1969 …2020

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The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring

Rose, G., Passarino, G., Scornaienchi, V., Romeo, G., Dato, S., Bellizzi, D., Mari, V., Feraco, E., Maletta, R., Bruni, A., Franceschi, C. & De Benedictis, G., Aug 29 2007, In : BMC Genomics. 8, 293.

Research output: Contribution to journalArticle

The methylation of nuclear and mitochondrial DNA in ageing phenotypes and longevity

Bacalini, M. G., D'Aquila, P., Marasco, E., Nardini, C., Montesanto, A., Franceschi, C., Passarino, G., Garagnani, P. & Bellizzi, D., 2017, In : Mechanisms of Ageing and Development. 165, Pt B, p. 156-61

Research output: Contribution to journalArticle

The MALVA (MAntova LongeVA) study: An investigation on people 98 years of age and over in a province of Northern Italy

Gueresi, P., Troiano, L., Minicuci, N., Bonafé, M., Pini, G., Salvioli, G., Carani, C., Ferrucci, L., Spazzafumo, L., Olivieri, F., Cavrini, G., Valentini, D. & Franceschi, C., Oct 2003, In : Experimental Gerontology. 38, 10, p. 1189-1197 9 p.

Research output: Contribution to journalArticle

The invertebrate phagocytic immunocyte: Clues to a common evolution of immune and neuroendocrine systems

Ottaviani, E. & Franceschi, C., Apr 1997, In : Immunology Today. 18, 4, p. 169-174 6 p.

Research output: Contribution to journalArticle

The invertebrate blueprint of the connection between aging and immune neuroendocrine responses

Ottaviani, E., Malagoli, D. & Franceschi, C., 2009, In : Invertebrate Survival Journal. 6, 2, p. 102-105 4 p.

Research output: Contribution to journalArticle

The interleukin-6 -174 G>C promoter polymorphism is associated with a higher risk of death after an acute coronary syndrome in male elderly patients

Antonicelli, R., Olivieri, F., Bonafè, M., Cavallone, L., Spazzafumo, L., Marchegiani, F., Cardelli, M., Recanatini, A., Testarmata, P., Boemi, M., Parati, G. & Franceschi, C., Sep 1 2005, In : International Journal of Cardiology. 103, 3, p. 266-271 6 p.

Research output: Contribution to journalArticle

The influences on human longevity by HUMTHO1.STR polymorphism (Tyrosine Hydroxylase gene): A relative risk approach

Tan, Q., Bellizzi, D., Rose, G., Garasto, S., Franceschi, C., Kruse, T., Vaupel, J. W., De Benedictis, G. & Yashin, A. I., Jul 2002, In : Mechanisms of Ageing and Development. 123, 10, p. 1403-1410 8 p.

Research output: Contribution to journalArticle

The impact of phenocopy on the genetic analysis of complex traits

Lescai, F. & Franceschi, C., 2010, In : PLoS One. 5, 7, e11876.

Research output: Contribution to journalArticle

The impact of mitochondrial DNA on human lifespan: A view from studies on centenarians

Salvioli, S., Capri, M., Santoro, A., Raule, N., Sevini, F., Lukas, S., Lanzarini, C., Monti, D., Passarino, G., Rose, G., De Benedictis, G. & Franceschi, C., Jun 2008, In : Biotechnology Journal. 3, 6, p. 740-749 10 p.

Research output: Contribution to journalArticle

The immunology of exceptional individuals: the lesson of centenarians

Franceschi, C., Monti, D., Sansoni, P. & Cossarizza, A., 1995, In : Immunology Today. 16, 1, p. 12-16 5 p.

Research output: Contribution to journalArticle

The immune system in the elderly: Activation-induced and damage-induced apoptosis

Ginaldi, L., De Martinis, M., Monti, D. & Franceschi, C., 2004, In : Immunologic Research. 30, 1, p. 81-94 14 p.

