• 2486 Citations
  • 21 h-Index
20062019
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Research Output 2006 2019

  • 2486 Citations
  • 21 h-Index
  • 45 Article
  • 4 Review article
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Article
2019

Dissecting the mechanisms of bone loss in Gorham-Stout disease

Rossi, M., Buonuomo, P. S., Battafarano, G., Conforti, A., Mariani, E., Algeri, M., Pelle, S., D'Agostini, M., Macchiaiolo, M., De Vito, R., Gonfiantini, M. V., Jenkner, A., Rana, I., Bartuli, A. & Del Fattore, A., Sep 13 2019, In : Bone. p. 115068

Research output: Contribution to journalArticle

Essential Osteolysis
Bone and Bones
Osteoclasts
Serum
Osteoblasts

Intrinsic Bone Defects in Cystinotic Mice

Battafarano, G., Rossi, M., Rega, L. R., Di Giovamberardino, G., Pastore, A., D'Agostini, M., Porzio, O., Nevo, N., Emma, F., Taranta, A. & Del Fattore, A., Feb 19 2019, In : American Journal of Pathology.

Research output: Contribution to journalArticle

Bone and Bones
Osteoclasts
Osteoblasts
Cystinosis
Fanconi Syndrome

NRF2 orchestrates the redox regulation induced by radiation therapy, sustaining embryonal and alveolar rhabdomyosarcoma cells radioresistance

Marampon, F., Codenotti, S., Megiorni, F., Del Fattore, A., Camero, S., Gravina, G. L., Festuccia, C., Musio, D., De Felice, F., Nardone, V., Santoro, A. N., Dominici, C., Fanzani, A., Pirtoli, L., Fioravanti, A., Tombolini, V., Cheleschi, S. & Tini, P., Apr 2019, In : Journal of Cancer Research and Clinical Oncology. 145, 4, p. 881-893 13 p.

Research output: Contribution to journalArticle

Alveolar Rhabdomyosarcoma
Embryonal Rhabdomyosarcoma
Alveolar Epithelial Cells
Rhabdomyosarcoma
Oxidation-Reduction

Pro-differentiating and radiosensitizing effects of inhibiting HDACs by PXD-101 (Belinostat) in in vitro and in vivo models of human rhabdomyosarcoma cell lines

Marampon, F., Di Nisio, V., Pietrantoni, I., Petragnano, F., Fasciani, I., Scicchitano, B. M., Ciccarelli, C., Gravina, G. L., Festuccia, C., Del Fattore, A., Tombolini, M., De Felice, F., Musio, D., Cecconi, S., Tini, P., Maddalo, M., Codenotti, S., Fanzani, A., Polimeni, A., Maggio, R. & 1 others, Tombolini, V., Oct 1 2019, In : Cancer Letters. 461, p. 90-101 12 p.

Research output: Contribution to journalArticle

Radiation-Sensitizing Agents
Rhabdomyosarcoma
Cell Line
DNA Damage
G2 Phase Cell Cycle Checkpoints
2018

Disruption of MEK/ERK/c-Myc signaling radiosensitizes prostate cancer cells in vitro and in vivo

Ciccarelli, C., Di Rocco, A., Gravina, G. L., Mauro, A., Festuccia, C., Del Fattore, A., Berardinelli, P., De Felice, F., Musio, D., Bouché, M., Tombolini, V., Zani, B. M. & Marampon, F., Sep 2018, In : Journal of Cancer Research and Clinical Oncology. 144, 9, p. 1685-1699 15 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Prostatic Neoplasms
Heterografts
Proto-Oncogene Proteins c-myc
Apoptosis

Imaging of extracellular vesicles derived from human bone marrow mesenchymal stem cells using fluorescent and magnetic labels

Dabrowska, S., Del Fattore, A., Karnas, E., Frontczak-Baniewicz, M., Kozlowska, H., Muraca, M., Janowski, M. & Lukomska, B., 2018, In : International Journal of Nanomedicine. 13, p. 1653-1664 12 p.

