1969 …2020

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2000

A cytofluorimetric study of T lymphocyte subsets in rat lymphoid tissues (thymus, lymph nodes) and peripheral blood: A continuous remodelling during the first year of life

Capri, M., Quaglino, D., Verzella, G., Monti, D., Bonafè, M., Cossarizza, A., Troiano, L., Zecca, L., Pasquali-Ronchetti, I. & Franceschi, C., Aug 1 2000, In : Experimental Gerontology. 35, 5, p. 613-625 13 p.

Research output: Contribution to journalArticle

Apoptosis induced by 2-chloro-adenosine and 2-chloro-2'-deoxy-adenosine in a human astrocytoma cell line: Differential mechanisms and possible clinical relevance

Ceruti, S., Franceschi, C., Barbieri, D., Malorni, W., Camurri, A., Giammarioli, A. M., Ambrosini, A., Racagni, G., Cattabeni, F. & Abbracchio, M. P., May 1 2000, In : Journal of Neuroscience Research. 60, 3, p. 388-400 13 p.

Research output: Contribution to journalArticle

Biology of ageing

Toussaint, O., Remacle, J., Clark, B. F. C., Gonos, E. S., Franceschi, C. & Kirkwood, T. B. L., 2000, In : BioEssays. 22, 10, p. 954-956 3 p.

Research output: Contribution to journalArticle

C3-fullero-tris-methanodicarboxylic acid protects cerebellar granule cells from apoptosis

Bisaglia, M., Natalini, B., Pellicciari, R., Straface, E., Malorni, W., Monti, D., Franceschi, C. & Schettini, G., 2000, In : Journal of Neurochemistry. 74, 3, p. 1197-1204 8 p.

Research output: Contribution to journalArticle

C60 carboxyfullerene exerts a protective activity against oxidative stress-induced apoptosis in human peripheral blood mononuclear cells

Monti, D., Moretti, L., Salvioli, S., Straface, E., Malorni, W., Pellicciari, R., Schettini, G., Bisaglia, M., Pincelli, C., Fumelli, C., Bonafè, M. & Franceschi, C., Nov 2 2000, In : Biochemical and Biophysical Research Communications. 277, 3, p. 711-717 7 p.

Research output: Contribution to journalArticle

Carboxyfullerenes protect human keratinocytes from ultraviolet-B-induced apoptosis

Fumelli, C., Marconi, A., Salvioli, S., Straface, E., Malorni, W., Offidani, A. M., Pellicciari, R., Schettini, G., Giannetti, A., Monti, D., Franceschi, C. & Pincelli, C., 2000, In : Journal of Investigative Dermatology. 115, 5, p. 835-841 7 p.

Research output: Contribution to journalArticle

Cellular resistance to homocysteine: A key for longevity? [1]

Mutus, B., Rabini, R. A., Franceschi, C., Paolisso, G., Rizzo, M. R., Ragno, E., Rappelli, A., Braconi, M. & Mazzanti, L., 2000, In : Atherosclerosis. 152, 2, p. 527-528 2 p.

Research output: Contribution to journalArticle

Cytoskeleton alterations of erythrocytes from patients with Fanconi's anemia

Malorni, W., Straface, E., Pagano, G., Monti, D., Zatterale, A., Del Principe, D., Deeva, I. B., Franceschi, C., Masella, R. & Korkina, L. G., Feb 25 2000, In : FEBS Letters. 468, 2-3, p. 125-128 4 p.

Research output: Contribution to journalArticle

Deregulation of the CD95/CD95L system in lymphocytes from patients with primary acute HIV infection

Cossarizza, A., Stent, G., Mussini, C., Paganelli, R., Borghi, V., Nuzzo, C., Pinti, M., Pedrazzi, J., Benatti, F., Esposito, R., Røsok, B., Nagata, S., Vella, S., Franceschi, C. & De Rienzo, B., 2000, In : AIDS (London, England). 14, 4, p. 345-355 11 p.

Research output: Contribution to journalArticle

Does a retrograde response in human aging and longevity exist?

De Benedictis, G., Carrieri, G., Garasto, S., Rose, G., Varcasia, O., Bonafè, M., Franceschi, C. & Jazwinski, S. M., 2000, In : Experimental Gerontology. 35, 6-7, p. 795-801 7 p.

