• 856 Citations
  • 15 h-Index
20052018
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Research Output 2005 2018

  • 856 Citations
  • 15 h-Index
  • 23 Article
  • 2 Conference contribution
  • 1 Chapter
2018

Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells

Petrillo, C., Thorne, LG., Unali, G., Schiroli, G., Giordano, AMS., Piras, F., Cuccovillo, I., Petit, SJ., Ahsan, F., Noursadeghi, M., Clare, S., Genovese, P., Gentner, B., Naldini, L., Towers, GJ. & Kajaste-Rudnitski, A., 2018, In : Cell Stem Cell. 23, 6, p. 820-832 13 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Genetic Therapy
Interferons
Permissiveness
Cell Engineering
2017
50 Citations (Scopus)

Efficient Ex Vivo Engineering and Expansion of Highly Purified Human Hematopoietic Stem and Progenitor Cell Populations for Gene Therapy

Zonari, E., Desantis, G., Petrillo, C., Boccalatte, FE., Lidonnici, MR., Kajaste-Rudnitski, A., Aiuti, A., Ferrari, G., Naldini, L. & Gentner, B., 2017, In : Stem Cell Reports. 8, 4, p. 977-990 14 p.

Research output: Contribution to journalArticle

Gene therapy
Hematopoietic Stem Cells
Stem cells
Genetic Therapy
Cells

Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells

Piras, F., Riba, M., Petrillo, C., Lazarevic, D., Cuccovillo, I., Bartolaccini, S., Stupka, E., Gentner, B., Cittaro, D., Naldini, L. & Kajaste-Rudnitski, A., 2017, In : EMBO Molecular Medicine. 9, 1-2, p. 1198-1211 14 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Genetic Therapy
Cell- and Tissue-Based Therapy
Cell Biology
Apoptosis
2015
14 Citations (Scopus)
Virus Diseases
Innate Immunity
Cellular Immunity
Genetic Therapy
Hematopoietic Stem Cells
31 Citations (Scopus)

Cyclosporin A and rapamycin relieve distinct lentiviral restriction blocks in hematopoietic stem and progenitor cells

Petrillo, C., Cesana, D., Piras, F., Bartolaccini, S., Naldini, L., Montini, E. & Kajaste-Rudnitski, A., Feb 3 2015, In : Molecular Therapy. 23, 2, p. 352-362 11 p.

Research output: Contribution to journalArticle

Sirolimus
Hematopoietic Stem Cells
Cyclosporine
Capsid
Genetic Therapy
29 Citations (Scopus)

HIV-1 transcriptional silencing caused by TRIM22 inhibition of Sp1 binding to the viral promoter

Turrini, F., Marelli, S., Kajaste-Rudnitski, A., Lusic, M., Lint, C., Das, A. T., Harwig, A., Berkhout, B. & Vicenzi, E., Dec 18 2015, In : Retrovirology. 12, 1, 104.

Research output: Contribution to journalArticle

Protein Binding
HIV Long Terminal Repeat
HIV-1
Proteins
Plasmids
7 Citations (Scopus)

Inhibition of influenza H5N1 invasion by modified heparin derivatives

Skidmore, M. A., Kajaste-Rudnitski, A., Wells, N. M., Guimond, S. E., Rudd, T. R., Yates, E. A. & Vicenzi, E., Apr 1 2015, In : MedChemComm. 6, 4, p. 640-646 7 p.

Research output: Contribution to journalArticle

Human Influenza
Heparin
Derivatives
Inhibitory Concentration 50
Anticoagulants
2014
36 Citations (Scopus)

Dual-regulated lentiviral vector for gene therapy of X-linked chronic granulomatosis

Chiriaco, M., Farinelli, G., Capo, V., Zonari, E., Scaramuzza, S., Di Matteo, G., Sergi, L. S., Migliavacca, M., Hernandez, R. J., Bombelli, F., Giorda, E., Kajaste-Rudnitski, A., Trono, D., Grez, M., Rossi, P., Finocchi, A., Naldini, L., Gentner, B. & Aiuti, A., 2014, In : Molecular Therapy. 22, 8, p. 1472-1483 12 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cells
Genetic Therapy
Chronic Granulomatous Disease
Myeloid Cells
Transgenes
42 Citations (Scopus)

Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression

Escobar, G., Moi, D., Ranghetti, A., Ozkal-Baydin, P., Squadrito, M. L., Kajaste-Rudnitski, A., Bondanza, A., Gentner, B., De Palma, M., Mazzieri, R. & Naldini, L., Jan 1 2014, In : Science Translational Medicine. 6, 217, 217ra3.

