Brunella Grigolo

2022

Do Synovial Inflammation and Meniscal Degeneration Impact Clinical Outcomes of Patients Undergoing Arthroscopic Partial Meniscectomy? A Histological Study

Olivotto, E., Belluzzi, E., Pozzuoli, A., Cigolotti, A., Scioni, M., Goldring, S. R., Goldring, M. B., Ruggieri, P., Ramonda, R., Grigolo, B., Trisolino, G. & Favero, M., Mar 31 2022, In: International journal of molecular sciences. 23, 7, p. 1-17 17 p.

Research output: Contribution to journal › Article › peer-review

Effective Label-Free Sorting of Multipotent Mesenchymal Stem Cells from Clinical Bone Marrow Samples

Zia, S., Cavallo, C., Vigliotta, I., Parisi, V., Grigolo, B., Buda, R., Marrazzo, P., Alviano, F., Bonsi, L., Zattoni, A., Reschiglian, P. & Roda, B., Jan 22 2022, In: Bioengineering. 9, 2, p. 1-15 15 p.

Research output: Contribution to journal › Article › peer-review

Glucoraphanin Increases Intracellular Hydrogen Sulfide (H2S) Levels and Stimulates Osteogenic Differentiation in Human Mesenchymal Stromal Cell

Gambari, L., Barone, M., Amore, E., Grigolo, B., Filardo, G., Iori, R., Citi, V., Calderone, V. & Grassi, F., Jan 19 2022, In: Nutrients. 14, 3

Research output: Contribution to journal › Article › peer-review

Macroscopic Synovial Inflammation Correlates with Symptoms and Cartilage Lesions in Patients Undergoing Arthroscopic Partial Meniscectomy: A Clinical Study

Olivotto, E., Trisolino, G., Belluzzi, E., Lazzaro, A., Strazzari, A., Pozzuoli, A., Cigolotti, A., Ruggieri, P., Evangelista, A., Ometto, F., Stallone, S., Goldring, S. R., Goldring, M. B., Ramonda, R., Grigolo, B. & Favero, M., Jul 26 2022, In: Journal of Clinical Medicine. 11, 15, p. 1-14 14 p.

Research output: Contribution to journal › Article › peer-review

Micro-fragmentation is a valid alternative to cell expansion and enzymatic digestion of adipose tissue for the treatment of knee osteoarthritis: a comparative preclinical study

Filardo, G., Tschon, M., Perdisa, F., Brogini, S., Cavallo, C., Desando, G., Giavaresi, G., Grigolo, B., Martini, L., Nicoli Aldini, N., Roffi, A., Fini, M. & Kon, E., Mar 2022, In: Knee Surgery, Sports Traumatology, Arthroscopy. 30, 3, p. 773-781 9 p.

Research output: Contribution to journal › Article › peer-review

Optimization of a Monobromobimane (MBB) Derivatization and RP-HPLC-FLD Detection Method for Sulfur Species Measurement in Human Serum after Sulfur Inhalation Treatment

Roda, B., Zhang, N., Gambari, L., Grigolo, B., Eller-Vainicher, C., Gennari, L., Zappi, A., Giordani, S., Marassi, V., Zattoni, A., Reschiglian, P. & Grassi, F., May 10 2022, In: Antioxidants. 11, 5

Research output: Contribution to journal › Article › peer-review

Optimization of a Monobromobimane (MBB) Derivatization and RP-HPLC-FLD Detection Method for Sulfur Species Measurement in Human Serum after Sulfur Inhalation Treatment

Roda, B., Zhang, N., Gambari, L., Grigolo, B., Eller-Vainicher, C., Gennari, L., Zappi, A., Giordani, S., Marassi, V., Zattoni, A., Reschiglian, P. & Grassi, F., May 2022, In: Antioxidants. 11, 5, 939.

Research output: Contribution to journal › Article › peer-review

Open Access

Small Extracellular Vesicles from Inflamed Adipose Derived Stromal Cells Enhance the NF-κB-Dependent Inflammatory/Catabolic Environment of Osteoarthritis

Cavallo, C., Merli, G., Zini, N., D'Adamo, S., Cattini, L., Guescini, M., Grigolo, B., Di Martino, A., Santi, S., Borzì, R. M. & Filardo, G., Jul 2022, In: Stem Cells International. 2022, p. 1-19 19 p.

