• 832 Citations
  • 16 h-Index
1978 …2019
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Research Output 1978 2019

  • 832 Citations
  • 16 h-Index
  • 82 Article
  • 2 Review article
  • 1 Conference contribution
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Article

LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice

Malavolta, M., Dato, S., Villa, F., De Rango, F., Iannone, F., Ferrario, A., Maciag, A., Ciaglia, E., D'amato, A., Carrizzo, A., Basso, A., Orlando, F., Provinciali, M., Madeddu, P., Passarino, G., Vecchione, C., Rose, G. & Puca, A. A., Jan 1 2019, In : Aging. 11, 16, p. 6555-6568 14 p.

Research output: Contribution to journalArticle

Open Access
Haplotypes
Genes
Life Expectancy
Genetic Markers
Italy
1 Citation (Scopus)
Escherichia coli O157
Hand Strength
Locomotion
Inbred C57BL Mouse
locomotion
2018
5 Citations (Scopus)

Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE study

Rietman, M. L., Spijkerman, A. M. W., Wong, A., van Steeg, H., Bürkle, A., Moreno-Villanueva, M., Sindlinger, T., Franceschi, C., Grubeck-Loebenstein, B., Bernhardt, J., Slagboom, P. E., Toussaint, O., Debacq-Chainiaux, F., Sikora, E., Gonos, E. S., Breusing, N., Stuetz, W., Weber, D., Grune, T., Basso, A. & 6 others, Piacenza, F., Malavolta, M., Collino, S., Jansen, E. H. J. M., Verschuren, W. M. M. & Dollé, M. E. T., Apr 30 2018, In : Mechanisms of Ageing and Development. 177, p. 135-143 9 p.

Research output: Contribution to journalArticle

Antioxidants
Biomarkers
Psychology
Health
Carotenoids
1 Citation (Scopus)

Measuring zinc in biological nanovesicles by multiple analytical approaches

Piacenza, F., Biesemeier, A., Farina, M., Piva, F., Jin, X., Pavoni, E., Nisi, L., Cardelli, M., Costarelli, L., Giacconi, R., Basso, A., Pierpaoli, E., Provinciali, M., Hwang, J. C. M., Morini, A., di Donato, A. & Malavolta, M., Jul 1 2018, In : Journal of Trace Elements in Medicine and Biology. 48, p. 58-66 9 p.

Research output: Contribution to journalArticle

Zinc
Exosomes
Plasma (human)
Membranes
Electron Probe Microanalysis
4 Citations (Scopus)

Zinc supplementation can reduce accumulation of cadmium in aged metallothionein transgenic mice

Pabis, K., Gundacker, C., Giacconi, R., Basso, A., Costarelli, L., Piacenza, F., Strizzi, S., Provinciali, M. & Malavolta, M., Nov 1 2018, In : Chemosphere. 211, p. 855-860 6 p.

Research output: Contribution to journalArticle

metallothionein
Metallothionein
Cadmium
Liver
Transgenic Mice
1 Citation (Scopus)
Zinc
Blood Cells
Cytokines
Interleukin-1
Lipopolysaccharides
2017
9 Citations (Scopus)
Cell Aging
Endothelial cells
Cell culture
Homeostasis
Endothelial Cells
5 Citations (Scopus)
Lansoprazole
Omeprazole
Proton Pump Inhibitors
Coronary Vessels
Endothelial Cells

Gene Expression, Oxidative Stress, and Senescence of Primary Coronary Endothelial Cells Exposed to Postprandial Serum of Healthy Adult and Elderly Volunteers after Oven-Cooked Meat Meals

Laura, C., Robertina, G., Piacenza, F., Basso, A., Pacetti, D., Balzano, M., Gagliardi, R., Frega, N. G., Mocchegiani, E., Provinciali, M. & Malavolta, M., Jan 1 2017, In : Mediators of Inflammation. 2017, 3868545.

Research output: Contribution to journalArticle

Meat
Meals
Volunteers
Oxidative Stress
Endothelial Cells
16 Citations (Scopus)

Main biomarkers associated with age-related plasma zinc decrease and copper/zinc ratio in healthy elderly from ZincAge study

Giacconi, R., Costarelli, L., Piacenza, F., Basso, A., Rink, L., Mariani, E., Fulop, T., Dedoussis, G., Herbein, G., Provinciali, M., Jajte, J., Lengyel, I., Mocchegiani, E. & Malavolta, M., Dec 2017, In : European Journal of Nutrition. 56, 8, p. 2457-2466 10 p.