Research output: Contribution to journalArticle

Stem cells
Mesenchymal Stromal Cells
Labels
Bone
Bone Marrow

Testosterone-mediated activation of androgenic signalling sustains in vitro the transformed and radioresistant phenotype of rhabdomyosarcoma cell lines

Giannattasio, S., Megiorni, F., Di Nisio, V., Del Fattore, A., Fontanella, R., Camero, S., Antinozzi, C., Festuccia, C., Gravina, G. L., Cecconi, S., Dominici, C., Di Luigi, L., Ciccarelli, C., De Cesaris, P., Riccioli, A., Zani, B. M., Lenzi, A., Pestell, R. G., Filippini, A., Crescioli, C. & 2 others, Tombolini, V. & Marampon, F., May 22 2018, In : Journal of Endocrinological Investigation. 15 p.

Research output: Contribution to journalArticle

Rhabdomyosarcoma
Androgens
Testosterone
Phenotype
Cell Line
2017

Percentiles of serum uric acid and cardiometabolic abnormalities in obese Italian children and adolescents

Luciano, R., Shashaj, B., Spreghini, M. R., Del Fattore, A., Rustico, C., Wietrzykowska Sforza, R., Morino, G. S., Dallapiccola, B. & Manco, M., Jan 3 2017, In : Italian Journal of Pediatrics. 43, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Uric Acid
Serum
Triglycerides
Waist Circumference
Linear Models

Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embryonal rhabdomyosarcoma cells

Megiorni, F., Gravina, G. L., Camero, S., Ceccarelli, S., Del Fattore, A., Desiderio, V., Papaccio, F., McDowell, H. P., Shukla, R., Pizzuti, A., Beirinckx, F., Pujuguet, P., Saniere, L., Der Aar, E. V., Maggio, R., De Felice, F., Marchese, C., Dominici, C., Tombolini, V., Festuccia, C. & 1 others, Marampon, F., Oct 6 2017, In : Journal of Hematology and Oncology. 10, 1, 161.

Research output: Contribution to journalArticle

Eph Family Receptors
Embryonal Rhabdomyosarcoma
Erythropoietin
Phosphotransferases
Pharmacology
2016

Nanoparticles-based treatment for bone metastasis

Saracino, R., Luciano, R., Battafarano, G., Perrotta, A., Muraca, M. & Del Fattore, A., 2016, In : Current Drug Targets. 17, 3, p. 303-310 8 p.

Research output: Contribution to journalArticle

Nanoparticles
Bone
Neoplasm Metastasis
Bone and Bones
Therapeutics

New Perspectives in Glioblastoma: Nanoparticles-based Approaches

Luciano, R., Battafarano, G., Saracino, R., Rossi, M., Perrotta, A., Manco, M., Muraca, M. & Del Fattore, A., Aug 13 2016, In : Current Cancer Drug Targets. 17, 3, p. 203-220 18 p.

Research output: Contribution to journalArticle

Glioblastoma
Nanoparticles
Glioma
Nanomedicine
Central Nervous System Neoplasms

The use of mesenchymal stem cells for the treatment of autoimmunity: From animals models to human disease

Fierabracci, A., Fattore, A. D., Muraca, M., Delfino, D. V. & Muraca, M., Feb 1 2016, In : Current Drug Targets. 17, 2, p. 229-238 10 p.

Research output: Contribution to journalArticle

Stem cells
Autoimmunity
Mesenchymal Stromal Cells
Animals
Animal Models

ZNF687 Mutations in Severe Paget Disease of Bone Associated with Giant Cell Tumor

Divisato, G., Formicola, D., Esposito, T., Merlotti, D., Pazzaglia, L., Del Fattore, A., Siris, E. S., Orcel, P., Brown, J. P., Nuti, R., Strazzullo, P., Benassi, M. S., Cancela, M. L., Michou, L., Rendina, D., Gennari, L. & Gianfrancesco, F., Feb 4 2016, In : American Journal of Human Genetics. 98, 2, p. 275-286 12 p.

Research output: Contribution to journalArticle

Osteitis Deformans
Giant Cell Tumors
Zinc Fingers
Giant Cell Tumor of Bone
Mutation

ZNF687 Mutations in Severe Paget Disease of Bone Associated with Giant Cell Tumor

Divisato, G., Formicola, D., Esposito, T., Merlotti, D., Pazzaglia, L., Del Fattore, A., Siris, E. S., Orcel, P., Brown, J. P., Nuti, R., Strazzullo, P., Benassi, M. S., Cancela, M. L., Michou, L., Rendina, D., Gennari, L. & Gianfrancesco, F., Feb 4 2016, In : American Journal of Human Genetics. 98, 2, p. 275-286 12 p.

