• 43514 Citations
  • 101 h-Index
1969 …2019
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Research Output 1969 2019

2019

Dissecting the pre-Columbian genomic ancestry of Native Americans along the Andes–Amazonia divide

Gnecchi-Ruscone, G. A., Sarno, S., De Fanti, S., Gianvincenzo, L., Giuliani, C., Boattini, A., Bortolini, E., Corcia, T. D., Mellado, C. S., Francia, T. J. D., Gentilini, D., Di Blasio, A. M., Cosimo, P. D., Cilli, E., Gonzalez-Martin, A., Franceschi, C., Franceschi, Z. A., Rickards, O., Sazzini, M., Luiselli, D. & 1 others, Pettener, D., Jun 1 2019, In : Molecular Biology and Evolution. 36, 6, p. 1254-1269 16 p.

Research output: Contribution to journalArticle

Open Access
North American Indians
American Indians
ancestry
genomics
genome

Erythropoietin (EPO) haplotype associated with all-cause mortality in a cohort of Italian patients with Type-2 Diabetes

Montesano, A., Bonfigli, A. R., De Luca, M., Crocco, P., Garagnani, P., Marasco, E., Pirazzini, C., Giuliani, C., Romagnoli, F., Franceschi, C., Passarino, G., Testa, R., Olivieri, F. & Rose, G., Dec 1 2019, In : Scientific Reports. 9, 1, 10395.

Research output: Contribution to journalArticle

Open Access
Erythropoietin
Type 2 Diabetes Mellitus
Haplotypes
Mortality
Diabetes Complications

Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study

Santoro, A., Guidarelli, G., Ostan, R., Giampieri, E., Fabbri, C., Bertarelli, C., Nicoletti, C., Kadi, F., de Groot, L. C. P. G. M., Feskens, E., Berendsen, A., Brzozowska, A., Januszko, O., Kozlowska, K., Fairweather-Tait, S., Jennings, A., Meunier, N., Caumon, E., Napoli, A., Mercatelli, D. & 4 others, Battista, G., Capri, M., Franceschi, C. & Bazzocchi, A., Feb 4 2019, In : European Radiology. p. 1-12 12 p.

Research output: Contribution to journalArticle

Body Composition
Receptors, Tumor Necrosis Factor, Type II
Interleukin-10
Sarcopenia
Interleukin-6

Genomic stability, anti-inflammatory phenotype, and up-regulation of the RNAseH2 in cells from centenarians

Storci, G., De Carolis, S., Papi, A., Bacalini, M. G., Gensous, N., Marasco, E., Tesei, A., Fabbri, F., Arienti, C., Zanoni, M., Sarnelli, A., Santi, S., Olivieri, F., Mensà, E., Latini, S., Ferracin, M., Salvioli, S., Garagnani, P., Franceschi, C. & Bonafè, M., Jan 8 2019, In : Cell Death and Differentiation. p. 1-14 14 p.

Research output: Contribution to journalArticle

Genomic Instability
Interferon Type I
Anti-Inflammatory Agents
Up-Regulation
DNA Damage

Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO)

Biver, E., Berenbaum, F., Valdes, A. M., Araujo de Carvalho, I., Bindels, L. B., Brandi, M. L., Calder, P. C., Castronovo, V., Cavalier, E., Cherubini, A., Cooper, C., Dennison, E., Franceschi, C., Fuggle, N., Laslop, A., Miossec, P., Thomas, T., Tuzun, S., Veronese, N., Vlaskovska, M. & 2 others, Reginster, J. Y. & Rizzoli, R., Nov 1 2019, In : Ageing Research Reviews. 55, 100946.

Research output: Contribution to journalReview article

Open Access
Musculoskeletal Diseases
Nutrition
Metabolites
Metabolism
Sugars
7 Citations (Scopus)

Heterogeneity of Thyroid Function and Impact of Peripheral Thyroxine Deiodination in Centenarians and Semi-Supercentenarians: Association With Functional Status and Mortality

Ostan, R., Monti, D., Mari, D., Arosio, B., Gentilini, D., Ferri, E., Passarino, G., De Rango, F., D'Aquila, P., Mariotti, S., Pasquali, R., Fanelli, F., Bucci, L., Franceschi, C. & Vitale, G., May 16 2019, In : The journals of gerontology. Series A, Biological sciences and medical sciences. 74, 6, p. 802-810 9 p.

