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1969 …2019
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Research Output 1969 2019

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Article
2008
229 Citations (Scopus)

Aging of the immune system as a prognostic factor for human longevity

Larbi, A., Franceschi, C., Mazzatti, D., Solana, R., Wikby, A. & Pawelec, G., Apr 2008, In : Physiology. 23, 2, p. 64-74 11 p.

Research output: Contribution to journalArticle

Immune System
Vaccination
Health
Immunosenescence
21 Citations (Scopus)

Analysis of HLA-DRB1,DQA1,DQB1 haplotypes in Sardinian centenarians

Scola, L., Lio, D., Candore, G., Forte, G. I., Crivello, A., Colonna-Romano, G., Pes, M. G., Carru, C., Ferrucci, L., Deiana, L., Baggio, G., Franceschi, C. & Caruso, C., Feb 2008, In : Experimental Gerontology. 43, 2, p. 114-118 5 p.

Research output: Contribution to journalArticle

HLA-DRB1 Chains
HLA-DR Antigens
Haplotypes
Polymorphism
HLA-DQ Antigens
17 Citations (Scopus)

A novel sampling design to explore gene-longevity associations: The ECHA study

De Rango, F., Dato, S., Bellizzi, D., Rose, G., Marzi, E., Cavallone, L., Franceschi, C., Skytthe, A., Jeune, B., Cournil, A., Robine, J. M., Gampe, J., Vaupel, J. W., Mari, V., Feraco, E., Passarino, G., Novelletto, A. & De Benedictis, G., Feb 2008, In : European Journal of Human Genetics. 16, 2, p. 236-242 7 p.

Research output: Contribution to journalArticle

Haplotypes
Genes
Siblings
Medical Genetics
Denmark
80 Citations (Scopus)

Association between the interleukin-1β polymorphisms and Alzheimer's disease: A systematic review and meta-analysis

Di Bona, D., Plaia, A., Vasto, S., Cavallone, L., Lescai, F., Franceschi, C., Licastro, F., Colonna-Romano, G., Lio, D., Candore, G. & Caruso, C., Nov 2008, In : Brain Research Reviews. 59, 1, p. 155-163 9 p.

Research output: Contribution to journalArticle

Interleukin-1
Meta-Analysis
Alzheimer Disease
Genotype
Single Nucleotide Polymorphism
43 Citations (Scopus)

Association of metabolic syndrome with cognitive function: The role of sex and age

Laudisio, A., Marzetti, E., Pagano, F., Cocchi, A., Franceschi, C., Bernabei, R. & Zuccalà, G., Oct 2008, In : Clinical Nutrition. 27, 5, p. 747-754 8 p.

Research output: Contribution to journalArticle

Cognition
Intelligence Tests
Independent Living
Italy
Population
24 Citations (Scopus)

Calcium metabolism and vitamin D in the extreme longevity

Passeri, G., Vescovini, R., Sansoni, P., Galli, C., Franceschi, C. & Passeri, M., Feb 2008, In : Experimental Gerontology. 43, 2, p. 79-87 9 p.

Research output: Contribution to journalArticle

Metabolism
Vitamin D
Bone
Calcium
Bone and Bones
7 Citations (Scopus)

Combination of biomarkers to predict mortality in elderly patients with myocardial infarction

Olivieri, F., Spazzafumo, L., Antonicelli, R., Marchegiani, F., Cardelli, M., Sirolla, C., Galeazzi, R., Giovagnetti, S., Mocchegiani, E. & Franceschi, C., Apr 2008, In : Mechanisms of Ageing and Development. 129, 4, p. 231-237 7 p.

Research output: Contribution to journalArticle

Biomarkers
Myocardial Infarction
Plasmas
Mortality
Homocysteine
6 Citations (Scopus)

Differential course of HIV-1 infection and APOE polymorphism.

