1969 …2020

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2001

Neuroinflammation and the genetics of Alzheimer's disease: The search for a pro-inflammatory phenotype

Franceschi, C., Valensin, S., Lescai, F., Olivieri, F., Licastro, F., Grimaldi, L. M. E., Monti, D., De Benedictis, G. & Bonafè, M., 2001, In : Aging clinical and experimental research. 13, 3, p. 163-170 8 p.

Research output: Contribution to journalArticle

Paradoxes in longevity: Sequence analysis of mtDNA haplogroup J in centenarians

Rose, G., Passarino, G., Carrieri, G., Altomare, K., Greco, V., Bertolini, S., Bonafè, M., Franceschi, C. & De Benedictis, G., 2001, In : European Journal of Human Genetics. 9, 9, p. 701-707 7 p.

Research output: Contribution to journalArticle

Polymorphisms of drug-metabolizing enzymes in healthy nonagenarians and centenarians: Difference at GSTT1 locus

Taioli, E., Mari, D., Franceschi, C., Bonafè, M., Monti, D., Bertolini, S., Marinelli, D. & Garte, S., 2001, In : Biochemical and Biophysical Research Communications. 280, 5, p. 1389-1392 4 p.

Research output: Contribution to journalArticle

Recent advances in human gene-longevity association studies

De Benedictis, G., Tan, Q., Jeune, B., Christensen, K., Ukraintseva, S. V., Bonafè, M., Franceschi, C., Vaupel, J. W. & Yashin, A. I., Jul 15 2001, In : Mechanisms of Ageing and Development. 122, 9, p. 909-920 12 p.

Research output: Contribution to journalArticle

Replication studies in longevity: Puzzling findings in Danish centenarians at the 3′ APOB-VNTR locus

Varcasia, O., Garasto, S., Rizza, T., Andersen-Ranberg, K., Jeune, B., Bathum, L., Andreev, K., Tan, Q., Yashin, A. I., Bonafè, M., Franceschi, C. & De Benedictis, G., 2001, In : Annals of Human Genetics. 65, 4, p. 371-376 6 p.

Research output: Contribution to journalArticle

Sex-specific longevity associations defined by Tyrosine Hydroxylase-Insulin-Insulin Growth Factor 2 haplotypes on the 11p15.5 chromosomal region

De Luca, M., Rose, G., Bonafè, M., Garasto, S., Greco, V., Weir, B. S., Franceschi, C. & De Benedictis, G., 2001, In : Experimental Gerontology. 36, 10, p. 1663-1671 9 p.

Research output: Contribution to journalArticle

TCR Vβ repertoire in an Italian longeval population including centenarians

Pennesi, G., Morellini, M., Lulli, P., Cappellacci, S., Brioli, G., Franceschi, C. & Trabace, S., 2001, In : Age. 24, 2, p. 63-70 8 p.

Research output: Contribution to journalArticle

The BB-paraoxonase genotype is associated with impaired brachial reactivity after acute hypertriglyceridemia in healthy subjects

Paolisso, G., Manzella, D., Tagliamonte, M. R., Barbieri, M., Marfella, R., Zito, G., Bonafè, M., Giugliano, D., Franceschi, C. & Varricchio, M., 2001, In : Journal of Clinical Endocrinology and Metabolism. 86, 3, p. 1078-1082 5 p.

Research output: Contribution to journalArticle

The effect of light regimen and melatonin on the development of spontaneous mammary tumors in HER-2/neu transgenic mice is related to a downregulation of HER-2/neu gene expression

Baturin, D. A., Alimova, I. N., Anisimov, V. N., Popovich, I. G., Zabezhinski, M. A., Provinciali, M., Mancini, R. & Franceschi, C., 2001, In : Neuroendocrinology Letters. 22, 6, p. 441-447 7 p.

Research output: Contribution to journalArticle

The unexpected contribution of immunosenescence to the leveling off of cancer incidence and mortality in the oldest old

Bonafè, M., Valensin, S., Gianni, W., Marigliano, V. & Franceschi, C., 2001, In : Critical Reviews in Oncology/Hematology. 39, 3, p. 227-233 7 p.