Research output: Contribution to journal › Article › peer-review

2021

3D printing of PCL/nano-hydroxyapatite scaffolds derived from biogenic sources for bone tissue engineering

Cestari, F., Petretta, M., Yang, Y., Motta, A., Grigolo, B. & Sglavo, V. M., Sep 2021, In: Sustainable Materials and Technologies. 29, p. 1-10 10 p.

Research output: Contribution to journal › Article › peer-review

A Roadmap of In Vitro Models in Osteoarthritis: A Focus on Their Biological Relevance in Regenerative Medicine

Bartolotti, I., Roseti, L., Petretta, M., Grigolo, B. & Desando, G., Apr 28 2021, In: Journal of Clinical Medicine. 10, 9, p. 1-23 23 p.

Research output: Contribution to journal › Review article › peer-review

Cartilage Tissue Engineering by Extrusion Bioprinting: Process Analysis, Risk Evaluation, and Mitigation Strategies

Petretta, M., Desando, G., Grigolo, B. & Roseti, L., Jun 24 2021, In: Materials. 14, 13, p. 1-20 20 p.

Research output: Contribution to journal › Article › peer-review

Composite Scaffolds for Bone Tissue Regeneration Based on PCL and Mg-Containing Bioactive Glasses

Petretta, M., Gambardella, A., Boi, M., Berni, M., Cavallo, C., Marchiori, G., Maltarello, M. C., Bellucci, D., Fini, M., Baldini, N., Grigolo, B. & Cannillo, V., May 4 2021, In: Biology. 10, 5, p. 1-19 19 p.

Research output: Contribution to journal › Article › peer-review

COVID-19 Impact on Musculoskeletal Regenerative Medicine Research: Maintaining Lab Continuity

Roseti, L. & Grigolo, B., Jun 5 2021, In: Int J Environ Res Public Health. 18, 11, p. 1-13 13 p.

Research output: Contribution to journal › Article › peer-review

Multifunctional 3D-Printed Magnetic Polycaprolactone/Hydroxyapatite Scaffolds for Bone Tissue Engineering

Petretta, M., Gambardella, A., Desando, G., Cavallo, C., Bartolotti, I., Shelyakova, T., Goranov, V., Brucale, M., Dediu, V. A., Fini, M. & Grigolo, B., Nov 5 2021, In: Polymers. 13, 21, p. 1-16 16 p.

Research output: Contribution to journal › Article › peer-review

Preclinical Evidence of Intra-Articular Autologous Cartilage Micrograft for Osteochondral Repair: Evaluation in a Rat Model

Desando, G., Grigolo, B., Deangelles Pereira Florentino, Á., Teixeira, M. W., Barbagallo, F., Naro, F., da Silva-Júnior, V. A. & Soares, A. F., Dec 2021, In: Cartilage. 13, 2_suppl, p. 1770S-1779S 10 p.

Research output: Contribution to journal › Article › peer-review

Prospects on the Potential In Vitro Regenerative Features of Mechanically Treated-Adipose Tissue for Osteoarthritis Care

Desando, G., Bartolotti, I., Cattini, L., Tschon, M., Martini, L., Fini, M., Schiavinato, A., Soranzo, C. & Grigolo, B., Aug 2021, In: Stem Cell Reviews and Reports. 17, 4, p. 1362-1373 12 p.

Research output: Contribution to journal › Article › peer-review

Small Extracellular Vesicles from adipose derived stromal cells significantly attenuate in vitro the NF-κB dependent inflammatory/catabolic environment of osteoarthritis

Cavallo, C., Merli, G., Borzì, R. M., Zini, N., D'Adamo, S., Guescini, M., Grigolo, B., Di Martino, A., Santi, S. & Filardo, G., Jan 13 2021, In: Sci. Rep.. 11, 1, p. 1-16 16 p.