Research output: Contribution to journalArticle

Zinc
Copper
Biomarkers
Linear Models
Inflammation
1 Citation (Scopus)

Zinc-induced Metallothionein in centenarian offspring from a large European population: the MARK-AGE Project

Giacconi, R., Costarelli, L., Piacenza, F., Basso, A., Bürkle, A., Moreno-Villanueva, M., Grune, T., Weber, D., Stuetz, W., Gonos, E. S., Schön, C., Grubeck-Loebenstein, B., Sikora, E., Toussaint, O., Debacq-Chainiaux, F., Franceschi, C., Hervonen, A., Slagboom, E., Ciccarone, F., Zampieri, M. & 6 others, Caiafa, P., Jansen, E., Dollé, M. E. T., Breusing, N., Mocchegiani, E. & Malavolta, M., Oct 17 2017, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences.

Research output: Contribution to journalArticle

Metallothionein
Zinc
Population
Blood Cells
Homeostasis
2016
6 Citations (Scopus)

Circadian rhythms of body temperature and locomotor activity in aging BALB/c mice: early and late life span predictors

Basso, A., Del Bello, G., Piacenza, F., Giacconi, R., Costarelli, L. & Malavolta, M., Jan 28 2016, (Accepted/In press) In : Biogerontology. p. 1-12 12 p.

Research output: Contribution to journalArticle

Locomotion
Circadian Rhythm
Body Temperature
Body Temperature Changes
Telemetry
5 Citations (Scopus)

Investigation of Fullerene Exposure of Breast Cancer Cells by Time-Gated Scanning Microwave Microscopy

Farina, M., Piacenza, F., De Angelis, F., Mencarelli, D., Morini, A., Venanzoni, G., Pietrangelo, T., Malavolta, M., Basso, A., Provinciali, M., Hwang, J. C. M., Jin, X. & Di Donato, A., 2016, In : IEEE Transactions on Microwave Theory and Techniques.

Research output: Contribution to journalArticle

electromagnetic properties
Fullerenes
breast
fullerenes
Microscopic examination

Main biomarkers associated with age-related plasma zinc decrease and copper/zinc ratio in healthy elderly from ZincAge study

Giacconi, R., Costarelli, L., Piacenza, F., Basso, A., Rink, L., Mariani, E., Fulop, T., Dedoussis, G., Herbein, G., Provinciali, M., Jajte, J., Lengyel, I., Mocchegiani, E. & Malavolta, M., Jul 26 2016, In : European Journal of Nutrition.

Research output: Contribution to journalArticle

Zinc
Copper
Biomarkers
Linear Models
Inflammation

Main biomarkers associated with age-related plasma zinc decrease and copper/zinc ratio in healthy elderly from ZincAge study

Giacconi, R., Costarelli, L., Piacenza, F., Basso, A., Rink, L., Mariani, E., Fülöp, T., Dedoussis, G., Herbein, G., Provinciali, M., Jajte, J., Lengyel, I., Mocchegiani, E. & Malavolta, M., Jul 26 2016, (Accepted/In press) In : European Journal of Nutrition. p. 1-10 10 p.

Research output: Contribution to journalArticle

Zinc
Copper
Biomarkers
Linear Models
Inflammation
17 Citations (Scopus)
Tocotrienols
Cell Aging
Quercetin
Phytochemicals
Cells
2015
1 Citation (Scopus)

Effect of 6-month caloric restriction on Cu bound to ceruloplasmin in adult overweight subjects

Piacenza, F., Malavolta, M., Basso, A., Costarelli, L., Giacconi, R., Ravussin, E., Redman, L. M. & Mocchegiani, E., Aug 1 2015, In : Journal of Nutritional Biochemistry. 26, 8, p. 876-882 7 p.

Research output: Contribution to journalArticle

Caloric Restriction
Ceruloplasmin
Biomarkers
Exercise
Health

Effect of ZIP2 Gln/Arg/Leu (rs2234632) polymorphism on zinc homeostasis and inflammatory response following zinc supplementation

Giacconi, R., Costarelli, L., Malavolta, M., Cardelli, M., Galeazzi, R., Piacenza, F., Gasparini, N., Basso, A., Mariani, E., Fülöp, T., Rink, L., Dedoussis, G., Herbein, G., Jajte, J., Provinciali, M., Busco, F. & Mocchegiani, E., 2015, In : BioFactors. p. 414-423 10 p.