Research output: Contribution to journalArticle

Genetic Engineering
Hematopoiesis
Interferons
Breast Neoplasms
Transgenes
2013
13 Citations (Scopus)

Identification of TRIM22 single nucleotide polymorphisms associated with loss of inhibition of HIV-1 transcription and advanced HIV-1 disease

Ghezzi, S., Galli, L., Kajaste-Rudnitski, A., Turrini, F., Marelli, S., Toniolo, D., Casoli, C., Riva, A., Poli, G., Castagna, A. & Vicenzi, E., Sep 24 2013, In : AIDS (London, England). 27, 15, p. 2335-2344 10 p.

Research output: Contribution to journalArticle

Single Nucleotide Polymorphism
HIV-1
Disease Progression
Blood Cells
Renilla Luciferases
21 Citations (Scopus)

Lipid-based nanoparticles as nonviral gene delivery vectors

Pezzoli, D., Kajaste-Rudnitski, A., Chiesa, R. & Candiani, G., 2013, Methods in Molecular Biology. Humana Press Inc., Vol. 1025. p. 269-279 11 p. (Methods in Molecular Biology; vol. 1025).

Research output: Chapter in Book/Report/Conference proceedingChapter

Nanoparticles
Transfection
Lipids
Liposomes
Nucleic Acids
36 Citations (Scopus)

M1 polarization of human monocyte-derived macrophages restricts pre and postintegration steps of HIV-1 replication

Cassetta, L., Kajaste-Rudnitski, A., Coradin, T., Saba, E., Della Chiara, G., Barbagallo, M., Graziano, F., Alfano, M., Cassol, E., Vicenzi, E. & Poli, G., Jul 31 2013, In : AIDS (London, England). 27, 12, p. 1847-1856 10 p.

Research output: Contribution to journalArticle

HIV-1
Macrophages
Fluorescence
Viral DNA
DNA
86 Citations (Scopus)

TRIM22 inhibits influenza A virus infection by targeting the viral nucleoprotein for degradation

Di Pietro, A., Kajaste-Rudnitski, A., Oteiza, A., Nicora, L., Towers, G. J., Mechti, N. & Vicenzi, E., Apr 2013, In : Journal of Virology. 87, 8, p. 4523-4533 11 p.

Research output: Contribution to journalArticle

nucleoproteins
Nucleoproteins
Influenza A virus
Virus Diseases
degradation
2012
2 Citations (Scopus)

Assessment of efficacy and safety of pandemic A/H1N1/2009 influenza vaccine in a group of health care workers

Mascagni, P., Vicenzi, E., Kajaste-Rudnitski, A., Pellicciotta, G., Monti, A., Cervi, C., Vitalucci, R. & Toffoletto, F., May 2012, In : Medicina del Lavoro. 103, 3, p. 220-229 10 p.

Research output: Contribution to journalArticle

Influenza Vaccines
Pandemics
Vaccines
H1N1 Subtype Influenza A Virus
Delivery of Health Care
3 Citations (Scopus)

HIV-1 envelope-dependent restriction of CXCR4-using viruses in child but not adult untransformed CD4 + T-lymphocyte lines

Mariani, S. A., Brigida, I., Kajaste-Rudnitski, A., Ghezzi, S., Rocchi, A., Plebani, A., Vicenzi, E., Aiuti, A. & Poli, G., Mar 1 2012, In : Blood. 119, 9, p. 2013-2023 11 p.

Research output: Contribution to journalArticle

T-cells
Viruses
HIV-1
T-Lymphocytes
Feeder Cells
2011
35 Citations (Scopus)

Induction of protective antibody response by MF59-adjuvanted 2009 pandemic A/H1N1v influenza vaccine in HIV-1-infected individuals

Kajaste-Rudnitski, A., Galli, L., Nozza, S., Tambussi, G., Di Pietro, A., Pellicciotta, G., Monti, A., Mascagni, P., Moro, M. & Vicenzi, E., Jan 14 2011, In : AIDS (London, England). 25, 2, p. 177-183 7 p.

Research output: Contribution to journalArticle

Influenza Vaccines
Pandemics
Antibody Formation
HIV-1
Hemagglutination
60 Citations (Scopus)

TRIM22 inhibits HIV-1 transcription independently of Its E3 ubiquitin ligase activity, Tat, and NF-κB-responsive long terminal repeat elements

Kajaste-Rudnitski, A., Marelli, S. S., Pultrone, C., Pertel, T., Uchil, P. D., Mechti, N., Mothes, W., Poli, G., Luban, J. & Vicenzi, E., May 2011, In : Journal of Virology. 85, 10, p. 5183-5196 14 p.

