20082019

Research output per year

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Research Output

2019

Adaptive mutability of colorectal cancers in response to targeted therapies

Russo, M., Crisafulli, G., Sogari, A., Reilly, N. M., Arena, S., Lamba, S., Bartolini, A., Amodio, V., Magrì, A., Novara, L., Sarotto, I., Nagel, Z. D., Piett, C. G., Amatu, A., Sartore-Bianchi, A., Siena, S., Bertotti, A., Trusolino, L., Corigliano, M., Gherardi, M. & 3 others, Lagomarsino, M. C., Di Nicolantonio, F. & Bardelli, A., Dec 20 2019, In : Science. 366, 6472, p. 1473-1480 8 p.

Research output: Contribution to journalArticle

A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin

Arena, S., Corti, G., Durinikova, E., Montone, M., Reilly, N. M., Russo, M., Lorenzato, A., Arcella, P., Lazzari, L., Rospo, G., Pagani, M., Cancelliere, C., Negrino, C., Isella, C., Bartolini, A., Cassingena, A., Amatu, A., Mauri, G., Sartore-Bianchi, A., Mittica, G. & 7 others, Medico, E., Marsoni, S., Linnebacher, M., Abrignani, S., Siena, S., Di Nicolantonio, F. & Bardelli, A., Dec 12 2019, In : Clin. Cancer Res..

Research output: Contribution to journalArticle

Evolving neoantigen profiles in colorectal cancers with DNA repair defects

Rospo, G., Lorenzato, A., Amirouchene-Angelozzi, N., Magrì, A., Cancelliere, C., Corti, G., Negrino, C., Amodio, V., Montone, M., Bartolini, A., Barault, L., Novara, L., Isella, C., Medico, E., Bertotti, A., Trusolino, L., Germano, G., Di Nicolantonio, F. & Bardelli, A., Jun 28 2019, In : Genome Medicine. 11, 1, p. 42

Research output: Contribution to journalArticle

2018

Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer

Siravegna, G., Lazzari, L., Crisafulli, G., Sartore-Bianchi, A., Mussolin, B., Cassingena, A., Martino, C., Lanman, R. B., Nagy, R. J., Fairclough, S., Rospo, G., Corti, G., Bartolini, A., Arcella, P., Montone, M., Lodi, F., Lorenzato, A., Vanzati, A., Valtorta, E., Cappello, G. & 17 others, Bertotti, A., Lonardi, S., Zagonel, V., Leone, F., Russo, M., Balsamo, A., Truini, M., Di Nicolantonio, F., Amatu, A., Bonazzina, E., Ghezzi, S., Regge, D., Vanzulli, A., Trusolino, L., Siena, S., Marsoni, S. & Bardelli, A., Jul 9 2018, In : Cancer Cell. 34, 1, p. 148-162.e7

Research output: Contribution to journalArticle

Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer

Siravegna, G., Lazzari, L., Crisafulli, G., Sartore-Bianchi, A., Mussolin, B., Cassingena, A., Martino, C., Lanman, R. B., Nagy, R. J., Fairclough, S., Rospo, G., Corti, G., Bartolini, A., Arcella, P., Montone, M., Lodi, F., Lorenzato, A., Vanzati, A., Valtorta, E., Cappello, G. & 17 others, Bertotti, A., Lonardi, S., Zagonel, V., Leone, F., Russo, M., Balsamo, A., Truini, M., Di Nicolantonio, F., Amatu, A., Bonazzina, E., Ghezzi, S., Regge, D., Vanzulli, A., Trusolino, L., Siena, S., Marsoni, S. & Bardelli, A., Jul 9 2018, In : Cancer Cell. 34, 1, p. 148-162.e7

Research output: Contribution to journalArticle

Trabectedin and olaparib in patients with advanced and non-resectable bone and soft-tissue sarcomas (TOMAS): an open-label, phase 1b study from the Italian Sarcoma Group

Grignani, G., D'Ambrosio, L., Pignochino, Y., Palmerini, E., Zucchetti, M., Boccone, P., Aliberti, S., Stacchiotti, S., Bertulli, R., Piana, R., Miano, S., Tolomeo, F., Chiabotto, G., Sangiolo, D., Pisacane, A., Dei Tos, A. P., Novara, L., Bartolini, A., Marchesi, E., D'Incalci, M. & 4 others, Bardelli, A., Picci, P., Ferrari, S. & Aglietta, M., Oct 2018, In : The Lancet Oncology. 19, 10, p. 1360-1371 12 p.