Research output: Contribution to journalArticle

Osteitis Deformans
Giant Cell Tumors
Zinc Fingers
Giant Cell Tumor of Bone
Mutation

ZNF687 Mutations in Severe Paget Disease of Bone Associated with Giant Cell Tumor

Divisato, G., Formicola, D., Esposito, T., Merlotti, D., Pazzaglia, L., Del Fattore, A., Siris, E., Orcel, P., Brown, J. P., Nuti, R., Strazzullo, P., Benassi, M. S., Cancela, M. L., Michou, L., Rendina, D., Gennari, L. & Gianfrancesco, F., Feb 4 2016, In : American Journal of Human Genetics. 98, 2, p. 275-286 12 p.

Research output: Contribution to journalArticle

Osteitis Deformans
Giant Cell Tumors
Zinc Fingers
Giant Cell Tumor of Bone
Mutation
2015

Differential effects of extracellular vesicles secreted by mesenchymal stem cells from different sources on glioblastoma cells

Del Fattore, A., Luciano, R., Saracino, R., Battafarano, G., Rizzo, C., Pascucci, L., Alessandri, G., Pessina, A., Perrotta, A., Fierabracci, A. & Muraca, M., Apr 1 2015, In : Expert Opinion on Biological Therapy. 15, 4, p. 495-504 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Stem cells
Mesenchymal Stromal Cells
Umbilical Cord
Tissue

Immunoregulatory effects of mesenchymal stem cell-derived extracellular vesicles on T lymphocytes

Fattore, A. D., Luciano, R., Pascucci, L., Goffredo, B. M., Giorda, E., Scapaticci, M., Fierabracci, A. & Muraca, M., 2015, In : Cell Transplantation. 24, 12, p. 2615-2627 13 p.

Research output: Contribution to journalArticle

T-cells
Stem cells
Mesenchymal Stromal Cells
T-Lymphocytes
Cell death

Osteopetrosis and its relevance for the discovery of new functions associated with the skeleton

Coudert, A. E., De Vernejoul, M. C., Muraca, M. & Del Fattore, A., 2015, In : International Journal of Endocrinology. 2015, 372156.

Research output: Contribution to journalArticle

Osteopetrosis
Skeleton
Deaf-Blind Disorders
Bone and Bones
Spontaneous Fractures

Recent advances in mesenchymal stem cell immunomodulation: The role of microvesicles

Fierabracci, A., Del Fattore, A., Luciano, R., Muraca, M., Teti, A. & Muraca, M., 2015, In : Cell Transplantation. 24, 2, p. 133-149 17 p.

Research output: Contribution to journalArticle

Immunomodulation
Stem cells
Mesenchymal Stromal Cells
Molecules
Bioactivity

The endocrine role of the skeleton

Rauner, M., Coudert, A., Sobacchi, C. & Del Fattore, A., 2015, In : International Journal of Endocrinology. 2015, 265151.

Research output: Contribution to journalArticle

2014

An experimental therapy to improve skeletal growth and prevent bone loss in a mouse model overexpressing IL-6

Del Fattore, A., Cappariello, A., Capulli, M., Rucci, N., Muraca, M., De Benedetti, F. & Teti, A., 2014, In : Osteoporosis International. 25, 2, p. 681-692 12 p.

Research output: Contribution to journalArticle

Investigational Therapies
Bone Development
Interleukin-6
Growth Disorders
Osteoclasts

CLCN7 and TCIRG1 mutations differentially affect bone matrix mineralization in osteopetrotic individuals

Barvencik, F., Kurth, I., Koehne, T., Stauber, T., Zustin, J., Tsiakas, K., Ludwig, C. F., Beil, F. T., Pestka, J. M., Hahn, M., Santer, R., Supanchart, C., Kornak, U., Fattore, A. D., Jentsch, T. J., Teti, A., Schulz, A., Schinke, T. & Amling, M., 2014, In : Journal of Bone and Mineral Research. 29, 4, p. 982-991 10 p.

