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Is aging as complex as it would appear? New perspectives in aging research

Kirkwood, T. B. L. & Franceschi, C., 1992, In : Annals of the New York Academy of Sciences. 663, p. 412-417 6 p.

Research output: Contribution to journalArticle

Involvement of ornithine decarboxylase and polyamines in glucocorticoid- induced apoptosis of rat thymocytes

Desiderio, M. A., Grassilli, E., Bellesia, E., Salomoni, P. & Franceschi, C., 1995, In : Cell Growth and Differentiation. 6, 5, p. 505-513 9 p.

Research output: Contribution to journalArticle

Involvement of Ets transcription factors and targets in osteoblast differentiation and matrix mineralization

Vary, C. P. H., Li, V., Raouf, A., Kitching, R., Kola, I., Franceschi, C., Venanzoni, M. & Seth, A., May 25 2000, In : Experimental Cell Research. 257, 1, p. 213-222 10 p.

Research output: Contribution to journalArticle

Involvement of CD45 in dexamethasone- and heat shock-induced apoptosis of rat thymocytes

Troiano, L., Monti, D., Cossarizza, A., Lovato, E., Tropea, F., Barbieri, D., Morale, M. C., Gallo, F., Marchetti, B. & Franceschi, C., 1995, In : Biochemical and Biophysical Research Communications. 214, 3, p. 941-948 8 p.

Research output: Contribution to journalArticle

In vivo accumulation of sulfated glycoprotein 2 mRNA in rat thymocytes upon dexamethasone-induced cell death

Bettuzzi, S., Troiano, L., Davalli, P., Tropea, F., Ingletti, M. C., Grassilli, E., Monti, D., Corti, A. & Franceschi, C., Mar 29 1991, In : Biochemical and Biophysical Research Communications. 175, 3, p. 810-815 6 p.

Research output: Contribution to journalArticle

In vitro peroxidase oxidation induces stable dimers of β-amyloid (1- 42) through dityrosine bridge formation

Galeazzi, L., Ronchi, P., Franceschi, C. & Giunta, S., 1999, In : Amyloid. 6, 1, p. 7-13 7 p.

Research output: Contribution to journalArticle

In vitro IL-6 production by EBV-immortalized B lymphocytes from young and elderly people genotyped for -174 C/G polymorphism in IL-6 gene: A model to study the genetic basis of inflamm-aging

Olivieri, F., Bonafè, M., Giovagnetti, S., Stecconi, R., Cardelli, M., Cavallone, L., Spazzafumo, L., Marchegiani, F., Carrieri, G., Mugianesi, E., Giampieri, C., Centurelli, M., Moresi, R., Tesei, S., Lisa, R., Viticchi, C., Falsetti, L., Salvioli, S. & Franceschi, C., Apr 1 2003, In : Mechanisms of Ageing and Development. 124, 4, p. 549-553 5 p.

Research output: Contribution to journalArticle

In vitro hypersensitivity to oxygen of Fanconi Anemia (FA) cells is linked to ex vivo evidence for oxidative stress in fa homozygotes and heterozygotes [2]

Pagano, G., Korkina, L. G., Del Principe, D., Lindau-Shepard, B., Zatterale, A. & Franceschi, C., 1997, In : Blood. 89, 3, p. 1111-1112 2 p.

Research output: Contribution to journalArticle

In vitro exposure of human lymphocytes to 900 MHz CW and GSM modulated radio-frequency: Studies of proliferation, apoptosis and mitochondrial membrane potential

Capri, M., Scarcella, E., Fumelli, C., Bianchi, E., Salvioli, S., Mesirca, P., Agostini, C., Antolini, A., Schiavoni, A., Castellani, G., Bersani, F. & Franceschi, C., Aug 2004, In : Radiation Research. 162, 2, p. 211-218 8 p.

