1969 …2020

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The "immune-mobile brain": Evolutionary evidence

Ottaviani, E., Caselgrandi, E., Bondi, M., Cossarizza, A., Monti, D. & Franceschi, C., 1991, In : Advances in Neuroimmunology. 1, 1, p. 27-39 13 p.

Research output: Contribution to journalArticle

The immune system in extreme longevity

Sansoni, P., Vescovini, R., Fagnoni, F., Biasini, C., Zanni, F., Zanlari, L., Telera, A., Lucchini, G., Passeri, G., Monti, D., Franceschi, C. & Passeri, M., Feb 2008, In : Experimental Gerontology. 43, 2, p. 61-65 5 p.

Research output: Contribution to journalArticle

The immune system in the elderly: Activation-induced and damage-induced apoptosis

Ginaldi, L., De Martinis, M., Monti, D. & Franceschi, C., 2004, In : Immunologic Research. 30, 1, p. 81-94 14 p.

Research output: Contribution to journalArticle

The immunology of exceptional individuals: the lesson of centenarians

Franceschi, C., Monti, D., Sansoni, P. & Cossarizza, A., 1995, In : Immunology Today. 16, 1, p. 12-16 5 p.

Research output: Contribution to journalArticle

The impact of mitochondrial DNA on human lifespan: A view from studies on centenarians

Salvioli, S., Capri, M., Santoro, A., Raule, N., Sevini, F., Lukas, S., Lanzarini, C., Monti, D., Passarino, G., Rose, G., De Benedictis, G. & Franceschi, C., Jun 2008, In : Biotechnology Journal. 3, 6, p. 740-749 10 p.

Research output: Contribution to journalArticle

The impact of phenocopy on the genetic analysis of complex traits

Lescai, F. & Franceschi, C., 2010, In : PLoS One. 5, 7, e11876.

Research output: Contribution to journalArticle

The influences on human longevity by HUMTHO1.STR polymorphism (Tyrosine Hydroxylase gene): A relative risk approach

Tan, Q., Bellizzi, D., Rose, G., Garasto, S., Franceschi, C., Kruse, T., Vaupel, J. W., De Benedictis, G. & Yashin, A. I., Jul 2002, In : Mechanisms of Ageing and Development. 123, 10, p. 1403-1410 8 p.

Research output: Contribution to journalArticle

The interleukin-6 -174 G>C promoter polymorphism is associated with a higher risk of death after an acute coronary syndrome in male elderly patients

Antonicelli, R., Olivieri, F., Bonafè, M., Cavallone, L., Spazzafumo, L., Marchegiani, F., Cardelli, M., Recanatini, A., Testarmata, P., Boemi, M., Parati, G. & Franceschi, C., Sep 1 2005, In : International Journal of Cardiology. 103, 3, p. 266-271 6 p.

Research output: Contribution to journalArticle

The invertebrate blueprint of the connection between aging and immune neuroendocrine responses

Ottaviani, E., Malagoli, D. & Franceschi, C., 2009, In : Invertebrate Survival Journal. 6, 2, p. 102-105 4 p.

Research output: Contribution to journalArticle

The invertebrate phagocytic immunocyte: Clues to a common evolution of immune and neuroendocrine systems

Ottaviani, E. & Franceschi, C., Apr 1997, In : Immunology Today. 18, 4, p. 169-174 6 p.

Research output: Contribution to journalArticle

The MALVA (MAntova LongeVA) study: An investigation on people 98 years of age and over in a province of Northern Italy

Gueresi, P., Troiano, L., Minicuci, N., Bonafé, M., Pini, G., Salvioli, G., Carani, C., Ferrucci, L., Spazzafumo, L., Olivieri, F., Cavrini, G., Valentini, D. & Franceschi, C., Oct 2003, In : Experimental Gerontology. 38, 10, p. 1189-1197 9 p.

Research output: Contribution to journalArticle

The methylation of nuclear and mitochondrial DNA in ageing phenotypes and longevity

Bacalini, M. G., D'Aquila, P., Marasco, E., Nardini, C., Montesanto, A., Franceschi, C., Passarino, G., Garagnani, P. & Bellizzi, D., 2017, In : Mechanisms of Ageing and Development. 165, Pt B, p. 156-61

Research output: Contribution to journalArticle

The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring

Rose, G., Passarino, G., Scornaienchi, V., Romeo, G., Dato, S., Bellizzi, D., Mari, V., Feraco, E., Maletta, R., Bruni, A., Franceschi, C. & De Benedictis, G., Aug 29 2007, In : BMC Genomics. 8, 293.

Research output: Contribution to journalArticle

The network and the remodeling theories of aging: Historical background and new perspectives

Franceschi, C., Valensin, S., Bonafè, M., Paolisso, G., Yashin, A. I., Monti, D. & De Benedictis, G., 2000, In : Experimental Gerontology. 35, 6-7, p. 879-896 18 p.

