1969 …2020

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2004

The immune system in the elderly: Activation-induced and damage-induced apoptosis

Ginaldi, L., De Martinis, M., Monti, D. & Franceschi, C., 2004, In : Immunologic Research. 30, 1, p. 81-94 14 p.

Research output: Contribution to journalArticle

2005

Age-related changes on platelet membrane: A study on elderly and centenarian monozygotic twins

Laura, N., Cinzia, M., Arianna, V., Patrizia, V., Claudio, F. & Laura, M., Jun 2005, In : Experimental Gerontology. 40, 6, p. 519-525 7 p.

Research output: Contribution to journalArticle

Age-related modifications in circulating IL-15 levels in humans

Gangemi, S., Basile, G., Monti, D., Merendino, R. A., Di Pasquale, G., Bisignano, U., Nicita-Mauro, V. & Franceschi, C., Aug 31 2005, In : Mediators of Inflammation. 2005, 4, p. 245-247 3 p.

Research output: Contribution to journalArticle

A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages

Bellizzi, D., Rose, G., Cavalcante, P., Covello, G., Dato, S., De Rango, F., Greco, V., Maggiolini, M., Feraco, E., Mari, V., Franceschi, C., Passarino, G. & De Benedictis, G., Feb 2005, In : Genomics. 85, 2, p. 258-263 6 p.

Research output: Contribution to journalArticle

Cholesteryl ester transfer protein (CETP) I405V polymorphism and longevity in Italian centenarians

Cellini, E., Nacmias, B., Olivieri, F., Ortenzi, L., Tedde, A., Bagnoli, S., Petruzzi, C., Franceschi, C. & Sorbi, S., Jun 2005, In : Mechanisms of Ageing and Development. 126, 6-7, p. 826-828 3 p.

Research output: Contribution to journalArticle

Chronic antigenic load and apoptosis in immunosenescence

Ginaldi, L., De Martinis, M., Monti, D. & Franceschi, C., Feb 2005, In : Trends in Immunology. 26, 2, p. 79-84 6 p.

Research output: Contribution to journalArticle

Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

Anisimov, V. N., Berstein, L. M., Egormin, P. A., Piskunova, T. S., Popovich, I. G., Zabezhinski, M. A., Kovalenko, I. G., Poroshina, T. E., Semenchenko, A. V., Provinciali, M., Re, F. & Franceschi, C., Aug 2005, In : Experimental Gerontology. 40, 8-9, p. 685-693 9 p.

Research output: Contribution to journalArticle

Erratum: Age-related changes on platelet membrance: A study on elderly and centenarian monozygotic twins (Experimental Gerontology (2005) 40/16 (519-525) DOI: 10.1016/j.exger.2005.03.009)

Nanetti, L., Moroni, C., Vignini, A., Vannini, P., Franceschi, C. & Mazzanti, L., Oct 2005, In : Experimental Gerontology. 40, 10, p. 839 1 p.

Research output: Contribution to journalArticle

Erratum: What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? (Mechanisms of Ageing and Development (2005) 126 (421-429) PII: S0047637404001897 and DOI: 10.1016/j.mad.2004.07.012)

Leroi, A. M., Bartke, A., De Benedictis, G., Franceschi, C., Gartner, A., Gonos, E. S., Fedei, M. E., Kivisild, T., Lee, S., Kartaf-Ozer, N., Schumacher, M., Sikora, E., Slagboom, E., Tatar, M., Yashin, A. I., Vijg, J. & Zwaan, B., Aug 2005, In : Mechanisms of Ageing and Development. 126, 8, p. 906 1 p.

Research output: Contribution to journalArticle

Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: The lesson of centenarians

Franceschi, C., Olivieri, F., Marchegiani, F., Cardelli, M., Cavallone, L., Capri, M., Salvioli, S., Valensin, S., De Benedictis, G., Di Iorio, A., Caruso, C., Paolisso, G. & Monti, D., Feb 2005, In : Mechanisms of Ageing and Development. 126, 2, p. 351-361 11 p.

Research output: Contribution to journalArticle

Genotype of inflammatory cytokines in limbal stem cell graft in Italian patients

Lescai, F., Conti, L., Bartolozzi, M., Ramazzotti, G., Mazzi, M., Sarnicola, V. & Franceschi, C., Jun 24 2005, In : Biochemical and Biophysical Research Communications. 332, 1, p. 95-100 6 p.

Research output: Contribution to journalArticle

Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity

De Martinis, M., Franceschi, C., Monti, D. & Ginaldi, L., Apr 11 2005, In : FEBS Letters. 579, 10, p. 2035-2039 5 p.

Research output: Contribution to journalArticle

Inflammation and life-span [4] (multiple letters)

Caruso, C., Candore, G., Colonna-Romano, G., Lio, D., Franceschi, C., Payne, A. G., Finch, C. E. & Crimmins, E. M., Jan 14 2005, In : Science. 307, 5707, p. 208-209 2 p.

