• 3725 Citations
  • 30 h-Index
1993 …2019
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Research Output 1993 2019

  • 3725 Citations
  • 30 h-Index
  • 98 Article
2019

Detection of iron deficiency in children with Down syndrome

Hart, S. J., Zimmerman, K., Linardic, C. M., Cannon, S., Pastore, A., Patsiogiannis, V., Rossi, P., Santoro, S. L., Skotko, B. G., Torres, A., Valentini, D., Vellody, K., Worley, G. & Kishnani, P. S., Aug 16 2019, In : Genetics in Medicine.

Research output: Contribution to journalArticle

Erythrocyte Indices
Down Syndrome
Iron-Deficiency Anemias
Iron
Ferritins

Glutathione transferase P silencing promotes neuronal differentiation of retinal R28 cells

Sciarretta, F., Fulci, C., Palumbo, C., Aquilano, K., Pastore, A., Iorio, E., Lettieri-Barbato, D., Cicconi, R., Minutolo, A., Parravano, M., Gilardi, M., Varano, M. & Caccuri, A. M., Feb 11 2019, In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

Glutathione Transferase
Clone Cells
Phenotype
Neuroglia
Oxidation-Reduction

Intrinsic Bone Defects in Cystinotic Mice

Battafarano, G., Rossi, M., Rega, L. R., Di Giovamberardino, G., Pastore, A., D'Agostini, M., Porzio, O., Nevo, N., Emma, F., Taranta, A. & Del Fattore, A., Feb 19 2019, In : American Journal of Pathology.

Research output: Contribution to journalArticle

Bone and Bones
Osteoclasts
Osteoblasts
Cystinosis
Fanconi Syndrome

Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy

Pauletti, A., Terrone, G., Shekh-Ahmad, T., Salamone, A., Ravizza, T., Rizzi, M., Pastore, A., Pascente, R., Liang, L-P., Villa, B. R., Balosso, S., Abramov, A. Y., van Vliet, E. A., Del Giudice, E., Aronica, E., Patel, M., Walker, M. C. & Vezzani, A., May 30 2019, In : Brain : a journal of neurology.

Research output: Contribution to journalArticle

Epilepsy
Oxidative Stress
Seizures
Status Epilepticus
Pharmaceutical Preparations
2018

ACTN1 mutations lead to a benign form of platelet macrocytosis not always associated with thrombocytopenia

Faleschini, M., Melazzini, F., Marconi, C., Giangregorio, T., Pippucci, T., Cigalini, E., Pecci, A., Bottega, R., Ramenghi, U., Siitonen, T., Seri, M., Pastore, A., Savoia, A. & Noris, P., 2018, In : British Journal of Haematology. 183, 2, p. 276-288 13 p.

Research output: Contribution to journalArticle

FarmaREL: An Italian pharmacovigilance project to monitor and evaluate adverse drug reactions in haematologic patients

Fracchiolla, N. S., Artuso, S., Cortelezzi, A., Pelizzari, A. M., Tozzi, P., Bonfichi, M., Bocchio, F., Gargantini, L., De Rosa, E., Vighi, G. D., Prestini, L., Sammassimo, S., Frungillo, N., Pasquini, M. C., Ragazzi, A., Boghi, D., Pastore, A., Lanzi, E., Gritti, G., Quaresmini, G. & 11 others, Voltolini, S., Gaiardoni, R., Corti, C., Vilardo, M. C., La Targia, M. L., Berini, G., Magagnoli, M., Bacci, C., Consonni, D., Rivolta, A. L. & Muti, G., 2018, In : Hematological Oncology. 36, 1, p. 299-306 8 p.

Research output: Contribution to journalArticle

Pharmacovigilance
Drug-Related Side Effects and Adverse Reactions
Hematology
Italy
Delivery of Health Care

Pitfalls in the quantitative imaging of glutathione in living cells

Cossetti, C., Di Giovamberardino, G., Rota, R. & Pastore, A., Apr 23 2018, In : Nature Communications. 9, 1, p. 1588 3 p.