Corder, E. H., Paganelli, R., Giunta, S. & Franceschi, C., Nov 18 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 46

Research output: Contribution to journalArticle

10 Citations (Scopus)

Different types of cell death in organismal aging and longevity: State of the art and possible systems biology approach

Salvioli, S., Capri, M., Tieri, P., Loroni, J., Barbi, C., Invidia, L., Altilia, S., Santoro, A., Pirazzini, C., Pierini, M., Bellavista, E., Alberghina, L. & Franceschi, C., Jan 2008, In : Current Pharmaceutical Design. 14, 3, p. 226-236 11 p.

Research output: Contribution to journalArticle

Systems Biology
Cell Death
Mitochondrial Degradation
Autophagy
Cell Proliferation
29 Citations (Scopus)

Ecoimmunology: Is there any room for the neuroendocrine system?

Ottaviani, E., Malagoli, D., Capri, M. & Franceschi, C., Sep 2008, In : BioEssays. 30, 9, p. 868-874 7 p.

Research output: Contribution to journalArticle

neurosecretory system
pleiotropy
Neurosecretory Systems
knots
immunology
49 Citations (Scopus)

Human longevity within an evolutionary perspective: The peculiar paradigm of a post-reproductive genetics

Capri, M., Salvioli, S., Monti, D., Caruso, C., Candore, G., Vasto, S., Olivieri, F., Marchegiani, F., Sansoni, P., Baggio, G., Mari, D., Passarino, G., De Benedictis, G. & Franceschi, C., Feb 2008, In : Experimental Gerontology. 43, 2, p. 53-60 8 p.

Research output: Contribution to journalArticle

Genes
Aging of materials
Polymorphism
Mitochondrial DNA
Throughput
79 Citations (Scopus)

Human models of aging and longevity

Cevenini, E., Invidia, L., Lescai, F., Salvioli, S., Tieri, P., Castellani, G. & Franceschi, C., Sep 2008, In : Expert Opinion on Biological Therapy. 8, 9, p. 1393-1405 13 p.

Research output: Contribution to journalArticle

Aging of materials
Phenotype
Systems Biology
Epigenomics
4 Citations (Scopus)

Immunoproteasome in Macaca fascicularis: No age-dependent modification of abundance and activity in the brain and insight into an in silico structural model

Bellavista, E., Mishto, M., Santoro, A., Bertoni-Freddari, C., Sessions, R. B. & Franceschi, C., Feb 1 2008, In : Rejuvenation Research. 11, 1, p. 73-82 10 p.

Research output: Contribution to journalArticle

Macaca fascicularis
Structural Models
Proteasome Endopeptidase Complex
Computer Simulation
Primates
123 Citations (Scopus)

Immunosenescence and immunogenetics of human longevity

Ostan, R., Bucci, L., Capri, M., Salvioli, S., Scurti, M., Pini, E., Monti, D. & Franceschi, C., Nov 2008, In : NeuroImmunoModulation. 15, 4-6, p. 224-240 17 p.

Research output: Contribution to journalArticle

Immunogenetics
Pathology
Macrophage Activation
Environmental Exposure
Adaptive Immunity
13 Citations (Scopus)

Influence of f-MLP, ACTH(1-24) and CRH on in vitro chemotaxis of monocytes from centenarians

Genedani, S., Filaferro, M., Carone, C., Ostan, R., Bucci, L., Cevenini, E., Franceschi, C. & Monti, D., Nov 2008, In : NeuroImmunoModulation. 15, 4-6, p. 285-289 5 p.

