1969 …2020

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Human natural killer cytotoxic activity is not affected by in vitro exposure to 50-hz sinusoidal magnetic fields

Ramoni, C., Dupuis, M. L., Vecchia, P., Polichetti, A., Petrini, C., Bersani, F., Capri, M., Cossarizza, A., Franceschi, C. & Grandolfo, M., 1995, In : International Journal of Radiation Biology. 68, 6, p. 693-705 13 p.

Research output: Contribution to journalArticle

Human models of aging and longevity

Cevenini, E., Invidia, L., Lescai, F., Salvioli, S., Tieri, P., Castellani, G. & Franceschi, C., Sep 2008, In : Expert Opinion on Biological Therapy. 8, 9, p. 1393-1405 13 p.

Research output: Contribution to journalArticle

Human longevity within an evolutionary perspective: The peculiar paradigm of a post-reproductive genetics

Capri, M., Salvioli, S., Monti, D., Caruso, C., Candore, G., Vasto, S., Olivieri, F., Marchegiani, F., Sansoni, P., Baggio, G., Mari, D., Passarino, G., De Benedictis, G. & Franceschi, C., Feb 2008, In : Experimental Gerontology. 43, 2, p. 53-60 8 p.

Research output: Contribution to journalArticle

Human longevity and 11p15.5: A study in 1321 centenarians

Lescai, F., Blanché, H., Nebel, A., Beekman, M., Sahbatou, M., Flachsbart, F., Slagboom, E., Schreiber, S., Sorbi, S., Passarino, G. & Franceschi, C., 2009, In : European Journal of Human Genetics. 17, 11, p. 1515-1519 5 p.

Research output: Contribution to journalArticle

Human longevity: The gender difference

Franceschi, C. & Fabris, N., 1993, In : Aging clinical and experimental research. 5, 5, p. 333-336 4 p.

Research output: Contribution to journalArticle

Human intestinal microbiota: Cross-talk with the host and its potential role in colorectal cancer

Candela, M., Guidotti, M., Fabbri, A., Brigidi, P., Franceschi, C. & Fiorentini, C., Feb 2011, In : Critical Reviews in Microbiology. 37, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

Human immunosenescence: Does it have an infectious component?

Pawelec, G., Koch, S., Franceschi, C. & Wikby, A., May 2006, In : Annals of the New York Academy of Sciences. 1067, 1, p. 56-65 10 p.

Research output: Contribution to journalArticle

Human immunosenescence: The prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space

Franceschi, C., Bonafè, M. & Valensin, S., Feb 25 2000, In : Vaccine. 18, 16, p. 1717-1720 4 p.

Research output: Contribution to journalArticle

Human aging and longevity are characterized by high levels of mitokines

Conte, M., Ostan, R., Fabbri, C., Santoro, A., Guidarelli, G., Vitale, G., Mari, D., Sevini, F., Capri, M., Sandri, M., Monti, D., Franceschi, C. & Salvioli, S., May 1 2019, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, 5, p. 600-607 8 p.

Research output: Contribution to journalArticle

Open Access

Human aging and longevity are characterized by high levels of mitokines

Conte, M., Ostan, R., Fabbri, C., Santoro, A., Guidarelli, G., Vitale, G., Mari, D., Sevini, F., Capri, M., Sandri, M., Monti, D., Franceschi, C. & Salvioli, S., 2019, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, 5, p. 600-607 8 p.

Research output: Contribution to journalArticle

How to classify the oldest old according to their health status: A study on 1160 subjects belonging to 552 90+ Italian sib-ships characterized by familial longevity recruited within the GEHA EU Project

Cevenini, E., Cotichini, R., Stazi, M. A., Toccaceli, V., Scurti, M., Mari, V., Berardelli, M., Passarino, G., Jeune, B., Franceschi, C., Bezrukov, V., Blanché, H., Bolund, L., Christensen, K., Deiana, L., Gonos, E., Hervonen, A., Kirkwood, T. B. L., Kristensen, P., Leon, A. & 12 others, Pelicci, P. G., Perola, M., Poulain, M., Rea, I. M., Remacle, J., Robine, J. M., Schreiber, S., Sikora, E., Slagboom, P. E., Spazzafumo, L., Toussaint, O. & Vaupel, J. W., 2013, In : Mechanisms of Ageing and Development. 134, 11-12, p. 560-569 10 p.

