1969 …2020

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Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism

Collino, S., Montoliu, I., Martin, F. P. J., Scherer, M., Mari, D., Salvioli, S., Bucci, L., Ostan, R., Monti, D., Biagi, E., Brigidi, P., Franceschi, C. & Rezzi, S., Mar 6 2013, In : PLoS One. 8, 3, e56564.

Research output: Contribution to journalArticle

Metabolic gene polymorphisms and p53 mutations in healthy centenarians and younger controls

Gaspari, L., Pedotti, P., Bonafè, M., Franceschi, C., Marinelli, D., Mari, D., Garte, S. & Taioli, E., Nov 2003, In : Biomarkers. 8, 6, p. 522-528 7 p.

Research output: Contribution to journalArticle

Metabolic age modelling: The lesson from centenarians

Paolisso, G., Barbieri, M., Bonafè, M. & Franceschi, C., 2000, In : European Journal of Clinical Investigation. 30, 10, p. 888-894 7 p.

Research output: Contribution to journalArticle

Memory and selectivity in evolving scale-free immune networks

Tieri, P., Valensin, S., Franceschi, C., Morandi, C. & Castellani, G. C., 2003, In : Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 2787, p. 93-101 9 p.

Research output: Contribution to journalArticle

Megakaryocytopoiesis in bone marrow-derived stromal-hemopoietic cells co-cultures: action of Tamm-Horsfall glycoprotein

Bagnara, G. P., Valvassori, L., Marini, M., Franceschi, C. & Serafini-Cessi, F., 1984, In : Cell Differentiation. 14, 4, p. 277-285 9 p.

Research output: Contribution to journalArticle

Meeting report: Mitochondrial DNA and cancer epidemiology

Verma, M., Naviaux, R. K., Tanaka, M., Kumar, D., Franceschi, C. & Singh, K. K., Jan 15 2007, In : Cancer Research. 67, 2, p. 437-439 3 p.

Research output: Contribution to journalArticle

Meeting report: Breast cancer in the older woman

Martoni, A., Cucinotta, D., Balducci, L., Aapro, M., Anisimov, V., Ausili-Cefaro, G., Bernabei, R., Caraceni, A., Costa, A., Crivellari, D., Daidone, M. G., Extermann, M., Fabris, F., Franceschi, C., Hayman, J. A., Lelli, G., Masina, A., Monfardini, S., Mustacchi, G., Piana, E. & 9 others, Repetto, L., Della Cuna, G. R., Rosti, G., Valagussa, P., Taffurelli, M., Tanneberger, S., Torta, R., Zamagni, C. & Zappa, M., Jul 2004, In : Tumori. 90, 4, p. 437-445 9 p.

Research output: Contribution to journalArticle

Mediterranean diet and inflammaging in the elderly: the European project NU-AGE. Preface

Santoro, A., Brigidi, P., Gonos, E. S., Bohr, V. A. & Franceschi, C., 2014, In : Mechanisms of Ageing and Development. 136-137, p. 1-2 2 p.

Research output: Contribution to journalArticle

Measuring the genetic influence in modulating the human life span: Gene-environment interaction and the sex-specific genetic effect

Tan, Q., De Benedictis, G., Yashin, A. I., Bonafe, M., DeLuca, M., Valensin, S., Vaupel, J. W. & Franceschi, C., 2001, In : Biogerontology. 2, 3, p. 141-153 13 p.

Research output: Contribution to journalArticle

Maturation of the immkune response in vitro. Focal fluctuation and changes in affinity of anti-beta-D-galactosidase activating antibody.

Macario, A. J., De Macario, E. C., Franceschi, C. & Celada, F., Aug 1 1972, In : Journal of Experimental Medicine. 136, 2, p. 353-368 16 p.

Research output: Contribution to journalArticle

Maternal longevity is associated with lower infant mortality

Caselli, G., Lapucci, E., Lipsi, R. M., Pozzi, L., Baggio, G., Carru, C., Deiana, L., Franceschi, C. & Vaupel, J. W., 2014, In : Demographic Research. 31, 1, p. 1275-1296 22 p.

