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1969 …2019
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Research Output 1969 2019

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Article
2014
19 Citations (Scopus)

Circulating miR-21, miR-146a and Fas ligand respond to postmenopausal estrogen-based hormone replacement therapy - A study with monozygotic twin pairs

Kangas, R., Pöllänen, E., Rippo, M. R., Lanzarini, C., Prattichizzo, F., Niskala, P., Jylhävä, J., Sipilä, S., Kaprio, J., Procopio, A. D., Capri, M., Franceschi, C., Olivieri, F. & Kovanen, V., Dec 5 2014, In : Mechanisms of Ageing and Development. 143-144, p. 1-8 8 p.

Research output: Contribution to journalArticle

Fas Ligand Protein
Monozygotic Twins
Hormone Replacement Therapy
Estrogens
MicroRNAs
106 Citations (Scopus)

Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for "inflamm-aging"

Pinti, M., Cevenini, E., Nasi, M., De Biasi, S., Salvioli, S., Monti, D., Benatti, S., Gibellini, L., Cotichini, R., Stazi, M. A., Trenti, T., Franceschi, C. & Cossarizza, A., 2014, In : European Journal of Immunology. 44, 5, p. 1552-1562 11 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
Siblings
Cytokines
Interleukin 1 Receptor Antagonist Protein
Inflammation
65 Citations (Scopus)

Combating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design

Santoro, A., Pini, E., Scurti, M., Palmas, G., Berendsen, A., Brzozowska, A., Pietruszka, B., Szczecinska, A., Cano, N., Meunier, N., de Groot, C. P. G. M., Feskens, E., Fairweather-Tait, S., Salvioli, S., Capri, M., Brigidi, P., Franceschi, C., Fabbri, C., Bertarelli, C., Izzi, M. & 50 others, Mazzocchi, M., Chardigny, J. M., Morio, B., Rossi, D., Notarfonso, M., O'Toole, P. W., Cashman, K., Carding, S. R., Nicoletti, C., Jacobs, D., Xipsiti, M., Fernandez, L., Wills, J., Irz, X., Kuosmanen, N., Gonos, E. S., Voutetakis, K., Salmon, M., Toussaint, O., Traill, B. W., Nocella, G., Caracciolo, B., Xu, W., Mikko Ikonen, I., Tuure, T., Brummer, R., Kadi, F., Breton, S., Triomphe, M., Magario, G., Villani, F., Pancrazio, A., Teufner, B., Stocker, J., Echevarría, F. J., Iglesias, J. R., Smrž, F., Krejcirova, L., Koytsomitropoulou, E., Georgakidis, K., Yornuk, R., Ucar, C., Van Ommen, B., Bouwman, J., Collino, S., Jankovics, C., Losó, A., de Vos, W., Fuentes, S. & Commelin, E., 2014, In : Mechanisms of Ageing and Development. 136-137, p. 3-13 11 p.

Research output: Contribution to journalArticle

Mediterranean Diet
Metagenomics
Food
Metabolomics
Systems Biology

Correction: Analysis of population substructure in two sympatric populations of Gran Chaco, Argentina (PLoS ONE)

Sevini, F., Yao, D. Y., Lomartire, L., Barbieri, A., Vianello, D., Ferri, G., Moretti, E., Dasso, M. C., Garagnani, P., Pettener, D., Franceschi, C., Luiselli, D. & Franceschi, Z. A., Jan 3 2014, In : PLoS One. 9, 1

Research output: Contribution to journalArticle

1 Citation (Scopus)

Development of a pilot project on data sharing among partners of the Italian Hub of Population Biobanks (HIBP): Association between lipid profile and socio-demographic variables

Napolitano, M., Santoro, F., Puopolo, M., Donfancesco, C., Galluzzo, L., De Grandi, A., Cevenini, E., De Curtis, A., Sevini, F., Palmieri, L., Mascalzon, D., Roazzi, P., Scafato, E., Pramstaller, P., Iacoviello, L., Donati, M. B., Giampaoli, S., Franceschi, C., Belardelli, F. & Bravo, E., Aug 1 2014, In : Biopreservation and Biobanking. 12, 4, p. 225-233 9 p.

