If you made any changes in Pure these will be visible here soon.

Research Output 2008 2019

2019

Adaptive mutability of colorectal cancers in response to targeted therapies

Russo, M., Crisafulli, G., Sogari, A., Reilly, N. M., Arena, S., Lamba, S., Bartolini, A., Amodio, V., Magrì, A., Novara, L., Sarotto, I., Nagel, Z. D., Piett, C. G., Amatu, A., Sartore-Bianchi, A., Siena, S., Bertotti, A., Trusolino, L., Corigliano, M., Gherardi, M. & 3 others, Lagomarsino, M. C., Di Nicolantonio, F. & Bardelli, A., Dec 20 2019, In : Science. 366, 6472, p. 1473-1480 8 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
DNA Mismatch Repair
Epidermal Growth Factor Receptor
Neoplasms
Therapeutics
Workflow
Colorectal Neoplasms
Computational Biology
Gene Dosage
Neoplasm Staging

A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin

Arena, S., Corti, G., Durinikova, E., Montone, M., Reilly, N. M., Russo, M., Lorenzato, A., Arcella, P., Lazzari, L., Rospo, G., Pagani, M., Cancelliere, C., Negrino, C., Isella, C., Bartolini, A., Cassingena, A., Amatu, A., Mauri, G., Sartore-Bianchi, A., Mittica, G. & 7 others, Medico, E., Marsoni, S., Linnebacher, M., Abrignani, S., Siena, S., Di Nicolantonio, F. & Bardelli, A., Dec 12 2019, In : Clin. Cancer Res..

Research output: Contribution to journalArticle

oxaliplatin
Colorectal Neoplasms
Organoids
Homologous Recombination
Cell Line

Evolving neoantigen profiles in colorectal cancers with DNA repair defects

Rospo, G., Lorenzato, A., Amirouchene-Angelozzi, N., Magrì, A., Cancelliere, C., Corti, G., Negrino, C., Amodio, V., Montone, M., Bartolini, A., Barault, L., Novara, L., Isella, C., Medico, E., Bertotti, A., Trusolino, L., Germano, G., Di Nicolantonio, F. & Bardelli, A., Jun 28 2019, In : Genome Medicine. 11, 1, p. 42

Research output: Contribution to journalArticle

DNA Repair
Colorectal Neoplasms
Down-Regulation
Clonal Evolution
Exome
2018

Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer

Siravegna, G., Lazzari, L., Crisafulli, G., Sartore-Bianchi, A., Mussolin, B., Cassingena, A., Martino, C., Lanman, R. B., Nagy, R. J., Fairclough, S., Rospo, G., Corti, G., Bartolini, A., Arcella, P., Montone, M., Lodi, F., Lorenzato, A., Vanzati, A., Valtorta, E., Cappello, G. & 17 others, Bertotti, A., Lonardi, S., Zagonel, V., Leone, F., Russo, M., Balsamo, A., Truini, M., Di Nicolantonio, F., Amatu, A., Bonazzina, E., Ghezzi, S., Regge, D., Vanzulli, A., Trusolino, L., Siena, S., Marsoni, S. & Bardelli, A., Jul 9 2018, In : Cancer Cell. 34, 1, p. 148-162.e7

Research output: Contribution to journalArticle

Colorectal Neoplasms
Neoplasm Metastasis
Therapeutics
Trastuzumab
lapatinib

Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer

Siravegna, G., Lazzari, L., Crisafulli, G., Sartore-Bianchi, A., Mussolin, B., Cassingena, A., Martino, C., Lanman, R. B., Nagy, R. J., Fairclough, S., Rospo, G., Corti, G., Bartolini, A., Arcella, P., Montone, M., Lodi, F., Lorenzato, A., Vanzati, A., Valtorta, E., Cappello, G. & 17 others, Bertotti, A., Lonardi, S., Zagonel, V., Leone, F., Russo, M., Balsamo, A., Truini, M., Di Nicolantonio, F., Amatu, A., Bonazzina, E., Ghezzi, S., Regge, D., Vanzulli, A., Trusolino, L., Siena, S., Marsoni, S. & Bardelli, A., Jul 9 2018, In : Cancer Cell. 34, 1, p. 148-162.e7

Research output: Contribution to journalArticle

Colorectal Neoplasms
Neoplasm Metastasis
DNA
Neoplasms
Therapeutics

Trabectedin and olaparib in patients with advanced and non-resectable bone and soft-tissue sarcomas (TOMAS): an open-label, phase 1b study from the Italian Sarcoma Group

Grignani, G., D'Ambrosio, L., Pignochino, Y., Palmerini, E., Zucchetti, M., Boccone, P., Aliberti, S., Stacchiotti, S., Bertulli, R., Piana, R., Miano, S., Tolomeo, F., Chiabotto, G., Sangiolo, D., Pisacane, A., Dei Tos, A. P., Novara, L., Bartolini, A., Marchesi, E., D'Incalci, M. & 4 others, Bardelli, A., Picci, P., Ferrari, S. & Aglietta, M., Oct 2018, In : The Lancet Oncology. 19, 10, p. 1360-1371 12 p.