Research output: Contribution to journalArticle

2017
5 Citations (Scopus)

Cystinosis (ctns) zebrafish mutant shows pronephric glomerular and tubular dysfunction

Elmonem, M. A., Khalil, R., Khodaparast, L., Khodaparast, L., Arcolino, F. O., Morgan, J., Pastore, A., Tylzanowski, P., Ny, A., Lowe, M., De Witte, P. A., Baelde, H. J., Van Den Heuvel, L. P. & Levtchenko, E., Feb 15 2017, In : Scientific Reports. 7, 42583.

Research output: Contribution to journalArticle

Cystinosis
Zebrafish
Cystine
Larva
Fanconi Syndrome
16 Citations (Scopus)
ataxia
Friedreich Ataxia
antioxidants
Motor Neurons
Antioxidants
63 Citations (Scopus)

Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy

Pauletti, A., Terrone, G., Shekh-Ahmad, T., Salamone, A., Ravizza, T., Rizzi, M., Pastore, A., Pascente, R., Liang, L. P., Villa, B. R., Balosso, S., Abramov, A. Y., Van Vliet, E. A., Del Giudice, E., Aronica, E., Antoine, D. J., Patel, M., Walker, M. C. & Vezzani, A., Jul 1 2017, In : Brain. 140, 7, p. 1885-1899 15 p.

Research output: Contribution to journalArticle

Epilepsy
Oxidative Stress
Seizures
Status Epilepticus
Pharmaceutical Preparations
63 Citations (Scopus)

Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy

Pauletti, A., Terrone, G., Shekh-Ahmad, T., Salamone, A., Ravizza, T., Rizzi, M., Pastore, A., Pascente, R., Liang, L. P., Villa, B. R., Balosso, S., Abramov, A. Y., Van Vliet, E. A., Del Giudice, E., Aronica, E., Antoine, D. J., Patel, M., Walker, M. C. & Vezzani, A., Jul 1 2017, In : Brain. 140, 7, p. 1885-1899 15 p.

Research output: Contribution to journalArticle

Epilepsy
Oxidative Stress
Seizures
Status Epilepticus
Pharmaceutical Preparations
2016
30 Citations (Scopus)

Activation of the transcription factor EB rescues lysosomal abnormalities in cystinotic kidney cells

Rega, L. R., Polishchuk, E., Montefusco, S., Napolitano, G., Tozzi, G., Zhang, J., Bellomo, F., Taranta, A., Pastore, A., Polishchuk, R., Piemonte, F., Medina, D. L., Catz, S. D., Ballabio, A. & Emma, F., Apr 1 2016, In : Kidney International. 89, 4, p. 862-873 12 p.

Research output: Contribution to journalArticle

Transcription Factors
Kidney
Cystine
Cystinosis
Fanconi Syndrome
14 Citations (Scopus)

Altered mTOR signalling in nephropathic cystinosis

Ivanova, E. A., van Den Heuvel, L. P., Elmonem, M. A., de Smedt, H., Missiaen, L., Pastore, A., Mekahli, D., Bultynck, G. & Levtchenko, E. N., Feb 24 2016, (Accepted/In press) In : Journal of Inherited Metabolic Disease. p. 1-8 8 p.

Research output: Contribution to journalArticle

Cystinosis
Cystine
Autophagy
Starvation
Fanconi Syndrome

Cystinosin-LKG rescues cystine accumulation and decreases apoptosis rate in cystinotic proximal tubular epithelial cells

Taranta, A., Bellomo, F., Petrini, S., Polishchuk, E. V., De Leo, E., Rega, L. R., Pastore, A., Polishchuk, R. S., De Matteis, M. A. & Emma, F., Sep 22 2016, In : Pediatric Research. 81, 1-1, p. 113-119 7 p.

Research output: Contribution to journalArticle

Cystine
Madin Darby Canine Kidney Cells
Protein Isoforms
Epithelial Cells
Apoptosis
1 Citation (Scopus)

Evaluation of carbohydrate-cysteamine thiazolidines as pro-drugs for the treatment of cystinosis

Ramazani, Y., Levtchenko, E. N., Van Den Heuvel, L., Van Schepdael, A., Paul, P., Ivanova, E. A., Pastore, A., Hartman, T. M. & Price, N. P. J., Dec 18 2016, In : Carbohydrate Research. 439, p. 9-15 7 p.

