20052019

Research output per year

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2019

Assessing the Impact of Cyclosporin A on Lentiviral Transduction and Preservation of Human Hematopoietic Stem Cells in Clinically Relevant Ex Vivo Gene Therapy Settings

Petrillo, C., Calabria, A., Piras, F., Capotondo, A., Spinozzi, G., Cuccovillo, I., Benedicenti, F., Naldini, L., Montini, E., Biffi, A., Gentner, B. & Kajaste-Rudnitski, A., Sep 2019, In : Human Gene Therapy. 30, 9, p. 1133-1146 14 p.

Research output: Contribution to journalArticle

Open Access
2018

Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells

Petrillo, C., Thorne, LG., Unali, G., Schiroli, G., Giordano, AMS., Piras, F., Cuccovillo, I., Petit, SJ., Ahsan, F., Noursadeghi, M., Clare, S., Genovese, P., Gentner, B., Naldini, L., Towers, GJ. & Kajaste-Rudnitski, A., 2018, In : Cell Stem Cell. 23, 6, p. 820-832 13 p.

Research output: Contribution to journalArticle

2017

Efficient Ex Vivo Engineering and Expansion of Highly Purified Human Hematopoietic Stem and Progenitor Cell Populations for Gene Therapy

Zonari, E., Desantis, G., Petrillo, C., Boccalatte, FE., Lidonnici, MR., Kajaste-Rudnitski, A., Aiuti, A., Ferrari, G., Naldini, L. & Gentner, B., 2017, In : Stem Cell Reports. 8, 4, p. 977-990 14 p.

Research output: Contribution to journalArticle

Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells

Piras, F., Riba, M., Petrillo, C., Lazarevic, D., Cuccovillo, I., Bartolaccini, S., Stupka, E., Gentner, B., Cittaro, D., Naldini, L. & Kajaste-Rudnitski, A., 2017, In : EMBO Molecular Medicine. 9, 1-2, p. 1198-1211 14 p.

Research output: Contribution to journalArticle

2015

Cyclosporin A and rapamycin relieve distinct lentiviral restriction blocks in hematopoietic stem and progenitor cells

Petrillo, C., Cesana, D., Piras, F., Bartolaccini, S., Naldini, L., Montini, E. & Kajaste-Rudnitski, A., Feb 3 2015, In : Molecular Therapy. 23, 2, p. 352-362 11 p.

Research output: Contribution to journalArticle

HIV-1 transcriptional silencing caused by TRIM22 inhibition of Sp1 binding to the viral promoter

Turrini, F., Marelli, S., Kajaste-Rudnitski, A., Lusic, M., Lint, C., Das, A. T., Harwig, A., Berkhout, B. & Vicenzi, E., Dec 18 2015, In : Retrovirology. 12, 1, 104.

Research output: Contribution to journalArticle

Inhibition of influenza H5N1 invasion by modified heparin derivatives

Skidmore, M. A., Kajaste-Rudnitski, A., Wells, N. M., Guimond, S. E., Rudd, T. R., Yates, E. A. & Vicenzi, E., Apr 1 2015, In : MedChemComm. 6, 4, p. 640-646 7 p.

Research output: Contribution to journalArticle

2014

Dual-regulated lentiviral vector for gene therapy of X-linked chronic granulomatosis

Chiriaco, M., Farinelli, G., Capo, V., Zonari, E., Scaramuzza, S., Di Matteo, G., Sergi, L. S., Migliavacca, M., Hernandez, R. J., Bombelli, F., Giorda, E., Kajaste-Rudnitski, A., Trono, D., Grez, M., Rossi, P., Finocchi, A., Naldini, L., Gentner, B. & Aiuti, A., 2014, In : Molecular Therapy. 22, 8, p. 1472-1483 12 p.

Research output: Contribution to journalArticle

Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression

Escobar, G., Moi, D., Ranghetti, A., Ozkal-Baydin, P., Squadrito, M. L., Kajaste-Rudnitski, A., Bondanza, A., Gentner, B., De Palma, M., Mazzieri, R. & Naldini, L., Jan 1 2014, In : Science Translational Medicine. 6, 217, 217ra3.

Research output: Contribution to journalArticle

2013

Identification of TRIM22 single nucleotide polymorphisms associated with loss of inhibition of HIV-1 transcription and advanced HIV-1 disease

Ghezzi, S., Galli, L., Kajaste-Rudnitski, A., Turrini, F., Marelli, S., Toniolo, D., Casoli, C., Riva, A., Poli, G., Castagna, A. & Vicenzi, E., Sep 24 2013, In : AIDS (London, England). 27, 15, p. 2335-2344 10 p.

Research output: Contribution to journalArticle

M1 polarization of human monocyte-derived macrophages restricts pre and postintegration steps of HIV-1 replication

Cassetta, L., Kajaste-Rudnitski, A., Coradin, T., Saba, E., Della Chiara, G., Barbagallo, M., Graziano, F., Alfano, M., Cassol, E., Vicenzi, E. & Poli, G., Jul 31 2013, In : AIDS (London, England). 27, 12, p. 1847-1856 10 p.