Research output: Contribution to journalArticle

Open Access
Euthyroid Sick Syndromes
Thyrotropin
Thyroxine
Thyroid Gland
Mortality
6 Citations (Scopus)

Human aging and longevity are characterized by high levels of mitokines

Conte, M., Ostan, R., Fabbri, C., Santoro, A., Guidarelli, G., Vitale, G., Mari, D., Sevini, F., Capri, M., Sandri, M., Monti, D., Franceschi, C. & Salvioli, S., May 1 2019, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, 5, p. 600-607 8 p.

Research output: Contribution to journalArticle

Open Access
Growth Differentiation Factor 15
Down Syndrome
Health Status
Insulin Resistance
Siblings
1 Citation (Scopus)

Recovery from 6-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting

Capri, M., Morsiani, C., Santoro, A., Moriggi, M., Conte, M., Martucci, M., Bellavista, E., Fabbri, C., Giampieri, E., Albracht, K., Flück, M., Ruoss, S., Brocca, L., Canepari, M., Longa, E., Di Giulio, I., Bottinelli, R., Cerretelli, P., Salvioli, S., Gelfi, C. & 3 others, Franceschi, C., Narici, M. & Rittweger, J., Apr 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 4, p. 5168-5180 13 p.

Research output: Contribution to journalArticle

Open Access
Space Flight
Space stations
Muscle
MicroRNAs
Recovery

Regulatory T cells from patients with end-stage organ disease can be isolated, expanded and cryopreserved according good manufacturing practice improving their function

Ulbar, F., Montemurro, T., Jofra, T., Capri, M., Comai, G., Bertuzzo, V., Lavazza, C., Mandelli, A., Viganò, M., Budelli, S., Bacalini, M. G., Pirazzini, C., Garagnani, P., Giudice, V., Sollazzo, D., Curti, A., Arpinati, M., La Manna, G., Cescon, M., Pinna, A. D. & 5 others, Franceschi, C., Battaglia, M., Giordano, R., Catani, L. & Lemoli, R. M., Aug 5 2019, In : Journal of Translational Medicine. 17, 1, 250.

Research output: Contribution to journalArticle

Open Access
T-cells
Regulatory T-Lymphocytes
Adoptive Immunotherapy
Liver
Transplantation (surgical)
2 Citations (Scopus)

The Aging Thyroid: A Reappraisal Within the Geroscience Integrated Perspective

Franceschi, C., Ostan, R., Mariotti, S., Monti, D. & Vitale, G., May 10 2019, In : Endocrine Reviews. 40, 5, p. 1250-1270 21 p.

Research output: Contribution to journalReview article

Thyroid Gland
Epigenomics
Stem Cells
Mitochondrial Degradation
Dysbiosis
2018

A Cross-Sectional Analysis of Body Composition Among Healthy Elderly From the European NU-AGE Study: Sex and Country Specific Features

Santoro, A., Bazzocchi, A., Guidarelli, G., Ostan, R., Giampieri, E., Mercatelli, D., Scurti, M., Berendsen, A., Surala, O., Jennings, A., Meunier, N., Caumon, E., Gillings, R., Kadi, F., Capel, F., Cashman, K. D., Pietruszka, B., Feskens, E. J. M., De Groot, L. C. P. G. M., Battista, G. & 2 others, Salvioli, S. & Franceschi, C., Nov 30 2018, In : Frontiers in Physiology. 9, p. 1-16 16 p.

