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2019

A novel 3'-tRNAGlu-derived fragment acts as a tumor suppressor in breast cancer by targeting nucleolin

Falconi, M., Giangrossi, M., Zabaleta, M. E., Wang, J., Gambini, V., Tilio, M., Bencardino, D., Occhipinti, S., Belletti, B., Laudadio, E., Galeazzi, R., Marchini, C. & Amici, A., Dec 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 12, p. 13228-13240 13 p.

Research output: Contribution to journalArticle

Downregulation of miR-223 expression is an early event during mammary transformation and confers resistance to CDK4/6 inhibitors in luminal breast cancer

Citron, F., Segatto, I., Rampioni Vinciguerra, G. L., Musco, L., Russo, F., Mungo, G., D'Andrea, S., Mattevi, M. C., Perin, T., Schiappacassi, M., Massarut, S., Marchini, C., Amici, A., Vecchione, A., Baldassarre, G. & Belletti, B., Dec 20 2019, In : Cancer Research. p. canres.1793.2019

Research output: Contribution to journalArticle

Stathmin is required for normal mouse mammary gland development and D16Her2-driven tumorigenesis

Segatto, I., De Marco Zompit, M., Citron, F., D'Andrea, S., Vinciguerra, G. L. R., Perin, T., Berton, S., Mungo, G., Schiappacassi, M., Marchini, C., Amici, A., Vecchione, A., Baldassarre, G. & Belletti, B., Jan 15 2019, In : Cancer Research. 79, 2, p. 397-409 13 p.

Research output: Contribution to journalArticle

USP1 links platinum resistance to cancer cell dissemination by regulating Snail stability

Sonego, M., Pellarin, I., Costa, A., Vinciguerra, G. L. R., Coan, M., Kraut, A., D'Andrea, S., Dall'Acqua, A., Castillo-Tong, D. C., Califano, D., Losito, S., Spizzo, R., Couté, Y., Vecchione, A., Belletti, B., Schiappacassi, M. & Baldassarre, G., May 8 2019, In : Science advances. 5, 5, p. eaav3235-eaav3235 16 p.

Research output: Contribution to journalArticle

2017

An integrated approach identifies mediators of local recurrence in head and neck squamous carcinoma

Citron, F., Armenia, J., Franchin, G., Polesel, J., Talamini, R., D'Andrea, S., Sulfaro, S., Croce, C. M., Klement, W., Otasek, D., Pastrello, C., Tokar, T., Jurisica, I., French, D., Bomben, R., Vaccher, E., Serraino, D., Belletti, B., Vecchione, A., Barzan, L. & 1 others, Baldassarre, G., Jul 15 2017, In : Clinical Cancer Research. 23, 14, p. 3769-3780 12 p.

Research output: Contribution to journalArticle

CDK6 protects epithelial ovarian cancer from platinum-induced death via FOXO3 regulation

Dall'Acqua, A., Sonego, M., Pellizzari, I., Pellarin, I., Canzonieri, V., D'Andrea, S., Benevol, S., Sorio, R., Giorda, G., Califano, D., Bagnoli, M., Militello, L., Mezzanzanica, D., Chiappetta, G., Armenia, J., Belletti, B., Schiappacassi, M. & Baldassarre, G., 2017, In : EMBO Molecular Medicine. 9, 10, p. 1415-1433 19 p.

Research output: Contribution to journalArticle

CDK6 protects epithelial ovarian cancer from platinum-induced death via FOXO3 regulation

Dall'Acqua, A., Sonego, M., Pellizzari, I., Pellarin, I., Canzonieri, V., D'Andrea, S., Benevol, S., Sorio, R., Giorda, G., Califano, D., Bagnoli, M., Militello, L., Mezzanzanica, D., Chiappetta, G., Armenia, J., Belletti, B., Schiappacassi, M. & Baldassarre, G., Oct 2017, In : EMBO Molecular Medicine. 9, 10, p. 1415-1433 19 p.

Research output: Contribution to journalArticle

Common biological phenotypes characterize the acquisition of platinum-resistance in epithelial ovarian cancer cells

Sonego, M., Pellizzari, I., Dall'Acqua, A., Pivetta, E., Lorenzon, I., Benevol, S., Bomben, R., Spessotto, P., Sorio, R., Gattei, V., Belletti, B., Schiappacassi, M. & Baldassarre, G., Dec 1 2017, In : Scientific Reports. 7, 1, 7104.