Research output: Contribution to journalArticle

Do men and women follow different trajectories to reach extreme longevity?

Franceschi, C., Motta, L., Valensin, S., Rapisarda, R., Franzone, A., Berardelli, M., Motta, M., Monti, D., Bonafè, M., Ferrucci, L., Deiana, L., Pes, G. M., Carru, C., Desole, M. S., Barbi, C., Sartoni, G., Gemelli, C., Lescai, F., Olivieri, F., Marchegiani, F. & 18 others, Cardelli, M., Cavallone, L., Gueresi, P., Cossarizza, A., Troiano, L., Pini, G., Sansoni, P., Passeri, G., Lisa, R., Spazzafumo, L., Amadio, L., Giunta, S., Stecconi, R., Morresi, R., Viticchi, C., Mattace, R., De Benedictis, G. & Baggio, G., Apr 2000, In : Aging clinical and experimental research. 12, 2, p. 77-84 8 p.

Research output: Contribution to journalArticle

Erratum: Plasma antioxidants and longevity: A study on healthy centenarians (Free Radical Biology and Medicine (2000) 28 (1243-1248) PII: S089158490000246X)

Mecocci, P., Polidori, M. C., Troiano, L., Cherubini, A., Ceccheti, R., Pini, G., Straatman, M., Monti, D., Stahl, W., Sies, H., Franceschi, C. & Senin, U., Sep 1 2000, In : Free Radical Biology and Medicine. 29, 5, p. 486 1 p.

Research output: Contribution to journalArticle

Erythrocyte plasma membranes obtained from centenarians show different functional properties [7]

Mazzanti, L., Rabin, R. A., Petruzzi, E., Staffolani, R., Salvolini, E., Vignini, A., Braconi, M. & Franceschi, C., 2000, In : Journal of the American Geriatrics Society. 48, 3, p. 350-351 2 p.

Research output: Contribution to journalArticle

Evidence for an association between the SRD5A2 (type II steroid 5α-reductase) locus and prostate cancer in Italian patients

Margiotti, K., Sangiuolo, F., De Luca, A., Froio, F., Pearce, C. L., Ricci-Barbini, V., Micali, F., Bonafe, M., Franceschi, C., Dallapiccola, B., Novelli, G. & Reichardt, J. K. V., 2000, In : Disease Markers. 16, 3-4, p. 147-150 4 p.

Research output: Contribution to journalArticle

Fibroblast cultures from healthy centenarians have an active proteasome

Chondrogianni, N., Petropoulos, I., Franceschi, C., Friguet, B. & Gonos, E. S., 2000, In : Experimental Gerontology. 35, 6-7, p. 721-728 8 p.

Research output: Contribution to journalArticle

Gene polymorphism affecting α1-antichymotrypsin and interleukin-1 plasma levels increases Alzheimer's disease risk

Licastro, F., Pedrini, S., Ferri, C., Casadei, V., Govoni, M., Pession, A., Sciacca, F. L., Veglia, F., Annoni, G., Bonafè, M., Olivieri, F., Franceschi, C. & Grimaldi, L. M. E., 2000, In : Annals of Neurology. 48, 3, p. 388-391 4 p.

Research output: Contribution to journalArticle

Genes and longevity: Lessons from studies of centenarians

Yashin, A. I., De Benedictis, G., Vaupel, J. W., Tan, Q., Andreev, K. F., Iachine, I. A., Bonafe, M., Valensin, S., De Luca, M., Carotenuto, L. & Franceschi, C., Jul 2000, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 55, 7

Research output: Contribution to journalArticle

Genetic epidemiologic studies on age-specified traits

Bailey-Wilson, J., Baron, J., Cawthon, R., Christian, J. C., Corder, E. H., Franceschi, C., Kestenbaum, B., Kruglyak, L., Lauderdale, D. S., Lubitz, J., Martin, G. M., McClearn, G. E., McGue, M., Miles, T., Mineau, G., Ouellett, G., Pedersen, N. L., Preston, S. H., Page, W. F., Province, M. & 8 others, Schachter, F., Schork, N. J., Vaupel, J. W., Vijg, J., Wallace, R., Wang, E., Wijsman, E. M. & Hadley, E., Dec 1 2000, In : American Journal of Epidemiology. 152, 11, p. 1003-1008 6 p.