Research output: Contribution to journalArticle

Polymorphism
Zinc
Homeostasis
Chemokine CCL5
Genotype
7 Citations (Scopus)

Effect of ZIP2 Gln/Arg/Leu (rs2234632) polymorphism on zinc homeostasis and inflammatory response following zinc supplementation

Giacconi, R., Costarelli, L., Malavolta, M., Cardelli, M., Galeazzi, R., Piacenza, F., Gasparini, N., Basso, A., Mariani, E., Fulop, T., Rink, L., Dedoussis, G., Herbein, G., Jajte, J., Provinciali, M., Busco, F. & Mocchegiani, E., Nov 1 2015, In : BioFactors. 41, 6, p. 414-423 10 p.

Research output: Contribution to journalArticle

Polymorphism
Zinc
Homeostasis
Chemokine CCL5
Genotype
54 Citations (Scopus)

Serum copper to zinc ratio: Relationship with aging and health status

Malavolta, M., Piacenza, F., Basso, A., Giacconi, R., Costarelli, L. & Mocchegiani, E., Nov 1 2015, In : Mechanisms of Ageing and Development. 151, p. 93-100 8 p.

Research output: Contribution to journalArticle

Health Status
Zinc
Copper
Serum
Reproduction
2014
10 Citations (Scopus)

Association among 1267 A/G HSP70-2, -308 G/A TNF-α polymorphisms and pro-inflammatory plasma mediators in old ZincAge population

Giacconi, R., Costarelli, L., Malavolta, M., Piacenza, F., Galeazzi, R., Gasparini, N., Basso, A., Mariani, E., Fulop, T., Rink, L., Dedoussis, G., Kanoni, S., Herbein, G., Jajte, J., Busco, F. & Mocchegiani, E., Feb 2014, In : Biogerontology. 15, 1, p. 65-79 15 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
Zinc
Population
Cytokines
Linear Models

Effects of zinc-fortified drinking skim milk (as functional food) on cytokine release and thymic hormone activity in very old persons: a pilot study

Costarelli, L., Giacconi, R., Malavolta, M., Basso, A., Piacenza, F., DeMartiis, M. L., Giannandrea, E., Renieri, C., Busco, F., Galeazzi, R. & Mocchegiani, E., Jun 1 2014, In : Age. 36, 3, p. 9656 1 p.

Research output: Contribution to journalArticle

Thymus Hormones
Functional Food
Drinking
Zinc
Milk
2 Citations (Scopus)

Effects of zinc-fortified drinking skim milk (as functional food) on cytokine release and thymic hormone activity in very old persons: A pilot study

Costarelli, L., Giacconi, R., Malavolta, M., Basso, A., Piacenza, F., DeMartiis, M., Giannandrea, E., Renieri, C., Busco, F., Galeazzi, R. & Mocchegiani, E., 2014, In : Age. 36, 3, p. 1421-1431 11 p.

Research output: Contribution to journalArticle

Thymus Hormones
Functional Food
Drinking
Zinc
Milk
1 Citation (Scopus)

Il modello del siero postprandiale, un "tool" trascurato per le sperimentazioni in vitro di nutrienti

Translated title of the contribution: The postprandial serum: A neglected "tool" for nutritional studiesPiacenza, F., Malavolta, M., Costarelli, L., Giacconi, R., Basso, A. & Mocchegiani, E., Dec 1 2014, In : Progress in Nutrition. 16, 4, p. 276-283 8 p.

Research output: Contribution to journalArticle

Micronutrients
dietary minerals
Serum
Meals
Physiological Phenomena
8 Citations (Scopus)

Influence of +1245 A/G MT1A polymorphism on advanced glycation end-products (AGEs) in elderly: effect of zinc supplementation

Giacconi, R., Simm, A., Santos, A. N., Costarelli, L., Malavolta, M., Mecocci, P., Piacenza, F., Basso, A., Fulop, T., Rink, L., Dedoussis, G., Kanoni, S., Herbein, G., Jajte, J. & Mocchegiani, E., 2014, In : Genes and Nutrition. 9, 5

Research output: Contribution to journalArticle

Advanced Glycosylation End Products
Zinc
Reactive Oxygen Species
Antioxidants
Blood Cells
38 Citations (Scopus)

Micronutrient-gene interactions related to inflammatory/immune response and antioxidant activity in ageing and inflammation. A systematic review

Mocchegiani, E., Costarelli, L., Giacconi, R., Malavolta, M., Basso, A., Piacenza, F., Ostan, R., Cevenini, E., Gonos, E. S. & Monti, D., 2014, In : Mechanisms of Ageing and Development. 136-137, p. 29-49 21 p.