Research output: Contribution to journalArticle

Innate immunity and inflammation in ageing: A key for understanding age-related diseases

Licastro, F., Candore, G., Lio, D., Porcellini, E., Colonna-Romano, G., Franceschi, C. & Caruso, C., May 18 2005, In : Immunity and Ageing. 2, 8.

Research output: Contribution to journalArticle

p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1

Salvioli, S., Bonafé, M., Barbi, C., Storci, G., Trapassi, C., Tocco, F., Gravina, S., Rossi, M., Tiberi, L., Mondello, C., Monti, D. & Franceschi, C., Sep 2005, In : Cell Cycle. 4, 9, p. 1264-1271 8 p.

Research output: Contribution to journalArticle

p66shc is highly expressed in fibroblasts from centenarians

Pandolfi, S., Bonafè, M., Di Tella, L., Tiberi, L., Salvioli, S., Monti, D., Sorbi, S. & Franceschi, C., Aug 2005, In : Mechanisms of Ageing and Development. 126, 8, p. 839-844 6 p.

Research output: Contribution to journalArticle

Pathological relevance of the natural immune system

Salvioli, S., Capri, M., Fumelli, C., Lescai, F., Monti, D. & Franceschi, C., 2005, In : NeuroImmune Biology. 5, C, p. 331-350 20 p.

Research output: Contribution to journalArticle

Postoperative Delirium after elective and emergency surgery: Analysis and checking of risk factors. A study protocol

Agnoletti, V., Ansaloni, L., Catena, F., Chattat, R., De Cataldis, A., Di Nino, G., Franceschi, C., Gagliardi, S., Melotti, R. M., Potalivo, A. & Taffurelli, M., May 28 2005, In : BMC Surgery. 5

Research output: Contribution to journalArticle

Quantifying the relevance of different mediators in the human immune cell network

Tieri, P., Valensin, S., Latora, V., Castellani, G. C., Marchiori, M., Remondini, D. & Franceschi, C., Apr 15 2005, In : Bioinformatics. 21, 8, p. 1639-1643 5 p.

Research output: Contribution to journalArticle

Role of interaction between variants in the PPARG and interleukin-6 genes on obesity related metabolic risk factors

Barbieri, M., Rizzo, M. R., Papa, M., Acampora, R., De Angelis, L., Olivieri, F., Marchegiani, F., Franceschi, C. & Paolisso, G., Jul 2005, In : Experimental Gerontology. 40, 7, p. 599-604 6 p.

Research output: Contribution to journalArticle

Role of TLR4 receptor polymorphisms in Boutonneuse fever.

Balistreri, C. R., Candore, G., Lio, D., Colonna-Romano, G., Di Lorenzo, G., Mansueto, P., Rini, G., Mansueto, S., Cillari, E., Franceschi, C. & Caruso, C., Oct 2005, In : International Journal of Immunopathology and Pharmacology. 18, 4, p. 655-660 6 p.

Research output: Contribution to journalArticle

Study of the association with - 330T/G IL-2 in a population of centenarians from Centre and South Italy

Scola, L., Candore, G., Colonna-Romano, G., Crivello, A., Forte, G. I., Paolisso, G., Franceschi, C., Lio, D. & Caruso, C., Dec 2005, In : Biogerontology. 6, 6, p. 425-429 5 p.

Research output: Contribution to journalArticle

The -308G/A polymorphism of TNF-α influences immunological parameters in old subjects affected by infectious diseases

Cipriano, C., Caruso, C., Lio, D., Giacconi, R., Malavolta, M., Muti, E., Gasparini, N., Franceschi, C. & Mocchegiani, E., Feb 2005, In : International Journal of Immunogenetics. 32, 1, p. 13-18 6 p.

Research output: Contribution to journalArticle

The interleukin-6 -174 G>C promoter polymorphism is associated with a higher risk of death after an acute coronary syndrome in male elderly patients

Antonicelli, R., Olivieri, F., Bonafè, M., Cavallone, L., Spazzafumo, L., Marchegiani, F., Cardelli, M., Recanatini, A., Testarmata, P., Boemi, M., Parati, G. & Franceschi, C., Sep 1 2005, In : International Journal of Cardiology. 103, 3, p. 266-271 6 p.

Research output: Contribution to journalArticle

What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?

Kirkwood, T. B. L., Feder, M., Finch, C. E., Franceschi, C., Globerson, A., Klingenberg, C. P., LaMarco, K., Omholt, S. & Westendorp, R. G. J., Mar 2005, In : Mechanisms of Ageing and Development. 126, 3, p. 439-443 5 p.

Research output: Contribution to journalArticle

What evidence is there for the existence of individual genes with antagonistic pleiotropic effects?