Research output: Contribution to journalArticle

Information Dissemination
Transfer Agreement
Demography
Databases
Lipids
37 Citations (Scopus)

Discovery of novel and selective SIRT6 inhibitors

Parenti, M. D., Grozio, A., Bauer, I., Galeno, L., Damonte, P., Millo, E., Sociali, G., Franceschi, C., Ballestrero, A., Bruzzone, S., Rio, A. D. & Nencioni, A., Jun 12 2014, In : Journal of Medicinal Chemistry. 57, 11, p. 4796-4804 9 p.

Research output: Contribution to journalArticle

Genomic Instability
Immune System Diseases
Acetylation
Computer Simulation
NAD
10 Citations (Scopus)
Lower Extremity
Confounding Factors (Epidemiology)
Meta-Analysis
Genotype
Pathology
48 Citations (Scopus)

From lifetime to evolution: Timescales of human gut microbiota adaptation

Quercia, S., Candela, M., Giuliani, C., Turroni, S., Luiselli, D., Rampelli, S., Brigidi, P., Franceschi, C., Bacalini, M. G., Garagnani, P. & Pirazzini, C., 2014, In : Frontiers in Microbiology. 5, NOV

Research output: Contribution to journalArticle

History
Metagenomics
Microbiota
Feeding Behavior
Human Genome
12 Citations (Scopus)

Genes of human longevity: An endless quest?

Capri, M., Santoro, A., Garagnani, P., Bacalini, M. G., Pirazzini, C., Olivieri, F., Procopio, A., Salvioli, S. & Franceschi, C., 2014, In : Current Vascular Pharmacology. 12, 5, p. 707-717 11 p.

Research output: Contribution to journalArticle

Genes
Apolipoproteins E
Epigenomics
Somatomedin Receptors
Microbiota
121 Citations (Scopus)

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

Deelen, J., Beekman, M., Uh, H. W., Broer, L., Ayers, K. L., Tan, Q., Kamatani, Y., Bennet, A. M., Tamm, R., Trompet, S., Guobjartsson, D. F., Flachsbart, F., Rose, G., Viktorin, A., Fischer, K., Nygaard, M., Cordell, H. J., Crocco, P., Van Den Akker, E. B., Böhringer, S. & 67 others, Helmer, Q., Nelson, C. P., Saunders, G. I., Alver, M., Andersen-Ranberg, K., Breen, M. E., van Der Breggen, R., Caliebe, A., Capri, M., Cevenini, E., Collerton, J. C., Dato, S., Davies, K., Ford, I., Gampe, J., Garagnani, P., de Geus, E. J. C., Harrow, J., Van Heemst, D., Heijmans, B. T., Heinsen, F. A., Hottenga, J. J., Hofman, A., Jeune, B., Jonsson, P. V., Lathrop, M., Lechner, D., Martin-Ruiz, C., Mcnerlan, S. E., Mihailov, E., Montesanto, A., Mooijaart, S. P., Murphy, A., Nohr, E. A., Paternoster, L., Postmus, I., Rivadeneira, F., Ross, O. A., Salvioli, S., Sattar, N., Schreiber, S., Stefánsson, H., Stott, D. J., Tiemeier, H., Uitterlinden, A. G., Westendorp, R. G. J., Willemsen, G., Samani, N. J., Galan, P., Sørensen, T. I. A., Boomsma, D. I., Wouter Jukema, J., Rea, I. M., Passarino, G., de Craen, A. J. M., Christensen, K., Nebel, A., Stefánsson, K., Metspalu, A., Magnusson, P., Blanché, H., Christiansen, L., Kirkwood, T. B. L., Van Duijn, C. M., Franceschi, C., Houwing-Duistermaat, J. J. & Slagboom, P. E., 2014, In : Human Molecular Genetics. 23, 16, p. 4420-4432 13 p., ddu139.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Meta-Analysis
Alleles
Survival
Chromosomes
447 Citations (Scopus)