Research output: Contribution to journalArticle

Loss of p27kip1 increases genomic instability and induces radio-resistance in luminal breast cancer cells

Berton, S., Cusan, M., Segatto, I., Citron, F., D'Andrea, S., Benevol, S., Avanzo, M., Dall'Acqua, A., Schiappacassi, M., Bristow, R. G., Belletti, B. & Baldassarre, G., Dec 1 2017, In : Scientific Reports. 7, 1, 14 p., 595.

Research output: Contribution to journalArticle

2016

Irreversible inhibition of Δ16HER2 is necessary to suppress Δ16HER2-positive breast carcinomas resistant to Lapatinib

Tilio, M., Gambini, V., Wang, J., Garulli, C., Kalogris, C., Andreani, C., Bartolacci, C., Elexpuru Zabaleta, M., Pietrella, L., Hysi, A., Iezzi, M., Belletti, B., Orlando, F., Provinciali, M., Galeazzi, R., Marchini, C. & Amici, A., Oct 10 2016, In : Cancer Letters. 381, 1, p. 76-84 9 p.

Research output: Contribution to journalArticle

Irreversible inhibition of Δ16HER2 is necessary to suppress Δ16HER2-positive breast carcinomas resistant to Lapatinib

Tilio, M., Gambini, V., Wang, J., Garulli, C., Kalogris, C., Andreani, C., Bartolacci, C., Elexpuru Zabaleta, M., Pietrella, L., Hysi, A., Iezzi, M., Belletti, B., Orlando, F., Provinciali, M., Galeazzi, R., Marchini, C. & Amici, A., Oct 10 2016, In : Cancer Letters. 381, 1, p. 76-84 9 p.

Research output: Contribution to journalArticle

Irreversible inhibition of Δ16HER2 is necessary to suppress Δ16HER2-positive breast carcinomas resistant to Lapatinib

Tilio, M., Gambini, V., Wang, J., Garulli, C., Kalogris, C., Andreani, C., Bartolacci, C., Elexpuru Zabaleta, M., Pietrella, L., Hysi, A., Iezzi, M., Belletti, B., Orlando, F., Provinciali, M., Galeazzi, R., Marchini, C. & Amici, A., Oct 10 2016, In : Cancer Letters. 381, 1, p. 76-84 9 p.

Research output: Contribution to journalArticle

p27kip1 expression limits H-Ras-driven transformation and tumorigenesis by both canonical and non-canonical mechanisms

Pellizzari, I., Fabris, L., Berton, S., Segatto, I., Citron, F., D'Andrea, S., Cusan, M., Benevol, S., Perin, T., Massarut, S., Canzonieri, V., Schiappacassi, M., Belletti, B. & Baldassarre, G., 2016, In : Oncotarget. 7, 40, p. 64560-64574 15 p.

Research output: Contribution to journalArticle

Preclinical validation of a novel compound targeting p70S6 kinase in breast cancer

Segatto, I., Massarut, S., Boyle, R., Baldassarre, G., Walker, D. & Belletti, B., 2016, In : Aging. 8, 5, p. 958-976 19 p.

Research output: Contribution to journalArticle

Radiotherapy-induced miR-223 prevents relapse of breast cancer by targeting the EGF pathway

Fabris, L., Berton, S., Citron, F., D'Andrea, S., Segatto, I., Nicoloso, M. S., Massarut, S., Armenia, J., Zafarana, G., Rossi, S., Ivan, C., Perin, T., Vaidya, J. S., Avanzo, M., Roncadin, M., Schiappacassi, M., Bristow, R. G., Calin, G., Baldassarre, G. & Belletti, B., 2016, In : Oncogene. p. 4914-4926 13 p.

Research output: Contribution to journalArticle

SUMOylation regulates p27Kip1 stability and localization in response to TGFβ

Lovisa, S., Citro, S., Sonego, M., Dall'Acqua, A., Ranzuglia, V., Berton, S., Colombatti, A., Belletti, B., Chiocca, S., Schiappacassi, M. & Baldassarre, G., 2016, In : Journal of Molecular Cell Biology. 8, 1, p. 17-30 14 p.

Research output: Contribution to journalArticle

SUMOylation regulates p27Kip1 stability and localization in response to TGFβ

Lovisa, S., Citro, S., Sonego, M., Dall'Acqua, A., Ranzuglia, V., Berton, S., Colombatti, A., Belletti, B., Chiocca, S., Baldassarre, G. & Schiappacassi, M., 2016, In : Journal of Molecular Cell Biology. 8, 1, p. 17-30 14 p.

Research output: Contribution to journalArticle

2015

P27kip1 controls H-Ras/MAPK activation and cell cycle entry via modulation of MT stability

Fabris, L., Berton, S., Pellizzari, I., Segatto, I., D'Andrea, S., Armenia, J., Bomben, R., Schiappacassi, M., Gattei, V., Philips, M. R., Vecchione, A., Belletti, B. & Baldassarre, G., Nov 10 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 45, p. 13916-13921 6 p.