Research output: Contribution to journalArticle

Osteopetrosis
Physiologic Calcification
Bone Matrix
Mutation
Osteomalacia

Differentially expressed genes in autosomal dominant osteopetrosis type II osteoclasts reveal known and novel pathways for osteoclast biology

Coudert, A. E., Del Fattore, A., Baulard, C., Olaso, R., Schiltz, C., Collet, C., Teti, A. & De Vernejoul, M. C., Mar 2014, In : Laboratory Investigation. 94, 3, p. 275-285 11 p.

Research output: Contribution to journalArticle

Osteopetrosis
Osteoclasts
Genes
Ubiquitin Thiolesterase
Mutation

Generation of the first autosomal dominant osteopetrosis type II (ADO2) disease models

Alam, I., Gray, A. K., Chu, K., Ichikawa, S., Mohammad, K. S., Capannolo, M., Capulli, M., Maurizi, A., Muraca, M., Teti, A., Econs, M. J. & Del Fattore, A., 2014, In : Bone. 59, p. 66-75 10 p.

Research output: Contribution to journalArticle

Osteopetrosis
Osteoclasts
Missense Mutation
Genes
Modifier Genes
2012

Bone cells and the mechanisms of bone remodelling

Fattore, A. D., Teti, A. & Rucci, N., Jan 1 2012, In : Frontiers in Bioscience - Elite. 4 E, 6, p. 2302-2321 20 p.

Research output: Contribution to journalArticle

Bone Remodeling
Bone
Bone and Bones
Osteoblasts
Osteocytes

Bone cells and the mechanisms of bone remodelling.

Del Fattore, A., Teti, A. & Rucci, N., 2012, In : Frontiers in Bioscience - Elite. 4, p. 2302-2321 20 p.

Research output: Contribution to journalArticle

Bone Remodeling
Bone
Bone and Bones
Osteoblasts
Osteocytes

C-Src and IL-6 inhibit osteoblast differentiation and integrate IGFBP5 signalling

Peruzzi, B., Cappariello, A., Del Fattore, A., Rucci, N., De Benedetti, F. & Teti, A., 2012, In : Nature Communications. 3, 630.

Research output: Contribution to journalArticle

interleukins
osteoblasts
Osteoblasts
Interleukin-6
bones

Novel C16orf57 mutations in patients with Poikiloderma with Neutropenia: Bioinformatic analysis of the protein and predicted effects of all reported mutations

Colombo, E. A., Elcioglu, N. H., Yucelten, D., Altunay, I., Cetincelik, U., Teti, A., Del Fattore, A., Luciani, M., Sullivan, S. K., Yan, A. C., Volpi, L. & Larizza, L., 2012, In : Orphanet Journal of Rare Diseases. 7, 1, 7.

Research output: Contribution to journalArticle

Computational Biology
Mutation
Proteins
Catalytic Domain
RNA

The tight Relationship between Osteoclasts and the Immune System

del Fattore, A. & Teti, A., Jun 2012, In : Inflammation and Allergy - Drug Targets. 11, 3, p. 181-187 7 p.

Research output: Contribution to journalArticle

Osteoclasts
Immune System
Bone and Bones
Bone Resorption
Lymphopoiesis
2011

Mechanisms inducing low bone density in duchenne muscular dystrophy in mice and humans

Rufo, A., Del Fattore, A., Capulli, M., Carvello, F., De Pasquale, L., Ferrari, S., Pierroz, D., Morandi, L., De Simone, M., Rucci, N., Bertini, E., Bianchi, M. L., De Benedetti, F. & Teti, A., Aug 2011, In : Journal of Bone and Mineral Research. 26, 8, p. 1891-1903 13 p.

Research output: Contribution to journalArticle

Duchenne Muscular Dystrophy
Bone Density
Interleukin-6
Bone and Bones
Osteoclasts
2010

Bone and bone marrow: The same organ

Del Fattore, A., Capannolo, M. & Rucci, N., Nov 2010, In : Archives of Biochemistry and Biophysics. 503, 1, p. 28-34 7 p.

