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Research Output 2006 2019

  • 875 Citations
  • 16 h-Index
  • 29 Article
2019

CXCL12 loaded-dermal filler captures CXCR4 expressing melanoma circulating tumor cells

Ieranò, C., D’Alterio, C., Giarra, S., Napolitano, M., Rea, G., Portella, L., Santagata, A., Trotta, A. M., Barbieri, A., Campani, V., Luciano, A., Arra, C., Anniciello, A. M., Botti, G., Mayol, L., De Rosa, G., Pacelli, R. & Scala, S., Aug 1 2019, In : Cell Death and Disease. 10, 8, 562.

Research output: Contribution to journalArticle

Open Access
Circulating Neoplastic Cells
Melanoma
Neoplasms
Gels
Hyaluronic Acid
Open Access
Tumor Microenvironment
Neoplasms
Heterografts
Granzymes
Melanoma
2018
1 Citation (Scopus)

Cationic nucleopeptides as novel non-covalent carriers for the delivery of peptide nucleic acid (PNA) and RNA oligomers

Tomassi, S., Ieranò, C., Mercurio, M. E., Nigro, E., Daniele, A., Russo, R., Chambery, A., Baglivo, I., Pedone, P. V., Rea, G., Napolitano, M., Scala, S., Cosconati, S., Marinelli, L., Novellino, E., Messere, A. & Di Maro, S., 2018, In : Bioorganic and Medicinal Chemistry.

Research output: Contribution to journalArticle

Peptide Nucleic Acids
Oligomers
Nucleic Acids
RNA
Cytotoxicity
2 Citations (Scopus)

Engineering of thermoresponsive gels as a fake metastatic niche

Giarra, S., Ierano, C., Biondi, M., Napolitano, M., Campani, V., Pacelli, R., Scala, S., De Rosa, G. & Mayol, L., Jul 1 2018, In : Carbohydrate Polymers. 191, p. 112-118 7 p.

Research output: Contribution to journalArticle

Gels
Tumors
Methylcellulose
Cells
Hyaluronic acid
2017
11 Citations (Scopus)

Epithelial-to-mesenchymal transition in FHC-silenced cells: The role of CXCR4/CXCL12 axis

Aversa, I., Zolea, F., Ieranò, C., Bulotta, S., Trotta, A. M., Faniello, M. C., De Marco, C., Malanga, D., Biamonte, F., Viglietto, G., Cuda, G., Scala, S. & Costanzo, F., Aug 3 2017, In : Journal of Experimental and Clinical Cancer Research. 36, 1, 104.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Iron
MCF-7 Cells
Phenotype
Ceruloplasmin
2016

A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion

Fontanella, R., Pelagalli, A., Nardelli, A., D'Alterio, C., Ieranò, C., Cerchia, L., Lucarelli, E., Scala, S. & Zannetti, A., Jan 1 2016, In : Cancer Letters. 370, 1, p. 100-107 8 p.

Research output: Contribution to journalArticle

Osteosarcoma
Mesenchymal Stromal Cells
Cell Movement
Hepatocellular Carcinoma
Bone Marrow
31 Citations (Scopus)

A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion

Fontanella, R., Pelagalli, A., Nardelli, A., D'Alterio, C., Ieranò, C., Cerchia, L., Scala, S. & Zannetti, A., Jan 1 2016, In : Cancer Letters. 370, 1, p. 100-107 8 p.

Research output: Contribution to journalArticle

Osteosarcoma
Mesenchymal Stromal Cells
Cell Movement
Hepatocellular Carcinoma
Bone Marrow
16 Citations (Scopus)

CXCR4/CXCL12/CXCR7 axis is functional in neuroendocrine tumors and signals on mTOR

Circelli, L., Sciammarella, C., Guadagno, E., Tafuto, S., de Caro, M. D. B., Botti, G., Pezzullo, L., Aria, M., Ramundo, V., Tatangelo, F., Losito, N. S., Ieranò, C., D'Alterio, C., Izzo, F., Ciliberto, G., Colao, A., Faggiano, A. & Scala, S., 2016, In : Oncotarget. 7, 14, p. 18865-18875 11 p.