Research output: Contribution to journalArticle

Body Composition
Cross-Sectional Studies
Fats
Photon Absorptiometry
Physical Phenomena

A Mediterranean-like dietary pattern with vitamin D3 (10 µg/d) supplements reduced the rate of bone loss in older Europeans with osteoporosis at baseline: results of a 1-y randomized controlled trial

Jennings, A., Cashman, K. D., Gillings, R., Cassidy, A., Tang, J., Fraser, W., Dowling, K. G., Hull, G. L. J., Berendsen, A. A. M., de Groot, L. C. P. G. M., Pietruszka, B., Wierzbicka, E., Ostan, R., Bazzocchi, A., Battista, G., Caumon, E., Meunier, N., Malpuech-Brugère, C., Franceschi, C., Santoro, A. & 1 others, Fairweather-Tait, S. J., Sep 1 2018, In : American Journal of Clinical Nutrition. 108, 3, p. 633–640 8 p.

Research output: Contribution to journalArticle

Cholecalciferol
Mediterranean Diet
Bone Density
Osteoporosis
Randomized Controlled Trials
5 Citations (Scopus)

Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE study

Rietman, M. L., Spijkerman, A. M. W., Wong, A., van Steeg, H., Bürkle, A., Moreno-Villanueva, M., Sindlinger, T., Franceschi, C., Grubeck-Loebenstein, B., Bernhardt, J., Slagboom, P. E., Toussaint, O., Debacq-Chainiaux, F., Sikora, E., Gonos, E. S., Breusing, N., Stuetz, W., Weber, D., Grune, T., Basso, A. & 6 others, Piacenza, F., Malavolta, M., Collino, S., Jansen, E. H. J. M., Verschuren, W. M. M. & Dollé, M. E. T., Apr 30 2018, In : Mechanisms of Ageing and Development. 177, p. 135-143 9 p.

Research output: Contribution to journalArticle

Antioxidants
Biomarkers
Psychology
Health
Carotenoids
1 Citation (Scopus)

Evaluation of lymphocyte response to the induced oxidative stress in a cohort of ageing subjects, including semisupercentenarians and their offspring

Sizzano, F., Collino, S., Cominetti, O., Monti, D., Garagnani, P., Ostan, R., Pirazzini, C., Bacalini, M. G., Mari, D., Passarino, G., Franceschi, C. & Palini, A., Jan 1 2018, In : Mediators of Inflammation. 2018, 7109312.

Research output: Contribution to journalArticle

Oxidative Stress
Lymphocytes
Reactive Oxygen Species
Lymphocyte Subsets
Nucleic Acids
5 Citations (Scopus)

Genes associated with Type 2 Diabetes and vascular complications

Montesanto, A., Bonfigli, A. R., Crocco, P., Garagnani, P., De Luca, M., Boemi, M., Marasco, E., Pirazzini, C., Giuliani, C., Franceschi, C., Passarino, G., Testa, R., Olivieri, F. & Rose, G., Feb 1 2018, In : Aging. 10, 2, p. 178-196 19 p.

Research output: Contribution to journalArticle

Diabetes Complications
Type 2 Diabetes Mellitus
Blood Vessels
Genes
Single Nucleotide Polymorphism
3 Citations (Scopus)

Impact of demography and population dynamics on the genetic architecture of human longevity

Giuliani, C., Sazzini, M., Pirazzini, C., Bacalini, M. G., Marasco, E., Gnecchi-Ruscone, G. A., Fang, F., Sarno, S., Gentilini, D., Di Blasio, A. M., Crocco, P., Passarino, G., Mari, D., Monti, D., Nacmias, B., Sorbi, S., Salvarani, C., Catanoso, M., Pettener, D., Luiselli, D. & 4 others, Ukraintseva, S., Yashin, A., Franceschi, C. & Garagnani, P., Aug 1 2018, In : Aging. 10, 8, p. 1947-1963 17 p.

