19982019

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2017

Efficacy of lentivirus-mediated gene therapy in an Omenn syndrome recombination-activating gene 2 mouse model is not hindered by inflammation and immune dysregulation

Capo, V., Castiello, M. C., Fontana, E., Penna, S., Bosticardo, M., Draghici, E., Poliani, L. P., Sergi Sergi, L., Rigoni, R., Cassani, B., Zanussi, M., Carrera, P., Uva, P., Dobbs, K., Sacchetti, N., Notarangelo, L. D., van Til, N. P., Wagemaker, G. & Villa, A., Dec 11 2017, In : Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

The SIICA School of Immunology 2017: a gathering for NGS (next generation scientists)

Faculty, T. SIICA. J., Cassani, B., Castriconi, R., Mazzoni, A., Piconese, S. & Sciumè, G., 2017, In : European Journal of Immunology. 47, 9, p. 1402-1404 3 p.

Research output: Contribution to journalArticle

2016

Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects

Rigoni, R., Fontana, E., Guglielmetti, S., Fosso, B., D'Erchia, A. M., Maina, V., Taverniti, V., Castiello, M. C., Mantero, S., Pacchiana, G., Musio, S., Pedotti, R., Selmi, C. F., Rodrigo Mora, J., Pesole, G., Vezzoni, P., Poliani, P. L., Grassi, F., Villa, A. & Cassani, B., 2016, In : Journal of Experimental Medicine. 213, 3, p. 355-375 21 p.

Research output: Contribution to journalArticle

Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects

Rigoni, R., Fontana, E., Guglielmetti, S., Fosso, B., D'Erchia, A. M., Maina, V., Taverniti, V., Castiello, M. C., Mantero, S., Pacchiana, G., Musio, S., Pedotti, R., Selmi, C. F., Rodrigo Mora, J., Pesole, G., Vezzoni, P., Poliani, P. L., Grassi, F., Villa, A. & Cassani, B., 2016, In : Journal of Experimental Medicine. 213, 3, p. 355-375 21 p.

Research output: Contribution to journalArticle

Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects

Rigoni, R., Fontana, E., Guglielmetti, S., Fosso, B., D'Erchia, A. M., Maina, V., Taverniti, V., Castiello, M. C., Mantero, S., Pacchiana, G., Musio, S., Pedotti, R., Selmi, C., Rodrigo Mora, J., Pesole, G., Vezzoni, P., Poliani, P. L., Grassi, F., Villa, A. & Cassani, B., 2016, In : Journal of Experimental Medicine. 213, 3, p. 355-375 21 p.

Research output: Contribution to journalArticle

RAGs and BUGS: An alliance for autoimmunity

Rigoni, R., Grassi, F., Villa, A. & Cassani, B., Sep 11 2016, (Accepted/In press) In : Gut Microbes. p. 1-9 9 p.

Research output: Contribution to journalArticle

RAGs and BUGS: An alliance for autoimmunity

Rigoni, R., Grassi, F., Villa, A. & Cassani, B., Sep 11 2016, (Accepted/In press) In : Gut Microbes. p. 1-9 9 p.

Research output: Contribution to journalArticle

Therapeutic Potential of Immunoproteasome Inhibition in Duchenne Muscular Dystrophy

Farini, A., Sitzia, C., Cassani, B., Cassinelli, L., Rigoni, R., Colleoni, F., Fusco, N., Gatti, S., Bella, P., Villa, C., Napolitano, F., Maiavacca, R., Bosari, S., Villa, A. & Torrente, Y., 2016, In : Molecular Therapy. 24, 11, p. 1898-1912 15 p.

Research output: Contribution to journalArticle

Therapeutic Potential of Immunoproteasome Inhibition in Duchenne Muscular Dystrophy

Farini, A., Sitzia, C., Cassani, B., Cassinelli, L., Rigoni, R., Colleoni, F., Fusco, N., Gatti, S., Bella, P., Villa, C., Napolitano, F., Maiavacca, R., Bosari, S., Villa, A. & Torrente, Y., Sep 27 2016, (Accepted/In press) In : Molecular Therapy.

Research output: Contribution to journalArticle

Therapeutic Potential of Immunoproteasome Inhibition in Duchenne Muscular Dystrophy

Farini, A., Sitzia, C., Cassani, B., Cassinelli, L., Rigoni, R., Colleoni, F., Fusco, N., Gatti, S., Bella, P., Villa, C., Napolitano, F., Maiavacca, R., Bosari, S., Villa, A. & Torrente, Y., Sep 27 2016, (Accepted/In press) In : Molecular Therapy.