Research output: Contribution to journalArticle

Bone
Bone Marrow
Bone and Bones
Bone Marrow Diseases
Hematopoiesis

Bone-targeted doxorubicin-loaded nanoparticles as a tool for the treatment of skeletal metastases

Salerno, M., Cenni, E., Fotia, C., Avnet, S., Granchi, D., Castelli, F., Micieli, D., Pignatello, R., Capulli, M., Rucci, N., Angelucci, A., Del Fattore, A., Teti, A., Zini, N., Giunti, A. & Baldini, N., Nov 2010, In : Current Cancer Drug Targets. 10, 7, p. 649-659 11 p.

Research output: Contribution to journalArticle

Nanoparticles
Doxorubicin
Neoplasm Metastasis
Bone and Bones
Alendronate

Committed osteoclast precursors colonize the bone and improve the phenotype of a mouse model of autosomal recessive osteopetrosis

Cappariello, A., Berardi, A. C., Peruzzi, B., Del Fattore, A., Ugazio, A., Bottazzo, G. F. & Teti, A., Jan 2010, In : Journal of Bone and Mineral Research. 25, 1, p. 106-113 8 p.

Research output: Contribution to journalArticle

Osteopetrosis
Osteoclasts
Phenotype
Bone and Bones
Hematopoietic Stem Cell Transplantation

Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism

Ferron, M., Wei, J., Yoshizawa, T., Del Fattore, A., DePinho, R. A., Teti, A., Ducy, P. & Karsenty, G., Jul 2010, In : Cell. 142, 2, p. 296-308 13 p.

Research output: Contribution to journalArticle

Bone Remodeling
Osteoblasts
Energy Metabolism
Bone
Osteocalcin

Receptor activator of NF-κB ligand enhances breast cancer-induced osteolytic lesions through upregulation of extracellular matrix metalloproteinase inducer/CD147

Rucci, N., Millimaggi, D., Mari, M., Del Fattore, A., Bologna, M., Teti, A., Angelucci, A. & Dolo, V., Aug 1 2010, In : Cancer Research. 70, 15, p. 6150-6160 11 p.

Research output: Contribution to journalArticle

CD147 Antigens
Up-Regulation
Breast Neoplasms
Ligands
Matrix Metalloproteinases
2009

Impaired gastric acidification negatively affects calcium homeostasis and bone mass

Schinke, T., Schilling, A. F., Baranowsky, A., Seitz, S., Marshall, R. P., Linn, T., Blaeker, M., Huebner, A. K., Schulz, A., Simon, R., Gebauer, M., Priemel, M., Kornak, U., Perkovic, S., Barvencik, F., Beil, F. T., Del Fattore, A., Frattini, A., Streichert, T., Pueschel, K. & 7 others, Villa, A., Debatin, K. M., Rueger, J. M., Teti, A., Zustin, J., Sauter, G. & Amling, M., Jun 8 2009, In : Nature Medicine. 15, 6, p. 674-681 8 p.

Research output: Contribution to journalArticle

Acidification
Osteoclasts
Stomach
Bone
Homeostasis

The glycosaminoglycan-binding domain of PRELP acts as a cell type-specific NF-κB inhibitor that impairs osteoclastogenesis

Rucci, N., Rufo, A., Alamanou, M., Capulli, M., Del Fattore, A., Åhrman, E., Capece, D., Iansante, V., Zazzeroni, F., Alesse, E., Heinegård, D. & Teti, A., Nov 30 2009, In : Journal of Cell Biology. 187, 5, p. 669-683 15 p.

Research output: Contribution to journalArticle

Osteoclasts
Glycosaminoglycans
Proline
Osteogenesis
Arginine
2008

A new heterozygous mutation (R714C) of the osteopetrosis gene, Pleckstrin homolog domain containing family M (with run domain) member 1 (PLEKHM1), impairs vesicular acidification and increases TRACP secretion in osteoclasts

Del Fattore, A., Fornari, R., Van Wesenbeeck, L., De Freitas, F., Timmermans, J. P., Peruzzi, B., Cappariello, A., Rucci, N., Spera, G., Helfrich, M. H., Van Hul, W., Migliaccio, S. & Teti, A., Mar 2008, In : Journal of Bone and Mineral Research. 23, 3, p. 380-391 12 p.