Research output: Contribution to journalArticle

Cystinosis
Thiazolidines
Cysteamine
Prodrugs
Carbohydrates

Evaluation of carbohydrate-cysteamine thiazolidines as pro-drugs for the treatment of cystinosis

Ramazani, Y., Levtchenko, E. N., van Den Heuvel, L. P., Van Schepdael, A., Paul, P., Ivanova, E. A., Pastore, A., Hartman, T. M. & Price, N. P. J., Dec 18 2016, In : Carbohydrate Research. 439, p. 9-15 7 p.

Research output: Contribution to journalArticle

Cystinosis
Thiazolidines
Cysteamine
Prodrugs
Carbohydrates

Frataxin silencing alters microtubule stability in motor neurons: implications for Friedreich's ataxia

Piermarini, E., Cartelli, D., Pastore, A., Tozzi, G., Compagnucci, C., Giorda, E., D'Amico, J., Petrini, S., Bertini, E., Cappelletti, G. & Piemonte, F., Oct 1 2016, In : Human Molecular Genetics. 25, 19, p. 4288-4301 14 p.

Research output: Contribution to journalArticle

Friedreich Ataxia
Motor Neurons
Microtubules
Glutathione Disulfide
Polymerization
4 Citations (Scopus)
Phosphoric Monoester Hydrolases
Cardiac Myocytes
Phosphorylation
Glutathione Disulfide
Atrial Natriuretic Factor
1 Citation (Scopus)
High performance liquid chromatography
Reverse-Phase Chromatography
High Pressure Liquid Chromatography
Plasmas
Pulmonary Hypertension
2015
21 Citations (Scopus)

Endo-lysosomal dysfunction in human proximal tubular epithelial cells deficient for lysosomal cystine transporter cystinosin

Ivanova, E. A., De Leo, M. G., Van Den Heuvel, L., Pastore, A., Dijkman, H., De Matteis, M. A. & Levtchenko, E. N., Mar 26 2015, In : PLoS One. 10, 3, e0120998.

Research output: Contribution to journalArticle

Cystinosis
Cystine
Fanconi syndrome
cystine
Fanconi Syndrome
14 Citations (Scopus)

Homocysteine, cysteine, folate and vitamin B12 status in type 2 diabetic patients with chronic kidney disease

Pastore, A., Noce, A., Di Giovamberardino, G., De Stefano, A., Callà, C., Zenobi, R., Dessì, M. & Di Daniele, N., Oct 13 2015, In : Journal of Nephrology. 28, 5, p. 571-576 6 p.

Research output: Contribution to journalArticle

Homocysteine
Vitamin B 12
Chronic Renal Insufficiency
Folic Acid
Cysteine
4 Citations (Scopus)

Influence of dialysis techniques and alternate vitamin supplementation on homocysteine levels in patients with known MTHFR genotypes

Dessì, M., Di Giovamberardino, G., Pieri, M., Noce, A., Zenobi, R., Di Daniele, N. & Pastore, A., Feb 1 2015, In : Clinical and Experimental Nephrology. 19, 1, p. 140-145 6 p.

Research output: Contribution to journalArticle

Homocysteine
Vitamin B 12
Folic Acid
Vitamins
Dialysis
6 Citations (Scopus)

Systemic redox biomarkers in neurodegenerative diseases

Pastore, A., Petrillo, S., Piermarini, E. & Piemonte, F., Jul 1 2015, In : Current Drug Metabolism. 16, 1, p. 46-70 25 p.

Research output: Contribution to journalArticle

Neurodegenerative diseases
Oxidative stress
Biomarkers
Neurodegenerative Diseases
Oxidation-Reduction
18 Citations (Scopus)

The proteome of cblC defect: in vivo elucidation of altered cellular pathways in humans

Caterino, M., Pastore, A., Strozziero, M. G., Di Giovamberardino, G., Imperlini, E., Scolamiero, E., Ingenito, L., Boenzi, S., Ceravolo, F., Martinelli, D., Dionisi-Vici, C. & Ruoppolo, M., Oct 1 2015, In : Journal of Inherited Metabolic Disease. 38, 5, p. 969-979 11 p.

