., Budillon, A., Ungaro, F., Russo, G. & Quaglia, F., Sep 10 2016, In : International Journal of Pharmaceutics. 511, 1, p. 127-139 13 p.

Research output: Contribution to journalArticle

UCON 50-HB-5100
Niclosamide
Micelles
Biotin
Lung Neoplasms
30 Citations (Scopus)

Endothelial progenitor cells, defined by the simultaneous surface expression of VEGFR2 and CD133, are not detectable in healthy peripheral and cord blood

Lanuti, P., Rotta, G., Almici, C., Avvisati, G., Budillon, A., Doretto, P., Malara, N., Marini, M., Neva, A., Simeone, P., Di Gennaro, E., Leone, A., Falda, A., Tozzoli, R., Gregorj, C., Di Cerbo, M., Trunzo, V., Marchisio, M. & Miscia, S., Mar 1 2016, In : Cytometry Part A. 89, 3, p. 259-270 12 p.

Research output: Contribution to journalArticle

Fetal Blood
Endothelial Cells
Flow Cytometry
Hematopoietic Stem Cells
Bone Marrow Cells
14 Citations (Scopus)

Enhancement of 5-FU sensitivity by the proapoptotic rpL3 gene in p53 null colon cancer cells through combined polymer nanoparticles

Russo, A., Maiolino, S., Pagliara, V., Ungaro, F., Tatangelo, F., Leone, A., Scalia, G., Budillon, A., Quaglia, F. & Russo, G., Nov 8 2016, In : Oncotarget. 7, 48, p. 79670-79687 18 p.

Research output: Contribution to journalArticle

p53 Genes
Fluorouracil
Nanoparticles
Colonic Neoplasms
Polymers
3 Citations (Scopus)

Impact of subsequent therapies on outcome of the FIRE-3/AIO KRK0306 trial

Avallone, A. & Budillon, A., May 1 2016, In : Journal of Clinical Oncology. 34, 13, p. 1564 1 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
Valproic Acid
Cisplatin
Epidermal Growth Factor Receptor
Histone Deacetylases
Histone Deacetylase Inhibitors
7 Citations (Scopus)

Potential anticancer effects of polyphenols from chestnut shell extracts: Modulation of cell growth, and cytokinomic and metabolomic profiles

Sorice, A., Siano, F., Capone, F., Guerriero, E., Picariello, G., Budillon, A., Ciliberto, G., Paolucci, M., Costantini, S. & Volpe, M. G., Oct 1 2016, In : Molecules. 21, 10, 1411.

Research output: Contribution to journalArticle

Metabolomics
Catechin
Depolarization
Cell growth
Polyphenols

Potential Anticancer Effects of Polyphenols from Chestnut Shell Extracts: Modulation of Cell Growth, and Cytokinomic and Metabolomic Profiles

Sorice, A., Siano, F., Capone, F., Guerriero, E., Picariello, G., Budillon, A., Ciliberto, G., Paolucci, M., Costantini, S. & Volpe, M. G., Oct 21 2016, In : Molecules. 21, 10

Research output: Contribution to journalArticle

Metabolomics
Catechin
Depolarization
Cell growth
Polyphenols
5 Citations (Scopus)
Peroxisome Proliferator-Activated Receptors
Proteomics
Colorectal Neoplasms
Phenotype
Proteins

Proteomic screening identifies calreticulin as a MIR-27a direct target repressing MHC class I cell surface exposure in colorectal cancer

Colangelo, T., Polcaro, G., Ziccardi, P., Pucci, B., Muccillo, L., Galgani, M., Fucci, A., Milone, M. R., Budillon, A., Santopaolo, M., Votino, C., Pancione, M., Binaschi, M., Bigioni, M., Maggi, C. A., Fassan, M., Laudanna, C., Sabatino, L. & Colantuoni, V., Feb 25 2016, In : Cell Death and Disease. 7, 2, e2120.