Research output: Contribution to journalArticle

Roles of CDKN1B in cancer?

Belletti, B. & Baldassarre, G., 2015, In : Aging. 7, 8, p. 529-530 2 p.

Research output: Contribution to journalArticle

Time-tuning cancer therapy

Baldassarre, G., Segatto, I. & Belletti, B., 2015, In : Aging. 7, 8, p. 531-532 2 p.

Research output: Contribution to journalArticle

Wound response after intraoperative radiotherapy

Massarut, S., Belletti, B., Segatto, I., Piccoli, E. & Baldassarre, G., Apr 1 2015, In : Translational Cancer Research. 4, 2, p. 161-172 12 p.

Research output: Contribution to journalArticle

2014

Contact inhibition modulates intracellular levels of miR-223 in a p27kip1-dependent manner

Armenia, J., Fabris, L., Lovat, F., Berton, S., Segatto, I., D'Andrea, S., Ivan, C., Calin, C. A., Croce, C. M., Colombatti, A., Vecchione, A., Belletti, B. & Baldassarre, G., 2014, In : Oncotarget. 5, 5, p. 1185-1197 13 p.

Research output: Contribution to journalArticle

Corrigendum to Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer [EMBO Molecular Medicine]

Sonego, M., Schiappacassi, M., Lovisa, S., Dall'Acqua, A., Bagnoli, M., Lovat, F., Libra, M., D'Andrea, S., Canzonieri, V., Militello, L., Napoli, M., Giorda, G., Pivetta, B., Mezzanzanica, D., Barbareschi, M., Valeri, B., Canevari, S., Colombatti, A., Belletti, B., Del Sal, G. & 1 others, Baldassarre, G., Feb 2014, In : EMBO Molecular Medicine. 6, 2, p. 295 1 p.

Research output: Contribution to journalArticle

Genetic characterization of p27kip1and stathmin in controlling cell proliferation in vivo

Berton, S., Pellizzari, I., Fabris, L., D'Andrea, S., Segatto, I., Canzonieri, V., Marconi, D., Schiappacassi, M., Benevol, S., Gattei, V., Colombatti, A., Beletti, B. & Baldassarre, G., Oct 1 2014, In : Cell Cycle. 13, 19, p. 3100-3111 12 p.

Research output: Contribution to journalArticle

P70S6 kinase mediates breast cancer cell survival in response to surgical wound fluid stimulation

Segatto, I., Berton, S., Sonego, M., Massarut, S., Fabris, L., Armenia, J., Mileto, M., Colombatti, A., Vecchione, A., Baldassarre, G. & Belletti, B., 2014, In : Molecular Oncology. 8, 3, p. 766-780 15 p.

Research output: Contribution to journalArticle

Sanguinarine suppresses basal-like breast cancer growth through dihydrofolate reductase inhibition

Kalogris, C., Garulli, C., Pietrella, L., Gambini, V., Pucciarelli, S., Lucci, C., Tilio, M., Zabaleta, M. E., Bartolacci, C., Andreani, C., Giangrossi, M., Iezzi, M., Belletti, B., Marchini, C. & Amici, A., Aug 1 2014, In : Biochemical Pharmacology. 90, 3, p. 226-234 9 p.

Research output: Contribution to journalArticle

Surgery-induced wound response promotes stem-like and tumor-initiating features of breast cancer cells, via STAT3 signaling

Segatto, I., Berton, S., Sonego, M., Massarut, S., Perin, T., Piccoli, E., Colombatti, A., Vecchione, A., Baldassarre, G. & Belletti, B., 2014, In : Oncotarget. 5, 15, p. 6267-6279 13 p.

Research output: Contribution to journalArticle

2013

A microRNA signature defines chemoresistance in ovarian cancer through modulation of angiogenesis

Vecchione, A., Belletti, B., Lovat, F., Volinia, S., Chiappetta, G., Giglio, S., Sonego, M., Cirombella, R., Onesti, E. C., Pellegrini, P., Califano, D., Pignata, S., Losito, S., Canzonieri, V., Sorio, R., Alder, H., Wernicke, D., Stoppacciaro, A., Baldassarre, G. & Croce, C. M., Jun 11 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 24, p. 9845-9850 6 p.