Research output: Contribution to journalArticle

Proteome
Vitamin B 12
Glutathione
Proteins
Two-Dimensional Difference Gel Electrophoresis
2014
36 Citations (Scopus)
Type C Niemann-Pick Disease
Ionization
Esters
Filipin
Plasmas
24 Citations (Scopus)

Effects of levosimendan on mitochondrial function in patients with septic shock: A randomized trial

Torraco, A., Carrozzo, R., Piemonte, F., Pastore, A., Tozzi, G., Verrigni, D., Assenza, M., Orecchioni, A., D'Egidio, A., Marraffa, E., Landoni, G., Bertini, E. & Morelli, A., 2014, In : Biochimie. 102, 1, p. 166-173 8 p.

Research output: Contribution to journalArticle

Septic Shock
Electron Transport
Antioxidants
Mitochondria
Organelle Biogenesis
9 Citations (Scopus)

Erythrocyte glutathione transferase activity: A possible early biomarker for blood toxicity in uremic diabetic patients

Noce, A., Fabrini, R., Dessì, M., Bocedi, A., Santini, S., Rovella, V., Pastore, A., Tesauro, M., Bernardini, S., Di Daniele, N. & Ricci, G., 2014, In : Acta Diabetologica. 51, 2, p. 219-224 6 p.

Research output: Contribution to journalArticle

Glutathione Transferase
Homocysteine
Erythrocytes
Biomarkers
Chronic Renal Insufficiency
11 Citations (Scopus)

Frataxin silencing inactivates mitochondrial complex i in NSC34 motoneuronal cells and alters glutathione homeostasis

Carletti, B., Piermarini, E., Tozzi, G., Travaglini, L., Torraco, A., Pastore, A., Sparaco, M., Petrillo, S., Carrozzo, R., Bertini, E. & Piemonte, F., Apr 4 2014, In : International Journal of Molecular Sciences. 15, 4, p. 5789-5806 18 p.

Research output: Contribution to journalArticle

ataxia
homeostasis
glutathione
neurons
Neurons
4 Citations (Scopus)

Gender-related effects on urine l-cystine metastability

Masotti, A., Laurenzi, C., Boenzi, S., Pastore, A., Taranta, A., Bellomo, F., Muraca, M., Dionisi-Vici, C., Bertucci, P., Strologo, L. D. & Emma, F., Feb 2014, In : Amino Acids. 46, 2, p. 415-427 13 p.

Research output: Contribution to journalArticle

Cystine
Urine
Solubility
Cystinuria
Vanilmandelic Acid
26 Citations (Scopus)

Glutathione metabolism in cobalamin deficiency type C (cblC)

Pastore, A., Martinelli, D., Piemonte, F., Tozzi, G., Boenzi, S., Di Giovamberardino, G., Petrillo, S., Bertini, E. & Dionisi-Vici, C., Jan 2014, In : Journal of Inherited Metabolic Disease. 37, 1, p. 125-129 5 p.

Research output: Contribution to journalArticle

Vitamin B 12
Glutathione
Oxidation-Reduction
Homocystinuria
Glutathione Disulfide
33 Citations (Scopus)
Pediatrics
cysteine
Homocysteine
liver
Liver
15 Citations (Scopus)

The fine-tuning of TRAF2-GSTP1-1 interaction: effect of ligand binding and in situ detection of the complex.

De Luca, A., Mei, G., Rosato, N., Nicolai, E., Federici, L., Palumbo, C., Pastore, A., Serra, M. & Caccuri, A. M., 2014, In : Cell Death and Disease. 5

Research output: Contribution to journalArticle

TNF Receptor-Associated Factor 2
Ligands
G2 Phase
Cell Division
Catalytic Domain
2013

Drastic reduction of piperacillin-tazobactam concentrations in an in-vitro model of continuous venovenous hemofiltration: Proposal of an innovative modality of administration to maintain them at constant concentration

Ferrannini, M., Niscola, P., Falcone, C., Noce, A., Pastore, A., Di Giovamberardino, G., Tendas, A., Scaramucci, L., Di Daniele, N. & Palumbo, R., 2013, In : Cardiovascular and Hematological Agents in Medicinal Chemistry. 11, 3, p. 187-193 7 p.