Research output: Contribution to journalArticle

Medical Genetics
Population Dynamics
Demography
Italy
Population

Impact of demography and population dynamics on the genetic architecture of human longevity

Giuliani, C., Sazzini, M., Pirazzini, C., Bacalini, M. G., Marasco, E., Gnecchi-Ruscone, G. A., Fang, F., Sarno, S., Gentilini, D., Di Blasio, A. M., Crocco, P., Passarino, G., Mari, D., Monti, D., Nacmias, B., Sorbi, S., Salvarani, C., Catanoso, M., Pettener, D., Luiselli, D. & 4 others, Ukraintseva, S., Yashin, A., Franceschi, C. & Garagnani, P., 2018, In : Aging. 10, 8, p. 1947-1963 17 p.

Research output: Contribution to journalArticle

Impact of demography and population dynamics on the genetic architecture of human longevity

Giuliani, C., Sazzini, M., Pirazzini, C., Bacalini, M. G., Marasco, E., Gnecchi-Ruscone, G. A., Fang, F., Sarno, S., Gentilini, D., Di Blasio, A. M., Crocco, P., Passarino, G., Mari, D., Monti, D., Nacmias, B., Sorbi, S., Salvarani, C., Catanoso, M., Pettener, D., Luiselli, D. & 4 others, Ukraintseva, S., Yashin, A., Franceschi, C. & Garagnani, P., 2018, In : Aging. 10, 8, p. 1947-1963 17 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Inflammaging 2018: An update and a model

Franceschi, C., Zaikin, A., Gordleeva, S., Ivanchenko, M., Bonifazi, F., Storci, G. & Bonafe, M., Dec 1 2018, In : Seminars in Immunology. 40, p. 1-5 5 p.

Research output: Contribution to journalEditorial

1 Citation (Scopus)

Responders and non-responders to influenza vaccination: A DNA methylation approach on blood cells

Gensous, N., Franceschi, C., Blomberg, B. B., Pirazzini, C., Ravaioli, F., Gentilini, D., Di Blasio, A. M., Garagnani, P., Frasca, D. & Bacalini, M. G., May 1 2018, In : Experimental Gerontology. 105, p. 94-100 7 p.

Research output: Contribution to journalArticle

DNA Methylation
Human Influenza
Blood Cells
Vaccination
Blood

Sex-Specific Associations of Blood-Based Nutrient Profiling With Body Composition in the Elderly

Konz, T., Santoro, A., Goulet, L., Bazzocchi, A., Battista, G., Nicoletti, C., Kadi, F., Ostan, R., Goy, M., Monnard, C., Martin, F-P., Feige, J. N., Franceschi, C. & Rezzi, S., 2018, In : Frontiers in Physiology. 9, p. 1935

Research output: Contribution to journalArticle

Body Composition
Food
Skeletal Muscle
Folic Acid
Sulfur
8 Citations (Scopus)

The Prognostic Roles of Gender and O6-Methylguanine-DNA Methyltransferase Methylation Status in Glioblastoma Patients: The Female Power

PERNO Study Group, Apr 1 2018, In : World Neurosurgery. 112, p. e342-e347

Research output: Contribution to journalArticle

Methyltransferases
DNA Methylation
Glioblastoma
Karnofsky Performance Status
Survival
2017
23 Citations (Scopus)

Acceleration of leukocytes' epigenetic age as an early tumorand sex-specific marker of breast and colorectal cancer

Durso, D. F., Bacalini, M. G., Sala, C., Pirazzini, C., Marasco, E., Bonafé, M., do Valle, Í. F., Gentilini, D., Castellani, G., Faria, A. M. C., Franceschi, C., Garagnani, P. & Nardini, C., Jan 1 2017, In : Oncotarget. 8, 14, p. 23237-23245 9 p.