Research output: Contribution to journalArticle

Micronutrients
Nutrigenomics
Antioxidants
Inflammation
Genes
19 Citations (Scopus)
Cell Aging
Dietary Supplements
Neoplasms
Clinical Trials
Polyphenols
56 Citations (Scopus)

Vitamin E-gene interactions in aging and inflammatory age-related diseases: Implications for treatment. A systematic review

Mocchegiani, E., Costarelli, L., Giacconi, R., Malavolta, M., Basso, A., Piacenza, F., Ostan, R., Cevenini, E., Gonos, E. S., Franceschi, C. & Monti, D., 2014, In : Ageing Research Reviews. 14, 1, p. 81-101 21 p.

Research output: Contribution to journalArticle

Vitamin E
Genes
Aging of materials
Oxidative stress
Nutrigenomics
2013
7 Citations (Scopus)
Thymus Gland
Zinc
Arginine
Melatonin
Circulating Thymic Factor
23 Citations (Scopus)

Metallothioneins, ageing and cellular senescence: A future therapeutic target

Mocchegiani, E., Costarelli, L., Basso, A., Giacconi, R., Piacenza, F. & Malavolta, M., 2013, In : Current Pharmaceutical Design. 19, 9, p. 1753-1764 12 p.

Research output: Contribution to journalArticle

Metallothionein
Cell Aging
Zinc
Antioxidants
Therapeutics
11 Citations (Scopus)
Rejuvenation
Cell Aging
Microglia
Alzheimer Disease
Phagocytes
2012
21 Citations (Scopus)

Cu to Zn ratio, physical function, disability, and mortality risk in older elderly (ilSIRENTE study)

Mocchegiani, E., Malavolta, M., Lattanzio, F., Piacenza, F., Basso, A., Abbatecola, A. M., Russo, A., Giovannini, S., Capoluongo, E., Bustacchini, S., Guffanti, E. E., Bernabei, R. & Landi, F., Jun 2012, In : Age. 34, 3, p. 539-552 14 p.

Research output: Contribution to journalArticle

Zinc
Copper
Mortality
Biomarkers
Linear Models
44 Citations (Scopus)
Micronutrients
Genes
Aging of materials
Nutrigenomics
Antioxidants
20 Citations (Scopus)
Inductively coupled plasma mass spectrometry
Trace Elements
High performance liquid chromatography
Chromatography
Edetic Acid
14 Citations (Scopus)
Metallothionein
Transgenic Mice
Zinc
Inbred C57BL Mouse
Genetic Therapy
2011

Nutrizione e infiammazione: Le basi di un alterato rapporto tra rame e zinco plasmatico nell'anziano

Translated title of the contribution: Nutrition and inflammation: The basis for an altered plasma copper to zinc ratio in elderlyMalavolta, M., Giacconi, R., Piacenza, F., Cipriano, C., Costarelli, L., Pierpaoli, S., Basso, A., Orlandoni, P., Lattanzio, F. & Mocchegiani, E., 2011, In : Progress in Nutrition. 13, 1, p. 48-54 7 p.

Research output: Contribution to journalArticle

Zinc
Copper
biomarkers
inflammation
Biomarkers
23 Citations (Scopus)

Zinc, metallothioneins and immunosenescence: Effect of zinc supply as nutrigenomic approach

Mocchegiani, E., Costarelli, L., Giacconi, R., Piacenza, F., Basso, A. & Malavolta, M., Oct 2011, In : Biogerontology. 12, 5, p. 455-465 11 p.

Research output: Contribution to journalArticle

Nutrigenomics
Metallothionein
Zinc
Interleukin-6
Immunosenescence
2010
4 Citations (Scopus)

Diet (zinc)-gene interaction related to inflammatory/immune response in ageing: Possible link with frailty syndrome?

Mocchegiani, E., Basso, A., Giacconi, R., Piacenza, F., Costarelli, L., Pierpaoli, S. & Malavolta, M., Oct 2010, In : Biogerontology. 11, 5, p. 589-595 7 p.