Research output: Contribution to journalArticle

CXC Chemokines
Neuroendocrine Tumors
Chemokine Receptors
Sirolimus
Chemokine CXCL12
5 Citations (Scopus)

CXCR4-antagonist Peptide R-liposomes for combined therapy against lung metastasis

Ieranò, C., Portella, L., Lusa, S., Salzano, G., D'Alterio, C., Napolitano, M., Buoncervello, M., Macchia, D., Spada, M., Barbieri, A., Luciano, A., Barone, M. V., Gabriele, L., Caraglia, M., Arra, C., De Rosa, G. & Scala, S., Apr 14 2016, In : Nanoscale. 8, 14, p. 7562-7571 10 p.

Research output: Contribution to journalArticle

Liposomes
Peptides
Doxorubicin
Tumors
R peptide
14 Citations (Scopus)

Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists

Di Maro, S., Trotta, A. M., Brancaccio, D., Di Leva, F. S., La Pietra, V., Ieranò, C., Napolitano, M., Portella, L., D'Alterio, C., Siciliano, R. A., Sementa, D., Tomassi, S., Carotenuto, A., Novellino, E., Scala, S. & Marinelli, L., Sep 22 2016, In : Journal of Medicinal Chemistry. 59, 18, p. 8369-8380 12 p.

Research output: Contribution to journalArticle

Chemokine CXCL12
CXC Chemokines
Cyclic Peptides
Chemokine Receptors
Leukemia
2015
18 Citations (Scopus)
Hepatocellular Carcinoma
Survival
Ligands
Chemokine Receptors
Chemokines
12 Citations (Scopus)

Everolimus and pancreatic neuroendocrine tumors (PNETs): Activity, resistance and how to overcome it

Capozzi, M., Caterina, I., De Divitiis, C., von Arx, C., Maiolino, P., Tatangelo, F., Cavalcanti, E., Di Girolamo, E., Iaffaioli, R. V., Scala, S. & Tafuto, S., Sep 1 2015, In : International Journal of Surgery. 21, S1, p. S89-S94

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Sirolimus
Drug Resistance
Neoplasms
Appendix
55 Citations (Scopus)

Identification of a distinct population of CD133 + CXCR4 + cancer stem cells in ovarian cancer

Cioffi, M., Dalterio, C., Camerlingo, R., Tirino, V., Consales, C., Riccio, A., Ieranò, C., Cecere, S. C., Losito, N. S., Greggi, S., Pignata, S., Pirozzi, G. & Scala, S., May 28 2015, In : Scientific Reports. 5, 10357.

Research output: Contribution to journalArticle

Neoplastic Stem Cells
Ovarian Neoplasms
Population
Stem Cells
Cell Line
2014
45 Citations (Scopus)

CXCR4 and CXCR7 transduce through mTOR in human renal cancer cells

Ieranò, C., Santagata, S., Napolitano, M., Guardia, F., Grimaldi, A., Antignani, E., Botti, G., Consales, C., Riccio, A., Nanayakkara, M., Barone, M. V., Caraglia, M. & Scala, S., 2014, In : Cell Death and Disease. 5, 7, e1310.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Kidney Neoplasms
Wound Healing
Actins
Ligands
2013
7 Citations (Scopus)

Histone deacetylase inhibitors induce CXCR4 mRNA but antagonize CXCR4 migration

Ierano, C., Basseville, A., To, K. K. W., Zhan, Z., Robey, R. W., Wilkerson, J., Bates, S. E. & Scala, S., Feb 2013, In : Cancer Biology and Therapy. 14, 2, p. 175-183 9 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Messenger RNA
Cell Movement
Neoplasms
Protein Transport
16 Citations (Scopus)

Loss of the proteins Bak and Bax prevents apoptosis mediated by histone deacetylase inhibitors

Ierano, C., Chakraborty, A. R., Nicolae, A., Bahr, J. C., Zhan, Z., Pittaluga, S., Bates, S. E. & Robey, R. W., Sep 1 2013, In : Cell Cycle. 12, 17, p. 2829-2838 10 p.