Research output: Contribution to journalArticle

The immune system in extreme longevity

Sansoni, P., Vescovini, R., Fagnoni, F., Biasini, C., Zanni, F., Zanlari, L., Telera, A., Lucchini, G., Passeri, G., Monti, D., Franceschi, C. & Passeri, M., Feb 2008, In : Experimental Gerontology. 43, 2, p. 61-65 5 p.

Research output: Contribution to journalArticle

The "immune-mobile brain": Evolutionary evidence

Ottaviani, E., Caselgrandi, E., Bondi, M., Cossarizza, A., Monti, D. & Franceschi, C., 1991, In : Advances in Neuroimmunology. 1, 1, p. 27-39 13 p.

Research output: Contribution to journalArticle

The highly reducing sugar 2-deoxy-D-ribose induces apoptosis in human fibroblasts by reduced glutathione depletion and cytoskeletal disruption

Kletsas, D., Barbieri, D., Stathakos, D., Botti, B., Bergamini, S., Tomasi, A., Monti, D., Malorni, W. & Franceschi, C., Feb 13 1998, In : Biochemical and Biophysical Research Communications. 243, 2, p. 416-425 10 p.

Research output: Contribution to journalArticle

The genetics of successful aging

De Benedictis, G. & Franceschi, C., 1998, In : Aging clinical and experimental research. 10, 2, p. 147 1 p.

Research output: Contribution to journalArticle

The genetics of human longevity

Capri, M., Salvioli, S., Sevini, F., Valensin, S., Celani, L., Monti, D., Pawelec, G., De Benedictis, G., Gonos, E. S. & Franceschi, C., May 2006, In : Annals of the New York Academy of Sciences. 1067, 1, p. 252-263 12 p.

Research output: Contribution to journalArticle

The G/C915 polymorphism of transforming growth factor β1 is associated with human longevity: A study in Italian centenarians

Carrieri, G., Marzi, E., Olivieri, F., Marchegiani, F., Cavallone, L., Cardelli, M., Giovagnetti, S., Stecconi, R., Molendini, C., Trapassi, C., De Benedictis, G., Kletsas, D. & Franceschi, C., Dec 2004, In : Aging Cell. 3, 6, p. 443-448 6 p.

Research output: Contribution to journalArticle

The frequency of Klotho KL-VS polymorphism in a large Italian population, from young subjects to centenarians, suggests the presence of specific time windows for its effect

Invidia, L., Salvioli, S., Altilia, S., Pierini, M., Panourgia, M. P., Monti, D., De Rango, F., Passarino, G. & Franceschi, C., Feb 2010, In : Biogerontology. 11, 1, p. 67-73 7 p.

Research output: Contribution to journalArticle

The extreme longevity: The state of the art in Italy

Franceschi, C., Motta, L., Motta, M., Malaguarnera, M., Capri, M., Vasto, S., Candore, G. & Caruso, C., Feb 2008, In : Experimental Gerontology. 43, 2, p. 45-52 8 p.

Research output: Contribution to journalArticle

The evolution of the adipose tissue: A neglected enigma

Ottaviani, E., Malagoli, D. & Franceschi, C., Oct 1 2011, In : General and Comparative Endocrinology. 174, 1, p. 1-4 4 p.

Research output: Contribution to journalArticle

The epigenetic side of human adaptation: Hypotheses, evidences and theories

Giuliani, C., Bacalini, M. G., Sazzini, M., Pirazzini, C., Franceschi, C., Garagnani, P. & Luiselli, D., Jan 1 2015, In : Annals of Human Biology. 42, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

The emerging role of ECM crosslinking in T cell mobility as a hallmark of immunosenescence in humans

Moreau, J. F., Pradeu, T., Grignolio, A., Nardini, C., Castiglione, F., Tieri, P., Capri, M., Salvioli, S., Taupin, J. L., Garagnani, P. & Franceschi, C., Jun 1 2016, (Accepted/In press) In : Ageing Research Reviews.