Geroscience: Linking aging to chronic disease

Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., Franceschi, C., Lithgow, G. J., Morimoto, R. I., Pessin, J. E., Rando, T. A., Richardson, A., Schadt, E. E., Wyss-Coray, T. & Sierra, F., Nov 6 2014, In : Cell. 159, 4, p. 709-713 5 p.

Research output: Contribution to journalArticle

Chronic Disease
Aging of materials
Morbidity
Mortality
Research
17 Citations (Scopus)

Gut microbiome in down syndrome

Biagi, E., Cela, M., Centanni, M., Consoli, C., Rampelli, S., Turroni, S., Severgnini, M., Peano, C., Ghezzo, A., Scurti, M., Salvioli, S., Franceschi, C. & Brigidi, P., Nov 11 2014, In : PLoS One. 9, 11, e112023.

Research output: Contribution to journalArticle

Down syndrome
Down Syndrome
digestive system
Aging of materials
intestinal microorganisms
15 Citations (Scopus)

Health status and 6 years survival of 552 90+ Italian sib-ships recruited within the EU Project GEHA (GEnetics of Healthy Ageing)

Cevenini, E., Cotichini, R., Stazi, M. A., Toccaceli, V., Palmas, M. G., Capri, M., De Rango, F., Dato, S., Passarino, G., Jeune, B. & Franceschi, C., 2014, In : Age. 36, 2, p. 949-966 18 p.

Research output: Contribution to journalArticle

Ships
Health Status
Hand Strength
Italy
Body Mass Index
28 Citations (Scopus)

Hormone replacement therapy enhances IGF-1 signaling in skeletal muscle by diminishing miR-182 and miR-223 expressions: A study on postmenopausal monozygotic twin pairs

Olivieri, F., Ahtiainen, M., Lazzarini, R., Pöllänen, E., Capri, M., Lorenzi, M., Fulgenzi, G., Albertini, M. C., Salvioli, S., Alen, M. J., Kujala, U. M., Borghetti, G., Babini, L., Kaprio, J., Sipilä, S., Franceschi, C., Kovanen, V. & Procopio, A. D., Oct 1 2014, In : Aging Cell. 13, 5, p. 850-861 12 p.

Research output: Contribution to journalArticle

Monozygotic Twins
Hormone Replacement Therapy
MicroRNAs
Insulin-Like Growth Factor I
Skeletal Muscle

IL microbioma intestinale e la longevità

Translated title of the contribution: The intestinal microbiome and longevityBrigidi, P., Candela, M., Biagi, E., Turroni, S., Rampelli, S. & Franceschi, C., Jan 1 2014, In : Giornale di Gerontologia. 62, 5, p. 242 1 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Immune parameters identify Italian centenarians with a longer five-year survival independent of their health and functional status

Bucci, L., Ostan, R., Giampieri, E., Cevenini, E., Pini, E., Scurti, M., Vescovini, R., Sansoni, P., Caruso, C., Mari, D., Ronchetti, F., Borghi, M. O., Ogliari, G., Grossi, C., Capri, M., Salvioli, S., Castellani, G., Franceschi, C. & Monti, D., 2014, In : Experimental Gerontology. 54, p. 14-20 7 p.

Research output: Contribution to journalArticle

T-cells
Health Status
Health
Survival
Lymphocytes
35 Citations (Scopus)

Lamins are rapamycin targets that impact human longevity: A study in centenarians

Lattanzi, G., Ortolani, M., Columbaro, M., Prencipe, S., Mattioli, E., Lanzarini, C., Maraldi, N. M., Cenni, V., Garagnani, P., Salvioli, S., Storci, G., Bonafè, M., Capanni, C. & Franceschi, C., Jan 1 2014, In : Journal of Cell Science. 127, 1, p. 147-157 11 p.