Research output: Contribution to journalArticle

Epigenomics
Colorectal Neoplasms
Leukocytes
Breast Neoplasms
DNA Methylation
97 Citations (Scopus)

Age-Associated Loss of OPA1 in Muscle Impacts Muscle Mass, Metabolic Homeostasis, Systemic Inflammation, and Epithelial Senescence

Tezze, C., Romanello, V., Desbats, M. A., Fadini, G. P., Albiero, M., Favaro, G., Ciciliot, S., Soriano, M. E., Morbidoni, V., Cerqua, C., Loefler, S., Kern, H., Franceschi, C., Salvioli, S., Conte, M., Blaauw, B., Zampieri, S., Salviati, L., Scorrano, L. & Sandri, M., Jun 6 2017, In : Cell Metabolism. 25, 6, p. 1374-1389.e6

Research output: Contribution to journalArticle

Autosomal Dominant Optic Atrophy
Homeostasis
Inflammation
Muscles
Premature Mortality
11 Citations (Scopus)

Centenarians as extreme phenotypes: An ecological perspective to get insight into the relationship between the genetics of longevity and age-associated diseases

Giuliani, C., Pirazzini, C., Delledonne, M., Xumerle, L., Descombes, P., Marquis, J., Mengozzi, G., Monti, D., Bellizzi, D., Passarino, G., Luiselli, D., Franceschi, C. & Garagnani, P., Jul 1 2017, In : Mechanisms of Ageing and Development. 165, p. 195-201 7 p.

Research output: Contribution to journalReview article

Phenotype
Population Genetics
Genetic Association Studies
Genes
Genome
10 Citations (Scopus)

Cognitive status in the oldest old and centenarians: a condition crucial for quality of life methodologically difficult to assess

Arosio, B., Ostan, R., Mari, D., Damanti, S., Ronchetti, F., Arcudi, S., Scurti, M., Franceschi, C. & Monti, D., Jul 1 2017, In : Mechanisms of Ageing and Development. 165, p. 185-194 10 p.

Research output: Contribution to journalReview article

Quality of Life
Dementia
Aptitude
Life Expectancy
Cognition
10 Citations (Scopus)

Cognitive status in the oldest old and centenarians: a condition crucial for quality of life methodologically difficult to assess

Arosio, B., Ostan, R., Mari, D., Damanti, S., Ronchetti, F., Arcudi, S., Scurti, M., Monti, D. & Franceschi, C., 2017, In : Mechanisms of Ageing and Development. 165, PtB, p. 185-194 10 p.

Research output: Contribution to journalArticle

Correction to: Which elderly newly diagnosed glioblastoma patients can benefit from radiotherapy and temozolomide? A PERNO prospective study

Franceschi, E., Depenni, R., Paccapelo, A., Ermani, M., Faedi, M., Sturiale, C., Michiara, M., Servadei, F., Pavesi, G., Urbini, B., Pisanello, A., Crisi, G., Baruzzi, A., Baruzzi, A., Albani, F., Michelucci, R., Cavallo, M., Tosoni, A., Cavallo, M., Valentini, A. & 31 others, Pisanello, A., Testoni, S., Agati, R., Bacci, A., Baldin, E., Barbieri, E., Bisulli, F., Carelli, V., Crisci, M., de Biase, D., Franceschi, C., Leonardi, M., Marucci, G., Morandi, L., Mostacci, B., Palandri, G., Pasini, E., Riguzzi, P., Tinuper, P., Gentili, G., Faedi, M., Zumaglini, F., Amadori, A., Bertolini, F., Pinna, G., Ragazzi, M., Rizzi, R., Seraceni, S., Giorgi, C., Montanari, E. & The Perno Study Group, Nov 9 2017, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-2 2 p.

Research output: Contribution to journalArticle

temozolomide
Glioblastoma
Radiotherapy
Prospective Studies
Publications
4 Citations (Scopus)

DNA hydroxymethylation levels are altered in blood cells from Down syndrome persons enrolled in the MARK-AGE project

Ciccarone, F., Valentini, E., Malavolta, M., Zampieri, M., Bacalini, M. G., Calabrese, R., Guastafierro, T., Reale, A., Franceschi, C., Capri, M., Breusing, N., Grune, T., Moreno-Villanueva, M., Bürkle, A. & Caiafa, P., Oct 21 2017, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences.