Research output: Contribution to journal › Article › peer-review

2020

Bone marrow concentrate injections for the treatment of osteoarthritis: evidence from preclinical findings to the clinical application

Cavallo, C., Boffa, A., Andriolo, L., Silva, S., Grigolo, B., Zaffagnini, S. & Filardo, G., Jul 13 2020, (E-pub ahead of print) In: International Orthopaedics. 45, 2, p. 525-538 14 p.

Research output: Contribution to journal › Review article › peer-review

Histopathological signatures of the femoral head in patients with osteonecrosis and potential applications in a multi-targeted approach: A pilot study

Desando, G., Roseti, L., Bartolotti, I., Dallari, D., Stagni, C. & Grigolo, B., Jun 6 2020, In: Applied Sciences (Switzerland). 10, 11, p. 1-14 14 p., 3945.

Research output: Contribution to journal › Article › peer-review

Open Access

Labral calcification plays a key role in hip pain and symptoms in femoroacetabular impingement

Trisolino, G., Favero, M., Dallari, D., Tassinari, E., Traina, F., Otero, M., Goldring, S. R., Goldring, M. B., Carubbi, C., Ramonda, R., Stilli, S., Grigolo, B. & Olivotto, E., Feb 28 2020, In: Journal of Orthopaedic Surgery and Research. 15, 1, p. 1-9 9 p.

Research output: Contribution to journal › Article › peer-review

Learning from Monocyte-Macrophage Fusion and Multinucleation: Potential Therapeutic Targets for Osteoporosis and Rheumatoid Arthritis

Gambari, L., Grassi, F., Roseti, L., Grigolo, B. & Desando, G., Aug 20 2020, In: International Journal of Molecular Sciences. 21, 17, p. 1-30 30 p.

Research output: Contribution to journal › Review article › peer-review

Sulfurous thermal waters stimulate the osteogenic differentiation of human mesenchymal stromal cells - An in vitro study

Gambari, L., Grigolo, B., Filardo, G. & Grassi, F., Sep 2020, In: Biomedicine and Pharmacotherapy. 129, p. 1-10 10 p.

Research output: Contribution to journal › Article › peer-review

2019

3D printing of musculoskeletal tissues: impact on safety and health at work

Petretta, M., Desando, G., Grigolo, B. & Roseti, L., Sep 2019, In: Journal of Toxicology and Environmental Health - Part A: Current Issues. 82, 16, p. 891-912 22 p.

Research output: Contribution to journal › Article › peer-review

Articular Cartilage Regeneration in Osteoarthritis

Roseti, L., Desando, G., Cavallo, C., Petretta, M. & Grigolo, B., Oct 23 2019, In: Cells. 8, 11, p. 1-16 16 p.

Research output: Contribution to journal › Review article › peer-review

Bone marrow concentrate and expanded mesenchymal stromal cell surnatants as cell-free approaches for the treatment of osteochondral defects in a preclinical animal model

Veronesi, F., Desando, G., Fini, M., Parrilli, A., Lolli, R., Maglio, M., Martini, L., Giavaresi, G., Bartolotti, I., Grigolo, B. & Sartori, M., Jan 2019, In: International Orthopaedics. 43, 1, p. 25-34 10 p.

Research output: Contribution to journal › Article › peer-review

Design of a novel procedure for the optimization of the mechanical performances of 3D printed scaffolds for bone tissue engineering combining CAD, Taguchi method and FEA

Marchiori, G., Berni, M., Boi, M., Petretta, M., Grigolo, B., Bellucci, D., Cannillo, V., Garavelli, C. & Bianchi, M., Jul 2019, In: Medical Engineering and Physics. 69, p. 92-99 8 p.

Research output: Contribution to journal › Article › peer-review

Hydrogen Sulfide in Bone Tissue Regeneration and Repair: State of the Art and New Perspectives

Gambari, L., Grigolo, B. & Grassi, F., Oct 22 2019, In: International Journal of Molecular Sciences. 20, 20, p. 1-19 19 p.