Research output: Contribution to journalArticle

Masticatory dysfunction is associated with osteoporosis in older men

Laudisio, A., Marzetti, E., Antonica, L., Settanni, S., Georgakakis, I., Bernabei, R., Franceschi, C. & Zuccalà, G., Nov 2007, In : Journal of Clinical Periodontology. 34, 11, p. 964-968 5 p.

Research output: Contribution to journalArticle

Massive parallel sequencing of human whole mitochondrial genomes with Ion Torrent technology: an optimized workflow for Anthropological and Population Genetics studies

De Fanti, S., Vianello, D., Giuliani, C., Quagliariello, A., Cherubini, A., Sevini, F., Iaquilano, N., Franceschi, C., Sazzini, M. & Luiselli, D., Oct 31 2016, (Accepted/In press) In : Mitochondrial DNA Part A: DNA Mapping, Sequencing, and Analysis. p. 1-8 8 p.

Research output: Contribution to journalArticle

Massive load of functional effector CD4+ and CD8+ T cells against cytomegalovirus in very old subjects

Vescovini, R., Biasini, C., Fagnoni, F. F., Telera, A. R., Zanlari, L., Pedrazzoni, M., Bucci, L., Monti, D., Medici, M. C., Chezzi, C., Franceschi, C. & Sansoni, P., Sep 15 2007, In : Journal of Immunology. 179, 6, p. 4283-4291 9 p.

Research output: Contribution to journalArticle

Massive activation of immune cells with an intact t cell repertoire in acute human immunodeficiency virus syndrome

Cossarizza, A., Ortolani, C., Mussini, C., Borghi, V., Guaraldi, G., Mongiardo, N., Bellesia, E., Franceschini, M. G., De Rienzo, B. & Franceschi, C., 1995, In : Journal of Infectious Diseases. 172, 1, p. 105-112 8 p.

Research output: Contribution to journalArticle

Markers of inflammation, Vitamin E and peripheral nervous system function. The InCHIANTI study

Di Iorio, A., Cherubini, A., Volpato, S., Sparvieri, E., Lauretani, F., Franceschi, C., Senin, U., Abate, G., Paganelli, R., Martin, A., Andres-Lacueva, C. & Ferrucci, L., Sep 2006, In : Neurobiology of Aging. 27, 9, p. 1280-1288 9 p.

Research output: Contribution to journalArticle

Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: A contribution to understand the relationship between inflammation and immunosenescence

Zanni, F., Vescovini, R., Biasini, C., Fagnoni, F., Zanlari, L., Telera, A., Di Pede, P., Passeri, G., Pedrazzoni, M., Passeri, M., Franceschi, C. & Sansoni, P., Sep 1 2003, In : Experimental Gerontology. 38, 9, p. 981-987 7 p.

Research output: Contribution to journalArticle

MARK-AGE standard operating procedures (SOPs): A successful effort

Moreno-Villanueva, M., Capri, M., Breusing, N., Siepelmeyer, A., Sevini, F., Ghezzo, A., de Craen, A. J. M., Hervonen, A., Hurme, M., Schön, C., Grune, T., Franceschi, C. & Bürkle, A., Nov 1 2015, In : Mechanisms of Ageing and Development. 151, p. 18-25 8 p.

Research output: Contribution to journalArticle

MARK-AGE population: From the human model to new insights

Capri, M., Moreno-Villanueva, M., Cevenini, E., Pini, E., Scurti, M., Borelli, V., Palmas, M. G., Zoli, M., Schön, C., Siepelmeyer, A., Bernhardt, J., Fiegl, S., Zondag, G., de Craen, A. J. M., Hervonen, A., Hurme, M., Sikora, E., Gonos, E. S., Voutetakis, K., Toussaint, O. & 4 others, Debacq-Chainiaux, F., Grubeck-Loebenstein, B., Bürkle, A. & Franceschi, C., Nov 1 2015, In : Mechanisms of Ageing and Development. 151, p. 13-17 5 p.