Research output: Contribution to journalArticle

Down Syndrome
Blood Cells
DNA
DNA Methylation
Dioxygenases
13 Citations (Scopus)

Epigenome-wide association study in hepatocellular carcinoma: Identification of stochastic epigenetic mutations through an innovative statistical approach

Gentilini, D., Scala, S., Gaudenzi, G., Garagnani, P., Capri, M., Cescon, M., Grazi, G. L., Bacalini, M. G., Pisoni, S., Dicitore, A., Circelli, L., Santagata, S., Izzo, F., Di Blasio, A. M., Persani, L., Franceschi, C. & Vitale, G., Jun 27 2017, In : Oncotarget. 8, 26, p. 41890-41902 13 p.

Research output: Contribution to journalArticle

Epigenomics
Hepatocellular Carcinoma
Mutation
DNA Methylation
Neoplasms
13 Citations (Scopus)

Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome

Guastafierro, T., Bacalini, M. G., Marcoccia, A., Gentilini, D., Pisoni, S., Di Blasio, A. M., Corsi, A., Franceschi, C., Raimondo, D., Spanò, A., Garagnani, P. & Bondanini, F., Aug 30 2017, In : Clinical Epigenetics. 9, 1, 92.

Research output: Contribution to journalArticle

Werner Syndrome
DNA Methylation
Blood Cells
Genome
Methylation
61 Citations (Scopus)

Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition

Calder, P. C., Bosco, N., Bourdet-Sicard, R., Capuron, L., Delzenne, N., Doré, J., Franceschi, C., Lehtinen, M. J., Recker, T., Salvioli, S. & Visioli, F., Nov 1 2017, In : Ageing Research Reviews. 40, p. 95-119 25 p.

Research output: Contribution to journalReview article

Nutrition
Aging of materials
Health
Inflammation
Tissue
11 Citations (Scopus)

Healthy ageing in 2016: Obesity in geroscience-is cellular senescence the culprit?

Franceschi, C., Feb 1 2017, In : Nature Reviews Endocrinology. 13, 2, p. 76-78 3 p.

Research output: Contribution to journalReview article

Identification of a T cell gene expression clock obtained by exploiting a MZ twin design

Remondini, D., Intrator, N., Sala, C., Pierini, M., Garagnani, P., Zironi, I., Franceschi, C., Salvioli, S. & Castellani, G., Dec 1 2017, In : Scientific Reports. 7, 1, 6005.

Research output: Contribution to journalArticle

T-Lymphocytes
Gene Expression
Genes
Monozygotic Twins
Muscle Cells
136 Citations (Scopus)

Inflammaging and 'Garb-aging'

Franceschi, C., Garagnani, P., Vitale, G., Capri, M. & Salvioli, S., 2017, In : Trends in Endocrinology and Metabolism. 28, 3, p. 199-212

Research output: Contribution to journalArticle

Garbage
Macrophages
Mitochondrial DNA
Mitochondrial Degradation
Inflammasomes
41 Citations (Scopus)

Inflammaging and human longevity in the omics era

Monti, D., Ostan, R., Borelli, V., Castellani, G. & Franceschi, C., 2017, In : Mechanisms of Ageing and Development. 26, 11, p. 1480-5

Research output: Contribution to journalArticle

Garbage
Anti-Inflammatory Agents
Glycomics
Invertebrates
Systems Analysis
136 Citations (Scopus)

Inflammaging and ‘Garb-aging’

Franceschi, C., Garagnani, P., Vitale, G., Capri, M. & Salvioli, S., 2017, In : Trends in Endocrinology and Metabolism. 28, 3, p. 199-212 14 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis

Gorini, F., Azzimonti, L., Delfanti, G., Scarfò, L., Scielzo, C., Bertilaccio, MT., Ranghetti, P., Gulino, A., Doglioni, C., Di Napoli, A., Capri, M., Franceschi, C., Caligaris-Cappio, F., Ghia, P., Bellone, M., Dellabona, P., Casorati, G. & De Lalla, C., 2017, In : Blood. 129, 26, p. 3440-3451 12 p.