Research output: Contribution to journal › Review article › peer-review

Hydrogen sulfide-releasing silk fibroin scaffold for bone tissue engineering

Gambari, L., Amore, E., Raggio, R., Bonani, W., Barone, M., Lisignoli, G., Grigolo, B., Motta, A. & Grassi, F., Sep 1 2019, In: Materials Science and Engineering C. 102, p. 471-482 12 p.

Research output: Contribution to journal › Article › peer-review

Morphological and ultrastructural analysis of normal, injured and osteoarthritic human knee menisci

Battistelli, M., Favero, M., Burini, D., Trisolino, G., Dallari, D., De Franceschi, L., Goldring, S. R., Goldring, M. B., Belluzzi, E., Filardo, G., Grigolo, B., Falcieri, E. & Olivotto, E., Feb 11 2019, In: European journal of histochemistry : EJH. 63, 1, p. 17-23 7 p.

Research output: Contribution to journal › Article › peer-review

Patient-specific meniscus prototype based on 3D bioprinting of human cell-laden scaffold

Filardo, G., Petretta, M., Cavallo, C., Roseti, L., Durante, S., Albisinni, U. & Grigolo, B., Mar 2 2019, In: Bone and Joint Research. 8, 2, p. 101-106 6 p.

Research output: Contribution to journal › Article › peer-review

Regenerative Features of Adipose Tissue for Osteoarthritis Treatment in a Rabbit Model: Enzymatic Digestion Versus Mechanical Disruption

Desando, G., Bartolotti, I., Martini, L., Giavaresi, G., Nicoli Aldini, N., Fini, M., Roffi, A., Perdisa, F., Filardo, G., Kon, E. & Grigolo, B., May 29 2019, In: International Journal of Molecular Sciences. 20, 11, p. 1-16 16 p.

Research output: Contribution to journal › Article › peer-review

2018

Comparison of growth factor and interleukin content of adult peripheral blood and cord blood serum eye drops for cornea and ocular surface diseases

Buzzi, M., Versura, P., Grigolo, B., Cavallo, C., Terzi, A., Pellegrini, M., Giannaccare, G., Randi, V. & Campos, E. C., Aug 13 2018, In: Transfusion and Apheresis Science. 57, 4, p. 549-555 7 p.

Research output: Contribution to journal › Article › peer-review

Conditioned media from human osteoarthritic synovium induces inflammation in a synoviocyte cell line

Belluzzi, E., Olivotto, E., Toso, G., Cigolotti, A., Pozzuoli, A., Biz, C., Trisolino, G., Ruggieri, P., Grigolo, B., Ramonda, R. & Favero, M., May 2018, (E-pub ahead of print) In: Connective Tissue Research. p. 1-10 10 p.

Research output: Contribution to journal › Article › peer-review

Cultures of a human synovial cell line to evaluate platelet-rich plasma and hyaluronic acid effects

Olivotto, E., Merli, G., Assirelli, E., Cavallo, C., Belluzzi, E., Ramonda, R., Favero, M., Filardo, G., Roffi, A., Kon, E. & Grigolo, B., Aug 2018, In: Journal of Tissue Engineering and Regenerative Medicine. 12, 8, p. 1835-1842 8 p.

Research output: Contribution to journal › Article › peer-review

Inflammatory molecules produced by meniscus and synovium in early and end-stage osteoarthritis: a coculture study

Favero, M., Belluzzi, E., Trisolino, G., Goldring, M. B., Goldring, S. R., Cigolotti, A., Pozzuoli, A., Ruggieri, P., Ramonda, R., Grigolo, B., Punzi, L. & Olivotto, E., Nov 19 2018, (E-pub ahead of print) In: Journal of Cellular Physiology. p. 1-12 12 p.

Research output: Contribution to journal › Article › peer-review

PRP and MSCs on tenocytes artificial wound healing: an in vitro study comparing fresh and frozen PRP

Veronesi, F., Pagani, S., Torricelli, P., Filardo, G., Cavallo, C., Grigolo, B. & Fini, M., Dec 2018, In: Histology and Histopathology. 33, 12, p. 1323-1334 12 p.