Research output: Contribution to journalArticle

The effects of low frequency pulsing electromagnetic fields on the response of human lymphocytes to lectins. Changes at different values of induced electrical tension

Cadossi, R., Ceccherelli, G. B., Emilia, G., Torelli, G., Ruggieri, M. P., Bersani, F., Cossarizza, A. & Franceschi, C., 1988, In : Bioelectrochemistry and Bioenergetics. 19, 2, p. 315-322 8 p.

Research output: Contribution to journalArticle

The effects of low frequency pulsing electromagnetic fields on the response of human lymphocytes to lectins. Changes at different values of induced electrical tension

Cadossi, R., Ceccherelli, G. B., Emilia, G., Torelli, G., Ruggieri, M. P., Bersani, F., Cossarizza, A. & Franceschi, C., 1988, In : Journal of Electroanalytical Chemistry. 253, 2, p. 315-322 8 p.

Research output: Contribution to journalArticle

The effect on rat thymocytes of the simultaneous in vivo exposure to 50-Hz electric and magnetic field and to continuous light.

Quaglino, D., Capri, M., Zecca, L., Franceschi, C. & Ronchetti, I. P., Oct 20 2004, In : TheScientificWorldJournal. 4 Suppl 2, p. 91-99 9 p.

Research output: Contribution to journalArticle

The effect of light regimen and melatonin on the development of spontaneous mammary tumors in HER-2/neu transgenic mice is related to a downregulation of HER-2/neu gene expression

Baturin, D. A., Alimova, I. N., Anisimov, V. N., Popovich, I. G., Zabezhinski, M. A., Provinciali, M., Mancini, R. & Franceschi, C., 2001, In : Neuroendocrinology Letters. 22, 6, p. 441-447 7 p.

Research output: Contribution to journalArticle

The effect of L-carnitine and acetyl-L-carnitine on the disappearance of DNA single-strand breaks in human peripheral blood lymphocytes

Boerrigter, M. E. T. I., Franceschi, C., Arrigoni-Martelli, E., Wei, J. Y. & Vijg, J., Oct 1993, In : Carcinogenesis. 14, 10, p. 2131-2136 6 p.

Research output: Contribution to journalArticle

The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death

Bonafé, M., Salvioli, S., Barbi, C., Trapassi, C., Tocco, F., Storci, G., Invidia, L., Vannini, I., Rossi, M., Marzi, E., Mishto, M., Capri, M., Olivieri, F., Antonicelli, R., Memo, M., Uberti, D., Nacmias, B., Sorbi, S., Monti, D. & Franceschi, C., Sep 2004, In : Cell Death and Differentiation. 11, 9, p. 962-973 12 p.

Research output: Contribution to journalArticle

The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific

Raule, N., Sevini, F., Li, S., Barbieri, A., Tallaro, F., Lomartire, L., Vianello, D., Montesanto, A., Moilanen, J. S., Bezrukov, V., Blanché, H., Hervonen, A., Christensen, K., Deiana, L., Gonos, E. S., Kirkwood, T. B. L., Kristensen, P., Leon, A., Pelicci, P. G., Poulain, M. & 18 others, Rea, I. M., Remacle, J., Robine, J. M., Schreiber, S., Sikora, E., Eline Slagboom, P., Spazzafumo, L., Antonietta Stazi, M., Toussaint, O., Vaupel, J. W., Rose, G., Majamaa, K., Perola, M., Johnson, T. E., Bolund, L., Yang, H., Passarino, G. & Franceschi, C., 2014, In : Aging Cell. 13, 3, p. 401-407 7 p.

Research output: Contribution to journalArticle

The challenges in moving from ageing to successful longevity

Kolovou, G., Barzilai, N., Caruso, C., Sikora, E., Capri, M., Tzanetakou, I. P., Bilianou, H., Avery, P., Katsiki, N., Panotopoulos, G., Franceschi, C., Benetos, A. & Mikhailidis, D. P., 2014, In : Current Vascular Pharmacology. 12, 5, p. 662-673 12 p.