Research output: Contribution to journalArticle

Cosyntropin
Chemotaxis
Monocytes
Adrenocorticotropic Hormone
Hydrocortisone
22 Citations (Scopus)

Modeling the in Vitro 20S Proteasome Activity: The Effect of PA28-αβ and of the Sequence and Length of Polypeptides on the Degradation Kinetics

Mishto, M., Luciani, F., Holzhütter, H. G., Bellavista, E., Santoro, A., Textoris-Taube, K., Franceschi, C., Kloetzel, P. M. & Zaikin, A., Apr 11 2008, In : Journal of Molecular Biology. 377, 5, p. 1607-1617 11 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Peptides
Digestion
In Vitro Techniques
Antigen Presentation
33 Citations (Scopus)

Paraoxonase 1: Genetics and activities during aging

Marchegiani, F., Marra, M., Olivieri, F., Cardelli, M., James, R. W., Boemi, M. & Franceschi, C., Feb 1 2008, In : Rejuvenation Research. 11, 1, p. 113-127 15 p.

Research output: Contribution to journalArticle

Aryldialkylphosphatase
Oxidative Stress
Planets
Genetic Polymorphisms
Enzymes
8 Citations (Scopus)

Propagation of a transmissible cytotoxic activity on cultures of human peripheral blood lymphocytes

Portolani, M., Beretti, F., Bartoletti, A. M., Pietrosemoli, P., Salvioli, S., Franceschi, C., Sena, P. & De Pol, A., Jul 2008, In : New Microbiologica. 31, 3, p. 417-422 6 p.

Research output: Contribution to journalArticle

Cerebrospinal Fluid
Lymphocytes
Brain Injuries
Cell Culture Techniques
In Vitro Techniques
24 Citations (Scopus)

Role of polymorphisms of CC-chemokine receptor-5 gene in acute myocardial infarction and biological implications for longevity

Balistreri, C. R., Candore, G., Caruso, M., Incalcaterra, E., Franceschi, C. & Caruso, C., Apr 2008, In : Haematologica. 93, 4, p. 637-638 2 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)

The extreme longevity: The state of the art in Italy

Franceschi, C., Motta, L., Motta, M., Malaguarnera, M., Capri, M., Vasto, S., Candore, G. & Caruso, C., Feb 2008, In : Experimental Gerontology. 43, 2, p. 45-52 8 p.

Research output: Contribution to journalArticle

246 Citations (Scopus)

The immune system in extreme longevity

Sansoni, P., Vescovini, R., Fagnoni, F., Biasini, C., Zanni, F., Zanlari, L., Telera, A., Lucchini, G., Passeri, G., Monti, D., Franceschi, C. & Passeri, M., Feb 2008, In : Experimental Gerontology. 43, 2, p. 61-65 5 p.

Research output: Contribution to journalArticle

T-cells
Immune system
Immune System
T-Lymphocytes
Human Herpesvirus 4
36 Citations (Scopus)

The impact of mitochondrial DNA on human lifespan: A view from studies on centenarians

Salvioli, S., Capri, M., Santoro, A., Raule, N., Sevini, F., Lukas, S., Lanzarini, C., Monti, D., Passarino, G., Rose, G., De Benedictis, G. & Franceschi, C., Jun 2008, In : Biotechnology Journal. 3, 6, p. 740-749 10 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
Mutation
Genetic Phenomena
Germ Cells
Animal Models
2007
22 Citations (Scopus)

A cluster analysis to define human aging phenotypes

Passarino, G., Montesanto, A., De Rango, F., Garasto, S., Berardelli, M., Domma, F., Mari, V., Feraco, E., Franceschi, C. & Benedictis, G., Jun 2007, In : Biogerontology. 8, 3, p. 283-290 8 p.

Research output: Contribution to journalArticle

Cluster Analysis
Phenotype
Hand Strength
Geriatrics
Hospitalization
3 Citations (Scopus)

Alpha1-antitrypsin heterozygosity plays a positive role in attainment of longevity

Listì, F., Candore, G., Grimaldi, M. P., Lio, D., Colonna-Romano, G., Orlando, V., Caruso, M., Hoffmann, E., Paolisso, G., Franceschi, C. & Caruso, C., Apr 2007, In : Biogerontology. 8, 2, p. 139-145 7 p.