Research output: Contribution to journal › Article › peer-review

Three-dimensional bioprinting of cartilage by the use of stem cells: A strategy to improve regeneration

Roseti, L., Cavallo, C., Desando, G., Parisi, V., Petretta, M., Bartolotti, I. & Grigolo, B., Sep 17 2018, In: Materials. 11, 9, p. 1-20 20 p., 1749.

Research output: Contribution to journal › Review article › peer-review

2017

Is arthroscopic videotape a reliable tool for describing early joint tissue pathology of the knee?

Trisolino, G., Favero, M., Lazzaro, A., Martucci, E., Strazzari, A., Belluzzi, E., Goldring, S. R., Punzi, L., Grigolo, B. & Olivotto, E., Jan 1 2017, (Accepted/In press) In: Knee. 24, 6, p. 1374-1382 9 p.

Research output: Contribution to journal › Article › peer-review

Repair Potential of Matrix-Induced Bone Marrow Aspirate Concentrate and Matrix-Induced Autologous Chondrocyte Implantation for Talar Osteochondral Repair: Patterns of Some Catabolic, Inflammatory, and Pain Mediators

Desando, G., Bartolotti, I., Vannini, F., Cavallo, C., Castagnini, F., Buda, R., Giannini, S., Mosca, M., Mariani, E. & Grigolo, B., Jan 1 2017, In: Cartilage. 8, 1, p. 50-60 11 p.

Research output: Contribution to journal › Article › peer-review

Scaffolds for Bone Tissue Engineering: State of the art and new perspectives.

Roseti, L., Parisi, V., Petretta, M., Cavallo, C., Desando, G., Bartolotti, I. & Grigolo, B., May 5 2017, (E-pub ahead of print) In: Materials Science and Engineering C. 78, p. 1246-1262 17 p.

Research output: Contribution to journal › Article › peer-review

Short-Term Homing of Hyaluronan-Primed Cells: Therapeutic Implications for Osteoarthritis Treatment.

Desando, G., Bartolotti, I., Cavallo, C., Schiavinato, A., Secchieri, C., Kon, E., Filardo, G., Paro, M. & Grigolo, B., Dec 22 2017, In: Tissue Engineering - Part C: Methods. p. 1-13 13 p.

Research output: Contribution to journal › Article › peer-review

Subchondral bone response to injected adipose-derived stromal cells for treating osteoarthritis using an experimental rabbit model

Parrilli, A., Giavaresi, G., Ferrari, A., Salamanna, F., Desando, G., Grigolo, B., Martini, L. & Fini, M., Mar 19 2017, (Accepted/In press) In: Biotechnic and Histochemistry. 92, 3, p. 201-211 11 p.

Research output: Contribution to journal › Article › peer-review

2016

Autologous Bone Marrow Concentrate in a Sheep Model of Osteoarthritis: New Perspectives for Cartilage and Meniscus Repair

Desando, G., Giavaresi, G., Cavallo, C., Bartolotti, I., Sartoni, F., Nicoli Aldini, N., Martini, L., Parrilli, A., Mariani, E., Fini, M. & Grigolo, B., Jun 1 2016, In: Tissue Engineering - Part C: Methods. 22, 6, p. 608-619 12 p.

Research output: Contribution to journal › Article › peer-review

Chondroprotective activity of N-acetyl phenylalanine glucosamine derivative on knee joint structure and inflammation in a murine model of osteoarthritis

Veronesi, F., Giavaresi, G., Maglio, M., Scotto d'Abusco, A., Politi, L., Scandurra, R., Olivotto, E., Grigolo, B., Borzi', R. M. & Fini, M., May 27 2016, (Accepted/In press) In: Osteoarthritis and Cartilage. p. 589-599 11 p.

Research output: Contribution to journal › Article › peer-review

Failure mode and effects analysis to reduce risks of errors in the good manufacturing practice production of engineered cartilage for autologous chondrocyte implantation

Roseti, L., Serra, M., Bassi, A., Venezian, T., Maso, A., Fornasari, P. M., Di Denia, P., Munno, C., Storni, E. & Grigolo, B., 2016, In: Current Pharmaceutical Analysis. 12, 1, p. 43-54 12 p.

Research output: Contribution to journal › Article › peer-review