19942019

Research output per year

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Research Output

2019

Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure

Lombardi, M., Parolisi, R., Scaroni, F., Bonfanti, E., Gualerzi, A., Gabrielli, M., Kerlero de Rosbo, N., Uccelli, A., Giussani, P., Viani, P., Garlanda, C., Abbracchio, M. P., Chaabane, L., Buffo, A., Fumagalli, M. & Verderio, C., Dec 1 2019, In : Acta Neuropathologica. 138, 6, p. 987-1012 26 p.

Research output: Contribution to journalArticle

Open Access

Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure

Lombardi, M., Parolisi, R., Scaroni, F., Bonfanti, E., Gualerzi, A., Gabrielli, M., Kerlero de Rosbo, N., Uccelli, A., Giussani, P., Viani, P., Garlanda, C., Abbracchio, M. P., Chaabane, L., Buffo, A., Fumagalli, M. & Verderio, C., Dec 2019, In : Acta Neuropathologica. 138, 6, p. 987-1012 26 p.

Research output: Contribution to journalArticle

Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure

Lombardi, M., Parolisi, R., Scaroni, F., Bonfanti, E., Gualerzi, A., Gabrielli, M., Kerlero de Rosbo, N., Uccelli, A., Giussani, P., Viani, P., Garlanda, C., Abbracchio, M. P., Chaabane, L., Buffo, A., Fumagalli, M. & Verderio, C., Jan 1 2019, In : Acta Neuropathologica.

Research output: Contribution to journalArticle

IL1R8 Deficiency Drives Autoimmunity-Associated Lymphoma Development

Riva, F., Ponzoni, M., Supino, D., Bertilaccio, M. T. S., Polentarutti, N., Massara, M., Pasqualini, F., Carriero, R., Innocenzi, A., Anselmo, A., Veliz-Rodriguez, T., Simonetti, G., Anders, H-J., Caligaris-Cappio, F., Mantovani, A., Muzio, M. & Garlanda, C., Jun 2019, In : Cancer immunology research. 7, 6, p. 874-885 12 p.

Research output: Contribution to journalArticle

Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity

Mantovani, A., Dinarello, C. A., Molgora, M. & Garlanda, C., Apr 16 2019, In : Immunity. 50, 4, p. 778-795 18 p.

Research output: Contribution to journalReview article

Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors

Ponzetta, A., Carriero, R., Carnevale, S., Barbagallo, M., Molgora, M., Perucchini, C., Magrini, E., Gianni, F., Kunderfranco, P., Polentarutti, N., Pasqualini, F., Di Marco, S., Supino, D., Peano, C., Cananzi, F., Colombo, P., Pilotti, S., Alomar, S. Y., Bonavita, E., Galdiero, M. R. & 3 others, Garlanda, C., Mantovani, A. & Jaillon, S., Jul 11 2019, In : Cell. 178, 2, p. 346-360.e24

Research output: Contribution to journalArticle

Pentraxin 3 deficiency protects from the metabolic inflammation associated to diet-induced obesity

Bonacina, F., Moregola, A., Porte, R., Baragetti, A., Bonavita, E., Salatin, A., Grigore, L., Pellegatta, F., Molgora, M., Sironi, M., Barbati, E., Mantovani, A., Bottazzi, B., Catapano, A. L., Garlanda, C. & Norata, G. D., Nov 1 2019, In : Cardiovascular Research. 115, 13, p. 1861-1872 12 p.

Research output: Contribution to journalArticle

Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin

Fossati, G., Pozzi, D., Canzi, A., Mirabella, F., Valentino, S., Morini, R., Ghirardini, E., Filipello, F., Moretti, M., Gotti, C., Annis, D. S., Mosher, D. F., Garlanda, C., Bottazzi, B., Taraboletti, G., Mantovani, A., Matteoli, M. & Menna, E., Jan 3 2019, In : EMBO Journal. 38, 1, e99529.

Research output: Contribution to journalArticle

The Long Pentraxin 3 Contributes to Joint Inflammation in Gout by Facilitating the Phagocytosis of Monosodium Urate Crystals

Batista, N. V., Barbagallo, M., Oliveira, V. L. S., Castro-Gomes, T., Oliveira, R. D. R., Louzada-Junior, P., Pinheiro, G. R. C., Mantovani, A., Teixeira, M. M., Garlanda, C. & Amaral, F. A., Mar 15 2019, In : Journal of immunology (Baltimore, Md. : 1950). 202, 6, p. 1807-1814 8 p.

Research output: Contribution to journalArticle

TLR3 preconditioning induces anti-inflammatory and anti-ictogenic effects in mice mediated by the IRF3/IFN-β axis

Kostoula, C., Shaker, T., Cerovic, M., Craparotta, I., Marchini, S., Butti, E., Pascente, R., Iori, V., Garlanda, C., Aronica, E., Martino, G., Ravizza, T., Carmant, L. & Vezzani, A., Oct 2019, In : Brain, Behavior, and Immunity. 81, p. 598-607 10 p.