Research output: Contribution to journalArticle

The BB-paraoxonase genotype is associated with impaired brachial reactivity after acute hypertriglyceridemia in healthy subjects

Paolisso, G., Manzella, D., Tagliamonte, M. R., Barbieri, M., Marfella, R., Zito, G., Bonafè, M., Giugliano, D., Franceschi, C. & Varricchio, M., 2001, In : Journal of Clinical Endocrinology and Metabolism. 86, 3, p. 1078-1082 5 p.

Research output: Contribution to journalArticle

The allele (A) -110 in the promoter region of the HSP70-1 gene is unfavorable to longevity in women

Altomare, K., Greco, V., Bellizzi, D., Berardelli, M., Dato, S., DeRango, F., Garasto, S., Rose, G., Feraco, E., Mari, V., Passarino, G., Franceschi, C. & De Benedictis, G., 2003, In : Biogerontology. 4, 4, p. 215-220 6 p.

Research output: Contribution to journalArticle

The aging thyroid

Mariotti, S., Franceschi, C., Cossarizza, A. & Pinchera, A., 1995, In : Endocrine Reviews. 16, 6, p. 686-715 30 p.

Research output: Contribution to journalArticle

The aging gut microbiota: New perspectives

Biagi, E., Candela, M., Franceschi, C. & Brigidi, P., Sep 2011, In : Ageing Research Reviews. 10, 4, p. 428-429 2 p.

Research output: Contribution to journalArticle

The adapter protein CD2AP binds to p53 protein in the cytoplasm and can discriminate its polymorphic variants P72R

Panni, S., Salvioli, S., Santonico, E., Langone, F., Storino, F., Altilia, S., Franceschi, C., Cesareni, G. & Castagnoli, L., Feb 1 2015, In : Journal of Biochemistry. 157, 2, p. 101-111 11 p.

Research output: Contribution to journalArticle

The A3 adenosine receptor mediates cell spreading, reorganization of actin cytoskeleton, and distribution of Bcl-x(L): Studies in human astroglioma cells

Abbracchio, M. P., Rainaidi, G., Giammarioli, A. M., Ceruti, S., Brambilla, R., Cattabeni, F., Barbieri, D., Franceschi, C., Jacobson, K. A. & Malorni, W., Dec 18 1997, In : Biochemical and Biophysical Research Communications. 241, 2, p. 297-304 8 p.

Research output: Contribution to journalArticle

The -308G/A polymorphism of TNF-α influences immunological parameters in old subjects affected by infectious diseases

Cipriano, C., Caruso, C., Lio, D., Giacconi, R., Malavolta, M., Muti, E., Gasparini, N., Franceschi, C. & Mocchegiani, E., Feb 2005, In : International Journal of Immunogenetics. 32, 1, p. 13-18 6 p.

Research output: Contribution to journalArticle

The - 174G/C polymorphism of IL-6 is useful to screen old subjects at risk for atherosclerosis or to reach successful ageing

Giacconi, R., Cipriano, C., Albanese, F., Boccoli, G., Saba, V., Olivieri, F., Franceschi, C. & Mocchegiani, E., Apr 2004, In : Experimental Gerontology. 39, 4, p. 621-628 8 p.

Research output: Contribution to journalArticle

The - 174 C/G locus affects in vitro/in vivo IL-6 production during aging

Olivieri, F., Bonafè, M., Cavallone, L., Giovagnetti, S., Marchegiani, F., Cardelli, M., Mugianesi, E., Giampieri, C., Moresi, R., Stecconi, R., Lisa, R. & Franceschi, C., Jan 3 2002, In : Experimental Gerontology. 37, 2-3, p. 309-314 6 p.

Research output: Contribution to journalArticle

TET2 gene expression and 5-hydroxymethylcytosine level in multiple sclerosis peripheral blood cells

Calabrese, R., Valentini, E., Ciccarone, F., Guastafierro, T., Bacalini, M. G., Ricigliano, V. A. G., Zampieri, M., Annibali, V., Mechelli, R., Franceschi, C., Salvetti, M. & Caiafa, P., 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 7, p. 1130-1136 7 p.