Research output: Contribution to journalArticle

2015

IL-10 critically modulates B cell responsiveness in rankl-/- mice

Marrella, V., Lo Iacono, N., Fontana, E., Sobacchi, C., Sic, H., Schena, F., Sereni, L., Castiello, M. C., Poliani, P. L., Vezzoni, P., Cassani, B., Traggiai, E. & Villa, A., May 1 2015, In : Journal of Immunology. 194, 9, p. 4144-4153 10 p.

Research output: Contribution to journalArticle

Lentiviral-mediated gene therapy restores B cell tolerance in Wiskott-Aldrich syndrome patients

Pala, F., Morbach, H., Castiello, M. C., Schickel, J. N., Scaramuzza, S., Chamberlain, N., Cassani, B., Glauzy, S., Romberg, N., Candotti, F., Aiuti, A., Bosticardo, M., Villa, A. & Meffre, E., Oct 1 2015, In : Journal of Clinical Investigation. 125, 10, p. 3941-3951 11 p.

Research output: Contribution to journalArticle

2014

Recombination-activating gene 1 (Rag1)-deficient mice with severe combined immunodeficiency treated with lentiviral gene therapy demonstrate autoimmune Omenn-like syndrome

Van Til, N. P., Sarwari, R., Visser, T. P., Hauer, J., Lagresle-Peyrou, C., Van Der Velden, G., Malshetty, V., Cortes, P., Jollet, A., Danos, O., Cassani, B., Zhang, F., Thrasher, A. J., Fontana, E., Poliani, P. L., Cavazzana, M., Verstegen, M. M. A., Villa, A. & Wagemaker, G., 2014, In : Journal of Allergy and Clinical Immunology. 133, 4, p. 1116-1123 8 p.

Research output: Contribution to journalArticle

Reply

Van Til, N. P., Cortes, P., Danos, O., Cassani, B., Poliani, P. L., Villa, A. & Wagemaker, G., 2014, In : Journal of Allergy and Clinical Immunology. 134, 1, p. 243-244 2 p.

Research output: Contribution to journalArticle

β7 integrins are required to give rise to intestinal mononuclear phagocytes with tolerogenic potential

Villablanca, E. J., De Calisto, J., Paredes, P. T., Cassani, B., Nguyen, D. D., Gabrielsson, S. & Mora, J. R., 2014, In : Gut. 63, 9, p. 1431-1440 10 p.

Research output: Contribution to journalArticle

2013

Hypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration

Maina, V., Marrella, V., Mantero, S., Cassani, B., Fontana, E., Anselmo, A., Del Prete, A., Sozzani, S., Vezzoni, P., Poliani, P. L. & Villa, A., Dec 2013, In : Journal of Leukocyte Biology. 94, 6, p. 1221-1230 10 p.

Research output: Contribution to journalArticle

2012

Anti-CD3ε mAb improves thymic architecture and prevents autoimmune manifestations in a mouse model of Omenn syndrome: Therapeutic implications

Marrella, V., Poliani, P. L., Fontana, E., Casati, A., Maina, V., Cassani, B., Ficara, F., Cominelli, M., Schena, F., Paulis, M., Traggiai, E., Vezzoni, P., Grassi, F. & Villa, A., Aug 2 2012, In : Blood. 120, 5, p. 1005-1014 10 p.

Research output: Contribution to journalArticle

Correction of murine rag2 severe combined immunodeficiency by lentiviral gene therapy using a codon-optimized RAG2 therapeutic transgene

Van Til, N. P., De Boer, H., Mashamba, N., Wabik, A., Huston, M., Visser, T. P., Fontana, E., Poliani, P. L., Cassani, B., Zhang, F., Thrasher, A. J., Villa, A. & Wagemaker, G., Oct 2012, In : Molecular Therapy. 20, 10, p. 1968-1980 13 p.

Research output: Contribution to journalArticle

Osteopetrosis rescue upon RANKL administration to Rankl-/- mice: A new therapy for human RANKL-dependent ARO

Lo Iacono, N., Blair, H. C., Poliani, P. L., Marrella, V., Ficara, F., Cassani, B., Facchetti, F., Fontana, E., Guerrini, M. M., Traggiai, E., Schena, F., Paulis, M., Mantero, S., Inforzato, A., Valaperta, S., Pangrazio, A., Crisafulli, L., Maina, V., Kostenuik, P., Vezzoni, P. & 2 others, Villa, A. & Sobacchi, C., Dec 2012, In : Journal of Bone and Mineral Research. 27, 12, p. 2501-2510 10 p.