Research output: Contribution to journalArticle

Trabectedin and olaparib in patients with advanced and non-resectable bone and soft-tissue sarcomas (TOMAS): an open-label, phase 1b study from the Italian Sarcoma Group

Grignani, G., D'Ambrosio, L., Pignochino, Y., Palmerini, E., Zucchetti, M., Boccone, P., Aliberti, S., Stacchiotti, S., Bertulli, R., Piana, R., Miano, S., Tolomeo, F., Chiabotto, G., Sangiolo, D., Pisacane, A., Dei Tos, A. P., Novara, L., Bartolini, A., Marchesi, E., D'Incalci, M. & 4 others, Bardelli, A., Picci, P., Ferrari, S. & Aglietta, M., Oct 2018, In : The Lancet Oncology. 19, 10, p. 1360-1371 12 p.

Research output: Contribution to journalArticle

Trabectedin and olaparib in patients with advanced and non-resectable bone and soft-tissue sarcomas (TOMAS): an open-label, phase 1b study from the Italian Sarcoma Group

Grignani, G., D'Ambrosio, L., Pignochino, Y., Palmerini, E., Zucchetti, M., Boccone, P., Aliberti, S., Stacchiotti, S., Bertulli, R., Piana, R., Miano, S., Tolomeo, F., Chiabotto, G., Sangiolo, D., Pisacane, A., Dei Tos, A. P., Novara, L., Bartolini, A., Marchesi, E., D'Incalci, M. & 4 others, Bardelli, A., Picci, P., Ferrari, S. & Aglietta, M., 2018, In : The Lancet Oncology. 19, 10, p. 1360-1371 12 p.

Research output: Contribution to journalArticle

Trabectedin and olaparib in patients with advanced and non-resectable bone and soft-tissue sarcomas (TOMAS): an open-label, phase 1b study from the Italian Sarcoma Group.

Grignani, G., D'Ambrosio, L., Pignochino, Y., Palmerini, E., Zucchetti, M., Boccone, P., Aliberti, S., Stacchiotti, S., Bertulli, R., Piana, R., Miano, S., Tolomeo, F., Chiabotto, G., Sangiolo, D., Pisacane, A., Dei Tos, A. P., Novara, L., Bartolini, A., Marchesi, E., D'Incalci, M. & 4 others, Bardelli, A., Picci, P., Ferrari, S. & Aglietta, M., Oct 1 2018, In : The Lancet. Oncology. 19, p. 1360-1371 12 p.

Research output: Contribution to journalArticle

2017

Emergence of MET hyper-amplification at progression to MET and BRAF inhibition in colorectal cancer

Oddo, D., Siravegna, G., Gloghini, A., Vernieri, C., Mussolin, B., Morano, F., Crisafulli, G., Berenato, R., Corti, G., Volpi, C. C., Buscarino, M., Niger, M., Dunne, P. D., Rospo, G., Valtorta, E., Bartolini, A., Fucà, G., Lamba, S., Martinetti, A., Di Bartolomeo, M. & 4 others, De Braud, F., Bardelli, A., Pietrantonio, F. & Di Nicolantonio, F., 2017, In : British Journal of Cancer. 117, 3, p. 347-352 6 p.

Research output: Contribution to journalArticle

Emergence of MET hyper-amplification at progression to MET and BRAF inhibition in colorectal cancer

Oddo, D., Siravegna, G., Gloghini, A., Vernieri, C., Mussolin, B., Morano, F., Crisafulli, G., Berenato, R., Corti, G., Volpi, C. C., Buscarino, M., Niger, M., Dunne, P. D., Rospo, G., Valtorta, E., Bartolini, A., Fucà, G., Lamba, S., Martinetti, A., Di Bartolomeo, M. & 4 others, De Braud, F., Bardelli, A., Pietrantonio, F. & Di Nicolantonio, F., Jul 25 2017, In : British Journal of Cancer. 117, 3, p. 347-352 6 p.