Research output: Contribution to journalArticle

MARK-AGE biomarkers of ageing

Bürkle, A., Moreno-Villanueva, M., Bernhard, J., Blasco, M., Zondag, G., Hoeijmakers, J. H. J., Toussaint, O., Grubeck-Loebenstein, B., Mocchegiani, E., Collino, S., Gonos, E. S., Sikora, E., Gradinaru, D., Dollé, M., Salmon, M., Kristensen, P., Griffiths, H. R., Libert, C., Grune, T., Breusing, N. & 10 others, Simm, A., Franceschi, C., Capri, M., Talbot, D., Caiafa, P., Friguet, B., Slagboom, P. E., Hervonen, A., Hurme, M. & Aspinall, R., Nov 1 2015, In : Mechanisms of Ageing and Development. 151, p. 2-12 11 p.

Research output: Contribution to journalArticle

Male/female ratio in centenarians: A possible role played by population genetic structure

Passarino, G., Calignano, C., Vallone, A., Franceschi, C., Jeune, B., Robine, J. M., Yashin, A. I., Cavalli Sforza, L. L. & De Benedictis, G., Oct 2002, In : Experimental Gerontology. 37, 10-11, p. 1283-1289 7 p.

Research output: Contribution to journalArticle

Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians

Sansoni, P., Cossarizza, A., Brianti, V., Fagnoni, F., Snelli, G., Monti, D., Marcato, A., Passeri, G., Ortolani, C., Forti, E., Fagiolo, U., Passeri, M. & Franceschi, C., Nov 1 1993, In : Blood. 82, 9, p. 2767-2773 7 p.

Research output: Contribution to journalArticle

Lymphocytes and low-frequency electromagnetic fields

Cadossi, R., Bersani, F., Cossarizza, A., Zucchini, P., Emilia, G., Torelli, G. & Franceschi, C., Jun 1992, In : FASEB Journal. 6, 9, p. 2667-2674 8 p.

Research output: Contribution to journalArticle

Low Vitamin D Status, High Bone Turnover, and Bone Fractures in Centenarians

Passeri, G., Pini, G., Troiano, L., Vescovini, R., Sansoni, P., Passeri, M., Gueresi, P., Delsignore, R., Pedrazzoni, M. & Franceschi, C., Nov 2003, In : Journal of Clinical Endocrinology and Metabolism. 88, 11, p. 5109-5115 7 p.

Research output: Contribution to journalArticle

Low tobacco-related cancer incidence in offspring of long-lived siblings: A comparison with Danish national cancer registry data

Pedersen, J. K., Skytthe, A., McGue, M., Honig, L. S., Franceschi, C., Kirkwood, T. B. L., Passarino, G., Slagboom, P. E., Vaupel, J. W. & Christensen, K., Aug 1 2015, In : Annals of Epidemiology. 25, 8, p. 569-574 6 p.

Research output: Contribution to journalArticle

Low insulin resistance and preserved β-cell function contribute to human longevity but are not associated with TH-INS genes

Paolisso, G., Barbieri, M., Rizzo, M. R., Carella, C., Rotondi, M., Bonafè, M., Franceschi, C., Rose, G. & De Benedictis, G., 2001, In : Experimental Gerontology. 37, 1, p. 149-156 8 p.

Research output: Contribution to journalArticle

Lower platelet count in healthy centenarians correlates with dispersion of the QT interval

Gangemi, S., Basile, G., Merendino, R. A., Balbo, C. L., Mento, A., Nicita-Mauro, V., Franceschi, C. & Romano, M., Apr 2004, In : Aging clinical and experimental research. 16, 2, p. 169-171 3 p.

Research output: Contribution to journalArticle

Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians' offspring

Vitale, G., Brugts, M. P., Ogliari, G., Castaldi, D., Fatti, L. M., Varewijck, A. J., Lamberts, S. W., Monti, D., Bucci, L., Cevenini, E., Cavagnini, F., Franceschi, C., Hofland, L. J., Mari, D. & Janssen, J. A. M. J. L., 2012, In : Aging. 4, 9, p. 580-589 10 p.

Research output: Contribution to journalArticle

Long-term immunologic effects of thymectomy in patients with myasthenia gravis

Gerli, R., Paganelli, R., Cossarizza, A., Muscat, C., Piccolo, G., Barbieri, D., Mariotti, S., Monti, D., Bistoni, O., Raiola, E., Venanzi, F. M., Bertotto, A. & Franceschi, C., 1999, In : Journal of Allergy and Clinical Immunology. 103, 5 I, p. 865-872 8 p.