Research output: Contribution to journalArticle

Myocardial Infarction
Cardiovascular Diseases
Genotype
Sicily
Leukocyte Elastase
23 Citations (Scopus)

Apoptosis remodeling in immunosenescence: Implications for strategies to delay ageing

De Martinis, M., Franceschi, C., Monti, D. & Ginaldi, L., Jun 2007, In : Current Medicinal Chemistry. 14, 13, p. 1389-1397 9 p.

Research output: Contribution to journalArticle

Cell Death
Aging of materials
Cell death
Apoptosis
Immune System
43 Citations (Scopus)

Association studies on human mitochondrial DNA: Methodological aspects and results in the most common age-related diseases

Raule, N., Sevini, F., Santoro, A., Altilia, S. & Franceschi, C., Feb 2007, In : Mitochondrion. 7, 1-2, p. 29-38 10 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
Sample Size
Medicine
Research
54 Citations (Scopus)

Common evolutionary origin of the immune and neuroendocrine systems: from morphological and functional evidence to in silico approaches

Ottaviani, E., Malagoli, D. & Franceschi, C., Nov 2007, In : Trends in Immunology. 28, 11, p. 497-502 6 p.

Research output: Contribution to journalArticle

Neurosecretory Systems
Invertebrates
Computer Simulation
Immune System
Vertebrates
4 Citations (Scopus)

Correlation analysis reveals the emergence of coherence in the gene expression dynamics following system perturbation

Neretti, N., Remondini, D., Tatar, M., Sedivy, J. M., Pierini, M., Mazzatti, D., Powell, J., Franceschi, C. & Castellani, G. C., Mar 8 2007, In : BMC Bioinformatics. 8, SUPPL. 1, S16.

Research output: Contribution to journalArticle

Correlation Analysis
Gene expression
Gene Expression
Time series
Dynamical systems
100 Citations (Scopus)

Curcumin in cell death processes: A challenge for CAM of age-related pathologies

Salvioli, S., Sikora, E., Cooper, E. L. & Franceschi, C., Jun 2007, In : Evidence-based Complementary and Alternative Medicine. 4, 2, p. 181-190 10 p.

Research output: Contribution to journalArticle

Curcumin
Cell Death
Pathology
Curcuma
Phytochemicals
16 Citations (Scopus)

Different antioxidant profiles in Italian centenarians: The Sardinian peculiarity

Polidori, M. C., Mariani, E., Baggio, G., Deiana, L., Carru, C., Pes, G. M., Cecchetti, R., Franceschi, C., Senin, U. & Mecocci, P., Jul 2007, In : European Journal of Clinical Nutrition. 61, 7, p. 922-924 3 p.

Research output: Contribution to journalArticle

Italy
Antioxidants
Sardinia
antioxidants
vitamin A
4 Citations (Scopus)

Differential course of HIV-1 infection and apolipoprotein E polymorphism

Corder, E. H., Galeazzi, L., Franceschi, C., Cossarizza, A., Paganelli, R., Pinti, M., Mussini, C., Borghi, V., Pinter, E., De Cristofaro, R., Galeazzi, R., Perini, M., Aiuti, F. & Giunta, S., Dec 2007, In : Central European Journal of Medicine. 2, 4, p. 404-416 13 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Virus Diseases
HIV-1
Acquired Immunodeficiency Syndrome
CD4 Lymphocyte Count
62 Citations (Scopus)

Effect of Etanercept on insulin sensitivity in nine patients with psoriasis

Marra, M., Campanati, A., Testa, R., Sirolla, C., Bonfigli, A. R., Franceschi, C., Marchegiani, F. & Offidani, A., Oct 2007, In : International Journal of Immunopathology and Pharmacology. 20, 4, p. 731-736 6 p.

Research output: Contribution to journalArticle

Psoriasis
Insulin Resistance
Insulin
Tumor Necrosis Factor-alpha
Inflammation
37 Citations (Scopus)

Immunosupportive therapies in aging.