Research output: Contribution to journalArticle

Invertebrate and Vertebrate Immune Cells Express Pro-opiomelanocortin (POMC) mRNA

Ottaviani, E., Capriglione, T. & Franceschi, C., Mar 1995, In : Brain, Behavior, and Immunity. 9, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

Invecchiamento, infiammazione sistemica e malattie croniche complesse

Translated title of the contribution: Aging, systemic inflammation and complex chronic diseasesFranceschi, C., Pauletto, P., Incalzi, R. A. & Fabbri, L. M., Mar 2011, In : Italian Journal of Medicine. 5, 1 SUPPL. 1

Research output: Contribution to journalArticle

Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis

Gorini, F., Azzimonti, L., Delfanti, G., Scarfò, L., Scielzo, C., Bertilaccio, MT., Ranghetti, P., Gulino, A., Doglioni, C., Di Napoli, A., Capri, M., Franceschi, C., Caligaris-Cappio, F., Ghia, P., Bellone, M., Dellabona, P., Casorati, G. & De Lalla, C., 2017, In : Blood. 129, 26, p. 3440-3451 12 p.

Research output: Contribution to journalArticle

Introduction: The reshaping of the immune system with age

Franceschi, C. & Cossarizza, A., 1995, In : International Reviews of Immunology. 12, 1, p. 1-4 4 p.

Research output: Contribution to journalArticle

Interventions to Slow Aging in Humans: Are We Ready?

Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown-Borg, H. M., Caruso, C., Curiel, T. J., de Cabo, R., Franceschi, C., Gems, D., Ingram, D. K., Johnson, T. E., Kennedy, B. K., Kenyon, C., Klein, S., Kopchick, J. J., Lepperdinger, G., Madeo, F., Mirisola, M. G., Mitchell, J. R. & 10 others, Passarino, G., Rudolph, K. L., Sedivy, J. M., Shadel, G. S., Sinclair, D. A., Spindler, S. R., Suh, Y., Vijg, J., Vinciguerra, M. & Fontana, L., 2015, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

International conference on biomedical aspects of aging research December 10-13, 1997 Fondazione Cini, San Giorgio, Venezia, Italy

Evans, J. G., Kirkwood, T. B. L., Hayflick, L., Austad, S. N., De Benedictis, G., Franceschi, C., Martin, G. M., Sohal, R. S., Orr, W. C., Levine, R. L., Cristofalo, V. J., Tresini, M., Effros, R. B., Passeri, M., Motta, L., Miller, R. A., Jackson, A., Chrisp, C., Galecki, A., Burke, D. & 56 others, Michel, J. P., Hyman, B. T., Schneider, L. S., Sorbi, S., Nacmias, B., Forleo, P., Zaidi, M., Kowal, J., Adami, S., McGowan, J. A., Dere, W. H., Blanchard, F., Papapoulos, S., Compston, J., Maggi, S., Lye, M., Marchionni, N., Di Bari, M., Innocenti, F., Chiarlone, M., Nardi, M., Fini, R., Masotti, G., Pedersen, T. R., Schroll, M., Zanchetti, A., Rich, M. W., Manzato, E., Brody, J. A., Grant, M. D., Frateschi, L. J., Miller, S. C., Zhang, H., Heikkinen, E., Andrews, G. R., Masoro, E. J., Bergamini, E., Cavallini, G., Cecchi, L., Donati, A., Dolfi, C., Gori, Z., Innocenti, B., Maccheroni, M., Marino, M., Masini, M., Paradiso, C., Pollera, M., Trentalance, A., Bellia, V., Tilvis, R., Johnson, B. D., Grassi, V., Cossi, S., Leonardi, R. & Tantucci, C., Apr 1998, In : Aging clinical and experimental research. 10, 2, p. 141-177 37 p.

Research output: Contribution to journalArticle

Interleukin-6 is a determinant of PAI-1 levels in diabetic subjects with the 4G allele at position -675 of the PAI-1 gene [3]

Bonfigli, A. R., Marra, M., Sirolla, C., Boemi, M., Mari, D., Sacchi, E., Procopio, A., Recchioni, R., Franceschi, C., Giovagnetti, S. & Testa, R., Mar 2006, In : Thrombosis and Haemostasis. 95, 3, p. 587-588 2 p.