Research output: Contribution to journalArticle

Natural Killer T-Cells
T-cells
B-Cell Chronic Lymphocytic Leukemia
Disease Progression
Lymphocytes
9 Citations (Scopus)

Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing

Cenni, V., D'Apice, M. R., Garagnani, P., Columbaro, M., Novelli, G., Franceschi, C. & Lattanzi, G., Dec 2017, In : Ageing Research Reviews. 42, p. 1-13 13 p.

Research output: Contribution to journalReview article

Premature Aging
Aging of materials
Mutation
Chromatin
DNA Polymerase III
20 Citations (Scopus)

Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process

Bacalini, M. G., Deelen, J., Pirazzini, C., De Cecco, M., Giuliani, C., Lanzarini, C., Ravaioli, F., Marasco, E., Van Heemst, D., Suchiman, H. E. D., Slieker, R., Giampieri, E., Recchioni, R., Marcheselli, F., Salvioli, S., Vitale, G., Olivieri, F., Spijkerman, A. M. W., Dollé, M. E. T., Sedivy, J. M. & 4 others, Castellani, G., Franceschi, C., Slagboom, P. E. & Garagnani, P., Aug 2017, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 72, 8, p. 1015-1023 9 p.

Research output: Contribution to journalArticle

Methylation
DNA
Epigenomics
Genes
CpG Islands
20 Citations (Scopus)

Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and in Vitro Evidences of a Cell Replication Process

Bacalini, M. G., Deelen, J., Pirazzini, C., De Cecco, M., Giuliani, C., Lanzarini, C., Ravaioli, F., Marasco, E., Van Heemst, D., Suchiman, H. E. D., Slieker, R., Giampieri, E., Recchioni, R., Marcheselli, F., Salvioli, S., Vitale, G., Olivieri, F., Spijkerman, A. M. W., DollCrossed, M. E. T., Sedivy, J. M. & 4 others, Castellani, G., Franceschi, C., Slagboom, P. E. & Garagnani, P., 2017, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 72, 8, p. 1015-1023 9 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

The methylation of nuclear and mitochondrial DNA in ageing phenotypes and longevity

Bacalini, M. G., D'Aquila, P., Marasco, E., Nardini, C., Montesanto, A., Franceschi, C., Passarino, G., Garagnani, P. & Bellizzi, D., 2017, In : Mechanisms of Ageing and Development. 165, Pt B, p. 156-61

Research output: Contribution to journalArticle

Mitochondrial DNA
Epigenomics
Methylation
Phenotype
DNA Methylation
1 Citation (Scopus)

Zinc-induced Metallothionein in centenarian offspring from a large European population: the MARK-AGE Project

Giacconi, R., Costarelli, L., Piacenza, F., Basso, A., Bürkle, A., Moreno-Villanueva, M., Grune, T., Weber, D., Stuetz, W., Gonos, E. S., Schön, C., Grubeck-Loebenstein, B., Sikora, E., Toussaint, O., Debacq-Chainiaux, F., Franceschi, C., Hervonen, A., Slagboom, E., Ciccarone, F., Zampieri, M. & 6 others, Caiafa, P., Jansen, E., Dollé, M. E. T., Breusing, N., Mocchegiani, E. & Malavolta, M., Oct 17 2017, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences.

Research output: Contribution to journalArticle

Metallothionein
Zinc
Population
Blood Cells
Homeostasis
2016

Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study

Ciccarone, F., Malavolta, M., Calabrese, R., Guastafierro, T., Bacalini, M. G., Reale, A., Franceschi, C., Capri, M., Hervonen, A., Hurme, M., Grubeck-Loebenstein, B., Koller, B., Bernhardt, J., Schӧn, C., Slagboom, P. E., Toussaint, O., Sikora, E., Gonos, E. S., Breusing, N., Grune, T. & 7 others, Jansen, E. H. J. M., Dollé, M., Moreno-Villanueva, M., Sindlinger, T., Bürkle, A., Zampieri, M. & Caiafa, P., Aug 1 2016, In : Aging Cell. 15, 4, p. 755-765 11 p.