Research output: Contribution to journalArticle

Osteopetrosis
Osteoclasts
Mutation
Genes
Osteoblasts

Genetics, pathogenesis and complications of osteopetrosis

Del Fattore, A., Cappariello, A. & Teti, A., Jan 2008, In : Bone. 42, 1, p. 19-29 11 p.

Research output: Contribution to journalArticle

Osteopetrosis
Osteoclasts
Genes
Bone and Bones
Osteosclerosis

Osteoclast receptors and signaling

Del Fattore, A., Teti, A. & Rucci, N., May 15 2008, In : Archives of Biochemistry and Biophysics. 473, 2, p. 147-160 14 p.

Research output: Contribution to journalArticle

Osteoclasts
Bone
Bone Resorption
Cytoplasmic and Nuclear Receptors
RANK Ligand
2007

Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL

Sobacchi, C., Frattini, A., Guerrini, M. M., Abinun, M., Pangrazio, A., Susani, L., Bredius, R., Mancini, G., Cant, A., Bishop, N., Grabowski, P., Del Fattore, A., Messina, C., Errigo, G., Coxon, F. P., Scott, D. I., Teti, A., Rogers, M. J., Vezzoni, P., Villa, A. & 1 others, Helfrich, M. H., Aug 2007, In : Nature Genetics. 39, 8, p. 960-962 3 p.

Research output: Contribution to journalArticle

Osteoclasts
Cytoplasmic and Nuclear Receptors
Osteopetrosis
Ligands
Mutation

Osteopenia, decreased bone formation and impaired osteoblast development in Sox4 heterozygous mice

Nissen-Meyer, L. S. H., Jemtland, R., Gautvik, V. T., Pedersen, M. E., Paro, R., Fortunati, D., Pierroz, D., Stadelmann, V. A., Reppe, S., Reinholt, F. P., Del Fattore, A., Rucci, N., Teti, A., Ferrari, S. & Gautvik, K. M., Aug 15 2007, In : Journal of Cell Science. 120, 16, p. 2785-2795 11 p.

Research output: Contribution to journalArticle

Metabolic Bone Diseases
Osteoblasts
Osteogenesis
Bone and Bones
Growth Plate
2006

Clinical, genetic, and cellular analysis of 49 osteopetrotic patients: Implications for diagnosis and treatment

Del Fattore, A., Peruzzi, B., Rucci, N., Recchia, I., Cappariello, A., Longo, M., Fortunati, D., Ballanti, P., Iacobini, M., Luciani, M., Devito, R., Pinto, R., Caniglia, M., Lanino, E., Messina, C., Cesaro, S., Letizia, C., Bianchini, G., Fryssira, H., Grabowski, P. & 9 others, Shaw, N., Bishop, N., Hughes, D., Kapur, R. P., Datta, H. K., Taranta, A., Fornari, R., Migliaccio, S. & Teti, A., Apr 2006, In : Journal of Medical Genetics. 43, 4, p. 315-325 11 p.

Research output: Contribution to journalArticle

Osteopetrosis
Osteoclasts
Therapeutics
Bone and Bones
Osteoblasts

Impaired skeletal development in interleukin-6-transgenic mice: A model for the impact of chronic inflammation on the growing skeletal system

De Benedetti, F., Rucci, N., Del Fattore, A., Peruzzi, B., Paro, R., Longo, M., Vivarelli, M., Muratori, F., Berni, S., Ballanti, P., Ferrari, S. & Teti, A., Nov 2006, In : Arthritis and Rheumatism. 54, 11, p. 3551-3563 13 p.

Research output: Contribution to journalArticle

Transgenic Mice
Interleukin-6
Osteogenesis
Inflammation
Osteoblasts

Inhibition of protein kinase c-Src reduces the incidence of breast cancer metastases and increases survival in mice: Implications for therapy

Rucci, N., Recchia, I., Angelucci, A., Alamanou, M., Del Fattore, A., Fortunati, D., Šuša, M., Fabbro, D., Bologna, M. & Teti, A., 2006, In : Journal of Pharmacology and Experimental Therapeutics. 318, 1, p. 161-172 12 p.

Research output: Contribution to journalArticle

Protein Kinases
Breast Neoplasms
Neoplasm Metastasis
Survival
Incidence