Research output: Contribution to journalArticle

The neuroimmunology of stress from invertebrates to man

Ottaviani, E. & Franceschi, C., Mar 1996, In : Progress in Neurobiology. 48, 4-5, p. 421-440 20 p.

Research output: Contribution to journalArticle

The nucleolar size is associated to the methylation status of ribosomal DNA in breast carcinomas

Bacalini, M. G., Pacilli, A., Giuliani, C., Penzo, M., Treré, D., Pirazzini, C., Salvioli, S., Franceschi, C., Montanaro, L. & Garagnani, P., May 22 2014, In : BMC Cancer. 14, 1, 361.

Research output: Contribution to journalArticle

The "oldest man on the planet" [4]

Deiana, L., Pes, G. M., Carru, C., Ferrucci, L., Franceschi, C. & Baggio, G., Dec 1 2002, In : Journal of the American Geriatrics Society. 50, 12, p. 2098-2099 2 p.

Research output: Contribution to journalArticle

The onset of type 2 diabetes: Proposal for a multi-scale model

Castiglione, F., Tieri, P., De Graaf, A., Franceschi, C., Liò, P., Van Ommen, B., Mazzà, C., Tuchel, A., Bernaschi, M., Samson, C., Colombo, T., Castellani, G. C., Capri, M., Garagnani, P., Salvioli, S., Nguyen, V. A., Bobeldijk-Pastorova, I., Krishnan, S., Cappozzo, A., Sacchetti, M. & 2 others, Morettini, M. & Ernst, M., Oct 2013, In : Journal of Medical Internet Research. 15, 10, 2854.

Research output: Contribution to journalArticle

The p53 codon 72 (Arg72Pro) polymorphism is associated with the degree of insulin resistance in type 2 diabetic subjects: A cross-sectional study

Bonfigli, A. R., Sirolla, C., Testa, R., Cucchi, M., Spazzafumo, L., Salvioli, S., Ceriello, A., Olivieri, F., Festa, R., Procopio, A. D., Brandoni, G., Boemi, M., Marra, M. & Franceschi, C., Jun 2013, In : Acta Diabetologica. 50, 3, p. 429-436 8 p.

Research output: Contribution to journalArticle

The PON1192RR genotype is associated with a higher prevalence of arterial hypertension

Marra, M., Marchegiani, F., Antonicelli, R., Sirolla, C., Spazzafumo, L., Olivieri, F., Franceschi, C., Testa, R., Paolisso, G., James, R. W., Boemi, M. & Parati, G., Jun 2006, In : Journal of Hypertension. 24, 7, p. 1293-1298 6 p.

Research output: Contribution to journalArticle

The Pro/Pro genotype of the p53 codon 72 polymorphism modulates PAI-1 plasma levels in ageing

Testa, R., Bonfigli, A. R., Salvioli, S., Invidia, L., Pierini, M., Sirolla, C., Marra, M., Testa, I., Fazioli, F., Recchioni, R., Marcheselli, F., Olivieri, F., Lanari, L. & Franceschi, C., Aug 2009, In : Mechanisms of Ageing and Development. 130, 8, p. 497-500 4 p.

Research output: Contribution to journalArticle

The Prognostic Roles of Gender and O6-Methylguanine-DNA Methyltransferase Methylation Status in Glioblastoma Patients: The Female Power

PERNO Study Group, Apr 1 2018, In : World Neurosurgery. 112, p. e342-e347

Research output: Contribution to journalArticle

The role of IL-1 gene cluster in longevity: A study in Italian population

Cavallone, L., Bonafè, M., Olivieri, F., Cardelli, M., Marchegiani, F., Giovagnetti, S., Di Stasio, G., Giampieri, C., Mugianesi, E., Stecconi, R., Sciacca, F., Grimaldi, L. M., De Benedictis, G., Lio, D., Caruso, C. & Franceschi, C., Apr 1 2003, In : Mechanisms of Ageing and Development. 124, 4, p. 533-538 6 p.

Research output: Contribution to journalArticle

The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: A systems biology approach

Calçada, D., Vianello, D., Giampieri, E., Sala, C., Castellani, G., de Graaf, A., Kremer, B., van Ommen, B., Feskens, E., Santoro, A., Franceschi, C. & Bouwman, J., 2014, In : Mechanisms of Ageing and Development. 136-137, p. 138-147 10 p.

Research output: Contribution to journalArticle

The role of platelet-activating factor in the biocompatibility of hemodialysis membranes

Tetta, C., Haeffner-Cavaillon, N., Navino, C., David, S., Franceschi, C., Mariano, F. & Camussi, G., 1997, In : Advances in Experimental Medicine and Biology. 416, p. 243-248 6 p.