Research output: Contribution to journalArticle

TLR3 preconditioning induces anti-inflammatory and anti-ictogenic effects in mice mediated by the IRF3/IFN-β axis

Kostoula, C., Shaker, T., Cerovic, M., Craparotta, I., Marchini, S., Butti, E., Pascente, R., Iori, V., Garlanda, C., Aronica, E., Martino, G., Ravizza, T., Carmant, L. & Vezzani, A., Oct 2019, In : Brain, Behavior, and Immunity. 81, p. 598-607 10 p.

Research output: Contribution to journalArticle

2018

IL-1 and IL-1 regulatory pathways in cancer progression and therapy

Mantovani, A., Barajon, I. & Garlanda, C., Jan 1 2018, In : Immunological Reviews. 281, 1, p. 57-61 5 p.

Research output: Contribution to journalReview article

Pentraxin 3 promotes long-term cerebral blood flow recovery, angiogenesis, and neuronal survival after stroke

Rajkovic, I., Wong, R., Lemarchand, E., Rivers-Auty, J., Rajkovic, O., Garlanda, C., Allan, S. M. & Pinteaux, E., Dec 2018, In : Journal of Molecular Medicine. 96, 12, p. 1319-1332 14 p.

Research output: Contribution to journalArticle

Role of a fluid-phase PRR in fighting an intracellular pathogen: PTX3 in Shigella infection

Ciancarella, V., Lembo-Fazio, L., Paciello, I., Bruno, A-K., Jaillon, S., Berardi, S., Barbagallo, M., Meron-Sudai, S., Cohen, D., Molinaro, A., Rossi, G., Garlanda, C. & Bernardini, M. L., Dec 2018, In : PLoS Pathogens. 14, 12, p. e1007469

Research output: Contribution to journalArticle

The long pentraxin PTX3 is an endogenous inhibitor of hyperoxaluria-related nephrocalcinosis and chronic kidney disease

Marschner, J. A., Mulay, S. R., Steiger, S., Anguiano, L., Zhao, Z., Boor, P., Rahimi, K., Inforzato, A., Garlanda, C., Mantovani, A. & Anders, H. J., Sep 25 2018, In : Frontiers in Immunology. 9, SEP, 2173.

Research output: Contribution to journalArticle

The yin-yang of the interaction between myelomonocytic cells and NK cells

Molgora, M., Supino, D., Mavilio, D., Santoni, A., Moretta, L., Mantovani, A. & Garlanda, C., Sep 2018, In : Scandinavian Journal of Immunology. 88, 3, p. e12705

Research output: Contribution to journalArticle

Tuning inflammation and immunity by the negative regulators IL-1R2 and IL-1R8

Molgora, M., Supino, D., Mantovani, A. & Garlanda, C., Jan 1 2018, In : Immunological Reviews. 281, 1, p. 233-247 15 p.

Research output: Contribution to journalReview article

2017

High IL-1R8 expression in breast tumors promotes tumor growth and contributes to impaired antitumor immunity

Campesato, L. F., Silva, A. P. M., Cordeiro, L., Correa, B. R., Navarro, F. C. P., Zanin, R. F., Marçola, M., Inoue, L. T., Duarte, M. L., Molgora, M., Pasqualini, F., Massara, M., Galante, P., Barroso-Sousa, R., Polentarutti, N., Riva, F., Costa, E. T., Mantovani, A., Garlanda, C. & Camargo, A. A., Jul 25 2017, In : Oncotarget. 8, 30, p. 49470-49483 14 p.

Research output: Contribution to journalArticle

IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity

Molgora, M., Bonavita, E., Ponzetta, A., Riva, F., Barbagallo, M., Jaillon, S., Popović, B., Bernardini, G., Magrini, E., Gianni, F., Zelenay, S., Jonjić, S., Santoni, A., Garlanda, C. & Mantovani, A., Nov 2 2017, In : Nature. 551, 7678, p. 110-114 5 p.

Research output: Contribution to journalArticle

IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity

Molgora, M., Bonavita, E., Ponzetta, A., Riva, F., Barbagallo, M., Jaillon, S., Popović, B., Bernardini, G., Magrini, E., Gianni, F., Zelenay, S., Jonjić, S., Santoni, A., Garlanda, C. & Mantovani, A., Nov 2 2017, In : Nature. 551, 7678, p. 110-114 5 p.