Research output: Contribution to journalArticle

Lamins
Sirolimus
Cell Aging
Cell Nucleus
Chromatin
16 Citations (Scopus)

Life expectancy in the immune recovery era: The evolving scenario of the HIV epidemic in northern Italy

Guaraldi, G., Cossarizza, A., Franceschi, C., Roverato, A., Vaccher, E., Tambussi, G., Garlassi, E., Menozzi, M., Mussini, C. & Monforte, A. D. A., 2014, In : Journal of Acquired Immune Deficiency Syndromes. 65, 2, p. 175-181 7 p.

Research output: Contribution to journalArticle

Life Expectancy
Italy
HIV
Highly Active Antiretroviral Therapy
Population
8 Citations (Scopus)

Lifelong maintenance of composition, function and cellular/subcellular distribution of proteasomes in human liver

Bellavista, E., Martucci, M., Vasuri, F., Santoro, A., Mishto, M., Kloss, A., Capizzi, E., Degiovanni, A., Lanzarini, C., Remondini, D., Dazzi, A., Pellegrini, S., Cescon, M., Capri, M., Salvioli, S., D'Errico-Grigioni, A., Dahlmann, B., Grazi, G. L. & Franceschi, C., Nov 1 2014, In : Mechanisms of Ageing and Development. 141-142, p. 26-34 9 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Maintenance
Tissue Donors
Liver
Transplantation
2 Citations (Scopus)

Maternal longevity is associated with lower infant mortality

Caselli, G., Lapucci, E., Lipsi, R. M., Pozzi, L., Baggio, G., Carru, C., Deiana, L., Franceschi, C. & Vaupel, J. W., 2014, In : Demographic Research. 31, 1, p. 1275-1296 22 p.

Research output: Contribution to journalArticle

infant mortality
genealogy
fertility
regression
3 Citations (Scopus)

Mediterranean diet and inflammaging in the elderly: the European project NU-AGE. Preface

Santoro, A., Brigidi, P., Gonos, E. S., Bohr, V. A. & Franceschi, C., 2014, In : Mechanisms of Ageing and Development. 136-137, p. 1-2 2 p.

Research output: Contribution to journalArticle

38 Citations (Scopus)

Mitochondria hyperfusion and elevated autophagic activity are key mechanisms for cellular bioenergetic preservation in centenarians

Sgarbi, G., Matarrese, P., Pinti, M., Lanzarini, C., Ascione, B., Gibellini, L., Dika, E., Patrizi, A., Tommasino, C., Capri, M., Cossarizza, A., Baracca, A., Lenaz, G., Solaini, G., Franceschi, C., Malorni, W. & Salvioli, S., 2014, In : Aging. 6, 4, p. 296-310 15 p.

Research output: Contribution to journalArticle

Energy Metabolism
Mitochondria
Mitochondrial Degradation
Fibroblasts
Cell Aging
22 Citations (Scopus)

MtDNA mutations in human aging and longevity: Controversies and new perspectives opened by high-throughput technologies

Sevini, F., Giuliani, C., Vianello, D., Giampieri, E., Santoro, A., Biondi, F., Garagnani, P., Passarino, G., Luiselli, D., Capri, M., Franceschi, C. & Salvioli, S., 2014, In : Experimental Gerontology. 56, p. 234-244 11 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
Aging of materials
Throughput
Technology
Mutation
14 Citations (Scopus)

Musculoskeletal system in the old age and the demand for healthy ageing biomarkers

Collino, S., Martin, F. P., Karagounis, L. G., Horcajada, M. N., Moco, S., Franceschi, C., Kussmann, M. & Offord, E., 2014, In : Mechanisms of Ageing and Development. 134, 11-12, p. 541-547 7 p.