Fülöp, T., Larbi, A., Hirokawa, K., Mocchegiani, E., Lesourds, B., Castle, S., Wikby, A., Franceschi, C. & Pawelec, G., 2007, In : Clinical Interventions in Aging. 2, 1, p. 33-54 22 p.

Research output: Contribution to journalArticle

T-Lymphocytes
Innate Immunity
Immunity
Antigens
Investigational Therapies
1039 Citations (Scopus)

Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans

Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., Cevenini, E., Castellani, G. C. & Salvioli, S., Jan 2007, In : Mechanisms of Ageing and Development. 128, 1, p. 92-105 14 p.

Research output: Contribution to journalArticle

Anti-Inflammatory Agents
Aging of materials
Systems Biology
Pathology
Phenotype
261 Citations (Scopus)

Inflammaging as a Major Characteristic of Old People: Can It Be Prevented or Cured?

Franceschi, C., Dec 2007, In : Nutrition Reviews. 65, SUPPL.3

Research output: Contribution to journalArticle

inflammation
Inflammation
Cytomegalovirus
chronic exposure
Names
1 Citation (Scopus)

Longevity genes across species: Conservation versus evolvability

Salvioli, S., Tieri, P., Castellani, G., Capri, M., Barbi, C., Santoro, A., Altilia, S., Invidia, L., Pierini, M., Bellavista, E., Monti, D. & Franceschi, C., 2007, In : Invertebrate Survival Journal. 4, 2, p. 112-118 7 p.

Research output: Contribution to journalArticle

genes
animal models
119 Citations (Scopus)

Massive load of functional effector CD4+ and CD8+ T cells against cytomegalovirus in very old subjects

Vescovini, R., Biasini, C., Fagnoni, F. F., Telera, A. R., Zanlari, L., Pedrazzoni, M., Bucci, L., Monti, D., Medici, M. C., Chezzi, C., Franceschi, C. & Sansoni, P., Sep 15 2007, In : Journal of Immunology. 179, 6, p. 4283-4291 9 p.

Research output: Contribution to journalArticle

Cytomegalovirus
T-Lymphocytes
Proteins
Newborn Infant
Cytokines
13 Citations (Scopus)

Masticatory dysfunction is associated with osteoporosis in older men

Laudisio, A., Marzetti, E., Antonica, L., Settanni, S., Georgakakis, I., Bernabei, R., Franceschi, C. & Zuccalà, G., Nov 2007, In : Journal of Clinical Periodontology. 34, 11, p. 964-968 5 p.

Research output: Contribution to journalArticle

Osteoporosis
Confidence Intervals
Bone Density
Hip Fractures
Malnutrition
38 Citations (Scopus)

Meeting report: Mitochondrial DNA and cancer epidemiology

Verma, M., Naviaux, R. K., Tanaka, M., Kumar, D., Franceschi, C. & Singh, K. K., Jan 15 2007, In : Cancer Research. 67, 2, p. 437-439 3 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Networks from gene expression time series: Characterization of correlation patterns

Remondini, D., Neretti, N., Franceschi, C., Tieri, P., Sedivy, J. M., Milanesi, L. & Castellani, G. C., Jul 2007, In : International Journal of Bifurcation and Chaos. 17, 7, p. 2477-2483 7 p.

Research output: Contribution to journalArticle

Gene expression
Gene Expression
Time series
Genes
Gene
75 Citations (Scopus)

N-glycomic changes in serum proteins during human aging

Vanhooren, V., Desmyter, L., Liu, X. E., Cardelli, M., Franceschi, C., Federico, A., Libert, C., Laroy, W., Dewaele, S., Contreras, R. & Chen, C., Dec 1 2007, In : Rejuvenation Research. 10, 4, p. 521-531 11 p.