Research output: Contribution to journalArticle

ubiquitin-protein ligase
Ubiquitin-Protein Ligases
terminal repeat sequences
Terminal Repeat Sequences
Human immunodeficiency virus 1
2010
12 Citations (Scopus)

Restriction factors of retroviral replication: The example of Tripartite Motif (TRIM) protein 5α and 22

Kajaste-Rudnitski, A., Pultrone, C., Marzetta, F., Ghezzi, S., Coradin, T. & Vicenzi, E., Jun 2010, In : Amino Acids. 39, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Retroviridae
Life Cycle Stages
Viruses
Life cycle
Viral Tropism
19 Citations (Scopus)

Viral determinants in the NS3 helicase and 2K peptide that promote West Nile virus resistance to antiviral action of 2′,5′-oligoadenylate synthetase 1b

Mertens, E., Kajaste-Rudnitski, A., Torres, S., Funk, A., Frenkiel, M. P., Iteman, I., Khromykh, A. A. & Desprès, P., Mar 30 2010, In : Virology. 399, 1, p. 176-185 10 p.

Research output: Contribution to journalArticle

West Nile virus
Ligases
Antiviral Agents
Viral RNA
Peptides
2009
12 Citations (Scopus)

Pandemic vaccine preparedness - Have we left something behind?

Capua, I., Kajaste-Rudnitski, A., Bertoli, E. & Vicenzi, E., Jun 2009, In : PLoS Pathogens. 5, 6, e1000482.

Research output: Contribution to journalArticle

2008
24 Citations (Scopus)

A dimerizable cationic lipid with potential for gene delivery

Candiani, G., Pezzoli, D., Cabras, M., Ristori, S., Pellegrini, C., Kajaste-Rudnitski, A., Vicenzi, E., Sala, C. & Zanda, M., Jun 2008, In : Journal of Gene Medicine. 10, 6, p. 637-645 9 p.

Research output: Contribution to journalArticle

Transfection
Lipids
Genes
Serum
Plasmids

A dimerizable serum-resistant cationic lipid for gene delivery

Candiani, G., Pezzoli, D., Cabras, M., Ristori, S., Kajaste-Rudnitski, A., Vicenzi, E., Cigada, A. & Zanda, M., 2008, 8th World Biomaterials Congress 2008. Vol. 4. p. 2081 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

22 Citations (Scopus)

Inhibition of herpes simplex virus types 1 and 2 in vitro infection by sulfated derivatives of Escherichia coli K5 polysaccharide

Pinna, D., Oreste, P., Coradin, T., Kajaste-Rudnitski, A., Ghezzi, S., Zoppetti, G., Rotola, A., Argnani, R., Poli, G., Manservigi, R. & Vicenzi, E., Sep 2008, In : Antimicrobial Agents and Chemotherapy. 52, 9, p. 3078-3084 7 p.

Research output: Contribution to journalArticle

Human Herpesvirus 2
Human Herpesvirus 1
Escherichia coli
HIV-1
Infection

In vitro transfection of the U87-MG cell line with pTNF-α induces death of cancer vasculature

Pezzoli, D., Kajaste-Rudnitski, A., Cabras, M., Pellegrini, C., Vicenzi, E., Zanda, M. & Candiani, G., 2008, 8th World Biomaterials Congress 2008. Vol. 4. p. 2074 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2006
80 Citations (Scopus)

The 2′,5′-oligoadenylate synthetase 1b is a potent inhibitor of West Nile virus replication inside infected cells

Kajaste-Rudnitski, A., Mashimo, T., Frenkiel, M. P., Guénet, J. L., Lucas, M. & Desprès, P., Feb 24 2006, In : Journal of Biological Chemistry. 281, 8, p. 4624-4637 14 p.

Research output: Contribution to journalArticle

West Nile virus
Ligases
Virus Replication
Viruses
Antiviral Agents
2005
222 Citations (Scopus)

A variant in the CD209 promoter is associated with severity of dengue disease

Sakuntabhai, A., Turbpaiboon, C., Casadémont, I., Chuansumrit, A., Lowhnoo, T., Kajaste-Rudnitski, A., Kalayanarooj, S. M., Tangnararatchakit, K., Tangthawornchaikul, N., Vasanawathana, S., Chaiyaratana, W., Yenchitsomanus, P. T., Suriyaphol, P., Avirutnan, P., Chokephaibulkit, K., Matsuda, F., Yoksan, S., Jacob, Y., Lathrop, G. M., Malasit, P. & 2 others, Desprès, P. & Julier, C., May 2005, In : Nature Genetics. 37, 5, p. 507-513 7 p.

Research output: Contribution to journalArticle

Dengue
Severe Dengue
Dendritic Cells
Odds Ratio
Population Control