Research output: Contribution to journalArticle

TRIM22 inhibits influenza A virus infection by targeting the viral nucleoprotein for degradation

Di Pietro, A., Kajaste-Rudnitski, A., Oteiza, A., Nicora, L., Towers, G. J., Mechti, N. & Vicenzi, E., Apr 2013, In : Journal of Virology. 87, 8, p. 4523-4533 11 p.

Research output: Contribution to journalArticle

2012

Assessment of efficacy and safety of pandemic A/H1N1/2009 influenza vaccine in a group of health care workers

Mascagni, P., Vicenzi, E., Kajaste-Rudnitski, A., Pellicciotta, G., Monti, A., Cervi, C., Vitalucci, R. & Toffoletto, F., May 2012, In : Medicina del Lavoro. 103, 3, p. 220-229 10 p.

Research output: Contribution to journalArticle

HIV-1 envelope-dependent restriction of CXCR4-using viruses in child but not adult untransformed CD4 + T-lymphocyte lines

Mariani, S. A., Brigida, I., Kajaste-Rudnitski, A., Ghezzi, S., Rocchi, A., Plebani, A., Vicenzi, E., Aiuti, A. & Poli, G., Mar 1 2012, In : Blood. 119, 9, p. 2013-2023 11 p.

Research output: Contribution to journalArticle

2011

Induction of protective antibody response by MF59-adjuvanted 2009 pandemic A/H1N1v influenza vaccine in HIV-1-infected individuals

Kajaste-Rudnitski, A., Galli, L., Nozza, S., Tambussi, G., Di Pietro, A., Pellicciotta, G., Monti, A., Mascagni, P., Moro, M. & Vicenzi, E., Jan 14 2011, In : AIDS (London, England). 25, 2, p. 177-183 7 p.

Research output: Contribution to journalArticle

TRIM22 inhibits HIV-1 transcription independently of Its E3 ubiquitin ligase activity, Tat, and NF-κB-responsive long terminal repeat elements

Kajaste-Rudnitski, A., Marelli, S. S., Pultrone, C., Pertel, T., Uchil, P. D., Mechti, N., Mothes, W., Poli, G., Luban, J. & Vicenzi, E., May 2011, In : Journal of Virology. 85, 10, p. 5183-5196 14 p.

Research output: Contribution to journalArticle

2010

Restriction factors of retroviral replication: The example of Tripartite Motif (TRIM) protein 5α and 22

Kajaste-Rudnitski, A., Pultrone, C., Marzetta, F., Ghezzi, S., Coradin, T. & Vicenzi, E., Jun 2010, In : Amino Acids. 39, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Viral determinants in the NS3 helicase and 2K peptide that promote West Nile virus resistance to antiviral action of 2′,5′-oligoadenylate synthetase 1b

Mertens, E., Kajaste-Rudnitski, A., Torres, S., Funk, A., Frenkiel, M. P., Iteman, I., Khromykh, A. A. & Desprès, P., Mar 30 2010, In : Virology. 399, 1, p. 176-185 10 p.

Research output: Contribution to journalArticle

2009

Pandemic vaccine preparedness - Have we left something behind?

Capua, I., Kajaste-Rudnitski, A., Bertoli, E. & Vicenzi, E., Jun 2009, In : PLoS Pathogens. 5, 6, e1000482.

Research output: Contribution to journalArticle

2008

A dimerizable cationic lipid with potential for gene delivery

Candiani, G., Pezzoli, D., Cabras, M., Ristori, S., Pellegrini, C., Kajaste-Rudnitski, A., Vicenzi, E., Sala, C. & Zanda, M., Jun 2008, In : Journal of Gene Medicine. 10, 6, p. 637-645 9 p.

Research output: Contribution to journalArticle

Inhibition of herpes simplex virus types 1 and 2 in vitro infection by sulfated derivatives of Escherichia coli K5 polysaccharide

Pinna, D., Oreste, P., Coradin, T., Kajaste-Rudnitski, A., Ghezzi, S., Zoppetti, G., Rotola, A., Argnani, R., Poli, G., Manservigi, R. & Vicenzi, E., Sep 2008, In : Antimicrobial Agents and Chemotherapy. 52, 9, p. 3078-3084 7 p.

Research output: Contribution to journalArticle

2006

The 2′,5′-oligoadenylate synthetase 1b is a potent inhibitor of West Nile virus replication inside infected cells

Kajaste-Rudnitski, A., Mashimo, T., Frenkiel, M. P., Guénet, J. L., Lucas, M. & Desprès, P., Feb 24 2006, In : Journal of Biological Chemistry. 281, 8, p. 4624-4637 14 p.

Research output: Contribution to journalArticle

2005

A variant in the CD209 promoter is associated with severity of dengue disease

Sakuntabhai, A., Turbpaiboon, C., Casadémont, I., Chuansumrit, A., Lowhnoo, T., Kajaste-Rudnitski, A., Kalayanarooj, S. M., Tangnararatchakit, K., Tangthawornchaikul, N., Vasanawathana, S., Chaiyaratana, W., Yenchitsomanus, P. T., Suriyaphol, P., Avirutnan, P., Chokephaibulkit, K., Matsuda, F., Yoksan, S., Jacob, Y., Lathrop, G. M., Malasit, P. & 2 others, Desprès, P. & Julier, C., May 2005, In : Nature Genetics. 37, 5, p. 507-513 7 p.

Research output: Contribution to journalArticle