Research output: Contribution to journalArticle

Interleukin-6 gene alleles affect the risk of Alzheimer's disease and levels of the cytokine in blood and brain

Licastro, F., Grimaldi, L. M. E., Bonafè, M., Martina, C., Olivieri, F., Cavallone, L., Giovanietti, S., Masliah, E. & Franceschi, C., Nov 2003, In : Neurobiology of Aging. 24, 7, p. 921-926 6 p.

Research output: Contribution to journalArticle

Interleukin-6-174 G > C polymorphism affects the association between IL-6 plasma levels and insulin resistance in type 2 diabetic patients

Testa, R., Olivieri, F., Bonfigli, A. R., Sirolla, C., Boemi, M., Marchegiani, F., Marra, M., Cenerelli, S., Antonicelli, R., Dolci, A., Paolisso, G. & Franceschi, C., Mar 2006, In : Diabetes Research and Clinical Practice. 71, 3, p. 299-305 7 p.

Research output: Contribution to journalArticle

Interleukin-10 promoter polymorphism in sporadic Alzheimer's disease

Lio, D., Licastro, F., Scola, L., Chiappelli, M., Grimaldi, L. M., Crivello, A., Colonna-Romano, G., Candore, G., Franceschi, C. & Caruso, C., Apr 2003, In : Genes and Immunity. 4, 3, p. 234-238 5 p.

Research output: Contribution to journalArticle

Interleukin-10 (IL-10) genotype frequencies in Italian centenarians

Lio, D., Romano, G. C., Candore, G., Scola, L., Crivello, A., Lisa, R. M., Olivieri, F., Franceschi, C. & Caruso, C., 2001, In : European Journal of Immunogenetics. 28, 2, p. 236 1 p.

Research output: Contribution to journalArticle

Interference between DNA binding activities of AP-1 and GR transcription factors in rat thymocytes undergoing dexamethasone-induced apoptosis

Sikora, E., Rossini, G. P., Grassilli, E., Bellesia, E., Salomoni, P. & Franceschi, C., 1996, In : Acta Biochimica Polonica. 43, 4, p. 721-732 12 p.

Research output: Contribution to journalArticle

Interdisciplinary views on Molecular Anthropology in the Genomic Era.

Atkinson, Q. D., Barbujani, G., Collard, M., Comas, D. & Franceschi, C., 2010, In : Journal of anthropological sciences = Rivista di antropologia : JASS / Istituto italiano di antropologia. 88, p. 231-250 20 p.

Research output: Contribution to journalArticle

Interaction between CRF, ACTH and biogenic amines in planorbarius corneus (L) (Gastropoda, pulmonata)

Ottaviani, E., Caselgrandi, E., Petraglia, F. & Franceschi, C., 1991, In : Developmental and Comparative Immunology. 15, SUPPL. 1

Research output: Contribution to journalArticle

Intense antiextracellular adaptive immune response to human cytomegalovirus in very old subjects with impaired health and cognitive and functional status

Vescovini, R., Biasini, C., Telera, A. R., Basaglia, M., Stella, A., Magalini, F., Bucci, L., Monti, D., Lazzarotto, T., Dal Monte, P., Pedrazzoni, M., Medici, M. C., Chezzi, C., Franceschi, C., Fagnoni, F. F. & Sansoni, P., Mar 15 2010, In : Journal of Immunology. 184, 6, p. 3242-3249 8 p.

Research output: Contribution to journalArticle

Integrating Omics data for signaling pathways, interactome reconstruction, and functional analysis.

Tieri, P., de la Fuente, A., Termanini, A. & Franceschi, C., 2011, In : Methods in molecular biology (Clifton, N.J.). 719, p. 415-433 19 p.