Research output: Contribution to journalArticle

Testosterone, gonadotropins, prolactin and sex hormone-binding globulin in healthy centenarians

Ognibene, A., Petruzzi, E., Troiano, L., Pini, G., Franceschi, C., Monti, D., Masotti, G., Messeri, G., Cilotti, A. & Forti, G., 1999, In : Journal of Endocrinological Investigation. 22, 10 SUPPL. 1, p. 64-65 2 p.

Research output: Contribution to journalArticle

Telomere length in fibroblasts and blood cells from healthy centenarians

Mondello, C., Petropoulou, C., Monti, D., Gonos, E. S., Franceschi, C. & Nuzzo, F., Apr 10 1999, In : Experimental Cell Research. 248, 1, p. 234-242 9 p.

Research output: Contribution to journalArticle

TCR Vβ repertoire in an Italian longeval population including centenarians

Pennesi, G., Morellini, M., Lulli, P., Cappellacci, S., Brioli, G., Franceschi, C. & Trabace, S., 2001, In : Age. 24, 2, p. 63-70 8 p.

Research output: Contribution to journalArticle

T cells and aging, January 2002 update.

Pawelec, G., Barnett, Y., Forsey, R., Frasca, D., Globerson, A., McLeod, J., Caruso, C., Franceschi, C., Fülöp, T., Gupta, S., Mariani, E., Mocchegiani, E. & Solana, R., 2002, In : Frontiers in Bioscience. 7

Research output: Contribution to journalArticle

T and B lymphocyte subpopulations in Down's syndrome. A study on non-institutionalised subjects

Franceschi, C., Licastro, F. & Paolucci, P., 1978, In : Journal of Mental Deficiency Research. 22, 3, p. 179-191 13 p.

Research output: Contribution to journalArticle

Systems medicine of inflammaging

Castellani, G. C., Menichetti, G., Garagnani, P., Bacalini, M. G., Pirazzini, C., Franceschi, C., Collino, S., Sala, C., Remondini, D., Giampieri, E., Mosca, E., Bersanelli, M., Vitali, S., Do Valle, I. F., Liò, P. & Milanesi, L., May 16 2016, In : Briefings in Bioinformatics. 17, 3, p. 527-540 14 p., bbv062.

Research output: Contribution to journalArticle

Systems biology and longevity: An emerging approach to identify innovative anti-aging targets and strategies

Cevenini, E., Bellavista, E., Tieri, P., Castellani, G., Lescai, F., Francesconi, M., Mishto, M., Santoro, A., Valensin, S., Salvioli, S., Capri, M., Zaikin, A., Monti, D., De Magalhães, J. P. & Franceschi, C., Mar 2010, In : Current Pharmaceutical Design. 16, 7, p. 802-813 12 p.

Research output: Contribution to journalArticle

Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and in Vitro Evidences of a Cell Replication Process

Bacalini, M. G., Deelen, J., Pirazzini, C., De Cecco, M., Giuliani, C., Lanzarini, C., Ravaioli, F., Marasco, E., Van Heemst, D., Suchiman, H. E. D., Slieker, R., Giampieri, E., Recchioni, R., Marcheselli, F., Salvioli, S., Vitale, G., Olivieri, F., Spijkerman, A. M. W., DollCrossed, M. E. T., Sedivy, J. M. & 4 others, Castellani, G., Franceschi, C., Slagboom, P. E. & Garagnani, P., 2017, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 72, 8, p. 1015-1023 9 p.

Research output: Contribution to journalArticle

Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process

Bacalini, M. G., Deelen, J., Pirazzini, C., De Cecco, M., Giuliani, C., Lanzarini, C., Ravaioli, F., Marasco, E., Van Heemst, D., Suchiman, H. E. D., Slieker, R., Giampieri, E., Recchioni, R., Marcheselli, F., Salvioli, S., Vitale, G., Olivieri, F., Spijkerman, A. M. W., Dollé, M. E. T., Sedivy, J. M. & 4 others, Castellani, G., Franceschi, C., Slagboom, P. E. & Garagnani, P., Aug 2017, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 72, 8, p. 1015-1023 9 p.

Research output: Contribution to journalArticle