Research output: Contribution to journalArticle

Hemofiltration
Renal Replacement Therapy
Microbial Sensitivity Tests
Adsorption
In Vitro Techniques
27 Citations (Scopus)

Glutathione: A redox signature in monitoring EPI-743 therapy in children with mitochondrial encephalomyopathies

Pastore, A., Petrillo, S., Tozzi, G., Carrozzo, R., Martinelli, D., Dionisi-Vici, C., Di Giovamberardino, G., Ceravolo, F., Klein, M. B., Miller, G., Enns, G. M., Bertini, E. & Piemonte, F., Jun 2013, In : Molecular Genetics and Metabolism. 109, 2, p. 208-214 7 p.

Research output: Contribution to journalArticle

Mitochondrial Encephalomyopathies
Oxidation-Reduction
Glutathione
Leigh Disease
Monitoring
26 Citations (Scopus)
Adrenoleukodystrophy
Glutathione
Lymphocytes
Oxidative stress
Plasmas
13 Citations (Scopus)

Glutathione S-transferase P1-1 as a target for mesothelioma treatment

De Luca, A., Pellizzari Tregno, F., Sau, A., Pastore, A., Palumbo, C., Alama, A., Cicconi, R., Federici, G. & Caccuri, A. M., Feb 2013, In : Cancer Science. 104, 2, p. 223-230 8 p.

Research output: Contribution to journalArticle

Glutathione S-Transferase pi
Mesothelioma
Glutathione Transferase
Cisplatin
Cell Line
8 Citations (Scopus)

Optimizing the dose of hydroxocobalamin in cobalamin C (cblC) defect

Dionisi-Vici, C., Martinelli, D., Ceravolo, F., Boenzi, S. & Pastore, A., Aug 2013, In : Molecular Genetics and Metabolism. 109, 4, p. 329-330 2 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)

Protein glutathionylation in cardiovascular diseases

Pastore, A. & Piemonte, F., Oct 17 2013, In : International Journal of Molecular Sciences. 14, 10, p. 20845-20876 32 p.

Research output: Contribution to journalArticle

Cardiovascular Diseases
Protein S
proteins
Proteins
Disulfides
2012
8 Citations (Scopus)

All glutathione forms are depleted in blood of obese and type 1 diabetic children

Pastore, A., Ciampalini, P., Tozzi, G., Pecorelli, L., Passarelli, C., Bertini, E. & Piemonte, F., May 2012, In : Pediatric Diabetes. 13, 3, p. 272-277 6 p.

Research output: Contribution to journalArticle

Glutathione
Type 1 Diabetes Mellitus
Oxidative Stress
Homeostasis
Obesity
25 Citations (Scopus)

Brown-Vialetto-van Laere and Fazio-Londe overlap syndromes: A clinical, biochemical and genetic study

Ciccolella, M., Catteruccia, M., Benedetti, S., Moroni, I., Uziel, G., Pantaleoni, C., Chiapparini, L., Bizzi, A., D'Amico, A., Fattori, F., Salsano, M. L., Pastore, A., Tozzi, G., Piemonte, F. & Bertini, E., Dec 2012, In : Neuromuscular Disorders. 22, 12, p. 1075-1082 8 p.

Research output: Contribution to journalArticle

Progressive Bulbar Palsy
Molecular Biology
Riboflavin
Deafness
Auditory Evoked Potentials
19 Citations (Scopus)

Characterization of a new trabectedin-resistant myxoid liposarcoma cell line that shows collateral sensitivity to methylating agents

Uboldi, S., Bernasconi, S., Romano, M., Marchini, S., Fuso Nerini, I., Damia, G., Ganzinelli, M., Marangon, E., Sala, F., Clivio, L., Chiorino, G., Giandomenico, S. D., Rocchi, M., Capozzi, O., Margison, G. P., Watson, A. J., Caccuri, A. M., Pastore, A., Fossati, A., Mantovani, R. & 4 others, Grosso, F., Tercero, J. C., Erba, E. & D'Incalci, M., Jul 1 2012, In : International Journal of Cancer. 131, 1, p. 59-69 11 p.