Leroi, A. M., Bartke, A., Benedictis, G. D., Franceschi, C., Gartner, A., Gonos, E., Feder, M. E., Kivisild, T., Lee, S., Kartal-Özer, N., Schumacher, M., Sikora, E., Slagboom, E., Tatar, M., Yashin, A. I., Vijg, J. & Zwaan, B., Mar 2005, In : Mechanisms of Ageing and Development. 126, 3, p. 421-429 9 p.

Research output: Contribution to journalArticle

2006

Age-dependent effects of in vitro radiofrequency exposure (mobile phone) on CD95+ T helper human lymphocytes

Capri, M., Salvioli, S., Altilia, S., Sevini, F., Remondini, D., Mesirca, P., Bersani, F., Monti, D. & Franceschi, C., May 2006, In : Annals of the New York Academy of Sciences. 1067, 1, p. 493-499 7 p.

Research output: Contribution to journalArticle

Age-dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4+ T cells in humans

Alberti, S., Cevenini, E., Ostan, R., Capri, M., Salvioli, S., Bucci, L., Ginaldi, L., De Martinis, M., Franceschi, C. & Monti, D., Jun 2006, In : Mechanisms of Ageing and Development. 127, 6, p. 560-566 7 p.

Research output: Contribution to journalArticle

Analysis of HLA-DQA, HLA-DQB frequencies in a group of Sardinian centenarians

Scola, L., Lio, D., Crivello, A., Candore, G., Forte, G. I., Colonna-Romano, G., Pes, M. G., Carru, C., Ferrucci, L., Deiana, L., Baggio, G., Franceschi, C. & Caruso, C., Mar 2006, In : Rejuvenation Research. 9, 1, p. 157-160 4 p.

Research output: Contribution to journalArticle

Association between the HLA-A2 allele and Alzheimer disease

Listì, F., Candore, G., Balistreri, C. R., Grimaldi, M. P., Orlando, V., Vasto, S., Colonna-Romano, G., Lio, D., Licastro, F., Franceschi, C. & Caruso, C., Mar 2006, In : Rejuvenation Research. 9, 1, p. 99-101 3 p.

Research output: Contribution to journalArticle

A structural model of 20S immunoproteasomes: Effect of LMP2 codon 60 polymorphism on expression, activity, intracellular localisation and insight into the regulatory mechanisms

Mishto, M., Santoro, A., Bellavista, E., Sessions, R., Textoris-Taube, K., Dal Piaz, F., Carrard, G., Forti, K., Salvioli, S., Friguet, B., Kloetzel, P. M., Rivett, A. J. & Franceschi, C., Apr 1 2006, In : Biological Chemistry. 387, 4, p. 417-429 13 p.

Research output: Contribution to journalArticle

Complexity of anti-immunosenescence strategies in humans

Capri, M., Monti, D., Salvioli, S., Lescai, F., Pierini, M., Altilia, S., Sevini, F., Valensin, S., Ostan, R., Bucci, L. & Franceschi, C., Oct 2006, In : Artificial Organs. 30, 10, p. 730-742 13 p.

Research output: Contribution to journalArticle

Effect of zinc ions on apoptosis in PBMCs from healthy aged subjects

Ostan, R., Alberti, S., Bucci, L., Salvioli, S., Pasi, S., Cevenini, E., Capri, M., Di Iorio, A., Ginaldi, L., De Martinis, M., Franceschi, C. & Monti, D., Oct 2006, In : Biogerontology. 7, 5-6, p. 437-447 11 p.

Research output: Contribution to journalArticle

Family clustering in Sardinian longevity: A genealogical approach

Caselli, G., Pozzi, L., Vaupel, J. W., Deiana, L., Pes, G., Carru, C., Franceschi, C. & Baggio, G., Aug 2006, In : Experimental Gerontology. 41, 8, p. 727-736 10 p.

Research output: Contribution to journalArticle

Gene expression changes in human cells after exposure to mobile phone microwaves

Remondini, D., Nylund, R., Reivinen, J., De Gannes, F. P., Veyret, B., Lagroye, I., Haro, E., Trillo, M. A., Capri, M., Franceschi, C., Schlatterer, K., Gminski, R., Fitzner, R., Tauber, R., Schuderer, J., Kuster, N., Leszczynski, D., Bersani, F. & Maercker, C., Sep 2006, In : Proteomics. 6, 17, p. 4745-4754 10 p.

Research output: Contribution to journalArticle

Gene expression of cytokines and cytokine receptors is modulated by the common variability of the mitochondrial DNA in cybrid cell lines

Bellizzi, D., Cavalcante, P., Taverna, D., Rose, G., Passarino, G., Salvioli, S., Franceschi, C. & De Benedictis, G., Aug 2006, In : Genes to Cells. 11, 8, p. 883-891 9 p.