Research output: Contribution to journalArticle

RANK-dependent autosomal recessive osteopetrosis: Characterization of five new cases with novel mutations

Pangrazio, A., Cassani, B., Guerrini, M. M., Crockett, J. C., Marrella, V., Zammataro, L., Strina, D., Schulz, A., Schlack, C., Kornak, U., Mellis, D. J., Duthie, A., Helfrich, M. H., Durandy, A., Moshous, D., Vellodi, A., Chiesa, R., Veys, P., Lo Iacono, N., Vezzoni, P. & 3 others, Fischer, A., Villa, A. & Sobacchi, C., 2012, In : Journal of Bone and Mineral Research. 27, 2, p. 342-351 10 p.

Research output: Contribution to journalArticle

Vitamin A and immune regulation: Role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance

Cassani, B., Villablanca, E. J., De Calisto, J., Wang, S. & Mora, J. R., Feb 2012, In : Molecular Aspects of Medicine. 33, 1, p. 63-76 14 p.

Research output: Contribution to journalArticle

2011

Blocking lymphocyte localization to the gastrointestinal mucosa as a therapeutic strategy for inflammatory bowel diseases

Villablanca, E. J., Cassani, B., Von Andrian, U. H. & Mora, J. R., May 2011, In : Gastroenterology. 140, 6, p. 1776-1784 9 p.

Research output: Contribution to journalArticle

Gut-tropic T cells that express integrin α4β7 and CCR9 Are required for induction of oral immune tolerance in mice

Cassani, B., Villablanca, E. J., Quintana, F. J., Love, P. E., Lacy-Hulbert, A., Blaner, W. S., Sparwasser, T., Snapper, S. B., Weiner, H. L. & Mora, J. R., Dec 2011, In : Gastroenterology. 141, 6, p. 2109-2118 10 p.

Research output: Contribution to journalArticle

Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy

Deichmann, A., Brugman, M. H., Bartholomae, C. C., Schwarzwaelder, K., Verstegen, M. M. A., Howe, S. J., Arens, A., Ott, M. G., Hoelzer, D., Seger, R., Grez, M., Hacein-Bey-Abina, S., Cavazzana-Calvo, M., Fischer, A., Paruzynski, A., Gabriel, R., Glimm, H., Abel, U., Cattoglio, C., Mavilio, F. & 9 others, Cassani, B., Aiuti, A., Dunbar, C. E., Baum, C., Gaspar, H. B., Thrasher, A. J., Von Kalle, C., Schmidt, M. & Wagemaker, G., Nov 2011, In : Molecular Therapy. 19, 11, p. 2031-2039 9 p.

Research output: Contribution to journalArticle

In vivo T-cell dynamics during immune reconstitution after hematopoietic stem cell gene therapy in adenosine deaminase severe combined immune deficiency

Selleri, S., Brigida, I., Casiraghi, M., Scaramuzza, S., Cappelli, B., Cassani, B., Ferrua, F., Aker, M., Slavin, S., Scarselli, A., Cancrini, C., Marktel, S., Grazia Roncarolo, M. & Aiuti, A., Jun 2011, In : Journal of Allergy and Clinical Immunology. 127, 6

Research output: Contribution to journalArticle

2010

Defect of regulatory T cells in patients with Omenn syndrome

Cassani, B., Poliani, P. L., Moratto, D., Sobacchi, C., Marrella, V., Imperatori, L., Vairo, D., Plebani, A., Giliani, S., Vezzoni, P., Facchetti, F., Porta, F., Notarangelo, L. D., Villa, A. & Badolato, R., Jan 2010, In : Journal of Allergy and Clinical Immunology. 125, 1-3, p. 209-216 8 p.

Research output: Contribution to journalArticle

Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome

Cassani, B., Poliani, P. L., Marrella, V., Schena, F., Sauer, A. V., Ravanini, M., Strina, D., Busse, C. E., Regenass, S., Wardemann, H., Martini, A., Facchetti, F., Van Der Burg, M., Rolink, A. G., Vezzoni, P., Grassi, F., Traggiai, E. & Villa, A., Jul 5 2010, In : Journal of Experimental Medicine. 207, 7, p. 1525-1540 16 p.

Research output: Contribution to journalArticle

2009

Fetal liver cells transplanted in utero rescue the osteopetrotic phenotype in the oc/oc mouse

Tondelli, B., Blair, H. C., Guerrini, M., Patrene, K. D., Cassani, B., Vezzoni, P. & Lucchini, F., Mar 2009, In : American Journal of Pathology. 174, 3, p. 727-735 9 p.