Research output: Contribution to journalArticle

bcl-2 Homologous Antagonist-Killer Protein
bcl-2-Associated X Protein
Histone Deacetylase Inhibitors
Burkitt Lymphoma
Aurora Kinases
47 Citations (Scopus)

Preclinical Development of a Novel Class of CXCR4 Antagonist Impairing Solid Tumors Growth and Metastases

Portella, L., Vitale, R., De Luca, S., D'Alterio, C., Ieranò, C., Napolitano, M., Riccio, A., Polimeno, M. N., Monfregola, L., Barbieri, A., Luciano, A., Ciarmiello, A., Arra, C., Castello, G., Amodeo, P. & Scala, S., Sep 13 2013, In : PLoS One. 8, 9, e74548.

Research output: Contribution to journalArticle

metastasis
Tumors
antagonists
peptides
Neoplasm Metastasis
2012
24 Citations (Scopus)

Histone deacetylase inhibitors influence chemotherapy transport by modulating expression and trafficking of a common polymorphic variant of the ABCG2 efflux transporter

Basseville, A., Tamaki, A., Ierano, C., Trostel, S., Ward, Y., Robey, R. W., Hegde, R. S. & Bates, S. E., Jul 15 2012, In : Cancer Research. 72, 14, p. 3642-3651 10 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Drug Therapy
Microtubules
Pharmaceutical Preparations
Proteins
41 Citations (Scopus)

Inhibition of stromal CXCR4 impairs development of lung metastases

D'Alterio, C., Barbieri, A., Portella, L., Palma, G., Polimeno, M., Riccio, A., Ieranó, C., Franco, R., Scognamiglio, G., Bryce, J., Luciano, A., Rea, D., Arra, C. & Scala, S., Oct 2012, In : Cancer Immunology, Immunotherapy. 61, 10, p. 1713-1720 8 p.

Research output: Contribution to journalArticle

Neoplasm Metastasis
Lung
Myeloid Cells
Stromal Cells
Experimental Melanomas
2011
54 Citations (Scopus)

The challenge of exploiting ABCG2 in the clinic

Robey, R. W., Ierano, C., Zhan, Z. & Bates, S. E., Apr 2011, In : Current Pharmaceutical Biotechnology. 12, 4, p. 595-608 14 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Proteins
ATP-Binding Cassette Transporters
Gout
Normal Distribution
108 Citations (Scopus)

The controversial role of ABC transporters in clinical oncology

Tamaki, A., Ierano, C., Szakacs, G., Robey, R. W. & Bates, S. E., 2011, In : Essays in Biochemistry. 50, 1, p. 209-232 24 p.

Research output: Contribution to journalArticle

Oncology
ATP-Binding Cassette Transporters
Medical Oncology
P-Glycoprotein
Chemotherapy
2010

CD4+CD45RA+CXCR4+ lymphocytes are inversely associated with progression in stages I-III melanoma patients

Napolitano, M., Ottaiano, A., Mauro, F., Leranò, C., Satriano, R., Pacelli, R., Franco, R., De Angelis, V., Castello, G. & Scala, S., Apr 2010, In : Cancer Immunology, Immunotherapy. 59, 4, p. 511-517 7 p.

Research output: Contribution to journalArticle

Melanoma
Lymphocyte Subsets
Lymphocytes
Disease-Free Survival
Chemokine Receptors
17 Citations (Scopus)

CXCR4-CXCL12 and VEGF correlate to uveal melanoma progression

Franco, R., Botti, G., Mascolo, M., Loquercio, G., Liguori, G., Ilardi, G., Losito, S., La Mura, A., Calemma, R., Ieranò, C., Bryce, J., D'Alterio, C. & Scala, S., Jan 1 2010, In : Frontiers in Bioscience - Elite. 2 E, 1, p. 13-21 9 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factor A
Neoplasm Metastasis
Liver
Tumors
Uveal melanoma
30 Citations (Scopus)

Mutational analysis of threonine 402 adjacent to the GXXXG dimerization motif in transmembrane segment 1 of ABCG2

Polgar, O., Ierano, C., Tamaki, A., Stanley, B., Ward, Y., Xia, D., Tarasova, N., Robey, R. W. & Batest, S. E., Mar 16 2010, In : Biochemistry. 49, 10, p. 2235-2245 11 p.