Research output: Contribution to journalArticle

Y chromosome binary markers to study the high prevalence of males in Sardinian centenarians and the genetic structure of the Sardinian population

Passarino, G., Underhill, P. A., Cavalli-Sforza, L. L., Semino, O., Pes, G. M., Carru, C., Ferrucci, L., Bonafè, M., Franceschi, C., Deiana, L., Baggio, G. & De Benedictis, G., 2001, In : Human Heredity. 52, 3, p. 136-139 4 p.

Research output: Contribution to journalArticle

2002

A centenarian-only approach for assessing gene - Gene interaction in human longevity

Tan, Q., De Benedictis, G., Ukraintseva, S. V., Franceschi, C., Vaupel, J. W. & Yashin, A. I., 2002, In : European Journal of Human Genetics. 10, 2, p. 119-124 6 p.

Research output: Contribution to journalArticle

Age dependent impact of LMP polymorphisms on TNFα-induced apoptosis in human peripheral blood mononuclear cells

Mishto, M., Bonafè, M., Salvioli, S., Olivieri, F. & Franceschi, C., Jan 3 2002, In : Experimental Gerontology. 37, 2-3, p. 301-308 8 p.

Research output: Contribution to journalArticle

Allele frequencies of +874T → A single nucleotide polymorphism at the first intron of interferon-γ gene in a group of Italian centenarians

Lio, D., Scola, L., Crivello, A., Bonafè, M., Franceschi, C., Olivieri, F., Colonna-Romano, G., Candore, G. & Caruso, C., Jan 3 2002, In : Experimental Gerontology. 37, 2-3, p. 315-319 5 p.

Research output: Contribution to journalArticle

An allele of HRAS1 3′variable number of tandem repeats is a frailty allele: Implication for an evolutionarily-conserved pathway involved in longevity

Bonafè, M., Barbi, C., Olivieri, F., Yashin, A., Andreev, K. F., Vaupel, J. W., De Benedictis, G., Rose, G., Carrieri, G., Jazwinski, S. M. & Franceschi, C., Mar 6 2002, In : Gene. 286, 1, p. 121-126 6 p.

Research output: Contribution to journalArticle

Association between the MHC class I gene HFE polymorphisms and longevity: A study in Sicilian population

Lio, D., Balistreri, C. R., Colonna-Romano, G., Motta, M., Franceschi, C., Malaguarnera, M., Candore, G. & Caruso, C., Feb 2002, In : Genes and Immunity. 3, 1, p. 20-24 5 p.

Research output: Contribution to journalArticle

Erratum: Sex-specific longevity associations defined by tyrosine hydroxylase-insulin-insulin growth factor 2 haplotypes on the 11p15.5 chromosomal region (Experimental Gerontology (2001) 36 (1663-1671) PII: S0531556501001462)

Luca, M. D., Rose, G., Bonafè, M., Garasto, S., Greco, V., Weir, B. S., Franceschi, C. & De Benedictis, G., 2002, In : Experimental Gerontology. 37, 4, p. 607-608 2 p.

Research output: Contribution to journalArticle

Genetic analysis of paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians

Bonafè, M., Marchegiani, F., Cardelli, M., Olivieri, F., Cavallone, L., Giovagnetti, S., Pieri, C., Marra, M., Antonicelli, R., Troiano, L., Gueresi, P., Passeri, G., Berardelli, M., Paolisso, G., Barbieri, M., Tesei, S., Lisa, R., De Benedictis, G. & Franceschi, C., 2002, In : European Journal of Human Genetics. 10, 5, p. 292-296 5 p.

Research output: Contribution to journalArticle

Genetic polymorphisms of Fas (CD95) and FasL (CD178) in human longevity: Studies on centenarians

Pinti, M., Troiano, L., Nasi, M., Moretti, L., Monterastelli, E., Mazzacani, A., Mussi, C., Ventura, P., Olivieri, F., Franceschi, C., Salvioli, G. & Cossarizza, A., 2002, In : Cell Death and Differentiation. 9, 4, p. 431-438 8 p.