Research output: Contribution to journalArticle

Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance

Cavalli, G., Justice, JN., Boyle, KE., D'Alessandro, A., Eisenmesser, EZ., Herrera, JJ., Hansen, KC., Nemkov, T., Stienstra, R., Garlanda, C., Mantovani, A., Seals, DR., Dagna, L., Joosten, LAB., Ballak, DB. & Dinarello, CA., 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 9, p. 2313-2318 6 p.

Research output: Contribution to journalArticle

Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance

Cavalli, G., Justice, J. N., Boyle, K. E., D'Alessandro, A., Eisenmesser, E. Z., Herrera, J. J., Hansen, K. C., Nemkov, T., Stienstra, R., Garlanda, C., Mantovani, A., Seals, D. R., Dagna, L., Joosten, L. A. B., Ballak, D. B. & Dinarello, C. A., Feb 28 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 9, p. 2313-2318 6 p.

Research output: Contribution to journalArticle

Lack of IL-1r8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects

Tomasoni, R., Morini, R., Lopez-Atalaya, J. P., Corradini, I., Canzi, A., Rasile, M., Mantovani, C., Pozzi, D., Garlanda, C., Mantovani, A., Menna, E., Barco, A. & Matteoli, M., Mar 28 2017, In : eLife. 6, e21735.

Research output: Contribution to journalArticle

Pro-inflammatory M1/Th1 type immune network and increased expression of TSG-6 in the eutopic endometrium from women with endometriosis

Matteo, M., Cicinelli, E., Neri, M., Carrubba, R., Carpagnano, F. A., Romeo, F., Scutiero, G., Greco, P., Garlanda, C., Vendemiale, G., Levi Setti, P. E. & Serviddio, G., Nov 1 2017, In : European Journal of Obstetrics Gynecology and Reproductive Biology. 218, p. 99-105 7 p.

Research output: Contribution to journalArticle

Sexual Dimorphism in Innate Immunity

Jaillon, S., Berthenet, K. & Garlanda, C., Sep 30 2017, (Accepted/In press) In : Clinical Reviews in Allergy and Immunology. p. 1-14 14 p.

Research output: Contribution to journalArticle

2016

Clearance of cell remnants and regeneration of injured muscle depend on soluble pattern recognition receptor PTX3

Vezzoli, M., Sciorati, C., Campana, L., Monno, A., Doglio, M. G., Rigamonti, E., Corna, G., Touvier, T., Castiglioni, A., Capobianco, A., Mantovani, A., Manfredi, A. A., Garlanda, C. & Rovere-Querini, P., 2016, In : Molecular Medicine. 22, p. 809-820 12 p.

Research output: Contribution to journalArticle

Clearance of cell remnants and regeneration of injured muscle depend on soluble pattern recognition receptor PTX3

Vezzoli, M., Sciorati, C., Campana, L., Monno, A., Doglio, M. G., Rigamonti, E., Corna, G., Touvier, T., Castiglioni, A., Capobianco, A., Mantovani, A., Manfredi, A. A., Garlanda, C. & Rovere-Querini, P., 2016, In : Molecular Medicine. 22, p. 809 - 820 12 p.

Research output: Contribution to journalArticle

Cytokine decoy and scavenger receptors as key regulators of immunity and inflammation

Bonecchi, R., Garlanda, C., Mantovani, A. & Riva, F., Nov 1 2016, In : Cytokine. 87, p. 37-45 9 p.

Research output: Contribution to journalArticle

Expression and function of IL-1R8 (TIR8/SIGIRR): A regulatory member of the IL-1 receptor family in platelets

Anselmo, A., Riva, F., Gentile, S., Soldani, C., Barbagallo, M., Mazzon, C., Feruglio, F., Polentarutti, N., Somma, P., Carullo, P., Angelini, C., Bacci, M., Mendolicchio, G. L., Voza, A., Nebuloni, M., Mantovani, A. & Garlanda, C., Sep 1 2016, In : Cardiovascular Research. 111, 4, p. 373-384 12 p.

Research output: Contribution to journalArticle

Fluid phase recognition molecules in neutrophil-dependent immune responses

Jaillon, S., Ponzetta, A., Magrini, E., Barajon, I., Barbagallo, M., Garlanda, C. & Mantovani, A., Mar 1 2016, (Accepted/In press) In : Seminars in Immunology.

Research output: Contribution to journalArticle

Fluid phase recognition molecules in neutrophil-dependent immune responses

Jaillon, S., Ponzetta, A., Magrini, E., Barajon, I., Barbagallo, M., Garlanda, C. & Mantovani, A., Mar 1 2016, (Accepted/In press) In : Seminars in Immunology.

Research output: Contribution to journalArticle

Glucose availability enhances lipopolysaccharide production and immunogenicity in the opportunistic pathogen Acinetobacter baumannii

Rossi, E., Longo, F., Barbagallo, M., Peano, C., Consolandi, C., Pietrelli, A., Jaillon, S., Garlanda, C. & Landini, P., Mar 1 2016, In : Future Microbiology. 11, 3, p. 335-349 15 p.