Research output: Contribution to journalArticle

The second international conference "genetics of aging and longevity".

Anisimov, V. N., Bartke, A., Barzilai, N., Batin, M. A., Blagosklonny, M. V., Brown-Borg, H., Budovskaya, Y., Campisi, J., Friguet, B., Fraifeld, V., Franceschi, C., Gems, D., Gladyshev, V., Gorbunova, V., Gudkov, A. V., Kennedy, B., Konovalenko, M., Kraemer, B., Moskalev, A., Petropoulos, I. & 10 others, Pasyukova, E., Rattan, S., Rogina, B., Seluanov, A., Shaposhnikov, M., Shmookler Reis, R., Tavernarakis, N., Vijg, J., Yashin, A. & Zimniak, P., May 2012, In : Aging. 4, 5, p. 305-317 13 p.

Research output: Contribution to journalArticle

The study of APOA1, APOC3 and APOA4 variability in healthy ageing people reveals another paradox in the oldest old subjects

Garasto, S., Rose, G., Derango, F., Berardelli, M., Corsonello, A., Feraco, E., Mari, V., Maletta, R., Bruni, A., Franceschi, C., Carotenuto, L. & De Benedictis, G., Jan 2003, In : Annals of Human Genetics. 67, 1, p. 54-62 9 p.

Research output: Contribution to journalArticle

The three genetics (Nuclear DNA, mitochondrial DNA, and Gut microbiome) of longevity in humans considered as metaorganisms

Garagnani, P., Pirazzini, C., Giuliani, C., Candela, M., Brigidi, P., Sevini, F., Luiselli, D., Bacalini, M. G., Salvioli, S., Capri, M., Monti, D., Mari, D., Collino, S., Delledonne, M., Descombes, P. & Franceschi, C., 2014, In : BioMed Research International. 2014, 560340.

Research output: Contribution to journalArticle

The treatment of osteosarcoma of the extremities: Twenty year's experience at the Istituto Ortopedico Rizzoli

Campanacci, M., Bacci, G., Bertoni, F., Picci, P., Minutillo, A. & Franceschi, C., 1981, In : Cancer. 48, 7, p. 1569-1581 13 p.

Research output: Contribution to journalArticle

The unexpected contribution of immunosenescence to the leveling off of cancer incidence and mortality in the oldest old

Bonafè, M., Valensin, S., Gianni, W., Marigliano, V. & Franceschi, C., 2001, In : Critical Reviews in Oncology/Hematology. 39, 3, p. 227-233 7 p.

Research output: Contribution to journalArticle

The unusual genetics of human longevity.

De Benedictis, G. & Franceschi, C., May 25 2006, In : Science of aging knowledge environment : SAGE KE. 2006, 10

Research output: Contribution to journalArticle

The use of non-variant sites to improve the clinical assessment of whole-genome sequence data

Ferrarini, A., Xumerle, L., Griggio, F., Garonzi, M., Cantaloni, C., Centomo, C., Vargas, S. M., Descombes, P., Marquis, J., Collino, S., Franceschi, C., Garagnani, P., Salisbury, B. A., Harvey, J. M. & Delledonne, M., Jul 6 2015, In : PLoS One. 10, 7, e0132180.

Research output: Contribution to journalArticle

The variability of the mitochondrial genome in human aging: A key for life and death?

Rose, G., Passarino, G., Franceschi, C. & De Benedictis, G., Nov 2002, In : International Journal of Biochemistry and Cell Biology. 34, 11, p. 1449-1460 12 p.

Research output: Contribution to journalArticle

Through ageing, and beyond: Gut microbiota and inflammatory status in seniors and centenarians

Biagi, E., Nylund, L., Candela, M., Ostan, R., Bucci, L., Pini, E., Nikkïla, J., Monti, D., Satokari, R., Franceschi, C., Brigidi, P. & de Vos, W., 2010, In : PLoS One. 5, 5, e10667.

Research output: Contribution to journalArticle

THYMIC HORMONE DEFICIENCY IN NORMAL AGEING AND DOWN'S SYNDROME: IS THERE A PRIMARY FAILURE OF THE THYMUS?

Fabris, N., Amadio, L., Licastro, F., Mocchegiani, E., Zannotti, M. & Franceschi, C., May 5 1984, In : Lancet. 323, 8384, p. 983-986 4 p.

Research output: Contribution to journalArticle

Thymic output and functionality of the IL-7/IL-7 receptor system in centenarians: Implications for the neolymphogenesis at the limit of human life

Nasi, M., Troiano, L., Lugli, E., Pinti, M., Ferraresi, R., Monterastelli, E., Mussi, C., Salvioli, G., Franceschi, C. & Cossarizza, A., Apr 2006, In : Aging Cell. 5, 2, p. 167-175 9 p.