Research output: Contribution to journalArticle

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

Germano, G., Lamba, S., Rospo, G., Barault, L., Magrì, A., Maione, F., Russo, M., Crisafulli, G., Bartolini, A., Lerda, G., Siravegna, G., Mussolin, B., Frapolli, R., Montone, M., Morano, F., de Braud, F., Amirouchene-Angelozzi, N., Marsoni, S., D'Incalci, M., Orlandi, A. & 6 others, Giraudo, E., Sartore-Bianchi, A., Siena, S., Pietrantonio, F., Di Nicolantonio, F. & Bardelli, A., Dec 7 2017, In : Nature. 552, 7683, p. 116-120 5 p.

Research output: Contribution to journalArticle

Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

Germano, G., Lamba, S., Rospo, G., Barault, L., Magri, A., Maione, F., Russo, M., Crisafulli, G., Bartolini, A., Lerda, G., Siravegna, G., Mussolin, B., Frapolli, R., Montone, M., Morano, F., De Braud, F., Amirouchene-Angelozzi, N., Marsoni, S., D'Incalci, M., Orlandi, A. & 6 others, Giraudo, E., Sartore-Bianchi, A., Siena, S., Pietrantonio, F., Di Nicolantonio, F. & Bardelli, A., Jan 1 2017, In : Nature. 552, p. 1-5 5 p.

Research output: Contribution to journalArticle

Tracking a CAD-ALK gene rearrangement in urine and blood of a colorectal cancer patient treated with an ALK inhibitor

Siravegna, G., Sartore-Bianchi, A., Mussolin, B., Cassingena, A., Amatu, A., Novara, L., Buscarino, M., Corti, G., Crisafulli, G., Bartolini, A., Tosi, F., Erlander, M., Di Nicolantonio, F., Siena, S. & Bardelli, A., Jun 1 2017, In : Annals of Oncology. 28, 6, p. 1302-1308 7 p., mdx095.

Research output: Contribution to journalArticle

2016

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer

Van Emburgh, B. O., Arena, S., Siravegna, G., Lazzari, L., Crisafulli, G., Corti, G., Mussolin, B., Baldi, F., Buscarino, M., Bartolini, A., Valtorta, E., Vidal, M. J., Bellosillo, B., Germano, G., Pietrantonio, F., Ponzetti, A., Albanell, J., Siena, S., Sartore-Bianchi, A., Di Nicolantonio, F. & 2 others, Montagut, C. & Bardelli, A., 2016, In : Nature Communications. 7

Research output: Contribution to journalArticle

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer

Van Emburgh, B. OB., Arena, S., Siravegna, G., Lazzari, L., Crisafulli, G., Corti, G., Mussolin, B., Baldi, F., Buscarino, M., Bartolini, A., Valtorta, E., Vidal, J., Bellosillo, B., Germano, G., Pietrantonio, F., Ponzetti, A., Albanell, J., Siena, S., Sartore-Bianchi, A., Di Nicolantonio, F. & 2 others, Montagut, C. & Bardelli, A., Dec 8 2016, In : Nature Communications. 7, 13665.

Research output: Contribution to journalArticle

Acquired resistance to the TRK inhibitor entrectinib in colorectal cancer

Russo, M., Misale, S., Wei, G., Siravegna, G., Crisafulli, G., Lazzari, L., Corti, G., Rospo, G., Novara, L., Mussolin, B., Bartolini, A., Cam, N., Patel, R., Yan, S., Shoemaker, R., Wild, R., di Nicolantonio, F., Sartore-Bianchi, A., Li, G., Siena, S. & 1 others, Bardelli, A., Jan 1 2016, In : Cancer Discovery. 6, 1, p. 36-44 9 p.