Research output: Contribution to journalArticle

trabectedin
Sarcoma
Bone and Bones
olaparib
Neutropenia

Trabectedin and olaparib in patients with advanced and non-resectable bone and soft-tissue sarcomas (TOMAS): an open-label, phase 1b study from the Italian Sarcoma Group

Grignani, G., D'Ambrosio, L., Pignochino, Y., Palmerini, E., Zucchetti, M., Boccone, P., Aliberti, S., Stacchiotti, S., Bertulli, R., Piana, R., Miano, S., Tolomeo, F., Chiabotto, G., Sangiolo, D., Pisacane, A., Dei Tos, A. P., Novara, L., Bartolini, A., Marchesi, E., D'Incalci, M. & 4 others, Bardelli, A., Picci, P., Ferrari, S. & Aglietta, M., Oct 2018, In : The Lancet Oncology. 19, 10, p. 1360-1371 12 p.

Research output: Contribution to journalArticle

Trabectedin and olaparib in patients with advanced and non-resectable bone and soft-tissue sarcomas (TOMAS): an open-label, phase 1b study from the Italian Sarcoma Group

Grignani, G., D'Ambrosio, L., Pignochino, Y., Palmerini, E., Zucchetti, M., Boccone, P., Aliberti, S., Stacchiotti, S., Bertulli, R., Piana, R., Miano, S., Tolomeo, F., Chiabotto, G., Sangiolo, D., Pisacane, A., Dei Tos, A. P., Novara, L., Bartolini, A., Marchesi, E., D'Incalci, M. & 4 others, Bardelli, A., Picci, P., Ferrari, S. & Aglietta, M., 2018, In : The Lancet Oncology. 19, 10, p. 1360-1371 12 p.

Research output: Contribution to journalArticle

Trabectedin and olaparib in patients with advanced and non-resectable bone and soft-tissue sarcomas (TOMAS): an open-label, phase 1b study from the Italian Sarcoma Group.

Grignani, G., D'Ambrosio, L., Pignochino, Y., Palmerini, E., Zucchetti, M., Boccone, P., Aliberti, S., Stacchiotti, S., Bertulli, R., Piana, R., Miano, S., Tolomeo, F., Chiabotto, G., Sangiolo, D., Pisacane, A., Dei Tos, A. P., Novara, L., Bartolini, A., Marchesi, E., D'Incalci, M. & 4 others, Bardelli, A., Picci, P., Ferrari, S. & Aglietta, M., Oct 1 2018, In : The Lancet. Oncology. 19, p. 1360-1371 12 p.

Research output: Contribution to journalArticle

2017

Emergence of MET hyper-amplification at progression to MET and BRAF inhibition in colorectal cancer

Oddo, D., Siravegna, G., Gloghini, A., Vernieri, C., Mussolin, B., Morano, F., Crisafulli, G., Berenato, R., Corti, G., Volpi, C. C., Buscarino, M., Niger, M., Dunne, P. D., Rospo, G., Valtorta, E., Bartolini, A., Fucà, G., Lamba, S., Martinetti, A., Di Bartolomeo, M. & 4 others, De Braud, F., Bardelli, A., Pietrantonio, F. & Di Nicolantonio, F., Jul 25 2017, In : British Journal of Cancer. 117, 3, p. 347-352 6 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Gene Amplification
Rectal Neoplasms
Exome
Drug Combinations

Emergence of MET hyper-amplification at progression to MET and BRAF inhibition in colorectal cancer

Oddo, D., Siravegna, G., Gloghini, A., Vernieri, C., Mussolin, B., Morano, F., Crisafulli, G., Berenato, R., Corti, G., Volpi, C. C., Buscarino, M., Niger, M., Dunne, P. D., Rospo, G., Valtorta, E., Bartolini, A., Fucà, G., Lamba, S., Martinetti, A., Di Bartolomeo, M. & 4 others, De Braud, F., Bardelli, A., Pietrantonio, F. & Di Nicolantonio, F., 2017, In : British Journal of Cancer. 117, 3, p. 347-352 6 p.