Research output: Contribution to journalArticle

trabectedin
Myxoid Liposarcoma
Cell Line
temozolomide
DNA
12 Citations (Scopus)

Creatine metabolism in urea cycle defects

Boenzi, S., Pastore, A., Martinelli, D., Goffredo, B. M., Boiani, A., Rizzo, C. & Dionisi-Vici, C., Jul 2012, In : Journal of Inherited Metabolic Disease. 35, 4, p. 647-653 7 p.

Research output: Contribution to journalArticle

Creatine
Urea
Argininosuccinic Aciduria
Citrullinemia
Arginine
30 Citations (Scopus)
Emodin
diets
fats
Nutrition
Oils and fats
94 Citations (Scopus)

EPI-743 reverses the progression of the pediatric mitochondrial disease-Genetically defined Leigh Syndrome

Martinelli, D., Catteruccia, M., Piemonte, F., Pastore, A., Tozzi, G., Dionisi-Vici, C., Pontrelli, G., Corsetti, T., Livadiotti, S., Kheifets, V., Hinman, A., Shrader, W. D., Thoolen, M., Klein, M. B., Bertini, E. & Miller, G., Nov 2012, In : Molecular Genetics and Metabolism. 107, 3, p. 383-388 6 p.

Research output: Contribution to journalArticle

Leigh Disease
Mitochondrial Diseases
Pediatrics
Disease Progression
Compassionate Use Trials
18 Citations (Scopus)

Erythrocyte glutathione transferase: A potential new biomarker in chronic kidney diseases which correlates with plasma homocysteine

Dessì, M., Noce, A., Dawood, K. F., Galli, F., Taccone-Gallucci, M., Fabrini, R., Bocedi, A., Massoud, R., Fucci, G., Pastore, A., Manca Di Villahermosa, S., Zingaretti, V., Federici, G. & Ricci, G., Jul 2012, In : Amino Acids. 43, 1, p. 347-354 8 p.

Research output: Contribution to journalArticle

Biomarkers
Homocysteine
Glutathione Transferase
Chronic Renal Insufficiency
Erythrocytes
1 Citation (Scopus)

Pediatric reference intervals for muscle coenzyme Q10

Pastore, A., Di Giovamberardino, G., Petrillo, S., Boenzi, S., Bertini, E., Dionisi-Vici, C. & Piemonte, F., Dec 2012, In : Biomarkers. 17, 8, p. 764-766 3 p.

Research output: Contribution to journalArticle

coenzyme Q10
Pediatrics
Muscle
Muscles
Tissue
6 Citations (Scopus)

Protein glutathionylation in cellular compartments: A constitutive redox signal

Petrini, S., Passarelli, C., Pastore, A., Tozzi, G., Coccetti, M., Colucci, M., Bianchi, M., Carrozzo, R., Bertini, E. & Piemonte, F., Mar 2012, In : Redox Report. 17, 2, p. 63-71 9 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Glutathione
Proteins
Nuclear Lamina
Oxidative stress
12 Citations (Scopus)
Post Translational Protein Processing
Nutrition
Phosphoric Monoester Hydrolases
Oxidation-Reduction
Rats
99 Citations (Scopus)

S-Glutathionylation signaling in cell biology: Progress and prospects

Pastore, A. & Piemonte, F., Aug 15 2012, In : European Journal of Pharmaceutical Sciences. 46, 5, p. 279-292 14 p.

Research output: Contribution to journalArticle

Oxidation-Reduction
Cell Biology
Ryanodine Receptor Calcium Release Channel
Signal Transduction
PTEN Phosphohydrolase

Studying nonobstructive azoospermia in cystinosis: Histologic examination of testes and epididymis and sperm analysis in a Ctns -/- mouse model

Besouw, M. T. P., Van Pelt, A. M. M., Gaide Chevronnay, H. P., Courtoy, P. J., Pastore, A., Goossens, E., Devuyst, O., Antignac, C. & Levtchenko, E. N., Jul 2012, In : Fertility and Sterility. 98, 1, p. 162-165 4 p.

Research output: Contribution to journalArticle

Cystinosis
Epididymis
Spermatozoa
Testis
Cystine