Research output: Contribution to journalArticle

Hormone replacement therapy enhances IGF-1 signaling in skeletal muscle by diminishing miR-182 and miR-223 expressions: A study on postmenopausal monozygotic twin pairs

Olivieri, F., Ahtiainen, M., Lazzarini, R., Pöllänen, E., Capri, M., Lorenzi, M., Fulgenzi, G., Albertini, M. C., Salvioli, S., Alen, M. J., Kujala, U. M., Borghetti, G., Babini, L., Kaprio, J., Sipilä, S., Franceschi, C., Kovanen, V. & Procopio, A. D., Oct 1 2014, In : Aging Cell. 13, 5, p. 850-861 12 p.

Research output: Contribution to journalArticle

HLA antigens and aging

Morellini, M., Trabace, S., Lulli, P., Cappellacci, S., Brioli, G., Orru, D., Pennesi, G., Monti, D., Cossarizza, A., Lambert-Gardini, S., Sansoni, P. & Franceschi, C., 1992, In : Annals of the New York Academy of Sciences. 663, p. 499-500 2 p.

Research output: Contribution to journalArticle

HLA, aging, and longevity: A critical reappraisal

Caruso, C., Candore, G., Colonna Romano, G., Lio, D., Bonafè, M., Valensin, S. & Franceschi, C., 2000, In : Human Immunology. 61, 9, p. 942-949 8 p.

Research output: Contribution to journalArticle

High-resolution quantitative metabolome analysis of urine by automated flow injection NMR

Da Silva, L., Godejohann, M., Martin, F. P. J., Collino, S., Bürkle, A., Moreno-Villanueva, M., Bernhardt, J., Toussaint, O., Grubeck-Loebenstein, B., Gonos, E. S., Sikora, E., Grune, T., Breusing, N., Franceschi, C., Hervonen, A., Spraul, M. & Moco, S., Jun 18 2013, In : Analytical Chemistry. 85, 12, p. 5801-5809 9 p.

Research output: Contribution to journalArticle

Heterogeneity of thyroid function and impact of peripheralthyroxine deiodination in centenarians and semi-supercentenarians: Association with functional status and mortality

Ostan, R., Monti, D., Mari, D., Arosio, B., Gentilini, D., Ferri, E., Passarino, G., De Rango, F., D’Aquila, P., Mariotti, S., Pasquali, R., Fanelli, F., Bucci, L., Franceschi, C. & Vitale, G., 2019, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 74, 6, p. 802-810 9 p.

Research output: Contribution to journalArticle

Heterogeneity of Thyroid Function and Impact of Peripheral Thyroxine Deiodination in Centenarians and Semi-Supercentenarians: Association With Functional Status and Mortality

Ostan, R., Monti, D., Mari, D., Arosio, B., Gentilini, D., Ferri, E., Passarino, G., De Rango, F., D'Aquila, P., Mariotti, S., Pasquali, R., Fanelli, F., Bucci, L., Franceschi, C. & Vitale, G., May 16 2019, In : The journals of gerontology. Series A, Biological sciences and medical sciences. 74, 6, p. 802-810 9 p.

Research output: Contribution to journalArticle

Open Access

Hemopoiesis in healthy old people and centenarians: Well-maintained responsiveness of CD34+ cells to hemopoietic growth factors and remodeling of cytokine network

Bagnara, G. P., Bonsi, L., Strippoli, P., Bonifazi, F., Tonelli, R., D'Addato, S., Paganelli, R., Scala, E., Fagiolo, U., Monti, D., Cossarizza, A., Bonafé, M. & Franceschi, C., Feb 2000, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 55, 2

Research output: Contribution to journalArticle

Helper activity of histocompatibility antigens on cell-mediated immunity.