Research output: Contribution to journalArticle

Inhibition of breast cancer local relapse by targeting p70S6 kinase activity

Segatto, I., Berton, S., Sonego, M., Massarut, S., D'Andrea, S., Perin, T., Fabris, L., Armenia, J., Rampioni, G., Lovisa, S., Schiappacassi, M., Colombatti, A., Bristow, R. G., Vecchione, A., Baldassarre, G. & Belletti, B., Dec 2013, In : Journal of Molecular Cell Biology. 5, 6, p. 428-431 4 p.

Research output: Contribution to journalArticle

Stathmin regulates mutant p53 stability and transcriptional activity in ovarian cancer

Sonego, M., Schiappacassi, M., Lovisa, S., Dall'Acqua, A., Bagnoli, M., Lovat, F., Libra, M., D'Andrea, S., Canzonieri, V., Militello, L., Napoli, M., Giorda, G., Pivetta, B., Mezzanzanica, D., Barbareschi, M., Valeri, B., Canevari, S., Colombatti, A., Belletti, B., Del Sal, G. & 1 others, Baldassarre, G., May 2013, In : EMBO Molecular Medicine. 5, 5, p. 707-722 16 p.

Research output: Contribution to journalArticle

2012

New light on p27kip1 in breast cancer

Belletti, B. & Baldassarre, G., Oct 1 2012, In : Cell Cycle. 11, 19, p. 3701-3702 2 p.

Research output: Contribution to journalArticle

Stathmin Is Dispensable for Tumor Onset in Mice

D'Andrea, S., Berton, S., Segatto, I., Fabris, L., Canzonieri, V., Colombatti, A., Vecchione, A., Belletti, B. & Baldassarre, G., Sep 20 2012, In : PLoS One. 7, 9, e45561.

Research output: Contribution to journalArticle

2011

Role of T198 modification in the regulation of p27Kip1 protein stability and function

Schiappacassi, M., Lovisa, S., Lovat, F., Fabris, L., Colombatti, A., Belletti, B. & Baldassarre, G., 2011, In : PLoS One. 6, 3, e17673.

Research output: Contribution to journalArticle

Stathmin: A protein with many tasks. New biomarker and potential target in cancer

Belletti, B. & Baldassarre, G., Nov 2011, In : Expert Opinion on Therapeutic Targets. 15, 11, p. 1249-1266 18 p.

Research output: Contribution to journalArticle

2010

p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling

Belletti, B., Pellizzari, I., Berton, S., Fabris, L., Wolf, K., Lovat, F., Schiappacassi, M., D'Andrea, S., Nicoloso, M. S., Lovisa, S., Sonego, M., Defilippi, P., Vecchione, A., Colombatti, A., Friedl, P. & Baldassarre, G., May 2010, In : Molecular and Cellular Biology. 30, 9, p. 2229-2240 12 p.

Research output: Contribution to journalArticle

2009

The tumor suppressor functions of p27kip1 include control of the mesenchymal/amoeboid transition

Berton, S., Belletti, B., Wolf, K., Canzonieri, V., Lovat, F., Vecchione, A., Colombatti, A., Friedl, P. & Baldassarre, G., Sep 2009, In : Molecular and Cellular Biology. 29, 18, p. 5031-5045 15 p.

Research output: Contribution to journalArticle

2008

p27Kip1 expression inhibits glioblastoma growth, invasion, and tumor-induced neoangiogenesis

Schiappacassi, M., Lovat, F., Canzonieri, V., Belletti, B., Berton, S., Di Stefano, D., Vecchione, A., Colombatti, A. & Baldassarre, G., 2008, In : Molecular Cancer Therapeutics. 7, 5, p. 1164-1175 12 p.

Research output: Contribution to journalArticle

Stathmin activity influences sarcoma cell shape, motility, and metastatic potential

Belletti, B., Nicoloso, M. S., Schiappacassi, M., Berton, S., Lovat, F., Wolf, K., Canzonieri, V., D'Andrea, S., Zucchetto, A., Friedl, P., Colombatti, A. & Baldassarre, G., May 2008, In : Molecular Biology of the Cell. 19, 5, p. 2003-2013 11 p.

Research output: Contribution to journalArticle

Targeted intraoperative radiotherapy impairs the stimulation of breast cancer cell proliferation and invasion caused by surgical wounding

Belletti, B., Vaidya, J. S., D'Andrea, S., Entschladen, F., Roncadin, M., Lovat, F., Berton, S., Perin, T., Candiani, E., Reccanello, S., AndreaVeronesi, N. V., Canzonieri, V., Trovò, M. G., Zaenker, K. S., Colombatti, A., Baldassarre, G. & Massarut, S., Mar 1 2008, In : Clinical Cancer Research. 14, 5, p. 1325-1332 8 p.