Research output: Contribution to journalArticle

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility

Vecchione, L., Gambino, V., Raaijmakers, J., Schlicker, A., Fumagalli, A., Russo, M., Villanueva, A., Beerling, E., Bartolini, A., Mollevi, D. G., El-Murr, N., Chiron, M., Calvet, L., Nicolazzi, C., Combeau, C., Henry, C., Simon, I. M., Tian, S., In 'T Veld, S., D'Ario, G. & 14 others, Mainardi, S., Beijersbergen, R. L., Lieftink, C., Linn, S., Rumpf-Kienzl, C., Delorenzi, M., Wessels, L., Salazar, R., Di Nicolantonio, F., Bardelli, A., Van Rheenen, J., Medema, R. H., Tejpar, S. & Bernards, R., Apr 7 2016, In : Cell. 165, 2, p. 317-330 14 p.

Research output: Contribution to journalArticle

A Vulnerability of a Subset of Colon Cancers with Potential Clinical Utility

Vecchione, L., Gambino, V., Raaijmakers, J., Schlicker, A., Fumagalli, A., Russo, M., Villanueva, A., Beerling, E., Bartolini, A., Mollevi, D. G., El-Murr, N., Chiron, M., Calvet, L., Nicolazzi, C., Combeau, C., Henry, C., Simon, I. M., Tian, S., In 'T Veld, S., D'Ario, G. & 14 others, Mainardi, S., Beijersbergen, R. L., Lieftink, C., Linn, S. C., Rumpf-Kienzl, C., Delorenzi, M., Wessels, L. F. A., Salazar, R., Di Nicolantonio, F., Bardelli, A., Van Rheenen, J., Medema, R. H., Tejpar, S. & Bernards, R., Apr 7 2016, In : Cell. 165, 2, p. 317-330 14 p.

Research output: Contribution to journalArticle

BCAM and LAMA5 mediate the recognition between tumor cells and the endothelium in the metastatic spreading of KRAS-mutant colorectal cancer

Bartolini, A., Cardaci, S., Lamba, S. E., Oddo, D., Marchiò, C., Cassoni, P., Amoreo, C. A., Corti, G., Testori, A., Bussolino, F., Pasqualini, R., Arap, W., Corà, D., Di Nicolantonio, F. & Marchiò, S., Oct 1 2016, In : Clinical Cancer Research. 22, 19, p. 4923-4933 11 p.

Research output: Contribution to journalArticle

BCAM and LAMA5 mediate the recognition between tumor cells and the endothelium in the metastatic spreading of KRAS-mutant colorectal cancer

Bartolini, A., Cardaci, S., Lamba, S., Oddo, D., Marchiò, C., Cassoni, P., Amoreo, C. A., Corti, G., Testori, A., Bussolino, F., Pasqualini, R., Arap, W., Corà, D., Di Nicolantonio, F. & Marchiò, S., Oct 1 2016, In : Clinical Cancer Research. 22, 19, p. 4923-4933 11 p.

Research output: Contribution to journalArticle

Molecular landscape of acquired resistance to targeted therapy combinations in BRAF-mutant colorectal cancer

Oddo, D., Sennott, E. M., Barault, L., Valtorta, E., Arena, S., Cassingena, A., Filiciotto, G., Marzolla, G., Elez, E., Van Geel, R. M. J. M., Bartolini, A., Crisafulli, G., Boscaro, V., Godfrey, J. T., Buscarino, M., Cancelliere, C., Linnebacher, M., Corti, G., Truini, M., Siravegna, G. & 11 others, Grasselli, J., Gallicchio, M., Bernards, R., Schellens, J. H. M., Tabernero, J., Engelman, J. A., Sartore-Bianchi, A., Bardelli, A., Siena, S., Corcoran, R. B. & Di Nicolantonio, F., Aug 1 2016, In : Cancer Research. 76, 15, p. 4504-4515 12 p.