Research output: Contribution to journalArticle

Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

Anisimov, V. N., Khavinson, V. K. H., Provinciali, M., Alimova, I. N., Baturin, D. A., Popovich, I. G., Zabezhinski, M. A., Imyanitov, E. N., Mancini, R. & Franceschi, C., Sep 1 2002, In : International Journal of Cancer. 101, 1, p. 7-10 4 p.

Research output: Contribution to journalArticle

LL-paraoxonase genotype is associated with a more severe degree of homeostasis model assessment IR in healthy subjects

Barbieri, M., Bonafè, M., Marfella, R., Ragno, E., Giugliano, D., Franceschi, C. & Paolisso, G., 2002, In : Journal of Clinical Endocrinology and Metabolism. 87, 1, p. 222-225 4 p.

Research output: Contribution to journalArticle

Male/female ratio in centenarians: A possible role played by population genetic structure

Passarino, G., Calignano, C., Vallone, A., Franceschi, C., Jeune, B., Robine, J. M., Yashin, A. I., Cavalli Sforza, L. L. & De Benedictis, G., Oct 2002, In : Experimental Gerontology. 37, 10-11, p. 1283-1289 7 p.

Research output: Contribution to journalArticle

Numerical and functional alterations of circulating γδ T lymphocytes in aged people and centenarians

Argentati, K., Re, F., Donnini, A., Tucci, M. G., Franceschi, C., Bartozzi, B., Bernardini, G. & Provinciali, M., Jul 1 2002, In : Journal of Leukocyte Biology. 72, 1, p. 65-71 7 p.

Research output: Contribution to journalArticle

p53 codon 72 genotype affects apoptosis by cytosine arabinoside in blood leukocytes

Bonafè, M., Salvioli, S., Barbi, C., Mishto, M., Trapassi, C., Gemelli, C., Storci, G., Olivieri, F., Monti, D. & Franceschi, C., 2002, In : Biochemical and Biophysical Research Communications. 299, 4, p. 539-541 3 p.

Research output: Contribution to journalArticle

Reduced susceptibility to peroxidation of erythrocyte plasma membranes from centenarians

Rabini, R. A., Moretti, N., Staffolani, R., Salvolini, E., Nanetti, L., Franceschi, C. & Mazzanti, L., 2002, In : Experimental Gerontology. 37, 5, p. 657-663 7 p.

Research output: Contribution to journalArticle

T cells and aging, January 2002 update.

Pawelec, G., Barnett, Y., Forsey, R., Frasca, D., Globerson, A., McLeod, J., Caruso, C., Franceschi, C., Fülöp, T., Gupta, S., Mariani, E., Mocchegiani, E. & Solana, R., 2002, In : Frontiers in Bioscience. 7

Research output: Contribution to journalArticle

The - 174 C/G locus affects in vitro/in vivo IL-6 production during aging

Olivieri, F., Bonafè, M., Cavallone, L., Giovagnetti, S., Marchegiani, F., Cardelli, M., Mugianesi, E., Giampieri, C., Moresi, R., Stecconi, R., Lisa, R. & Franceschi, C., Jan 3 2002, In : Experimental Gerontology. 37, 2-3, p. 309-314 6 p.

Research output: Contribution to journalArticle

The influences on human longevity by HUMTHO1.STR polymorphism (Tyrosine Hydroxylase gene): A relative risk approach

Tan, Q., Bellizzi, D., Rose, G., Garasto, S., Franceschi, C., Kruse, T., Vaupel, J. W., De Benedictis, G. & Yashin, A. I., Jul 2002, In : Mechanisms of Ageing and Development. 123, 10, p. 1403-1410 8 p.

Research output: Contribution to journalArticle

The "oldest man on the planet" [4]

Deiana, L., Pes, G. M., Carru, C., Ferrucci, L., Franceschi, C. & Baggio, G., Dec 1 2002, In : Journal of the American Geriatrics Society. 50, 12, p. 2098-2099 2 p.

Research output: Contribution to journalArticle

The variability of the mitochondrial genome in human aging: A key for life and death?