Research output: Contribution to journalArticle

Calreticulin
Proteomics
Colorectal Neoplasms
MicroRNAs
Adenoma
18 Citations (Scopus)

Proteomic screening identifies calreticulin as a MIR-27a direct target repressing MHC class I cell surface exposure in colorectal cancer

Colangelo, T., Polcaro, G., Ziccardi, P., Pucci, B., Muccillo, L., Galgani, M., Fucci, A., Milone, M. R., Budillon, A., Santopaolo, M., Votino, C., Pancione, M., Piepoli, A., Mazzoccoli, G., Binaschi, M., Bigioni, M., Maggi, C. A., Fassan, M., Laudanna, C., Matarese, G. & 2 others, Sabatino, L. & Colantuoni, V., Feb 25 2016, In : Cell Death and Disease. 7, 2, e2120.

Research output: Contribution to journalArticle

Calreticulin
Proteomics
Colorectal Neoplasms
MicroRNAs
Adenoma
8 Citations (Scopus)

Synergistic antitumor activity of histone deacetylase inhibitors and anti-ErbB3 antibody in NSCLC primary cultures via modulation of ErbB receptors expression

Ciardiello, C., Roca, M. S., Noto, A., Bruzzese, F., Moccia, T., Vitagliano, C., Di Gennaro, E., Ciliberto, G., Roscilli, G., Aurisicchio, L., Marra, E., Mancini, R., Budillon, A. & Leone, A., Apr 12 2016, In : Oncotarget. 7, 15, p. 19559-19574 16 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Non-Small Cell Lung Carcinoma
Anti-Idiotypic Antibodies
Valproic Acid
Down-Regulation
22 Citations (Scopus)

The MIR-27a-calreticulin axis affects drug-induced immunogenic cell death in human colorectal cancer cells

Colangelo, T., Polcaro, G., Ziccardi, P., Muccillo, L., Galgani, M., Pucci, B., Rita Milone, M., Budillon, A., Santopaolo, M., Mazzoccoli, G., Matarese, G., Sabatino, L. & Colantuoni, V., Feb 25 2016, In : Cell Death and Disease. 7, 2, e2108.

Research output: Contribution to journalArticle

Calreticulin
Colorectal Neoplasms
Cell Death
HMGB1 Protein
oxaliplatin

The MIR-27a-calreticulin axis affects drug-induced immunogenic cell death in human colorectal cancer cells

Colangelo, T., Polcaro, G., Ziccardi, P., Muccillo, L., Galgani, M., Pucci, B., Milone, A., Budillon, A., Santopaolo, M., Sabatino, L. & Colantuoni, V., Feb 25 2016, In : Cell Death and Disease. 7, 2, e2108.

Research output: Contribution to journalArticle

Calreticulin
Colorectal Neoplasms
Cell Death
HMGB1 Protein
oxaliplatin
23 Citations (Scopus)

Valproic acid potentiates the anticancer activity of capecitabine in vitro and in vivo in breast cancer models via induction of thymidine phosphorylase expression

Terranova-Barberio, M., Roca, M. S., Zotti, A. I., Leone, A., Bruzzese, F., Vitagliano, C., Scognamiglio, G., Russo, D., D'Angelo, G., Franco, R., Budillon, A. & Di Gennaro, E., 2016, In : Oncotarget. 7, 7, p. 7715-7731 17 p.

Research output: Contribution to journalArticle

Thymidine Phosphorylase
Valproic Acid
Histone Deacetylase Inhibitors
Breast Neoplasms
Protein Isoforms
2015
26 Citations (Scopus)

Annexin A1 is involved in the acquisition and maintenance of a stem cell-like/aggressive phenotype in prostate cancer cells with acquired resistance to zoledronic acid

Bizzarro, V., Belvedere, R., Milone, M. R., Pucci, B., Lombardi, R., Bruzzese, F., Popolo, A., Parente, L., Budillon, A. & Petrella, A., 2015, In : Oncotarget. 6, 28, p. 25076-25092 17 p.

Research output: Contribution to journalArticle

zoledronic acid
Annexins
Annexin A1
Prostatic Neoplasms
Stem Cells
2 Citations (Scopus)

A perspective on the current treatment strategies for locally advanced rectal cancer

Avallone, A., Aloj, L., Aprile, G., Rosati, G. & Budillon, A., Jun 19 2015, In : International Journal of Biochemistry and Cell Biology. 65, p. 192-196 5 p.