Research output: Contribution to journalArticle

Dimerization
Threonine
Mutation
Leucine
Glycosylation
2009
7 Citations (Scopus)

A point mutation (G574A) in the chemokine receptor CXCR4 detected in human cancer cells enhances migration

Ierano, C., Giuliano, P., D'Alterio, C., Cioffi, M., Mettivier, V., Portella, L., Napolitano, M., Barbieri, A., Arra, C., Liguori, G., Franco, R., Palmieri, G., Rozzo, C., Pacelli, R., Castello, G. & Scala, S., Apr 15 2009, In : Cell Cycle. 8, 8, p. 1228-1237 10 p.

Research output: Contribution to journalArticle

Chemokine Receptors
Point Mutation
Cell Movement
Neoplasms
Growth
2008
48 Citations (Scopus)

Bevacizumab increases viral distribution in human anaplastic thyroid carcinoma xenografts and enhances the effects of E1A-defective adenovirus d/922-947

Libertini, S., Lacuzzo, I., Perruolo, G., Scala, S., Leranò, C., Franco, R., Hallden, G. & Portella, G., Oct 15 2008, In : Clinical Cancer Research. 14, 20, p. 6505-6514 10 p.

Research output: Contribution to journalArticle

Heterografts
Adenoviridae
Neoplasms
Investigational Therapies
Therapeutics
2007
29 Citations (Scopus)

CXC chemokine receptor 4 is expressed in uveal malignant melanoma and correlates with the epithelioid-mixed cell type

Scala, S., Ieranò, C., Ottaiano, A., Franco, R., La Mura, A., Liguori, G., Mascolo, M., Staibano, S., Ascierto, P. A., Botti, G., De Rosa, G. & Castello, G., Oct 2007, In : Cancer Immunology, Immunotherapy. 56, 10, p. 1589-1595 7 p.

Research output: Contribution to journalArticle

CXCR4 Receptors
Epithelioid Cells
Melanoma
Neoplasms
Staining and Labeling
2006
102 Citations (Scopus)

Human melanoma metastases express functional CXCR4

Scala, S., Giuliano, P., Ascierto, P. A., Ieranò, C., Franco, R., Napolitano, M., Ottaiano, A., Lombardi, M. L., Luongo, M., Simeone, E., Castiglia, D., Mauro, F., De Michele, I., Calemma, R., Botti, G., Caracò, C., Nicoletti, G., Satriano, R. A. & Castello, G., Apr 15 2006, In : Clinical Cancer Research. 12, 8, p. 2427-2433 7 p.

Research output: Contribution to journalArticle

Melanoma
Neoplasm Metastasis
Cell Line
Chemokine Receptors
Apoptosis
135 Citations (Scopus)

Overexpression of both CXC chemokine receptor 4 and vascular endothelial growth factor proteins predicts early distant relapse in stage II-III colorectal cancer patients

Ottaiano, A., Franco, R., Talamanca, A. A., Liguori, G., Tatangelo, F., Delrio, P., Nasti, G., Barletta, E., Facchini, G., Daniele, B., Di Blasi, A., Napolitano, M., Ieranò, C., Calemma, R., Leonardi, E., Albino, V., De Angelis, V., Falanga, M., Boccia, V., Capuozzo, M. & 5 others, Parisi, V., Botti, G., Castello, G., Iaffaioli, R. V. & Scala, S., May 1 2006, In : Clinical Cancer Research. 12, 9, p. 2795-2803 9 p.

Research output: Contribution to journalArticle

CXCR4 Receptors
Vascular Endothelial Growth Factor A
Colorectal Neoplasms
Recurrence
Proteins