Research output: Contribution to journalArticle

Gene therapy for immunodeficiency due to adenosine deaminase deficiency

Aiuti, A., Cattaneo, F., Galimberti, S., Benninghoff, U., Cassani, B., Callegaro, L., Scaramuzza, S., Andolfi, G., Mirolo, M., Brigida, I., Tabucchi, A., Carlucci, F., Eibl, M., Aker, M., Slavin, S., Al-Mousa, H., Ghonaium, A. A., Ferster, A., Duppenthaler, A., Notarangelo, L. & 10 others, Wintergerst, U., Buckley, R. H., Bregni, M., Marktel, S., Valsecchi, M. G., Rossi, P., Ciceri, F., Miniero, R., Bordignon, C. & Roncarolo, M. G., Jan 29 2009, In : New England Journal of Medicine. 360, 5, p. 447-458 12 p.

Research output: Contribution to journalArticle

Human cholangiocarcinoma development is associated with dysregulation of opioidergic modulation of cholangiocyte growth

Marzioni, M., Invernizzi, P., Candelaresi, C., Maggioni, M., Saccomanno, S., Selmi, C., Rychlicki, C., Agostinelli, L., Cassani, B., Miozzo, M., Pasini, S., Fava, G., Alpini, G. & Benedetti, A., Jul 2009, In : Digestive and Liver Disease. 41, 7, p. 523-533 11 p.

Research output: Contribution to journalArticle

Infantile malignant, autosomal recessive osteopetrosis: The rich and the poor

Villa, A., Guerrini, M. M., Cassani, B., Pangrazio, A. & Sobacchi, C., Jan 2009, In : Calcified Tissue International. 84, 1, p. 1-12 12 p.

Research output: Contribution to journalArticle

Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy

Cassani, B., Montini, E., Maruggi, G., Ambrosi, A., Mirolo, M., Selleri, S., Biral, E., Frugnoli, I., Hernandez-Trujillo, V., Di Serio, C., Roncarolo, M. G., Naldini, L., Mavilio, F. & Aiuti, A., 2009, In : Blood. 114, 17, p. 3546-3556 11 p.

Research output: Contribution to journalArticle

2008

Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients

Cassani, B., Mirolo, M., Cattaneo, F., Benninghoff, U., Hershfield, M., Carlucci, F., Tabucchi, A., Bordignon, C., Roncarolo, M. G. & Aiuti, A., Apr 15 2008, In : Blood. 111, 8, p. 4209-4219 11 p.

Research output: Contribution to journalArticle

Human Osteoclast-Poor Osteopetrosis with Hypogammaglobulinemia due to TNFRSF11A (RANK) Mutations

Guerrini, M. M., Sobacchi, C., Cassani, B., Abinun, M., Kilic, S. S., Pangrazio, A., Moratto, D., Mazzolari, E., Clayton-Smith, J., Orchard, P., Coxon, F. P., Helfrich, M. H., Crockett, J. C., Mellis, D., Vellodi, A., Tezcan, I., Notarangelo, L. D., Rogers, M. J., Vezzoni, P., Villa, A. & 1 others, Frattini, A., Jul 11 2008, In : American Journal of Human Genetics. 83, 1, p. 64-76 13 p.

Research output: Contribution to journalArticle

2007

Hot spots of retroviral integration in human CD34+ hematopoietic cells

Cattoglio, C., Facchini, G., Sartori, D., Antonelli, A., Miccio, A., Cassani, B., Schmidt, M., Von Kalle, C., Howe, S., Thrasher, A. J., Aiuti, A., Ferrari, G., Recchia, A. & Mavilio, F., Sep 15 2007, In : Blood. 110, 6, p. 1770-1778 9 p.

Research output: Contribution to journalArticle

Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy

Aiuti, A., Cassani, B., Andolfi, G., Mirolo, M., Biasco, L., Recchia, A., Urbinati, F., Valacca, C., Scaramuzza, S., Aker, M., Slavin, S., Cazzola, M., Sartori, D., Ambrosi, A., Di Serio, C., Roncarolo, M. G., Mavilio, F. & Bordignon, C., Aug 1 2007, In : Journal of Clinical Investigation. 117, 8, p. 2233-2240 8 p.

Research output: Contribution to journalArticle

2005

Bone marrow clonogenic capability, cytokine production, and thymic output in patients with common variable immunodeficiency

Isgrò, A., Marziali, M., Mezzaroma, I., Luzi, G., Mazzone, A. M., Guazzi, V., Andolfi, G., Cassani, B., Aiuti, A. & Aiuti, F., Apr 15 2005, In : Journal of Immunology. 174, 8, p. 5074-5081 8 p.