Research output: Contribution to journalArticle

Insulin/IGF-I-signaling pathway: An evolutionarily conserved mechanism of longevity from yeast to humans

Barbieri, M., Bonafè, M., Franceschi, C. & Paolisso, G., Nov 2003, In : American Journal of Physiology - Endocrinology and Metabolism. 285, 5 48-5

Research output: Contribution to journalArticle

Innate immunity and inflammation in ageing: A key for understanding age-related diseases

Licastro, F., Candore, G., Lio, D., Porcellini, E., Colonna-Romano, G., Franceschi, C. & Caruso, C., May 18 2005, In : Immunity and Ageing. 2, 8.

Research output: Contribution to journalArticle

Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

Anisimov, V. N., Khavinson, V. K. H., Provinciali, M., Alimova, I. N., Baturin, D. A., Popovich, I. G., Zabezhinski, M. A., Imyanitov, E. N., Mancini, R. & Franceschi, C., Sep 1 2002, In : International Journal of Cancer. 101, 1, p. 7-10 4 p.

Research output: Contribution to journalArticle

Inhibition of proteasome function prevents thymocyte apoptosis: Involvement of ornithine decarboxylase

Grassilli, E., Benatti, F., Dansi, P., Giammarioli, A. M., Malorni, W., Franceschi, C. & Desiderio, M. A., Sep 18 1998, In : Biochemical and Biophysical Research Communications. 250, 2, p. 293-297 5 p.

Research output: Contribution to journalArticle

Inhibition of poly(ADP-ribosyl)ation does not prevent lymphocyte entry into the cell cycle

Marini, M., Zunica, G., Monti, D., Cossarizza, A., Ortolani, C. & Franceschi, C., Aug 14 1989, In : FEBS Letters. 253, 1-2, p. 146-150 5 p.

Research output: Contribution to journalArticle

Inhibition of c-fes expression by an antisense oligomer causes apoptosis of HL60 cells induced to granulocytic differentiation

Manfredini, R., Grande, A., Tagliafico, E., Barbieri, D., Zucchini, P., Citro, G., Zupi, G., Franceschi, C., Torelli, U. & Ferrari, S., Aug 1 1993, In : Journal of Experimental Medicine. 178, 2, p. 381-389 9 p.

Research output: Contribution to journalArticle

Inhibition of cell proliferation by d-ribose and deoxy-d-ribose

Marini, M., Zunica, G. & Franceschi, C., 1985, In : Proceedings of the Society for Experimental Biology and Medicine. 180, 2, p. 246-257 12 p.

Research output: Contribution to journalArticle

Inhibition of apoptosis by zinc: A reappraisal

Barbieri, D., Troiano, L., Grassilli, E., Agnesini, C., Cristofalo, E. A., Monti, D., Capri, M., Cossarizza, A. & Franceschi, C., Sep 30 1992, In : Biochemical and Biophysical Research Communications. 187, 3, p. 1256-1261 6 p.

Research output: Contribution to journalArticle

Inhibition and potentiation of T lymphocyte response to mitogens. Studies using two mitogenic stimuli simultaneously.

Franceschi, C., Cevolani, C., Licastro, F., Paolucci, P., Prodi, G. & Perocco, P., Jan 1978, In : Archivio di scienze biologiche. 62, 1-4, p. 139-154 16 p.

Research output: Contribution to journalArticle

Inhibin and activin modulate human monocyte chemotaxis and human lymphocyte interferon-γ production

Petraglia, F., Sacerdote, P., Cossarizza, A., Angioni, S., Genazzani, A. D., Franceschi, C., Muscettola, M. & Grasso, G., Feb 1991, In : Journal of Clinical Endocrinology and Metabolism. 72, 2, p. 496-502 7 p.

Research output: Contribution to journalArticle

Inherited variability of the mitochondrial genome and successful aging in humans

De Benedictis, G., Carrieri, G., Varcasia, O., Bonafè, M. & Franceschi, C., 2000, In : Annals of the New York Academy of Sciences. 908, p. 208-218 11 p.

Research output: Contribution to journalArticle

Influence of f-MLP, ACTH(1-24) and CRH on in vitro chemotaxis of monocytes from centenarians

Genedani, S., Filaferro, M., Carone, C., Ostan, R., Bucci, L., Cevenini, E., Franceschi, C. & Monti, D., Nov 2008, In : NeuroImmunoModulation. 15, 4-6, p. 285-289 5 p.