Research output: Contribution to journalArticle

Rectal Neoplasms
Surgery
Chemotherapy
Radiotherapy
Standard of Care
303 Citations (Scopus)

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

Siravegna, G., Mussolin, B., Buscarino, M., Corti, G., Cassingena, A., Crisafulli, G., Ponzetti, A., Cremolini, C., Amatu, A., Lauricella, C., Lamba, S., Hobor, S., Avallone, A., Valtorta, E., Rospo, G., Medico, E., Motta, V., Antoniotti, C., Tatangelo, F., Bellosillo, B. & 12 others, Veronese, S., Budillon, A., Montagut, C., Racca, P., Marsoni, S., Falcone, A., Corcoran, R. B., Di Nicolantonio, F., Loupakis, F., Siena, S., Sartore-Bianchi, A. & Bardelli, A., Jun 1 2015, In : Nature Medicine. 21, 7, p. 795-801 7 p.

Research output: Contribution to journalArticle

Clonal Evolution
Epidermal Growth Factor Receptor
Colorectal Neoplasms
Blood
Tumors
18 Citations (Scopus)
Rectal Neoplasms
Appointments and Schedules
Radiotherapy
oxaliplatin
Drug Therapy
84 Citations (Scopus)

Erratum: Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

Siravegna, G., Mussolin, B., Buscarino, M., Corti, G., Cassingena, A., Crisafulli, G., Ponzetti, A., Cremolini, C., Amatu, A., Lauricella, C., Lamba, S., Hobor, S., Avallone, A., Valtorta, E., Rospo, G., Medico, E., Motta, V., Antoniotti, C., Tatangelo, F., Bellosillo, B. & 12 others, Veronese, S., Budillon, A., Montagut, C., Racca, P., Marsoni, S., Falcone, A., Corcoran, R. B., Di Nicolantonio, F., Loupakis, F., Siena, S., Sartore-Bianchi, A. & Bardelli, A., Jul 7 2015, In : Nature Medicine. 21, 7, p. 827 1 p.

Research output: Contribution to journalArticle

Meet the editorial board

Budillon, A., Jan 1 2015, In : Recent Patents on Anti-Cancer Drug Discovery. 10, 1, p. 1 1 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)

Pathophysiologically relevant in vitro tumor models for drug screening

Das, V., Bruzzese, F., Konečný, P., Iannelli, F., Budillon, A. & Hajdúch, M., Jul 9 2015, In : Drug Discovery Today. 20, 7, p. 848-855 8 p., 1610.

Research output: Contribution to journalArticle

Preclinical Drug Evaluations
Neoplasms
Primary Cell Culture
Tumor Microenvironment
In Vitro Techniques
10 Citations (Scopus)
zoledronic acid
Proteomics
Prostatic Neoplasms
Phenotype
Proteins
3 Citations (Scopus)

Synthesis and Evaluation of the Antiproliferative Properties of a Tethered Tubercidin-Platinum(II) Complex

D'Errico, S., Oliviero, G., Borbone, N., Di Gennaro, E., Zotti, A. I., Budillon, A., Cerullo, V., Nici, F., Mayol, L., Piccialli, V. & Piccialli, G., Dec 1 2015, In : European Journal of Organic Chemistry. 2015, 34, p. 7550-7556 7 p.

Research output: Contribution to journalArticle

Tubercidin
purines
Platinum
lissamine rhodamine B
Cisplatin
26 Citations (Scopus)

Vorinostat synergizes with EGFR inhibitors in NSCLC cells by increasing ROS via up-regulation of the major mitochondrial porin VDAC1 and modulation of the c-Myc-NRF2-KEAP1 pathway

Leone, A., Roca, M. S., Ciardiello, C., Terranova-Barberio, M., Vitagliano, C., Ciliberto, G., Mancini, R., Di Gennaro, E., Bruzzese, F. & Budillon, A., Dec 1 2015, In : Free Radical Biology and Medicine. 89, p. 287-299 13 p., 12541.

Research output: Contribution to journalArticle

Voltage-Dependent Anion Channels
Porins
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Up-Regulation