Rose, G., Passarino, G., Franceschi, C. & De Benedictis, G., Nov 2002, In : International Journal of Biochemistry and Cell Biology. 34, 11, p. 1449-1460 12 p.

Research output: Contribution to journalArticle

Vliianie épitalona i vilona na prodolzhitel'nost' zhizni i razvitie opukholei molochnoi zhelezy u samok transgennykh mishei erB-2/neu.

Translated title of the contribution: Effect of Epitalon and Vilon treatment on mammary carcinogenesis in transgenic erbB-2/NEU miceAlimova, I. N., Bashurin, D. A., Popovich, I. G., Zabezhinskiǐ, M. A., Volkov, M. A., Provinciali, M., Franceschi, C., Khavincon, B. K. & Anisimov, V. N., 2002, In : Voprosy Onkologii. 48, 1, p. 57-60 4 p.

Research output: Contribution to journalArticle

What studies on human longevity tell us about the risk for cancer in the oldest old: Data and hypotheses on the genetics and immunology of centenarians

Bonafè, M., Barbi, C., Storci, G., Salvioli, S., Capri, M., Olivieri, F., Valensin, S., Monti, D., Gonos, E. S., De Benedictis, G. & Franceschi, C., Oct 2002, In : Experimental Gerontology. 37, 10-11, p. 1263-1271 9 p.

Research output: Contribution to journalArticle

2003

-174 G>C polymorphism of interleukin 6 gene promoter affects interleukin 6 serum level in patients with colorectal cancer

Belluco, C., Olivieri, F., Bonafè, M., Giovagnetti, S., Mammano, E., Scalerta, R., Ambrosi, A., Franceschi, C., Nitti, D. & Lise, M., Jun 1 2003, In : Clinical Cancer Research. 9, 6, p. 2173-2176 4 p.

Research output: Contribution to journalArticle

Age-dependent changes in the susceptibility to apoptosis of peripheral blood CD4+ and CD8+ T lymphocytes with virgin or memory phenotype

Salvioli, S., Capri, M., Scarcella, E., Mangherini, S., Faranca, I., Volterra, V., De Ronchi, D., Marini, M., Bonafè, M., Franceschi, C. & Monti, D., Apr 1 2003, In : Mechanisms of Ageing and Development. 124, 4, p. 409-418 10 p.

Research output: Contribution to journalArticle

Allele frequencies of +874T→A single nucleotide polymorphism at the first intron of IFN-γ gene in Alzheimer's disease patients

Scola, L., Licastro, F., Chiappelli, M., Franceschi, C., Grimaldi, L. M., Crivello, A., Colonna-Romano, G., Candore, G., Lio, D. & Caruso, C., Aug 2003, In : Aging clinical and experimental research. 15, 4, p. 292-295 4 p.

Research output: Contribution to journalArticle

Apoptosis-resistant phenotype in HL-60-derived cells HCW-2 is related to changes in expression of stress-induced proteins that impact on redox status and mitochondrial metabolism

Salvioli, S., Storci, G., Pinti, M., Quaglino, D., Moretti, L., Merlo-Pich, M., Lenaz, G., Filosa, S., Fico, A., Bonafè, M., Monti, D., Troiano, L., Nasi, M., Cossarizza, A. & Franceschi, C., Feb 1 2003, In : Cell Death and Differentiation. 10, 2, p. 163-174 12 p.

Research output: Contribution to journalArticle

Association between the HFE mutations and longevity: A study in Sardinian population

Carru, C., Pes, G. M., Deiana, L., Baggio, G., Franceschi, C., Lio, D., Balistreri, C. R., Candore, G., Colonna-Romano, G. & Caruso, C., Apr 1 2003, In : Mechanisms of Ageing and Development. 124, 4, p. 529-532 4 p.

Research output: Contribution to journalArticle

Association between the HFE mutations and unsuccessful ageing: A study in Alzheimer's disease patients from Northern Italy

Candore, G., Licastro, F., Chiappelli, M., Franceschi, C., Lio, D., Balistreri, C. R., Piazza, G., Colonna-Romano, G., Grimaldi, L. M. & Caruso, C., Apr 1 2003, In : Mechanisms of Ageing and Development. 124, 4, p. 525-528 4 p.