Research output: Contribution to journalArticle

2007

Fez1/Lzts1 Absence Impairs Cdk1/Cdc25C Interaction during Mitosis and Predisposes Mice to Cancer Development

Vecchione, A., Baldassarre, G., Ishii, H., Nicoloso, M. S., Belletti, B., Petrocca, F., Zanesi, N., Fong, L. Y. Y., Battista, S., Guarnieri, D., Baffa, R., Alder, H., Farber, J. L., Donovan, P. J. & Croce, C. M., Mar 13 2007, In : Cancer Cell. 11, 3, p. 275-289 15 p.

Research output: Contribution to journalArticle

2005

HMGA1 protein expression sensitizes cells to cisplatin-induced cell death

Baldassarre, G., Belletti, B., Battista, S., Nicoloso, M. S., Pentimalli, F., Fedele, M., Croce, C. M. & Fusco, A., Oct 13 2005, In : Oncogene. 24, 45, p. 6809-6819 11 p.

Research output: Contribution to journalArticle

p27kip1 functional regulation in human cancer: A potential target for therapeutic designs

Belletti, B., Nicoloso, M. S., Schiappacassi, M., Chimienti, E., Berton, S., Lovat, F., Colombatti, A. & Baldassarre, G., 2005, In : Current Medicinal Chemistry. 12, 14, p. 1589-1605 17 p.

Research output: Contribution to journalArticle

p27Kip1-stathmin interaction influences sarcoma cell migration and invasion

Baldassarre, G., Belletti, B., Nicoloso, M. S., Schiappacassi, M., Vecchione, A., Spessotto, P., Morrione, A., Canzonieri, V. & Colombatti, A., Jan 2005, In : Cancer Cell. 7, 1, p. 51-63 13 p.

Research output: Contribution to journalArticle

2004

Linking inflammation to cell cycle progression

Baldassarre, G., Nicoloso, M. S., Schiappacassi, M., Chimienti, E. & Belletti, B., 2004, In : Current Pharmaceutical Design. 10, 14, p. 1653-1666 14 p.

Research output: Contribution to journalArticle

The transformed phenotype.

Hoff, H., Belletti, B., Zhang, H. & Sell, C., 2004, In : Methods in molecular biology (Clifton, N.J.). 285, p. 95-104 10 p.

Research output: Contribution to journalArticle

2003

Critical role of cyclin D3 in TSH-dependent growth of thyrocytes and in hyperproliferative diseases of the thyroid gland

Motti, M. L., Boccia, A., Belletti, B., Bruni, P., Troncone, G., Cito, L., Monaco, M., Chiappetta, G., Baldassarre, G., Palombini, L., Fusco, A. & Viglietto, G., Oct 23 2003, In : Oncogene. 22, 48, p. 7576-7586 11 p.

Research output: Contribution to journalArticle

Negative regulation of BRCA1 gene expression by HMGA1 proteins accounts for the reduced BRCA1 protein levels in sporadic breast carcinoma

Baldassarre, G., Battista, S., Belletti, B., Thakur, S., Pentimalli, F., Trapasso, F., Fedele, M., Pierantoni, G., Croce, C. M. & Fusco, A., Apr 2003, In : Molecular and Cellular Biology. 23, 7, p. 2225-2238 14 p.

Research output: Contribution to journalArticle

2002

Glial cell line-derived neurotrophic factor induces proliferative inhibition of NT2/D1 cells through RET-mediated up-regulation of the cyclin-dependent kinase inhibitor p27kip1

Baldassarre, G., Bruni, P., Boccia, A., Salvatore, G., Melillo, R. M., Motti, M. L., Napolitano, M., Belletti, B., Fusco, A., Santoro, M. & Viglietto, G., Mar 7 2002, In : Oncogene. 21, 11, p. 1739-1749 11 p.

Research output: Contribution to journalArticle

Nuclear translocation of insulin receptor substrate-1 by oncogenes and Igf-I: Effect on ribosomal RNA synthesis

Tu, X., Batta, P., Innocent, N., Prisco, M., Casaburi, I., Belletti, B. & Baserga, R., Nov 15 2002, In : Journal of Biological Chemistry. 277, 46, p. 44357-44365 9 p.

Research output: Contribution to journalArticle

Regulation of Id1 protein expression in mouse embryo fibroblasts by the type 1 insulin-like growth factor receptor

Belletti, B., Drakas, R., Morrione, A., Tu, X., Prisco, M., Yuan, T., Casaburi, I. & Baserga, R., 2002, In : Experimental Cell Research. 277, 1, p. 107-118 12 p.

Research output: Contribution to journalArticle