Research output: Contribution to journalArticle

Long-term immune-endocrine effects of bereavement: Relationships with anxiety levels and mood

Gerra, G., Monti, D., Panerai, A. E., Sacerdote, P., Anderlini, R., Avanzini, P., Zaimovic, A., Brambilla, F. & Franceschi, C., Dec 1 2003, In : Psychiatry Research. 121, 2, p. 145-158 14 p.

Research output: Contribution to journalArticle

Long-term effects of vaccination on attentional performance

Nicoletti, R., Adolfo Porro, C., Brighetti, G., Monti, D., Pagnoni, G., Guido, M., Rubichi, S. & Franceschi, C., Sep 28 2004, In : Vaccine. 22, 29-30, p. 3877-3881 5 p.

Research output: Contribution to journalArticle

Long telomeres and well preserved proliferative vigor in cells from centenarians: A contribution to longevity?

Franceschi, C., Mondello, C., Bonafè, M., Valensin, S., Sansoni, P. & Sorbi, S., Apr 1999, In : Aging clinical and experimental research. 11, 2, p. 69-72 4 p.

Research output: Contribution to journalArticle

Longevity genes across species: Conservation versus evolvability

Salvioli, S., Tieri, P., Castellani, G., Capri, M., Barbi, C., Santoro, A., Altilia, S., Invidia, L., Pierini, M., Bellavista, E., Monti, D. & Franceschi, C., 2007, In : Invertebrate Survival Journal. 4, 2, p. 112-118 7 p.

Research output: Contribution to journalArticle

LL-paraoxonase genotype is associated with a more severe degree of homeostasis model assessment IR in healthy subjects

Barbieri, M., Bonafè, M., Marfella, R., Ragno, E., Giugliano, D., Franceschi, C. & Paolisso, G., 2002, In : Journal of Clinical Endocrinology and Metabolism. 87, 1, p. 222-225 4 p.

Research output: Contribution to journalArticle

Lipoprotein(a) and lipoprotein profile in healthy centenarians: A reappraisal of vascular risk factors

Baggio, G., Donazzan, S., Monti, D., Mari, D., Martini, S., Gabelli, C., Vestra, M. D., Previato, L., Guido, M., Pigozzo, S., Cortella, I., Crepaldi, G. & Franceschi, C., 1998, In : FASEB Journal. 12, 6, p. 433-437 5 p.

Research output: Contribution to journalArticle

Lifelong maintenance of composition, function and cellular/subcellular distribution of proteasomes in human liver

Bellavista, E., Martucci, M., Vasuri, F., Santoro, A., Mishto, M., Kloss, A., Capizzi, E., Degiovanni, A., Lanzarini, C., Remondini, D., Dazzi, A., Pellegrini, S., Cescon, M., Capri, M., Salvioli, S., D'Errico-Grigioni, A., Dahlmann, B., Grazi, G. L. & Franceschi, C., Nov 1 2014, In : Mechanisms of Ageing and Development. 141-142, p. 26-34 9 p.

Research output: Contribution to journalArticle

Life expectancy in the immune recovery era: The evolving scenario of the HIV epidemic in northern Italy

Guaraldi, G., Cossarizza, A., Franceschi, C., Roverato, A., Vaccher, E., Tambussi, G., Garlassi, E., Menozzi, M., Mussini, C. & Monforte, A. D. A., 2014, In : Journal of Acquired Immune Deficiency Syndromes. 65, 2, p. 175-181 7 p.

Research output: Contribution to journalArticle

Levamisole and HBsAg positive chronic persistent hepatitis

Masi, M., Paolucci, P., Timoncini, G., Fantini, M. P., Leggieri, G., Chiodo, F. & Franceschi, C., 1978, In : Archives of Disease in Childhood. 53, 9, p. 764-765 2 p.