Research output: Contribution to journalArticle

Musculoskeletal System
Biomarkers
Health
Biological Phenomena
Institutionalization
26 Citations (Scopus)

Naïve and memory CD8 T cell pool homeostasis in advanced aging: Impact of age and of antigen-specific responses to cytomegalovirus

Vescovini, R., Fagnoni, F. F., Telera, A. R., Bucci, L., Pedrazzoni, M., Magalini, F., Stella, A., Pasin, F., Medici, M. C., Calderaro, A., Volpi, R., Monti, D., Franceschi, C., Nikolich-Žugich, J. & Sansoni, P., 2014, In : Age. 36, 2, p. 625-640 16 p.

Research output: Contribution to journalArticle

Cytomegalovirus
Homeostasis
T-Lymphocytes
Antigens
T-Lymphocyte Subsets
78 Citations (Scopus)

New advances in CMV and immunosenescence

Sansoni, P., Vescovini, R., Fagnoni, F. F., Akbar, A., Arens, R., Chiu, Y. L., Čičin-Šain, L., Dechanet-Merville, J., Derhovanessian, E., Ferrando-Martinez, S., Franceschi, C., Frasca, D., Fulöp, T., Furman, D., Gkrania-Klotsas, E., Goodrum, F., Grubeck-Loebenstein, B., Hurme, M., Kern, F., Lilleri, D. & 20 others, López-Botet, M., Maier, A. B., Marandu, T., Marchant, A., Matheï, C., Moss, P., Muntasell, A., Remmerswaal, E. B. M., Riddell, N. E., Rothe, K., Sauce, D., Shin, E. C., Simanek, A. M., Smithey, M. J., Söderberg-Nauclér, C., Solana, R., Thomas, P. G., Van Lier, R., Pawelec, G. & Nikolich-Zugich, J., 2014, In : Experimental Gerontology. 55, p. 54-62 9 p.

Research output: Contribution to journalArticle

Immune system
Cytomegalovirus
Aging of materials
Cytomegalovirus Infections
Immune System
20 Citations (Scopus)

Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription

Ciccarone, F., Valentini, E., Bacalini, M. G., Zampieri, M., Calabrese, R., Guastafierro, T., Mariano, G., Reale, A., Franceschi, C. & Caiafa, P., 2014, In : Oncotarget. 5, 21, p. 10356-10367 12 p.

Research output: Contribution to journalArticle

Epigenomics
Adenosine Diphosphate
Genes
Neoplasms
CpG Islands
3 Citations (Scopus)

Preface

Santoro, A., Brigidi, P., Gonos, E. S., Bohr, V. A. & Franceschi, C., 2014, In : Mechanisms of Ageing and Development. 136-137, p. 1-2 2 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

Preoperative, high IL-6 blood level is a risk factor of postoperative delirium onset in old patients

Capri, M., Lukas-Yani, S., Chattat, R., Fortuna, D., Bucci, L., Lanzarini, C., Morsiani, C., Catena, F., Ansaloni, L., Adversi, M., Melotti, M. R., Di Nino, G. & Franceschi, C., 2014, In : Frontiers in Endocrinology. 5, SEP, 173.

Research output: Contribution to journalArticle

Delirium
Interleukin-6
Cytokines
Hospital Mortality
Interleukin-2
57 Citations (Scopus)

Present and future of anti-ageing epigenetic diets

Bacalini, M. G., Friso, S., Olivieri, F., Pirazzini, C., Giuliani, C., Capri, M., Santoro, A., Franceschi, C. & Garagnani, P., 2014, In : Mechanisms of Ageing and Development. 136-137, p. 101-115 15 p.

Research output: Contribution to journalArticle

Epigenomics
Diet
DNA Methylation
Food
Caloric Restriction
21 Citations (Scopus)

Reprint of: A parallel randomized trial on the effect of a healthful diet on inflammageing and its consequences in European elderly people: Design of the NU-AGE dietary intervention study

Berendsen, A., Santoro, A., Pini, E., Cevenini, E., Ostan, R., Pietruszka, B., Rolf, K., Cano, N., Caille, A., Lyon-Belgy, N., Fairweather-Tait, S., Feskens, E., Franceschi, C. & de Groot, C. P. G. M., 2014, In : Mechanisms of Ageing and Development. 136-137, p. 14-21 8 p.