Research output: Contribution to journalArticle

2015

Neuroblastoma-targeted nanocarriers improve drug delivery and penetration, delay tumor growth and abrogate metastatic diffusion

Cossu, I., Bottoni, G., Loi, M., Emionite, L., Bartolini, A., Di Paolo, D., Brignole, C., Piaggio, F., Perri, P., Sacchi, A., Curnis, F., Gagliani, M. C., Bruno, S., Marini, C., Gori, A., Longhi, R., Murgia, D., Sementa, A. R., Cilli, M., Tacchetti, C. & 5 others, Corti, A., Sambuceti, G., Marchiò, S., Ponzoni, M. & Pastorino, F., Nov 1 2015, In : Biomaterials. 68, p. 89-99 11 p.

Research output: Contribution to journalArticle

2013

BRAF V600E is a determinant of sensitivity to proteasome inhibitors

Zecchin, D., Boscaro, V., Medico, E., Barault, L., Martini, M., Arena, S., Cancelliere, C., Bartolini, A., Crowley, E. H., Bardelli, A., Gallicchio, M. & Di Nicolantonio, F., Dec 2013, In : Molecular Cancer Therapeutics. 12, 12, p. 2950-2961 12 p.

Research output: Contribution to journalArticle

Novel phage display-derived neuroblastoma-targeting peptides potentiate the effect of drug nanocarriers in preclinical settings

Loi, M., Di Paolo, D., Soster, M., Brignole, C., Bartolini, A., Emionite, L., Sun, J., Becherini, P., Curnis, F., Petretto, A., Sani, M., Gori, A., Milanese, M., Gambini, C., Longhi, R., Cilli, M., Allen, T. M., Bussolino, F., Arap, W., Pasqualini, R. & 4 others, Corti, A., Ponzoni, M., Marchiò, S. & Pastorino, F., 2013, In : Journal of Controlled Release. 170, 2, p. 233-241 9 p.

Research output: Contribution to journalArticle

2012

A complex of α6 integrin and E-cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6

Marchiò, S., Soster, M., Cardaci, S., Muratore, A., Bartolini, A., Barone, V., Ribero, D., Monti, M., Bovino, P., Sun, J., Giavazzi, R., Asioli, S., Cassoni, P., Capussotti, L., Pucci, P., Bugatti, A., Rusnati, M., Pasqualini, R., Arap, W. & Bussolino, F., Nov 2012, In : EMBO Molecular Medicine. 4, 11, p. 1156-1175 20 p.

Research output: Contribution to journalArticle

2011

G-CSF administration to adult mice stimulates the proliferation of microglia but does not modify the outcome of ischemic injury

Bartolini, A., Vigliani, M. C., Magrassi, L., Vercelli, A. & Rossi, F., Mar 2011, In : Neurobiology of Disease. 41, 3, p. 640-649 10 p.

Research output: Contribution to journalArticle

Modulation of cell-cycle dynamics is required to regulate the number of cerebellar GABAergic interneurons and their rhythm of maturation

Leto, K., Bartolini, A., di Gregorio, A., Imperiale, D., de Luca, A., Parmigiani, E., Filipkowski, R. K., Kaczmarek, L. & Rossi, F., Aug 15 2011, In : Development. 138, 16, p. 3463-3472 10 p.

Research output: Contribution to journalArticle

2010

The prospective white matter: An atypical neurogenic niche in the developing cerebellum

Leto, K., Bartolini, A. & Rossi, F., 2010, In : Archives Italiennes de Biologie. 148, 2, p. 137-146 10 p.

Research output: Contribution to journalArticle

2009

Laminar fate and phenotype specification of cerebellar GABAergic interneurons

Leto, K., Bartolini, A., Yanagawa, Y., Obata, K., Magrassi, L., Schilling, K. & Rossi, F., May 27 2009, In : Journal of Neuroscience. 29, 21, p. 7079-7091 13 p.

Research output: Contribution to journalArticle

2008

Development of cerebellar GABAergic interneurons: Origin and shaping of the "minibrain" local connections

Leto, K., Bartolini, A. & Rossi, F., Dec 2008, In : Cerebellum. 7, 4, p. 523-529 7 p.

Research output: Contribution to journalArticle