Research output: Contribution to journalArticle

Association between the HLA-DR alleles and longevity: A study in Sardinian population

Lio, D., Pes, G. M., Carru, C., Listì, F., Ferlazzo, V., Candore, G., Colonna-Romano, G., Ferrucci, L., Deiana, L., Baggio, G., Franceschi, C. & Caruso, C., Mar 1 2003, In : Experimental Gerontology. 38, 3, p. 313-318 6 p.

Research output: Contribution to journalArticle

Centenarians as a model for healthy aging

Franceschi, C. & Bonafè, M., Apr 2003, In : Biochemical Society Transactions. 31, 2, p. 457-461 5 p.

Research output: Contribution to journalArticle

Chronic antigenic stress, immunosenescence and human survivorship over the 3 last centuries: Heuristic value of a mathematical model

Mariani, L., Turchetti, G. & Franceschi, C., Apr 1 2003, In : Mechanisms of Ageing and Development. 124, 4, p. 453-458 6 p.

Research output: Contribution to journalArticle

Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons

Barbieri, M., Ferrucci, L., Ragno, E., Corsi, A., Bandinelli, S., Bonafé, M., Olivieri, F., Giovagnetti, S., Franceschi, C., Guralnik, J. M. & Paolisso, G., Mar 1 2003, In : American Journal of Physiology - Endocrinology and Metabolism. 284, 3 47-3

Research output: Contribution to journalArticle

Evidence for reduction of pro-atherosclerotic properties in platelets from healthy centenarians

Rabini, R. A., Vignini, A., Martarelli, D., Nanetti, L., Salvolini, E., Rizzo, M. R., Ragno, E., Paolisso, G., Franceschi, C. & Mazzanti, L., Apr 1 2003, In : Experimental Gerontology. 38, 4, p. 367-371 5 p.

Research output: Contribution to journalArticle

Genetics of neurodegenerative disorders.

Caruso, C., Franceschi, C. & Licastro, F., 2003, In : New England Journal of Medicine. 349, 2

Research output: Contribution to journalArticle

Genetics of neurodegenerative disorders [4] (multiple letters)

Caruso, C., Franceschi, C., Licastro, F., Nussbaum, R. & Ellis, C., Jul 10 2003, In : New England Journal of Medicine. 349, 2, p. 193-194 2 p.

Research output: Contribution to journalArticle

Immunoproteasomes and immunosenescence

Mishto, M., Santoro, A., Bellavista, E., Bonafé, M., Monti, D. & Franceschi, C., Oct 2003, In : Ageing Research Reviews. 2, 4, p. 419-432 14 p.

Research output: Contribution to journalArticle

Increased circulating Interleukin-18 levels in centenarians with no signs of vascular disease: Another paradox of longevity?

Gangemi, S., Basile, G., Merendino, R. A., Minciullo, P. L., Novick, D., Rubinstein, M., Dinarello, C. A., Balbo, C. L., Franceschi, C., Basili, S., D' Urbano, E., Davì, G., Nicita-Mauro, V. & Romano, M., Jun 1 2003, In : Experimental Gerontology. 38, 6, p. 669-672 4 p.

Research output: Contribution to journalArticle

Inflammation, genetics, and longevity: Further studies on the protective effects in men of IL-10-1082 promoter SNP and its interaction with TNF-α-308 promoter SNP [2]

Lio, D., Scola, L., Crivello, A., Colonna-Romano, G., Candore, G., Bonafè, M., Cavallone, L., Marchegiani, F., Olivieri, F., Franceschi, C. & Caruso, C., Apr 1 2003, In : Journal of Medical Genetics. 40, 4, p. 296-299 4 p.

Research output: Contribution to journalArticle

Insulin/IGF-I-signaling pathway: An evolutionarily conserved mechanism of longevity from yeast to humans

Barbieri, M., Bonafè, M., Franceschi, C. & Paolisso, G., Nov 2003, In : American Journal of Physiology - Endocrinology and Metabolism. 285, 5 48-5

Research output: Contribution to journalArticle