Research output: Contribution to journalArticle

Diet
Nutritional Requirements
Vitamin B 12
Vitamin D
C-Reactive Protein
5 Citations (Scopus)

Reprint of: Musculoskeletal system in the old age and the demand for healthy ageing biomarkers

Collino, S., Martin, F. P., Karagounis, L. G., Horcajada, M. N., Moco, S., Franceschi, C., Kussmann, M. & Offord, E., 2014, In : Mechanisms of Ageing and Development. 136-137, p. 94-100 7 p.

Research output: Contribution to journalArticle

Musculoskeletal System
Biomarkers
Health
Biological Phenomena
Institutionalization
43 Citations (Scopus)

Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity

Montoliu, I., Scherer, M., Beguelin, F., DaSilva, L., Mari, D., Salvioli, S., Martin, F. P. J., Capri, M., Bucci, L., Ostan, R., Garagnani, P., Monti, D., Biagi, E., Brigidi, P., Kussmann, M., Rezzi, S., Franceschi, C. & Collino, S., Jan 2014, In : Aging. 6, 1, p. 9-25 17 p.

Research output: Contribution to journalArticle

Sphingolipids
Phospholipids
Metabolomics
Firearms
Serum
1 Citation (Scopus)

Statistical strategies and stochastic predictive models for the MARK-AGE data

Giampieri, E., Remondini, D., Bacalini, M. G., Garagnani, P., Pirazzini, C., Yani, S. L., Giuliani, C., Menichetti, G., Zironi, I., Sala, C., Capri, M., Franceschi, C., Bürkle, A. & Castellani, G., Dec 2 2014, In : Mechanisms of Ageing and Development. 151, p. 45-53 9 p.

Research output: Contribution to journalArticle

Forensic Anthropology
Biomarkers
35 Citations (Scopus)

TET2 gene expression and 5-hydroxymethylcytosine level in multiple sclerosis peripheral blood cells

Calabrese, R., Valentini, E., Ciccarone, F., Guastafierro, T., Bacalini, M. G., Ricigliano, V. A. G., Zampieri, M., Annibali, V., Mechelli, R., Franceschi, C., Salvetti, M. & Caiafa, P., 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 7, p. 1130-1136 7 p.

Research output: Contribution to journalArticle

DNA Methylation
Multiple Sclerosis
Blood Cells
5-Methylcytosine
Gene Expression
16 Citations (Scopus)

The challenges in moving from ageing to successful longevity

Kolovou, G., Barzilai, N., Caruso, C., Sikora, E., Capri, M., Tzanetakou, I. P., Bilianou, H., Avery, P., Katsiki, N., Panotopoulos, G., Franceschi, C., Benetos, A. & Mikhailidis, D. P., 2014, In : Current Vascular Pharmacology. 12, 5, p. 662-673 12 p.

Research output: Contribution to journalArticle

Epigenomics
Nutrigenomics
Body Fat Distribution
Primary Prevention
Body Composition
54 Citations (Scopus)

The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific

Raule, N., Sevini, F., Li, S., Barbieri, A., Tallaro, F., Lomartire, L., Vianello, D., Montesanto, A., Moilanen, J. S., Bezrukov, V., Blanché, H., Hervonen, A., Christensen, K., Deiana, L., Gonos, E. S., Kirkwood, T. B. L., Kristensen, P., Leon, A., Pelicci, P. G., Poulain, M. & 18 others, Rea, I. M., Remacle, J., Robine, J. M., Schreiber, S., Sikora, E., Eline Slagboom, P., Spazzafumo, L., Antonietta Stazi, M., Toussaint, O., Vaupel, J. W., Rose, G., Majamaa, K., Perola, M., Johnson, T. E., Bolund, L., Yang, H., Passarino, G. & Franceschi, C., 2014, In : Aging Cell. 13, 3, p. 401-407 7 p.