Research output: Contribution to journalArticle

Genes, ageing and longevity in humans: Problems, advantages and perspectives

Salvioli, S., Olivieri, F., Marchegiani, F., Cardelli, M., Santoro, A., Bellavista, E., Mishto, M., Invidia, L., Capri, M., Valensin, S., Sevini, F., Cevenini, E., Celani, L., Lescai, F., Gonos, E., Caruso, C., Paolisso, G., De Benedictis, G., Monti, D. & Franceschi, C., Dec 2006, In : Free Radical Research. 40, 12, p. 1303-1323 21 p.

Research output: Contribution to journalArticle

Genetic polymorphisms of inflammatory cytokines and myocardial infarction in the elderly

Olivieri, F., Antonicelli, R., Cardelli, M., Marchegiani, F., Cavallone, L., Mocchegiani, E. & Franceschi, C., Jun 2006, In : Mechanisms of Ageing and Development. 127, 6, p. 552-559 8 p.

Research output: Contribution to journalArticle

Human immunosenescence: Does it have an infectious component?

Pawelec, G., Koch, S., Franceschi, C. & Wikby, A., May 2006, In : Annals of the New York Academy of Sciences. 1067, 1, p. 56-65 10 p.

Research output: Contribution to journalArticle

Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains

Mishto, M., Bellavista, E., Santoro, A., Stolzing, A., Ligorio, C., Nacmias, B., Spazzafumo, L., Chiappelli, M., Licastro, F., Sorbi, S., Pession, A., Ohm, T., Grune, T. & Franceschi, C., Jan 2006, In : Neurobiology of Aging. 27, 1, p. 54-66 13 p.

Research output: Contribution to journalArticle

Inflamm-aging, cytokines and aging: State of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology

Salvioli, S., Capri, M., Valensin, S., Tieri, P., Monti, D., Ottaviani, E. & Franceschi, C., Aug 2006, In : Current Pharmaceutical Design. 12, 24, p. 3161-3171 11 p.

Research output: Contribution to journalArticle

Inflammation markers predicting frailty and mortality in the elderly

De Martinis, M., Franceschi, C., Monti, D. & Ginaldi, L., Jun 2006, In : Experimental and Molecular Pathology. 80, 3, p. 219-227 9 p.

Research output: Contribution to journalArticle

Interleukin-6-174 G > C polymorphism affects the association between IL-6 plasma levels and insulin resistance in type 2 diabetic patients

Testa, R., Olivieri, F., Bonfigli, A. R., Sirolla, C., Boemi, M., Marchegiani, F., Marra, M., Cenerelli, S., Antonicelli, R., Dolci, A., Paolisso, G. & Franceschi, C., Mar 2006, In : Diabetes Research and Clinical Practice. 71, 3, p. 299-305 7 p.

Research output: Contribution to journalArticle

Interleukin-6 is a determinant of PAI-1 levels in diabetic subjects with the 4G allele at position -675 of the PAI-1 gene [3]

Bonfigli, A. R., Marra, M., Sirolla, C., Boemi, M., Mari, D., Sacchi, E., Procopio, A., Recchioni, R., Franceschi, C., Giovagnetti, S. & Testa, R., Mar 2006, In : Thrombosis and Haemostasis. 95, 3, p. 587-588 2 p.

Research output: Contribution to journalArticle

Markers of inflammation, Vitamin E and peripheral nervous system function. The InCHIANTI study

Di Iorio, A., Cherubini, A., Volpato, S., Sparvieri, E., Lauretani, F., Franceschi, C., Senin, U., Abate, G., Paganelli, R., Martin, A., Andres-Lacueva, C. & Ferrucci, L., Sep 2006, In : Neurobiology of Aging. 27, 9, p. 1280-1288 9 p.

Research output: Contribution to journalArticle

Mitochondrial DNA involvement in human longevity

Santoro, A., Salvioli, S., Raule, N., Capri, M., Sevini, F., Valensin, S., Monti, D., Bellizzi, D., Passarino, G., Rose, G., De Benedictis, G. & Franceschi, C., Sep 2006, In : Biochimica et Biophysica Acta - Bioenergetics. 1757, 9-10, p. 1388-1399 12 p.

Research output: Contribution to journalArticle

Opposite role of pro-inflammatory alleles in acute myocardial infarction and longevity: Results of studies performed in a Sicilian population

Candore, G., Balistreri, C. R., Grimaldi, M. P., Listì, F., Vasto, S., Caruso, M., Caimi, G., Hoffmann, E., Colonna-Romano, G., Lio, D., Paolisso, G., Franceschi, C. & Caruso, C., May 2006, In : Annals of the New York Academy of Sciences. 1067, 1, p. 270-275 6 p.

Research output: Contribution to journalArticle