Research output: Contribution to journalArticle

Hemopoiesis in healthy old people and centenarians: Well-maintained responsiveness of CD34+ cells to hemopoietic growth factors and remodeling of cytokine network

Bagnara, G. P., Bonsi, L., Strippoli, P., Bonifazi, F., Tonelli, R., D'Addato, S., Paganelli, R., Scala, E., Fagiolo, U., Monti, D., Cossarizza, A., Bonafé, M. & Franceschi, C., Feb 2000, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 55, 2

Research output: Contribution to journalArticle

HLA, aging, and longevity: A critical reappraisal

Caruso, C., Candore, G., Colonna Romano, G., Lio, D., Bonafè, M., Valensin, S. & Franceschi, C., 2000, In : Human Immunology. 61, 9, p. 942-949 8 p.

Research output: Contribution to journalArticle

Human immunosenescence: The prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space

Franceschi, C., Bonafè, M. & Valensin, S., Feb 25 2000, In : Vaccine. 18, 16, p. 1717-1720 4 p.

Research output: Contribution to journalArticle

Inflamm-aging. An evolutionary perspective on immunosenescence

Franceschi, C., Bonafè, M., Valensin, S., Olivieri, F., De Luca, M., Ottaviani, E. & De Benedictis, G., 2000, In : Annals of the New York Academy of Sciences. 908, p. 244-254 11 p.

Research output: Contribution to journalArticle

Inherited variability of the mitochondrial genome and successful aging in humans

De Benedictis, G., Carrieri, G., Varcasia, O., Bonafè, M. & Franceschi, C., 2000, In : Annals of the New York Academy of Sciences. 908, p. 208-218 11 p.

Research output: Contribution to journalArticle

Involvement of Ets transcription factors and targets in osteoblast differentiation and matrix mineralization

Vary, C. P. H., Li, V., Raouf, A., Kitching, R., Kola, I., Franceschi, C., Venanzoni, M. & Seth, A., May 25 2000, In : Experimental Cell Research. 257, 1, p. 213-222 10 p.

Research output: Contribution to journalArticle

Metabolic age modelling: The lesson from centenarians

Paolisso, G., Barbieri, M., Bonafè, M. & Franceschi, C., 2000, In : European Journal of Clinical Investigation. 30, 10, p. 888-894 7 p.

Research output: Contribution to journalArticle

Mitochondrial heterogeneity during staurosporine-induced apoptosis in HL60 cells: Analysis at the single cell and single organelle level

Salvioli, S., Dobrucki, J., Moretti, L., Troiano, L., Fernandez, M. G., Pinti, M., Pedrazzi, J., Franceschi, C. & Cossarizza, A., 2000, In : Cytometry. 40, 3, p. 189-197 9 p.

Research output: Contribution to journalArticle

Opposite role of changes in mitochondrial membrane potential in different apoptotic processes

Salvioli, S., Barbi, C., Dobrucki, J., Moretti, L., Pinti, M., Pedrazzi, J., Pazienza, T. L., Bobyleva, V., Franceschi, C. & Cossarizza, A., Mar 10 2000, In : FEBS Letters. 469, 2-3, p. 186-190 5 p.

Research output: Contribution to journalArticle

Plasma antioxidants and longevity: A study on healthy centenarians

Mecocci, P., Polidori, M. C., Troiano, L., Cherubini, A., Cecchetti, R., Pini, G., Straatman, M., Monti, D., Stahl, W., Sies, H., Franceschi, C. & Senin, U., Apr 15 2000, In : Free Radical Biology and Medicine. 28, 8, p. 1243-1248 6 p.

Research output: Contribution to journalArticle

Shortage of circulating naive CD8+ T cells provides new insights on immunodeficiency in aging

Fagnoni, F. F., Vescovini, R., Passeri, G., Bologna, G., Pedrazzoni, M., Lavagetto, G., Casti, A., Franceschi, C., Passeri, M. & Sansoni, P., May 1 2000, In : Blood. 95, 9, p. 2860-2868 9 p.