Research output: Contribution to journalArticle

Fetal and placental chromosomal mosaicism revealed by QF-PCR in severe IUGR pregnancies

Grati, F. R., Miozzo, M., Cassani, B., Rossella, F., Antonazzo, P., Gentilin, B., Sirchia, S. M., Mori, L., Rigano, S., Bulfamante, G., Cetin, I. & Simoni, G., Jan 2005, In : Placenta. 26, 1, p. 10-18 9 p.

Research output: Contribution to journalArticle

2004

BCL-6 gene mutations in primary cutaneous B-cell lymphomas

Gianelli, U., Cerri, A., Cassani, B., Moneghini, L., Raviele, P. R., Berti, E. & Bosari, S., May 2004, In : Haematologica. 89, 5, p. 624-626 3 p.

Research output: Contribution to journalArticle

Epstein-Barr virus-associated lymphoma in Crohn's disease

Losco, A., Gianelli, U., Cassani, B., Baldini, L., Conte, D. & Basilisco, G., Jul 2004, In : Inflammatory Bowel Diseases. 10, 4, p. 425-429 5 p.

Research output: Contribution to journalArticle

2003

HER-2/Neu alterations in non-small cell lung cancer: A comprehensive evaluation by real time reverse transcription-PCR, fluorescence in situ hybridization, and immunohistochemistry

Pellegrini, C., Falleni, M., Marchetti, A., Cassani, B., Miozzo, M., Buttitta, F., Roncalli, M., Coggi, G. & Bosari, S., Oct 1 2003, In : Clinical Cancer Research. 9, 10 I, p. 3645-3652 8 p.

Research output: Contribution to journalArticle

2001

Chromosome 7 monosomy and deletions in myeloproliferative diseases

Tripputi, P., Cassani, B., Alfano, R., Graziani, D., Cigognini, D., Doi, P., Bignotto, M., Corneo, G. & Coggi, G., 2001, In : Leukemia Research. 25, 9, p. 735-739 5 p.

Research output: Contribution to journalArticle

Loss of heterozygosity of the NOS3 dinucleotide repeat marker in atherosclerotic plaques of human carotid arteries

Grati, F. R., Ghilardi, G., Sirchia, S. M., Massaro, F., Cassani, B., Scorza, R., De Andreis, C., Sironi, E. & Simoni, G., 2001, In : Atherosclerosis. 159, 2, p. 261-267 7 p.

Research output: Contribution to journalArticle

Molecular alterations of Barrett's esophagus on microdissected endoscopic biopsies

Romagnoli, S., Roncalli, M., Graziani, D., Cassani, B., Roz, E., Bonavina, L., Peracchia, A., Bosari, S. & Coggi, G., 2001, In : Laboratory Investigation. 81, 2, p. 241-247 7 p.

Research output: Contribution to journalArticle

Molecular disorders in transitional vs. peripheral zone prostate adenocarcinoma

Colombo, P., Patriarca, C., Alfano, R. M., Cassani, B., Grimaldi, G. C., Roncalli, M., Bosari, S., Coggi, G., Campo, B. & Gould, V. E., Nov 1 2001, In : International Journal of Cancer. 94, 3, p. 383-389 7 p.

Research output: Contribution to journalArticle

Post-Zygotic origin of complete maternal chromosome 7 isodisomy and consequent loss of placental PEG1/MEST expression

Miozzo, M., Grati, F. R., Bulfamante, G., Rossella, F., Cribiù, M., Radaelli, T., Cassani, B., Persico, T., Cetin, I., Pardi, G. & Simoni, G., 2001, In : Placenta. 22, 10, p. 813-821 9 p.

Research output: Contribution to journalArticle

2000

A common T/C polymorphism in the promoter region of the beta T-cell receptor gene

Tripputi, P., Graziani, D., Alfano, R. M., Cassani, B. & Coggi, G., Jun 2000, In : Molecular and Cellular Probes. 14, 3, p. 195-197 3 p.

Research output: Contribution to journalArticle

Molecular changes in hepatocellular dysplastic nodules on microdissected liver biopsies

Maggioni, M., Coggi, G., Cassani, B., Bianchi, P., Romagnoli, S., Mandelli, A., Borzio, M., Colombo, P. & Roncalli, M., 2000, In : Hepatology. 32, 5, p. 942-946 5 p.

Research output: Contribution to journalArticle