Research output: Contribution to journalArticle

Influence of endorphins on the migration of molluscan hemocytes

Genedani, S., Bernardi, M., Fontanili, P., Ottaviani, E. & Franceschi, C., 1994, In : Comparative Biochemistry and Physiology. Part C: Pharmacology. 107, 1, p. 79-81 3 p.

Research output: Contribution to journalArticle

Inflammation markers predicting frailty and mortality in the elderly

De Martinis, M., Franceschi, C., Monti, D. & Ginaldi, L., Jun 2006, In : Experimental and Molecular Pathology. 80, 3, p. 219-227 9 p.

Research output: Contribution to journalArticle

Inflammation and life-span [4] (multiple letters)

Caruso, C., Candore, G., Colonna-Romano, G., Lio, D., Franceschi, C., Payne, A. G., Finch, C. E. & Crimmins, E. M., Jan 14 2005, In : Science. 307, 5707, p. 208-209 2 p.

Research output: Contribution to journalArticle

Inflammation, genetics, and longevity: Further studies on the protective effects in men of IL-10-1082 promoter SNP and its interaction with TNF-α-308 promoter SNP [2]

Lio, D., Scola, L., Crivello, A., Colonna-Romano, G., Candore, G., Bonafè, M., Cavallone, L., Marchegiani, F., Olivieri, F., Franceschi, C. & Caruso, C., Apr 1 2003, In : Journal of Medical Genetics. 40, 4, p. 296-299 4 p.

Research output: Contribution to journalArticle

Inflammaging as a Major Characteristic of Old People: Can It Be Prevented or Cured?

Franceschi, C., Dec 2007, In : Nutrition Reviews. 65, SUPPL.3

Research output: Contribution to journalArticle

Inflammaging and ‘Garb-aging’

Franceschi, C., Garagnani, P., Vitale, G., Capri, M. & Salvioli, S., 2017, In : Trends in Endocrinology and Metabolism. 28, 3, p. 199-212 14 p.

Research output: Contribution to journalArticle

Inflammaging and human longevity in the omics era

Monti, D., Ostan, R., Borelli, V., Castellani, G. & Franceschi, C., 2017, In : Mechanisms of Ageing and Development. 26, 11, p. 1480-5

Research output: Contribution to journalArticle

Inflammaging and 'Garb-aging'

Franceschi, C., Garagnani, P., Vitale, G., Capri, M. & Salvioli, S., 2017, In : Trends in Endocrinology and Metabolism. 28, 3, p. 199-212

Research output: Contribution to journalArticle

Inflammaging and 'Garb-aging'

Franceschi, C., Garagnani, P., Vitale, G., Capri, M. & Salvioli, S., 2016, (Accepted/In press) In : Trends in Endocrinology and Metabolism.

Research output: Contribution to journalArticle

Inflammaging and Cancer: A challenge for the mediterranean diet

Ostan, R., Lanzarini, C., Pini, E., Scurti, M., Vianello, D., Bertarelli, C., Fabbri, C., Izzi, M., Palmas, G., Biondi, F., Martucci, M., Bellavista, E., Salvioli, S., Capri, M., Franceschi, C. & Santoro, A., Apr 9 2015, In : Nutrients. 7, 4, p. 2589-2621 33 p.

Research output: Contribution to journalArticle

Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans

Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., Cevenini, E., Castellani, G. C. & Salvioli, S., Jan 2007, In : Mechanisms of Ageing and Development. 128, 1, p. 92-105 14 p.

Research output: Contribution to journalArticle

Inflamm-aging. An evolutionary perspective on immunosenescence

Franceschi, C., Bonafè, M., Valensin, S., Olivieri, F., De Luca, M., Ottaviani, E. & De Benedictis, G., 2000, In : Annals of the New York Academy of Sciences. 908, p. 244-254 11 p.

Research output: Contribution to journalArticle