Di Marco, A. T., Franceschi, C. & Prodi, G., Jun 1972, In : European Journal of Immunology. 2, 3, p. 240-242 3 p.

Research output: Contribution to journalArticle

Heat shock response by EBV-immortalized B-lymphocytes from centenarians and control subjects: A model to study the relevance of stress response in longevity

Marini, M., Lapalombella, R., Canaider, S., Farina, A., Monti, D., De Vescovi, V., Morellini, M., Bellizzi, D., Dato, S., De Benedictis, G., Passarino, G., Moresi, R., Tesei, S. & Franceschi, C., Jan 2004, In : Experimental Gerontology. 39, 1, p. 83-90 8 p.

Research output: Contribution to journalArticle

Health status and 6 years survival of 552 90+ Italian sib-ships recruited within the EU Project GEHA (GEnetics of Healthy Ageing)

Cevenini, E., Cotichini, R., Stazi, M. A., Toccaceli, V., Palmas, M. G., Capri, M., De Rango, F., Dato, S., Passarino, G., Jeune, B. & Franceschi, C., 2014, In : Age. 36, 2, p. 949-966 18 p.

Research output: Contribution to journalArticle

Have the oldest old adults ever been frail in the past? A hypothesis that explains modern trends in survival

Yashin, A. I., Ukraintseva, S. V., De Benedictis, G., Anisimov, V. N., Butov, A. A., Arbeev, K., Jdanov, D. A., Boiko, S. I., Begun, A. S., Bonafe, M. & Franceschi, C., 2001, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 56, 10

Research output: Contribution to journalArticle

HAPLOFIND: A new method for high-throughput mtDNA haplogroup assignment

Vianello, D., Sevini, F., Castellani, G., Lomartire, L., Capri, M. & Franceschi, C., Sep 2013, In : Human Mutation. 34, 9, p. 1189-1194 6 p.

Research output: Contribution to journalArticle

Haemagglutinating activity of modeccin

Gasperi-Campani, A., Franceschi, C., Perino, G. & Stirpe, F., Aug 1979, In : Experientia. 35, 8, p. 1086-1087 2 p.

Research output: Contribution to journalArticle

Gut neuroendocrine cells: Relationship to the proliferative activity and apoptosis of mucous epitheliocytes in aging

Kvetnoy, I., Popuichiev, V., Mikhina, L., Anisimov, V., Yuzhakov, V., Konovalov, S., Pogudina, N., Franceschi, C., Piantanelli, L., Rossolini, G., Zaia, A., Kvetnaia, T., Hernandez-Yago, J. & Blesa, J. R., 2001, In : Neuroendocrinology Letters. 22, 5, p. 337-341 5 p.

Research output: Contribution to journalArticle

Gut microbiota as a candidate for lifespan extension: An ecological/evolutionary perspective targeted on living organisms as metaorganisms

Ottaviani, E., Ventura, N., Mandrioli, M., Candela, M., Franchini, A. & Franceschi, C., Dec 2011, In : Biogerontology. 12, 6, p. 599-609 11 p.

Research output: Contribution to journalArticle

Gut Microbiota and Extreme Longevity

Biagi, E., Franceschi, C., Rampelli, S., Severgnini, M., Ostan, R., Turroni, S., Consolandi, C., Quercia, S., Scurti, M., Monti, D., Capri, M., Brigidi, P. & Candela, M., Feb 24 2016, (Accepted/In press) In : Current Biology.

Research output: Contribution to journalArticle

Gut microbiome in down syndrome

Biagi, E., Cela, M., Centanni, M., Consoli, C., Rampelli, S., Turroni, S., Severgnini, M., Peano, C., Ghezzo, A., Scurti, M., Salvioli, S., Franceschi, C. & Brigidi, P., Nov 11 2014, In : PLoS One. 9, 11, e112023.

Research output: Contribution to journalArticle

Growth properties and growth factor responsiveness in skin fibroblasts from centenarians

Tesco, G., Vergelli, M., Grassilli, E., Salomoni, P., Bellesia, E., Sikora, E., Radziszewska, E., Barbieri, D., Latorraca, S., Fagiolo, U., Santacaterina, S., Amaducci, L., Tiozzo, R., Franceschi, C. & Sorbi, S., Mar 27 1998, In : Biochemical and Biophysical Research Communications. 244, 3, p. 912-916 5 p.