Research output: Contribution to journalArticle

Cerebrospinal Fluid
Breast Neoplasms
Neoplasm Metastasis
DNA
Brain

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

Germano, G., Lamba, S., Rospo, G., Barault, L., Magri, A., Maione, F., Russo, M., Crisafulli, G., Bartolini, A., Lerda, G., Siravegna, G., Mussolin, B., Frapolli, R., Montone, M., Morano, F., De Braud, F., Amirouchene-Angelozzi, N., Marsoni, S., D'Incalci, M., Orlandi, A. & 6 others, Giraudo, E., Sartore-Bianchi, A., Siena, S., Pietrantonio, F., Di Nicolantonio, F. & Bardelli, A., Jan 1 2017, In : Nature. 552, p. 1-5 5 p.

Research output: Contribution to journalArticle

DNA Mismatch Repair
DNA Repair
Growth
Neoplasms
temozolomide

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

Germano, G., Lamba, S., Rospo, G., Barault, L., Magrì, A., Maione, F., Russo, M., Crisafulli, G., Bartolini, A., Lerda, G., Siravegna, G., Mussolin, B., Frapolli, R., Montone, M., Morano, F., de Braud, F., Amirouchene-Angelozzi, N., Marsoni, S., D'Incalci, M., Orlandi, A. & 6 others, Giraudo, E., Sartore-Bianchi, A., Siena, S., Pietrantonio, F., Di Nicolantonio, F. & Bardelli, A., Dec 7 2017, In : Nature. 552, 7683, p. 116-120 5 p.

Research output: Contribution to journalArticle

DNA Mismatch Repair
DNA Repair
Growth
Neoplasms
temozolomide

Tracking a CAD-ALK gene rearrangement in urine and blood of a colorectal cancer patient treated with an ALK inhibitor

Siravegna, G., Sartore-Bianchi, A., Mussolin, B., Cassingena, A., Amatu, A., Novara, L., Buscarino, M., Corti, G., Crisafulli, G., Bartolini, A., Tosi, F., Erlander, M., Di Nicolantonio, F., Siena, S. & Bardelli, A., Jun 1 2017, In : Annals of Oncology. 28, 6, p. 1302-1308 7 p., mdx095.

Research output: Contribution to journalArticle

Gene Rearrangement
Colorectal Neoplasms
Urine
DNA
Neoplasms
2016

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer

Van Emburgh, B. O., Arena, S., Siravegna, G., Lazzari, L., Crisafulli, G., Corti, G., Mussolin, B., Baldi, F., Buscarino, M., Bartolini, A., Valtorta, E., Vidal, M. J., Bellosillo, B., Germano, G., Pietrantonio, F., Ponzetti, A., Albanell, J., Siena, S., Sartore-Bianchi, A., Di Nicolantonio, F. & 2 others, Montagut, C. & Bardelli, A., 2016, In : Nature Communications. 7

Research output: Contribution to journalArticle

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer

Van Emburgh, B. OB., Arena, S., Siravegna, G., Lazzari, L., Crisafulli, G., Corti, G., Mussolin, B., Baldi, F., Buscarino, M., Bartolini, A., Valtorta, E., Vidal, J., Bellosillo, B., Germano, G., Pietrantonio, F., Ponzetti, A., Albanell, J., Siena, S., Sartore-Bianchi, A., Di Nicolantonio, F. & 2 others, Montagut, C. & Bardelli, A., Dec 8 2016, In : Nature Communications. 7, 13665.

Research output: Contribution to journalArticle

mutations
Epidermal Growth Factor Receptor
Colorectal Neoplasms
cancer
Mutation

Acquired resistance to the TRK inhibitor entrectinib in colorectal cancer

Russo, M., Misale, S., Wei, G., Siravegna, G., Crisafulli, G., Lazzari, L., Corti, G., Rospo, G., Novara, L., Mussolin, B., Bartolini, A., Cam, N., Patel, R., Yan, S., Shoemaker, R., Wild, R., di Nicolantonio, F., Sartore-Bianchi, A., Li, G., Siena, S. & 1 others, Bardelli, A., Jan 1 2016, In : Cancer Discovery. 6, 1, p. 36-44 9 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Phosphotransferases
Biopsy
Neoplasms
Mutation