Research output: Contribution to journalArticle

Spectrin changes occur in erythrocytes from patients with Fanconi's anemia and their parents

Straface, E., Masella, R., Principe, D. D., Franceschi, C., Korkina, L. G., Zatterale, A., Pagano, G. & Malorni, W., Jul 14 2000, In : Biochemical and Biophysical Research Communications. 273, 3, p. 899-901 3 p.

Research output: Contribution to journalArticle

The network and the remodeling theories of aging: Historical background and new perspectives

Franceschi, C., Valensin, S., Bonafè, M., Paolisso, G., Yashin, A. I., Monti, D. & De Benedictis, G., 2000, In : Experimental Gerontology. 35, 6-7, p. 879-896 18 p.

Research output: Contribution to journalArticle

Transformation of beta-amyloid (Aβ) (1-42) tyrosine to L-Dopa as the result of in vitro hydroxyl radical attack

Giunta, S., Ronchi, P., Valli, B., Franceschi, C. & Galeazzi, L., 2000, In : Amyloid. 7, 3, p. 189-193 5 p.

Research output: Contribution to journalArticle

2001

A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity

Bonafè, M., Olivieri, F., Cavallone, L., Giovagnetti, S., Marchegiani, F., Cardelli, M., Pieri, C., Marra, M., Antonicelli, R., Lisa, R., Rizzo, M. R., Paolisso, G., Monti, D. & Franceschi, C., 2001, In : European Journal of Immunology. 31, 8, p. 2357-2361 5 p.

Research output: Contribution to journalArticle

A logistic regression model for measuring gene-longevity associations

Tan, Q., Yashin, A. I., De Benedictis, G., Cintolesi, F., Rose, G., Bonafe, M., Franceschi, C., Vach, W. & Vaupel, J. W., 2001, In : Clinical Genetics. 60, 6, p. 463-469 7 p.

Research output: Contribution to journalArticle

A Mathematical Model for the Immunosenescence

Luciani, F., Turchetti, G., Franceschi, C. & Valensin, S., May 2001, In : Rivista di Biologia - Biology Forum. 94, 2, p. 305-318 14 p.

Research output: Contribution to journalArticle

A stochastic model for CD8+ T cell dynamics in human immunosenescence: Implications for survival and longevity

Luciani, F., Valensin, S., Vescovini, R., Sansoni, P., Fagnoni, F., Franceschi, C., Bonafè, M. & Turchetti, G., Dec 21 2001, In : Journal of Theoretical Biology. 213, 4, p. 587-597 11 p.

Research output: Contribution to journalArticle

BRCA1 gene sequence variation in centenarians

Vijg, J., Perls, T., Franceschi, C. & Van Orsouw, N. J., 2001, In : Annals of the New York Academy of Sciences. 928, p. 85-96 12 p.

Research output: Contribution to journalArticle

Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians

Gerli, R., Monti, D., Bistoni, O., M. Mazzone, A., Peri, G., Cossarizza, A., Di Gioacchino, M., E. F. Cesarotti, M., Doni, A., Mantovani, A., Franceschi, C. & Paganelli, R., Jan 20 2001, In : Mechanisms of Ageing and Development. 121, 1-3, p. 37-46 10 p.

Research output: Contribution to journalArticle

Decreased susceptibility to oxidative stress-induced apoptosis of peripheral blood mononuclear cells from healthy elderly and centenarians

Monti, D., Salvioli, S., Capri, M., Malorni, W., Straface, E., Cossarizza, A., Botti, B., Piacentini, M., Baggio, G., Barbi, C., Valensin, S., Bonafè, M. & Franceschi, C., Jan 20 2001, In : Mechanisms of Ageing and Development. 121, 1-3, p. 239-250 12 p.

Research output: Contribution to journalArticle

Elevated plasma homocysteine levels in centenarians are not associated with cognitive impairment

Ravaglia, G., Forti, P., Maioli, F., Vettori, C., Grossi, G., Mario Bargossi, A., Caldarera, M., Franceschi, C., Facchini, A., Mariani, E. & Cavalli, G., Jan 20 2001, In : Mechanisms of Ageing and Development. 121, 1-3, p. 251-261 11 p.