Research output: Contribution to journalArticle

Glycomics
Polysaccharides
Blood Proteins
Werner Syndrome
Health
34 Citations (Scopus)

Oxidative DNA damage repair and parp 1 and parp 2 expression in Epstein-Barr virus-immortalized B lymphocyte cells from young subjects, old subjects, and centenarians

Chevanne, M., Calia, C., Zampieri, M., Cecchinelli, B., Caldini, R., Monti, D., Bucci, L., Franceschi, C. & Caiafa, P., Jun 2007, In : Rejuvenation Research. 10, 2, p. 191-203 13 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4
DNA Repair
DNA Damage
B-Lymphocytes
Adenosine Diphosphate
58 Citations (Scopus)

Pathophysiology of ageing, longevity and age related diseases

Bürkle, A., Caselli, G., Franceschi, C., Mariani, E., Sansoni, P., Santoni, A., Vecchio, G., Witkowski, J. M. & Caruso, C., Aug 2 2007, In : Immunity and Ageing. 4, 4.

Research output: Contribution to journalArticle

Italy
Neoplasms
Immunosenescence
2 Citations (Scopus)

Proteasome modulation in brain: A new target for anti-aging drugs?

Mishto, M., Bellavista, E., Santoro, A. & Franceschi, C., Dec 2007, In : Central Nervous System Agents in Medicinal Chemistry. 7, 4, p. 236-240 5 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Brain
Pharmaceutical Preparations
Primates
Alzheimer Disease
1 Citation (Scopus)

Role of mitochondrial DNA in longevity, aging and age-related diseases in humans: A reappraisal

Sevini, F., Santoro, A., Raule, N., Lescai, F. & Franceschi, C., Dec 2007, In : Italian Journal of Biochemistry. 56, 4, p. 243-253 11 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
Aging of materials
Alzheimer Disease
Tissue
High-Throughput Nucleotide Sequencing
41 Citations (Scopus)

The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring

Rose, G., Passarino, G., Scornaienchi, V., Romeo, G., Dato, S., Bellizzi, D., Mari, V., Feraco, E., Maletta, R., Bruni, A., Franceschi, C. & De Benedictis, G., Aug 29 2007, In : BMC Genomics. 8, 293.

Research output: Contribution to journalArticle

Mitochondrial DNA
Leukocytes
Sequence Analysis
High Pressure Liquid Chromatography
Genome
2006
12 Citations (Scopus)

Age-dependent effects of in vitro radiofrequency exposure (mobile phone) on CD95+ T helper human lymphocytes

Capri, M., Salvioli, S., Altilia, S., Sevini, F., Remondini, D., Mesirca, P., Bersani, F., Monti, D. & Franceschi, C., May 2006, In : Annals of the New York Academy of Sciences. 1067, 1, p. 493-499 7 p.

Research output: Contribution to journalArticle

Cell Phones
T-cells
Lymphocytes
Helper-Inducer T-Lymphocytes
Mobile phones
88 Citations (Scopus)

Age-dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4+ T cells in humans

Alberti, S., Cevenini, E., Ostan, R., Capri, M., Salvioli, S., Bucci, L., Ginaldi, L., De Martinis, M., Franceschi, C. & Monti, D., Jun 2006, In : Mechanisms of Ageing and Development. 127, 6, p. 560-566 7 p.

Research output: Contribution to journalArticle

T-cells
Cytokines
T-Lymphocytes
Data storage equipment
Aging of materials
5 Citations (Scopus)

Analysis of HLA-DQA, HLA-DQB frequencies in a group of Sardinian centenarians

Scola, L., Lio, D., Crivello, A., Candore, G., Forte, G. I., Colonna-Romano, G., Pes, M. G., Carru, C., Ferrucci, L., Deiana, L., Baggio, G., Franceschi, C. & Caruso, C., Mar 2006, In : Rejuvenation Research. 9, 1, p. 157-160 4 p.

Research output: Contribution to journalArticle

HLA Antigens
Alleles
HLA-D Antigens
Life Expectancy
Population
24 Citations (Scopus)
Alu Elements
Genotype
Genes
Messenger RNA
Human Genome