Research output: Contribution to journalArticle

Zinc
Diet
Interleukin-6
Genes
Feeding Behavior
3 Citations (Scopus)

Noninvasive neonatal thymus graft into the axillary cavity extends the lifespan of old mice

Basso, A., Malavolta, M., Piacenza, F., Santarelli, L., Marcellini, F., Papa, R. & Mocchegiani, E., Apr 1 2010, In : Rejuvenation Research. 13, 2-3, p. 288-291 4 p.

Research output: Contribution to journalArticle

Thymus Gland
Transplants
Capsules
Survival Rate
Kidney
78 Citations (Scopus)

Plasma copper/zinc ratio: An inflammatory/nutritional biomarker as predictor of all-cause mortality in elderly population

Malavolta, M., Giacconi, R., Piacenza, F., Santarelli, L., Cipriano, C., Costarelli, L., Tesei, S., Pierpaoli, S., Basso, A., Galeazzi, R., Lattanzio, F. & Mocchegiani, E., Jun 2010, In : Biogerontology. 11, 3, p. 309-319 11 p.

Research output: Contribution to journalArticle

Zinc
Copper
Biomarkers
Mortality
Population
24 Citations (Scopus)

Zinc, metallothioneins and immunosenescence

Mocchegiani, E., Malavolta, M., Costarelli, L., Giacconi, R., Cipriano, C., Piacenza, F., Tesei, S., Basso, A., Pierpaoli, S. & Lattanzio, F., Aug 2010, In : Proceedings of the Nutrition Society. 69, 3, p. 290-299 10 p.

Research output: Contribution to journalArticle

Metallothionein
Zinc
Interleukin-6
Immunosenescence
Homeostasis
2009
5 Citations (Scopus)

l-Arginine normalizes NOS activity and zinc-MT homeostasis in the kidney of mice chronically exposed to inorganic mercury

Piacenza, F., Malavolta, M., Cipriano, C., Costarelli, L., Giacconi, R., Muti, E., Tesei, S., Pierpaoli, S., Basso, A., Bracci, M., Bonacucina, V., Santarelli, L. & Mocchegiani, E., Sep 28 2009, In : Toxicology Letters. 189, 3, p. 200-205 6 p.

Research output: Contribution to journalArticle

Mercuric Chloride
Metallothionein
Nitric Oxide Synthase Type II
Mercury
Arginine

Regolazione delle metallotionine in età molto avanzata: Ci sono altri fattori determinanti oltre all'infiammazione e all'apporto di zinco quotidiano?

Translated title of the contribution: Regulation of metallothioneins in the very elderly: Are there other determinants besides inflammation and daily zinc dietary intake?Malavolta, M., Cipriano, C., Costarelli, L., Giacconi, R., Tesei, S., Muti, E., Piacenza, F., Pierpaoli, S., Basso, A., Monti, D., Mariani, E., Lattanzio, F. & Mocchegiani, E., Apr 2009, In : Giornale di Gerontologia. 57, 2, p. 65-69 5 p.

Research output: Contribution to journalArticle

Metallothionein
Zinc
Interleukin-6
Inflammation
Poisons
2005
9 Citations (Scopus)

Aging reversibility: From thymus graft to vegetable extract treatment - Application to cure an age-associated pathology

Basso, A., Rossolini, G., Piantanelli, A., Amici, D., Calzuola, I., Mancinelli, L., Marsili, V. & Gianfranceschi, G. L., Sep 2005, In : Biogerontology. 6, 4, p. 245-253 9 p.

Research output: Contribution to journalArticle

Vegetables
Thymus Gland
Triticum
Pathology
Transplants
24 Citations (Scopus)

Fractal charaterisation of boundary irregularity in skin pigmented lesions

Piantanelli, A., Maponi, P., Cialabrini, A., Scalise, L., Basso, A. & Serresi, S., Jul 2005, In : Medical and Biological Engineering and Computing. 43, 4, p. 436-442 7 p.

Research output: Contribution to journalArticle

Fractals
Skin
Fractal dimension
Tumors
Melanoma
2002
Submandibular Gland
Circadian Rhythm
Adrenergic Receptors
Brain
Aging of materials
8 Citations (Scopus)
Submandibular Gland
Circadian Rhythm
Adrenergic Receptors
Brain
Aging of materials