Research output: Contribution to journalArticle

Geroscience: Linking aging to chronic disease

Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., Franceschi, C., Lithgow, G. J., Morimoto, R. I., Pessin, J. E., Rando, T. A., Richardson, A., Schadt, E. E., Wyss-Coray, T. & Sierra, F., Nov 6 2014, In : Cell. 159, 4, p. 709-713 5 p.

Research output: Contribution to journalArticle

Genotype of inflammatory cytokines in limbal stem cell graft in Italian patients

Lescai, F., Conti, L., Bartolozzi, M., Ramazzotti, G., Mazzi, M., Sarnicola, V. & Franceschi, C., Jun 24 2005, In : Biochemical and Biophysical Research Communications. 332, 1, p. 95-100 6 p.

Research output: Contribution to journalArticle

Genomic stability, anti-inflammatory phenotype, and up-regulation of the RNAseH2 in cells from centenarians

Storci, G., De Carolis, S., Papi, A., Bacalini, M. G., Gensous, N., Marasco, E., Tesei, A., Fabbri, F., Arienti, C., Zanoni, M., Sarnelli, A., Santi, S., Olivieri, F., Mensà, E., Latini, S., Ferracin, M., Salvioli, S., Garagnani, P., Franceschi, C. & Bonafè, M., 2019, In : Cell Death and Differentiation. 26, 9, p. 1845-1858 14 p.

Research output: Contribution to journalArticle

Genomic stability, anti-inflammatory phenotype, and up-regulation of the RNAseH2 in cells from centenarians

Storci, G., De Carolis, S., Papi, A., Bacalini, M. G., Gensous, N., Marasco, E., Tesei, A., Fabbri, F., Arienti, C., Zanoni, M., Sarnelli, A., Santi, S., Olivieri, F., Mensà, E., Latini, S., Ferracin, M., Salvioli, S., Garagnani, P., Franceschi, C. & Bonafè, M., Sep 2019, In : Cell Death and Differentiation. 26, 9, p. 1845-1858 14 p.

Research output: Contribution to journalArticle

Genomic stability, anti-inflammatory phenotype, and up-regulation of the RNAseH2 in cells from centenarians

Storci, G., De Carolis, S., Papi, A., Bacalini, M. G., Gensous, N., Marasco, E., Tesei, A., Fabbri, F., Arienti, C., Zanoni, M., Sarnelli, A., Santi, S., Olivieri, F., Mensà, E., Latini, S., Ferracin, M., Salvioli, S., Garagnani, P., Franceschi, C. & Bonafè, M., 2019, In : Cell Death and Differentiation. 26, 9, p. 1845-1858 14 p.

Research output: Contribution to journalArticle

Genomics and epigenomics

Garagnani, P., Terlizzi, R., Cevoli, S., Capellari, S., Pierangeli, G., Pirazzini, C., Bacalini, M. G., Franceschi, C. & Cortelli, P., Dec 1 2015, In : Journal of Headache and Pain. 16, p. 1 1 p., A7.

Research output: Contribution to journalArticle

Genomic instability and aging studies in centenarians (successful aging) and in patients with Down's syndrome (accelerated aging)

Franceschi, C., Monti, D., Scarfi, M. R., Zeni, O., Temperani, P., Emilia, G., Sansoni, P., Lio, M. B., Troiano, L., Agnesini, C., Salvioli, S. & Cossarlzza, A., 1992, In : Annals of the New York Academy of Sciences. 663, p. 4-16 13 p.

Research output: Contribution to journalArticle

Genomic instability: A challenge for aging research

Franceschi, C., 1990, In : Aging clinical and experimental research. 2, 2, p. 101-104 4 p.