Research output: Contribution to journalArticle

Oxidative Phosphorylation
Mitochondrial DNA
Mutation
Population
Genes
13 Citations (Scopus)

The nucleolar size is associated to the methylation status of ribosomal DNA in breast carcinomas

Bacalini, M. G., Pacilli, A., Giuliani, C., Penzo, M., Treré, D., Pirazzini, C., Salvioli, S., Franceschi, C., Montanaro, L. & Garagnani, P., May 22 2014, In : BMC Cancer. 14, 1, 361.

Research output: Contribution to journalArticle

Ribosomal DNA
Methylation
Breast Neoplasms
Genes
DNA Methylation
37 Citations (Scopus)

The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: A systems biology approach

Calçada, D., Vianello, D., Giampieri, E., Sala, C., Castellani, G., de Graaf, A., Kremer, B., van Ommen, B., Feskens, E., Santoro, A., Franceschi, C. & Bouwman, J., 2014, In : Mechanisms of Ageing and Development. 136-137, p. 138-147 10 p.

Research output: Contribution to journalArticle

Systems Biology
High-Throughput Screening Assays
Inflammation
Biological Phenomena
14 Citations (Scopus)

The three genetics (Nuclear DNA, mitochondrial DNA, and Gut microbiome) of longevity in humans considered as metaorganisms

Garagnani, P., Pirazzini, C., Giuliani, C., Candela, M., Brigidi, P., Sevini, F., Luiselli, D., Bacalini, M. G., Salvioli, S., Capri, M., Monti, D., Mari, D., Collino, S., Delledonne, M., Descombes, P. & Franceschi, C., 2014, In : BioMed Research International. 2014, 560340.

Research output: Contribution to journalArticle

Mitochondrial DNA
DNA
Genes
Aging of materials
Medical Genetics
28 Citations (Scopus)

Towards a liquid self: How time, geography, and life experiences reshape the biological identity

Grignolio, A., Mishto, M., Caetano Faria, A. M., Garagnani, P., Franceschi, C. & Tieri, P., 2014, In : Frontiers in Immunology. 5, APR, Article 153.

Research output: Contribution to journalArticle

Geography
Life Change Events
Immune System
Proteasome Endopeptidase Complex
Ecosystem
19 Citations (Scopus)

Transmission from centenarians to their offspring of mtDNA heteroplasmy revealed by ultra-deep sequencing

Giuliani, C., Barbieri, C., Li, M., Bucci, L., Monti, D., Passarino, G., Luiselli, D., Franceschi, C., Stoneking, M. & Garagnani, P., 2014, In : Aging. 6, 6, p. 454-467 14 p.

Research output: Contribution to journalArticle

High-Throughput Nucleotide Sequencing
Mitochondrial DNA
Gene Frequency
Quality Control
Parents
56 Citations (Scopus)

Vitamin E-gene interactions in aging and inflammatory age-related diseases: Implications for treatment. A systematic review

Mocchegiani, E., Costarelli, L., Giacconi, R., Malavolta, M., Basso, A., Piacenza, F., Ostan, R., Cevenini, E., Gonos, E. S., Franceschi, C. & Monti, D., 2014, In : Ageing Research Reviews. 14, 1, p. 81-101 21 p.

Research output: Contribution to journalArticle

Vitamin E
Genes
Aging of materials
Oxidative stress
Nutrigenomics
2013
5 Citations (Scopus)

16th IHIW: Immunogenetics of Aging

Naumova, E., Ivanova, M., Pawelec, G., Constantinescu, I., Bogunia-Kubik, K., Lange, A., Oguz, F., Ozdilli, K., Franceschi, C., Caruso, C., Mishra, M. & Middleton, D., Feb 2013, In : International Journal of Immunogenetics. 40, 1, p. 77-81 5 p.