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility

Vecchione, L., Gambino, V., Raaijmakers, J., Schlicker, A., Fumagalli, A., Russo, M., Villanueva, A., Beerling, E., Bartolini, A., Mollevi, D. G., El-Murr, N., Chiron, M., Calvet, L., Nicolazzi, C., Combeau, C., Henry, C., Simon, I. M., Tian, S., In 'T Veld, S., D'Ario, G. & 14 others, Mainardi, S., Beijersbergen, R. L., Lieftink, C., Linn, S., Rumpf-Kienzl, C., Delorenzi, M., Wessels, L., Salazar, R., Di Nicolantonio, F., Bardelli, A., Van Rheenen, J., Medema, R. H., Tejpar, S. & Bernards, R., Apr 7 2016, In : Cell. 165, 2, p. 317-330 14 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Tumors
Defects
Poisons
Cell death

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility

Vecchione, L., Gambino, V., Raaijmakers, J., Schlicker, A., Fumagalli, A., Russo, M., Villanueva, A., Beerling, E., Bartolini, A., Mollevi, D. G., El-Murr, N., Chiron, M., Calvet, L., Nicolazzi, C., Combeau, C., Henry, C., Simon, I. M., Tian, S., In 'T Veld, S., D'Ario, G. & 14 others, Mainardi, S., Beijersbergen, R. L., Lieftink, C., Linn, S. C., Rumpf-Kienzl, C., Delorenzi, M., Wessels, L. F. A., Salazar, R., Di Nicolantonio, F., Bardelli, A., Van Rheenen, J., Medema, R. H., Tejpar, S. & Bernards, R., Apr 7 2016, In : Cell. 165, 2, p. 317-330 14 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Tumors
Defects
Poisons
Cell death

BCAM and LAMA5 mediate the recognition between tumor cells and the endothelium in the metastatic spreading of KRAS-mutant colorectal cancer

Bartolini, A., Cardaci, S., Lamba, S. E., Oddo, D., Marchiò, C., Cassoni, P., Amoreo, C. A., Corti, G., Testori, A., Bussolino, F., Pasqualini, R., Arap, W., Corà, D., Di Nicolantonio, F. & Marchiò, S., Oct 1 2016, In : Clinical Cancer Research. 22, 19, p. 4923-4933 11 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Endothelium
Colorectal Neoplasms
Neoplasm Metastasis
Neoplasms

BCAM and LAMA5 mediate the recognition between tumor cells and the endothelium in the metastatic spreading of KRAS-mutant colorectal cancer

Bartolini, A., Cardaci, S., Lamba, S., Oddo, D., Marchiò, C., Cassoni, P., Amoreo, C. A., Corti, G., Testori, A., Bussolino, F., Pasqualini, R., Arap, W., Corà, D., Di Nicolantonio, F. & Marchiò, S., Oct 1 2016, In : Clinical Cancer Research. 22, 19, p. 4923-4933 11 p.

Research output: Contribution to journalArticle

Tumor Microenvironment
Endothelium
Colorectal Neoplasms
Neoplasm Metastasis
Neoplasms

Molecular landscape of acquired resistance to targeted therapy combinations in BRAF-mutant colorectal cancer

Oddo, D., Sennott, E. M., Barault, L., Valtorta, E., Arena, S., Cassingena, A., Filiciotto, G., Marzolla, G., Elez, E., Van Geel, R. M. J. M., Bartolini, A., Crisafulli, G., Boscaro, V., Godfrey, J. T., Buscarino, M., Cancelliere, C., Linnebacher, M., Corti, G., Truini, M., Siravegna, G. & 11 others, Grasselli, J., Gallicchio, M., Bernards, R., Schellens, J. H. M., Tabernero, J., Engelman, J. A., Sartore-Bianchi, A., Bardelli, A., Siena, S., Corcoran, R. B. & Di Nicolantonio, F., Aug 1 2016, In : Cancer Research. 76, 15, p. 4504-4515 12 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Drug Resistance
Therapeutics
Clinical Trials
Pharmaceutical Preparations
2015

Neuroblastoma-targeted nanocarriers improve drug delivery and penetration, delay tumor growth and abrogate metastatic diffusion

Cossu, I., Bottoni, G., Loi, M., Emionite, L., Bartolini, A., Di Paolo, D., Brignole, C., Piaggio, F., Perri, P., Sacchi, A., Curnis, F., Gagliani, M. C., Bruno, S., Marini, C., Gori, A., Longhi, R., Murgia, D., Sementa, A. R., Cilli, M., Tacchetti, C. & 5 others, Corti, A., Sambuceti, G., Marchiò, S., Ponzoni, M. & Pastorino, F., Nov 1 2015, In : Biomaterials. 68, p. 89-99 11 p.