Research output: Contribution to journalArticle

Leukocyte telomere length is associated with complications of Type 2 diabetes mellitus

Testa, R., Olivieri, F., Sirolla, C., Spazzafumo, L., Rippo, M. R., Marra, M., Bonfigli, A. R., Ceriello, A., Antonicelli, R., Franceschi, C., Castellucci, C., Testa, I. & Procopio, A. D., Nov 2011, In : Diabetic Medicine. 28, 11, p. 1388-1394 7 p.

Research output: Contribution to journalArticle

Legame del 3' metil-P-dimetilaminoazobenzene al DNA in differenti organi e nel fegato rigenerante di ratto.

Translated title of the contribution: Binding of 3-methyl-P-dimethylaminoazobenzene to DNA in different organs and in regenerating rat liverProdi, G., Finzi, C. & Franceschi, C., Jan 15 1969, In : Bollettino della Societa Italiana di Biologia Sperimentale. 45, 1, p. 24-26 3 p.

Research output: Contribution to journalArticle

La sindrome di Down. Un invecchiamento precoce del sistema immunitario.

Translated title of the contribution: Down's syndrome. Precocious aging of the immune systemBonetti, F., Licastro, F., Chiricolo, M. & Franceschi, C., Dec 1980, In : Recenti Progressi in Medicina. 69, 6, p. 679-709 31 p.

Research output: Contribution to journalArticle

Lamins are rapamycin targets that impact human longevity: A study in centenarians

Lattanzi, G., Ortolani, M., Columbaro, M., Prencipe, S., Mattioli, E., Lanzarini, C., Maraldi, N. M., Cenni, V., Garagnani, P., Salvioli, S., Storci, G., Bonafè, M., Capanni, C. & Franceschi, C., Jan 1 2014, In : Journal of Cell Science. 127, 1, p. 147-157 11 p.

Research output: Contribution to journalArticle

LAK activity is inducible in blood mononuclear cells from human fetus

Cossarizza, A., Monti, D., Dagna-Bricarelli, F., Montagnani, G. & Franceschi, C., 1990, In : Immunology Letters. 24, 2, p. 137-140 4 p.

Research output: Contribution to journalArticle

Lack of selective Vβ deletion in CD4+ or CD8+ T lymphocytes and functional integrity of T-cell repertoire during acute HIV syndrome

Cossarizza, A., Ortolani, C., Mussini, C., Guaraldi, G., Mongiardo, N., Borghi, V., Barbieri, D., Bellesia, E., Franceschini, M. G., De Rienzo, B. & Franceschi, C., 1995, In : AIDS (London, England). 9, 6, p. 547-553 7 p.

Research output: Contribution to journalArticle

Lack of chromosomal aberration and micronucleus induction in human lymphocytes exposed to pulsed magnetic fields

Scarfì, M. R., Lioi, M. B., Zeni, O., Franceschetti, G., Franceschi, C. & Bersani, F., Apr 15 1994, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 306, 2, p. 129-133 5 p.

Research output: Contribution to journalArticle

Karyotype instability and anchorage-independent growth in telomerase-immortalized fibroblasts from two centenarian individuals

Mondello, C., Chiesa, M., Rebuzzini, P., Zongaro, S., Verri, A., Colombo, T., Giulotto, E., D'Incalci, M., Franceschi, C. & Nuzzo, F., Sep 5 2003, In : Biochemical and Biophysical Research Communications. 308, 4, p. 914-921 8 p.

Research output: Contribution to journalArticle

Is polyamine decrease a common feature of apoptosis? Evidence from γ rays- and heat shock-induced cell death

Grassill, E., Desiderio, M. A., Bellesia, E., Salomoni, P., Benatti, F. & Franceschi, C., 1995, In : Biochemical and Biophysical Research Communications. 216, 2, p. 708-714 7 p.

Research output: Contribution to journalArticle

Is chronic inflammation a determinant of blood pressure in the elderly?

Barbieri, M., Ferrucci, L., Corsi, A. M., Macchi, C., Lauretani, F., Bonafè, M., Olivieri, F., Giovagnetti, S., Franceschi, C. & Paolisso, G., Jul 1 2003, In : American Journal of Hypertension. 16, 7, p. 537-543 7 p.

Research output: Contribution to journalArticle