Research output: Contribution to journalArticle

Immunogenetics
Haplotypes
Genes
Immune System
Education
52 Citations (Scopus)

Age-dependent alteration in muscle regeneration: The critical role of tissue niche

Barberi, L., Scicchitano, B. M., De Rossi, M., Bigot, A., Duguez, S., Wielgosik, A., Stewart, C., McPhee, J., Conte, M., Narici, M., Franceschi, C., Mouly, V., Butler-Browne, G. & Musarò, A., Jun 2013, In : Biogerontology. 14, 3, p. 273-292 20 p.

Research output: Contribution to journalArticle

Regeneration
Muscles
Skeletal Muscle
Basement Membrane
Wounds and Injuries
120 Citations (Scopus)

Ageing and gut microbes: Perspectives for health maintenance and longevity

Biagi, E., Candela, M., Turroni, S., Garagnani, P., Franceschi, C. & Brigidi, P., Mar 2013, In : Pharmacological Research. 69, 1, p. 11-20 10 p.

Research output: Contribution to journalArticle

Health
Inflammation
Prebiotics
Clostridium difficile
Influenza Vaccines
13 Citations (Scopus)

Analysis of Population Substructure in Two Sympatric Populations of Gran Chaco, Argentina

Sevini, F., Yao, D. Y., Lomartire, L., Barbieri, A., Vianello, D., Ferri, G., Moretti, E., Dasso, M. C., Garagnani, P., Pettener, D., Franceschi, C., Luiselli, D. & Franceschi, Z. A., May 22 2013, In : PLoS One. 8, 5, e64054.

Research output: Contribution to journalArticle

Argentina
sympatry
kinship
Population
Chromosomes
27 Citations (Scopus)

Anti-inflammatory effect of ubiquinol-10 on young and senescent endothelial cells via miR-146a modulation

Olivieri, F., Lazzarini, R., Babini, L., Prattichizzo, F., Rippo, M. R., Tiano, L., Di Nuzzo, S., Graciotti, L., Festa, R., Brugè, F., Orlando, P., Silvestri, S., Capri, M., Palma, L., Magnani, M., Franceschi, C., Littarru, G. P. & Procopio, A. D., 2013, In : Free Radical Biology and Medicine. 63, p. 410-420 11 p.

Research output: Contribution to journalArticle

coenzyme Q10
Endothelial cells
Lipopolysaccharides
Human Umbilical Vein Endothelial Cells
Anti-Inflammatory Agents
122 Citations (Scopus)

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

Mercken, E. M., Crosby, S. D., Lamming, D. W., Jebailey, L., Krzysik-Walker, S., Villareal, D. T., Capri, M., Franceschi, C., Zhang, Y., Becker, K., Sabatini, D. M., de Cabo, R. & Fontana, L., Aug 2013, In : Aging Cell. 12, 4, p. 645-651 7 p.

Research output: Contribution to journalArticle

Caloric Restriction
Phosphatidylinositol 3-Kinases
Skeletal Muscle
Insulin
Insulin-Like Growth Factor I
36 Citations (Scopus)

Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: A proof of principle on type 2 diabetes

Garagnani, P., Giuliani, C., Pirazzini, C., Olivieri, F., Bacalini, M. G., Ostan, R., Mari, D., Passarino, G., Monti, D., Bonfigli, A. R., Boemi, M., Ceriello, A., Genovese, S., Sevini, F., Luiselli, D., Tieri, P., Capri, M., Salvioli, S., Vijg, J., Suh, Y. & 3 others, Delledonne, M., Testa, R. & Franceschi, C., 2013, In : Aging. 5, 5, p. 373-385 13 p.

Research output: Contribution to journalArticle

Type 2 Diabetes Mellitus
Single Nucleotide Polymorphism
Metabolic Diseases
Telomere
Genetic Association Studies