Research output: Contribution to journalArticle

Neuroblastoma
Drug delivery
Tumors
Growth
Pharmaceutical Preparations
Neuroblastoma
Peptides
Neoplasms
Vascular Tissue Neoplasms
Ligands
2013

BRAF V600E is a determinant of sensitivity to proteasome inhibitors

Zecchin, D., Boscaro, V., Medico, E., Barault, L., Martini, M., Arena, S., Cancelliere, C., Bartolini, A., Crowley, E. H., Bardelli, A., Gallicchio, M. & Di Nicolantonio, F., Dec 2013, In : Molecular Cancer Therapeutics. 12, 12, p. 2950-2961 12 p.

Research output: Contribution to journalArticle

Proteasome Inhibitors
Colorectal Neoplasms
Neoplasms
Mutation
Pharmacogenetics

Novel phage display-derived neuroblastoma-targeting peptides potentiate the effect of drug nanocarriers in preclinical settings

Loi, M., Di Paolo, D., Soster, M., Brignole, C., Bartolini, A., Emionite, L., Sun, J., Becherini, P., Curnis, F., Petretto, A., Sani, M., Gori, A., Milanese, M., Gambini, C., Longhi, R., Cilli, M., Allen, T. M., Bussolino, F., Arap, W., Pasqualini, R. & 4 others, Corti, A., Ponzoni, M., Marchiò, S. & Pastorino, F., 2013, In : Journal of Controlled Release. 170, 2, p. 233-241 9 p.

Research output: Contribution to journalArticle

Neuroblastoma
Bacteriophages
Peptides
Pharmaceutical Preparations
Clone Cells
2012

A complex of α6 integrin and E-cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6

Marchiò, S., Soster, M., Cardaci, S., Muratore, A., Bartolini, A., Barone, V., Ribero, D., Monti, M., Bovino, P., Sun, J., Giavazzi, R., Asioli, S., Cassoni, P., Capussotti, L., Pucci, P., Bugatti, A., Rusnati, M., Pasqualini, R., Arap, W. & Bussolino, F., Nov 2012, In : EMBO Molecular Medicine. 4, 11, p. 1156-1175 20 p.

Research output: Contribution to journalArticle

Angiopoietins
Cadherins
Integrins
Hepatocytes
Colorectal Neoplasms
2011

G-CSF administration to adult mice stimulates the proliferation of microglia but does not modify the outcome of ischemic injury

Bartolini, A., Vigliani, M. C., Magrassi, L., Vercelli, A. & Rossi, F., Mar 2011, In : Neurobiology of Disease. 41, 3, p. 640-649 10 p.

Research output: Contribution to journalArticle

Microglia
Granulocyte Colony-Stimulating Factor
Wounds and Injuries
Purkinje Cells
Middle Cerebral Artery Infarction

Modulation of cell-cycle dynamics is required to regulate the number of cerebellar GABAergic interneurons and their rhythm of maturation

Leto, K., Bartolini, A., di Gregorio, A., Imperiale, D., de Luca, A., Parmigiani, E., Filipkowski, R. K., Kaczmarek, L. & Rossi, F., Aug 15 2011, In : Development. 138, 16, p. 3463-3472 10 p.

Research output: Contribution to journalArticle

Interneurons
Cell Cycle
Cyclin D2
G1 Phase
Cerebellum
2010

The prospective white matter: An atypical neurogenic niche in the developing cerebellum

Leto, K., Bartolini, A. & Rossi, F., 2010, In : Archives Italiennes de Biologie. 148, 2, p. 137-146 10 p.

Research output: Contribution to journalArticle

Interneurons
Cerebellum
Phenotype
Population
White Matter
2009

Laminar fate and phenotype specification of cerebellar GABAergic interneurons

Leto, K., Bartolini, A., Yanagawa, Y., Obata, K., Magrassi, L., Schilling, K. & Rossi, F., May 27 2009, In : Journal of Neuroscience. 29, 21, p. 7079-7091 13 p.

Research output: Contribution to journalArticle

Interneurons
Phenotype
Cerebellum
Cerebellar Cortex
Mitosis
2008

Development of cerebellar GABAergic interneurons: Origin and shaping of the "minibrain" local connections

Leto, K., Bartolini, A. & Rossi, F., Dec 2008, In : Cerebellum. 7, 4, p. 523-529 7 p.

Research output: Contribution to journalArticle

Interneurons
Phenotype
Automatic Data Processing
Quality Control
Cerebellum