Research output: Contribution to journalArticle

Genomic history of the Italian population recapitulates key evolutionary dynamics of both Continental and Southern Europeans

Sazzini, M., Abondio, P., Sarno, S., Gnecchi-Ruscone, G. A., Ragno, M., Giuliani, C., De Fanti, S., Ojeda-Granados, C., Boattini, A., Marquis, J., Valsesia, A., Carayol, J., Raymond, F., Pirazzini, C., Marasco, E., Ferrarini, A., Xumerle, L., Collino, S., Mari, D., Arosio, B. & 10 others, Monti, D., Passarino, G., D'Aquila, P., Pettener, D., Luiselli, D., Castellani, G., Delledonne, M., Descombes, P., Franceschi, C. & Garagnani, P., May 22 2020, In : BMC Biology. 18, 1, 51.

Research output: Contribution to journalArticle

Open Access

Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity

Fortney, K., Dobriban, E., Garagnani, P., Pirazzini, C., Monti, D., Mari, D., Atzmon, G., Barzilai, N., Franceschi, C., Owen, A. B. & Kim, S. K., 2015, In : PLoS Genetics. 11, 12, e1005728.

Research output: Contribution to journalArticle

Genome-wide linkage analysis for human longevity: Genetics of healthy aging study

Beekman, M., Blanché, H., Perola, M., Hervonen, A., Bezrukov, V., Sikora, E., Flachsbart, F., Christiansen, L., De Craen, A. J. M., Kirkwood, T. B. L., Rea, I. M., Poulain, M., Robine, J. M., Valensin, S., Stazi, M. A., Passarino, G., Deiana, L., Gonos, E. S., Paternoster, L., Sørensen, T. I. A. & 20 others, Tan, Q., Helmer, Q., Van Den Akker, E. B., Deelen, J., Martella, F., Cordell, H. J., Ayers, K. L., Vaupel, J. W., Törnwall, O., Johnson, T. E., Schreiber, S., Lathrop, M., Skytthe, A., Westendorp, R. G. J., Christensen, K., Gampe, J., Nebel, A., Houwing-Duistermaat, J. J., Slagboom, P. E. & Franceschi, C., 2013, In : Aging Cell. 12, 2, p. 184-193 10 p.

Research output: Contribution to journalArticle

Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome

Guastafierro, T., Bacalini, M. G., Marcoccia, A., Gentilini, D., Pisoni, S., Di Blasio, A. M., Corsi, A., Franceschi, C., Raimondo, D., Spanò, A., Garagnani, P. & Bondanini, F., Aug 30 2017, In : Clinical Epigenetics. 9, 1, 92.

Research output: Contribution to journalArticle

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

Deelen, J., Beekman, M., Uh, H. W., Broer, L., Ayers, K. L., Tan, Q., Kamatani, Y., Bennet, A. M., Tamm, R., Trompet, S., Guobjartsson, D. F., Flachsbart, F., Rose, G., Viktorin, A., Fischer, K., Nygaard, M., Cordell, H. J., Crocco, P., Van Den Akker, E. B., Böhringer, S. & 67 others, Helmer, Q., Nelson, C. P., Saunders, G. I., Alver, M., Andersen-Ranberg, K., Breen, M. E., van Der Breggen, R., Caliebe, A., Capri, M., Cevenini, E., Collerton, J. C., Dato, S., Davies, K., Ford, I., Gampe, J., Garagnani, P., de Geus, E. J. C., Harrow, J., Van Heemst, D., Heijmans, B. T., Heinsen, F. A., Hottenga, J. J., Hofman, A., Jeune, B., Jonsson, P. V., Lathrop, M., Lechner, D., Martin-Ruiz, C., Mcnerlan, S. E., Mihailov, E., Montesanto, A., Mooijaart, S. P., Murphy, A., Nohr, E. A., Paternoster, L., Postmus, I., Rivadeneira, F., Ross, O. A., Salvioli, S., Sattar, N., Schreiber, S., Stefánsson, H., Stott, D. J., Tiemeier, H., Uitterlinden, A. G., Westendorp, R. G. J., Willemsen, G., Samani, N. J., Galan, P., Sørensen, T. I. A., Boomsma, D. I., Wouter Jukema, J., Rea, I. M., Passarino, G., de Craen, A. J. M., Christensen, K., Nebel, A., Stefánsson, K., Metspalu, A., Magnusson, P., Blanché, H., Christiansen, L., Kirkwood, T. B. L., Van Duijn, C. M., Franceschi, C., Houwing-Duistermaat, J. J. & Slagboom, P. E., 2014, In : Human Molecular Genetics. 23, 16, p. 4420-4432 13 p., ddu139.