Research output: Contribution to journalArticle

Thyroid and other organ-specific autoantibodies in healthy ceritenarians

Mariotti, S., Barbesino, G., Caturegli, P., Giacomelli, T., Pinchera, A., Monti, D., Cossarizza, A., Franceschi, C., Sansoni, P., Passeri, G. & Fagiolo, U., Jun 20 1992, In : Lancet. 339, 8808, p. 1506-1508 3 p.

Research output: Contribution to journalArticle

Thyroid autoimmunity and ageing

Pinchera, A., Mariotti, S., Barbesino, G., Bechi, R., Sansoni, P., Fagiolo, U., Cossarizza, A. & Franceschi, C., 1995, In : Hormone Research. 43, 1-3, p. 64-68 5 p.

Research output: Contribution to journalArticle

Thyroid autoimmunity and aging

Mariotti, S., Chiovato, L., Franceschi, C. & Pinchera, A., Sep 1998, In : Experimental Gerontology. 33, 6, p. 535-541 7 p.

Research output: Contribution to journalArticle

Thyroid hormones and frailty in persons experiencing extreme longevity

Arosio, B., Monti, D., Mari, D., Passarino, G., Ostan, R., Ferri, E., De Rango, F., Franceschi, C., Cesari, M. & Vitale, G., Sep 2020, In : Experimental Gerontology. 138, 111000.

Research output: Contribution to journalArticle

T lymphocyte proliferative capability to defined stimuli and costimulatory CD28 pathway is not impaired in healthy centenarians

Sansoni, P., Fagnoni, F., Vescovini, R., Mazzola, M., Brianti, V., Bologna, G., Nigro, E., Lavagetto, G., Cossarizza, A., Monti, D., Franceschi, C. & Passeri, M., Jun 1997, In : Mechanisms of Ageing and Development. 96, 1-3, p. 127-136 10 p.

Research output: Contribution to journalArticle

Towards a liquid self: How time, geography, and life experiences reshape the biological identity

Grignolio, A., Mishto, M., Caetano Faria, A. M., Garagnani, P., Franceschi, C. & Tieri, P., 2014, In : Frontiers in Immunology. 5, APR, Article 153.

Research output: Contribution to journalArticle

Toxicity of Momordica charantia lectin and inhibitor for human normal and leukaemic lymphocytes

Licastro, F., Franceschi, C., Barbieri, L. & Stirpe, F., Dec 1980, In : Virchows Archiv B Cell Pathology Including Molecular Pathology. 33, 1, p. 257-265 9 p.

Research output: Contribution to journalArticle

TP53 codon 72 polymorphism affects accumulation of mtDNA damage in human cells

Altilia, S., Santoro, A., Malagoli, D., Lanzarini, C., Alvarez, J. A. B., Galazzo, G., Porter, D. C., Crocco, P., Rose, G., Passarino, G., Roninson, I. B., Franceschi, C. & Salvioli, S., Jan 2012, In : Aging. 4, 1, p. 28-39 12 p.

Research output: Contribution to journalArticle

Tracing Behçet's disease origins along the Silk Road: An anthropological evolutionary genetics perspective

Sazzini, M., Garagnani, P., Sarno, S., Fanti, S. D., Lazzano, T., Yao, D. Y., Boattini, A., Pazzola, G., Maramotti, S., Boiardi, L., Franceschi, C., Salvarani, C. & Luiselli, D., 2015, In : Clinical and Experimental Rheumatology. 33, p. 60-66 7 p.

Research output: Contribution to journalArticle

Transcription factors DNA-binding activity in rat thymocytes undergoing apoptosis after heat-shock or dexamethasone treatment

Sikora, E., Grassilli, E., Radziszewska, E., Bellesia, E., Barbieri, D. & Franceschi, C., 1993, In : Biochemical and Biophysical Research Communications. 197, 2, p. 709-715 7 p.

Research output: Contribution to journalArticle

Transformation of beta-amyloid (Aβ) (1-42) tyrosine to L-Dopa as the result of in vitro hydroxyl radical attack

Giunta, S., Ronchi, P., Valli, B., Franceschi, C. & Galeazzi, L., 2000, In : Amyloid. 7, 3, p. 189-193 5 p.

Research output: Contribution to journalArticle

Transmission from centenarians to their offspring of mtDNA heteroplasmy revealed by ultra-deep sequencing

Giuliani, C., Barbieri, C., Li, M., Bucci, L., Monti, D., Passarino, G., Luiselli, D., Franceschi, C., Stoneking, M. & Garagnani, P., 2014, In : Aging. 6, 6, p. 454-467 14 p.

Research output: Contribution to journalArticle