Research output: Contribution to journalArticle

Methyltransferases
DNA
Feeding Behavior
DNA Methylation
Epigenomics

Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARKAGE Study

Valentini, E., Zampieri, M., Malavolta, M., Bacalini, M. G., Calabrese, R., Guastafierro, T., Reale, A., Franceschi, C., Hervonen, A., Koller, B., Bernhardt, J., Eline Slagboom, P., Toussaint, O., Sikora, E., Gonos, E. S., Breusing, N., Grune, T., Jansen, E., Dollé, M. E. T., Moreno-Villanueva, M. & 4 others, Sindlinger, T., Bürkle, A., Ciccarone, F. & Caiafa, P., 2016, In : Aging. 8, 9, p. 1896-1922 27 p.

Research output: Contribution to journalArticle

5-Methylcytosine
Thymine DNA Glycosylase
DNA
DNA Methylation
Blood Cells
5 Citations (Scopus)

Ancient pathogen-driven adaptation triggers increased susceptibility to nonceliac wheat sensitivity in present-day European populations

Sazzini, M., De Fanti, S., Cherubini, A., Quagliariello, A., Profiti, G., Martelli, P. L., Casadio, R., Ricci, C., Campieri, M., Lanzini, A., Volta, U., Caio, G., Franceschi, C., Spisni, E. & Luiselli, D., 2016, In : Genes and Nutrition. 11, 1

Research output: Contribution to journalArticle

Triticum
Haplotypes
Population
Genetic Selection
Chemokines

Centenarians' offspring as a model of healthy aging: a reappraisal of the data on Italian subjects and a comprehensive overview

Bucci, L., Ostan, R., Cevenini, E., Pini, E., Scurti, M., Vitale, G., Mari, D., Caruso, C., Sansoni, P., Fanelli, F., Pasquali, R., Gueresi, P., Franceschi, C. & Monti, D., Mar 2016, In : Aging. 8, 3, p. 510-9 10 p.

Research output: Contribution to journalArticle

Health Status
Intracranial Thrombosis
Adipokines
Health
Cerebral Hemorrhage

Centenarians' offspring as a model of healthy aging: a reappraisal of the data on Italian subjects and a comprehensive overview

Bucci, L., Ostan, R., Cevenini, E., Pini, E., Scurti, M., Vitale, G., Mari, D., Caruso, C., Sansoni, P., Fanelli, F., Pasquali, R., Gueresi, P., Franceschi, C. & Monti, D., 2016, In : Aging. 8, 3, p. 510-519 10 p.

Research output: Contribution to journalArticle

14 Citations (Scopus)

Complex interplay between neutral and adaptive evolution shaped differential genomic background and disease susceptibility along the Italian peninsula

Sazzini, M., Gnecchi Ruscone, G. A., Giuliani, C., Sarno, S., Quagliariello, A., De Fanti, S., Boattini, A., Gentilini, D., Fiorito, G., Catanoso, M., Boiardi, L., Croci, S., Macchioni, P., Mantovani, V., Di Blasio, A. M., Matullo, G., Salvarani, C., Franceschi, C., Pettener, D., Garagnani, P. & 1 others, Luiselli, D., Sep 1 2016, In : Scientific Reports. 6, 32513.

Research output: Contribution to journalArticle

disease resistance
genomics
population structure
natural history
noninsulin-dependent diabetes mellitus

Complex interplay between neutral and adaptive evolution shaped differential genomic background and disease susceptibility along the Italian peninsula

Sazzini, M., Gnecchi Ruscone, G. A., Giuliani, C., Sarno, S., Quagliariello, A., De Fanti, S., Boattini, A., Gentilini, D., Fiorito, G., Catanoso, M. G., Boiardi, L., Croci, S., Macchioni, P., Mantovani, W., Di Blasio, A. M., Matullo, G., Salvarani, C., Franceschi, C., Pettener, D., Garagnani, P. & 1 others, Luiselli, D., Sep 1 2016, In : Scientific Reports. 6, 32513.

Research output: Contribution to journalArticle

disease resistance
genomics
population structure
natural history
noninsulin-dependent diabetes mellitus