Research output: Contribution to journalArticle

Genetics of neurodegenerative disorders [4] (multiple letters)

Caruso, C., Franceschi, C., Licastro, F., Nussbaum, R. & Ellis, C., Jul 10 2003, In : New England Journal of Medicine. 349, 2, p. 193-194 2 p.

Research output: Contribution to journalArticle

Genetics of neurodegenerative disorders.

Caruso, C., Franceschi, C. & Licastro, F., 2003, In : New England Journal of Medicine. 349, 2

Research output: Contribution to journalArticle

Genetics and anthropology in studies on aging and chagas disease

Franceschi, C., Yao, D. Y., Sevini, F., Santoro, A., Luiselli, D., Pettener, D., Ferri, G., Dasso, M. C., De La Hoz, R. P., Moretti, E., Basso, B., Castro, I., Ciannameo, A. & Franceschi, Z., 2010, In : Journal of anthropological sciences = Rivista di antropologia : JASS / Istituto italiano di antropologia. 88, p. 245-250 6 p.

Research output: Contribution to journalArticle

Genetic polymorphisms of inflammatory cytokines and myocardial infarction in the elderly

Olivieri, F., Antonicelli, R., Cardelli, M., Marchegiani, F., Cavallone, L., Mocchegiani, E. & Franceschi, C., Jun 2006, In : Mechanisms of Ageing and Development. 127, 6, p. 552-559 8 p.

Research output: Contribution to journalArticle

Genetic polymorphisms of Fas (CD95) and FasL (CD178) in human longevity: Studies on centenarians

Pinti, M., Troiano, L., Nasi, M., Moretti, L., Monterastelli, E., Mazzacani, A., Mussi, C., Ventura, P., Olivieri, F., Franceschi, C., Salvioli, G. & Cossarizza, A., 2002, In : Cell Death and Differentiation. 9, 4, p. 431-438 8 p.

Research output: Contribution to journalArticle

Genetic epidemiologic studies on age-specified traits

Bailey-Wilson, J., Baron, J., Cawthon, R., Christian, J. C., Corder, E. H., Franceschi, C., Kestenbaum, B., Kruglyak, L., Lauderdale, D. S., Lubitz, J., Martin, G. M., McClearn, G. E., McGue, M., Miles, T., Mineau, G., Ouellett, G., Pedersen, N. L., Preston, S. H., Page, W. F., Province, M. & 8 others, Schachter, F., Schork, N. J., Vaupel, J. W., Vijg, J., Wallace, R., Wang, E., Wijsman, E. M. & Hadley, E., Dec 1 2000, In : American Journal of Epidemiology. 152, 11, p. 1003-1008 6 p.

Research output: Contribution to journalArticle

Genetic and environmental influences on serum levels of immunoglobulins and complement components in monozygotic and dizygotic twins

Di Franco, P., Brai, M., Misiano, G., Piazza, A. M., Giorgi, G., Cossarizza, A. & Franceschi, C., 1988, In : Journal of Clinical and Laboratory Immunology. 27, 1, p. 5-10 6 p.

Research output: Contribution to journalArticle

Genetic analysis of paraoxonase (PON1) locus reveals an increased frequency of Arg192 allele in centenarians

Bonafè, M., Marchegiani, F., Cardelli, M., Olivieri, F., Cavallone, L., Giovagnetti, S., Pieri, C., Marra, M., Antonicelli, R., Troiano, L., Gueresi, P., Passeri, G., Berardelli, M., Paolisso, G., Barbieri, M., Tesei, S., Lisa, R., De Benedictis, G. & Franceschi, C., 2002, In : European Journal of Human Genetics. 10, 5, p. 292-296 5 p.

Research output: Contribution to journalArticle