Research output: Contribution to journalArticle

Gut neuroendocrine cells: Relationship to the proliferative activity and apoptosis of mucous epitheliocytes in aging

Kvetnoy, I., Popuichiev, V., Mikhina, L., Anisimov, V., Yuzhakov, V., Konovalov, S., Pogudina, N., Franceschi, C., Piantanelli, L., Rossolini, G., Zaia, A., Kvetnaia, T., Hernandez-Yago, J. & Blesa, J. R., 2001, In : Neuroendocrinology Letters. 22, 5, p. 337-341 5 p.

Research output: Contribution to journalArticle

Have the oldest old adults ever been frail in the past? A hypothesis that explains modern trends in survival

Yashin, A. I., Ukraintseva, S. V., De Benedictis, G., Anisimov, V. N., Butov, A. A., Arbeev, K., Jdanov, D. A., Boiko, S. I., Begun, A. S., Bonafe, M. & Franceschi, C., 2001, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 56, 10

Research output: Contribution to journalArticle

Immunogenetics of longevity: HLA antigens in Italian Centenarians

Caruso, C., Candore, G., Romano, G. C., Balistreri, C. R., Ferlazzo, V., List, F., Lisa, R. M., Troiano, L., Franceschi, C. & Lio, D., 2001, In : European Journal of Immunogenetics. 28, 2, p. 281 1 p.

Research output: Contribution to journalArticle

Immunogenetics of longevity. Is major histocompatibility complex polymorphism relevant to the control of human longevity? A review of literature data

Caruso, C., Candore, G., Romano, G. C., Lio, D., Bonafè, M., Valensin, S. & Franceschi, C., Apr 30 2001, In : Mechanisms of Ageing and Development. 122, 5, p. 445-462 18 p.

Research output: Contribution to journalArticle

Increase of homozygosity in centenarians revealed by a new inter-Alu PCR technique

Bonafè, M., Cardelli, M., Marchegiani, F., Cavallone, L., Giovagnetti, S., Olivieri, F., Lisa, R., Pieri, C. & Franceschi, C., 2001, In : Experimental Gerontology. 36, 7, p. 1063-1073 11 p.

Research output: Contribution to journalArticle

Interleukin-10 (IL-10) genotype frequencies in Italian centenarians

Lio, D., Romano, G. C., Candore, G., Scola, L., Crivello, A., Lisa, R. M., Olivieri, F., Franceschi, C. & Caruso, C., 2001, In : European Journal of Immunogenetics. 28, 2, p. 236 1 p.

Research output: Contribution to journalArticle

Low insulin resistance and preserved β-cell function contribute to human longevity but are not associated with TH-INS genes

Paolisso, G., Barbieri, M., Rizzo, M. R., Carella, C., Rotondi, M., Bonafè, M., Franceschi, C., Rose, G. & De Benedictis, G., 2001, In : Experimental Gerontology. 37, 1, p. 149-156 8 p.

Research output: Contribution to journalArticle

Measuring the genetic influence in modulating the human life span: Gene-environment interaction and the sex-specific genetic effect

Tan, Q., De Benedictis, G., Yashin, A. I., Bonafe, M., DeLuca, M., Valensin, S., Vaupel, J. W. & Franceschi, C., 2001, In : Biogerontology. 2, 3, p. 141-153 13 p.

Research output: Contribution to journalArticle

Mitochondria, aging and longevity - A new perspective

Salvioli, S., Bonafè, M., Capri, M., Monti, D. & Franceschi, C., Mar 9 2001, In : FEBS Letters. 492, 1-2, p. 9-13 5 p.

Research output: Contribution to journalArticle

Mitochondrial DNA haplogroups and APOE4 allele are non-independent variables in sporadic Alzheimer's disease

Carrieri, G., Bonafè, M., De Luca, M., Rose, G., Varcasia, O., Bruni, A., Maletta, R., Nacmias, B., Sorbi, S., Corsonello, F., Feraco, E., Andreev, K. F., Yashin, A. I., Franceschi, C. & De Benedictis, G., 2001, In : Human Genetics. 108, 3, p. 194-198 5 p.

Research output: Contribution to journalArticle