Research output: Contribution to journalArticle

Innate immunity, hemostasis and matrix remodeling: PTX3 as a link

Doni, A., Garlanda, C. & Mantovani, A., Dec 1 2016, In : Seminars in Immunology. 28, 6, p. 570-577 8 p.

Research output: Contribution to journalReview article

Mesenchymal stromal cell-derived PTX3 promotes wound healing via fibrin remodeling

Cappuzzello, C., Doni, A., Dander, E., Pasqualini, F., Nebuloni, M., Bottazzi, B., Mantovani, A., Biondi, A., Garlanda, C. & D'Amico, G., Jan 1 2016, In : Journal of Investigative Dermatology. 136, 1, p. 293-300 8 p.

Research output: Contribution to journalArticle

Occurrence and significance of tumor-associated neutrophils in patients with colorectal cancer

Galdiero, M. R., Bianchi, P., Grizzi, F., Di Caro, G., Basso, G., Ponzetta, A., Bonavita, E., Barbagallo, M., Tartari, S., Polentarutti, N., Malesci, A., Marone, G., Roncalli, M., Laghi, L., Garlanda, C., Mantovani, A. & Jaillon, S., 2016, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

Pentraxin-3 is upregulated in the central nervous system during MS and EAE, but does not modulate experimental neurological disease

Ummenthum, K., Peferoen, L. A. N., Finardi, A., Baker, D., Pryce, G., Mantovani, A., Bsibsi, M., Bottazzi, B., Peferoen-Baert, R., van der Valk, P., Garlanda, C., Kipp, M., Furlan, R., van Noort, J. M. & Amor, S., Mar 1 2016, In : European Journal of Immunology. 46, 3, p. 701-711 11 p.

Research output: Contribution to journalArticle

Pentraxin-3 is upregulated in the central nervous system during MS and EAE, but does not modulate experimental neurological disease

Ummenthum, K., Peferoen, L. A. N., Finardi, A., Baker, D., Pryce, G., Mantovani, A., Bsibsi, M., Bottazzi, B., Peferoen-Baert, R., Van-Der-Valk, P., Garlanda, C., Kipp, M., Furlan, R., Van Noort, J. M. & Amor, S., Mar 1 2016, In : European Journal of Immunology. 46, 3, p. 701-711 11 p.

Research output: Contribution to journalArticle

Pentraxin 3 plasma levels at graft-versus-host disease onset predict disease severity and response to therapy in children given haematopoietic stem cell transplantation

Dander, E., De Lorenzo, P., Bottazzi, B., Quarello, P., Vinci, P., Balduzzi, A., Masciocchi, F., Bonanomi, S., Cappuzzello, C., Prunotto, G., Pavan, F., Pasqualini, F., Sironi, M., Cuccovillo, I., Leone, R., Salvatori, G., Parma, M., Terruzzi, E., Pagni, F., Locatelli, F. & 7 others, Mantovani, A., Fagioli, F., Biondi, A., Garlanda, C., Valsecchi, M. G., Rovelli, A. & D'Amico, G., Dec 13 2016, In : Oncotarget. 7, 50, p. 82123-82138 16 p.

Research output: Contribution to journalArticle

Pentraxin 3 plasma levels at graft-versus-host disease onset predict disease severity and response to therapy in children given haematopoietic stem cell transplantation

Dander, E., De Lorenzo, P., Bottazzi, B., Quarello, P., Vinci, P., Balduzzi, A., Masciocchi, F., Bonanomi, S., Cappuzzello, C., Prunotto, G., Pavan, F., Pasqualini, F., Sironi, M., Cuccovillo, I., Leone, R., Salvatori, G., Parma, M., Terruzzi, E., Pagni, F., Locatelli, F. & 7 others, Mantovani, A., Fagioli, F., Biondi, A., Garlanda, C., Valsecchi, M. G., Rovelli, A. & D'Amico, G., 2016, In : Oncotarget. 7, 50, p. 82123-82138 16 p.

Research output: Contribution to journalArticle

Pentraxin 3 recruits complement factor H to protect against oxidative stress-induced complement and inflammasome overactivation

Wang, L., Cano, M., Datta, S., Wei, H., Ebrahimi, K. B., Gorashi, Y., Garlanda, C. & Handa, J. T., Dec 1 2016, In : Journal of Pathology. 240, 4, p. 495-506 12 p.

Research output: Contribution to journalArticle

Pentraxins in the activation and regulation of innate immunity

Daigo, K., Inforzato, A., Barajon, I., Garlanda, C., Bottazzi, B., Meri, S. & Mantovani, A., Nov 1 2016, In : Immunological Reviews. 274, 1, p. 202-217 16 p.

Research output: Contribution to journalReview article