• 43854 Citations
  • 101 h-Index
1969 …2019
If you made any changes in Pure these will be visible here soon.

Research Output 1969 2019

Filter
Article
2006
18 Citations (Scopus)

Association between the HLA-A2 allele and Alzheimer disease

Listì, F., Candore, G., Balistreri, C. R., Grimaldi, M. P., Orlando, V., Vasto, S., Colonna-Romano, G., Lio, D., Licastro, F., Franceschi, C. & Caruso, C., Mar 2006, In : Rejuvenation Research. 9, 1, p. 99-101 3 p.

Research output: Contribution to journalArticle

HLA-A2 Antigen
Alzheimer Disease
Alleles
Population
Molecular Typing
29 Citations (Scopus)

A structural model of 20S immunoproteasomes: Effect of LMP2 codon 60 polymorphism on expression, activity, intracellular localisation and insight into the regulatory mechanisms

Mishto, M., Santoro, A., Bellavista, E., Sessions, R., Textoris-Taube, K., Dal Piaz, F., Carrard, G., Forti, K., Salvioli, S., Friguet, B., Kloetzel, P. M., Rivett, A. J. & Franceschi, C., Apr 1 2006, In : Biological Chemistry. 387, 4, p. 417-429 13 p.

Research output: Contribution to journalArticle

Structural Models
Polymorphism
Codon
Molecular Weight
Molecular weight
55 Citations (Scopus)

Complexity of anti-immunosenescence strategies in humans

Capri, M., Monti, D., Salvioli, S., Lescai, F., Pierini, M., Altilia, S., Sevini, F., Valensin, S., Ostan, R., Bucci, L. & Franceschi, C., Oct 2006, In : Artificial Organs. 30, 10, p. 730-742 13 p.

Research output: Contribution to journalArticle

T-cells
T-Lymphocytes
Aging of materials
Rejuvenation
Thymus
20 Citations (Scopus)

Effect of zinc ions on apoptosis in PBMCs from healthy aged subjects

Ostan, R., Alberti, S., Bucci, L., Salvioli, S., Pasi, S., Cevenini, E., Capri, M., Di Iorio, A., Ginaldi, L., De Martinis, M., Franceschi, C. & Monti, D., Oct 2006, In : Biogerontology. 7, 5-6, p. 437-447 11 p.

Research output: Contribution to journalArticle

Zinc
Healthy Volunteers
Ions
Apoptosis
Oxidative Stress
51 Citations (Scopus)

Family clustering in Sardinian longevity: A genealogical approach

Caselli, G., Pozzi, L., Vaupel, J. W., Deiana, L., Pes, G., Carru, C., Franceschi, C. & Baggio, G., Aug 2006, In : Experimental Gerontology. 41, 8, p. 727-736 10 p.

Research output: Contribution to journalArticle

Cluster Analysis
Consanguinity
Sex Ratio
Pedigree
Registries
67 Citations (Scopus)

Gene expression changes in human cells after exposure to mobile phone microwaves

Remondini, D., Nylund, R., Reivinen, J., De Gannes, F. P., Veyret, B., Lagroye, I., Haro, E., Trillo, M. A., Capri, M., Franceschi, C., Schlatterer, K., Gminski, R., Fitzner, R., Tauber, R., Schuderer, J., Kuster, N., Leszczynski, D., Bersani, F. & Maercker, C., Sep 2006, In : Proteomics. 6, 17, p. 4745-4754 10 p.

Research output: Contribution to journalArticle

Cell Phones
Microwaves
Mobile phones
Gene expression
Genes
40 Citations (Scopus)

Gene expression of cytokines and cytokine receptors is modulated by the common variability of the mitochondrial DNA in cybrid cell lines

Bellizzi, D., Cavalcante, P., Taverna, D., Rose, G., Passarino, G., Salvioli, S., Franceschi, C. & De Benedictis, G., Aug 2006, In : Genes to Cells. 11, 8, p. 883-891 9 p.

Research output: Contribution to journalArticle

Cytokine Receptors
Mitochondrial DNA
Cytokines
Gene Expression
Cell Line
59 Citations (Scopus)

Genes, ageing and longevity in humans: Problems, advantages and perspectives

Salvioli, S., Olivieri, F., Marchegiani, F., Cardelli, M., Santoro, A., Bellavista, E., Mishto, M., Invidia, L., Capri, M., Valensin, S., Sevini, F., Cevenini, E., Celani, L., Lescai, F., Gonos, E., Caruso, C., Paolisso, G., De Benedictis, G., Monti, D. & Franceschi, C., Dec 2006, In : Free Radical Research. 40, 12, p. 1303-1323 21 p.

Research output: Contribution to journalArticle

Genes
Aging of materials
Gene Pool
Mitochondrial Genome
Polymorphism
31 Citations (Scopus)

Genetic polymorphisms of inflammatory cytokines and myocardial infarction in the elderly

Olivieri, F., Antonicelli, R., Cardelli, M., Marchegiani, F., Cavallone, L., Mocchegiani, E. & Franceschi, C., Jun 2006, In : Mechanisms of Ageing and Development. 127, 6, p. 552-559 8 p.

Research output: Contribution to journalArticle

Genetic Polymorphisms
Polymorphism
Cardiovascular Diseases
Myocardial Infarction
Cytokines
65 Citations (Scopus)

Human immunosenescence: Does it have an infectious component?

Pawelec, G., Koch, S., Franceschi, C. & Wikby, A., May 2006, In : Annals of the New York Academy of Sciences. 1067, 1, p. 56-65 10 p.

Research output: Contribution to journalArticle

T-cells
Immune system
Cytomegalovirus
Immune System
Biomarkers
126 Citations (Scopus)

Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains

Mishto, M., Bellavista, E., Santoro, A., Stolzing, A., Ligorio, C., Nacmias, B., Spazzafumo, L., Chiappelli, M., Licastro, F., Sorbi, S., Pession, A., Ohm, T., Grune, T. & Franceschi, C., Jan 2006, In : Neurobiology of Aging. 27, 1, p. 54-66 13 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Brain
Proteasome Endopeptidase Complex
Codon
Genotype
152 Citations (Scopus)

Inflamm-aging, cytokines and aging: State of the art, new hypotheses on the role of mitochondria and new perspectives from systems biology

Salvioli, S., Capri, M., Valensin, S., Tieri, P., Monti, D., Ottaviani, E. & Franceschi, C., Aug 2006, In : Current Pharmaceutical Design. 12, 24, p. 3161-3171 11 p.

Research output: Contribution to journalArticle

Systems Biology
Mitochondria
Cytokines
Toll-Like Receptors
Heat-Shock Proteins
231 Citations (Scopus)

Inflammation markers predicting frailty and mortality in the elderly

De Martinis, M., Franceschi, C., Monti, D. & Ginaldi, L., Jun 2006, In : Experimental and Molecular Pathology. 80, 3, p. 219-227 9 p.

Research output: Contribution to journalArticle

Biomarkers
Aging of materials
Inflammation
Phenotype
Mortality
36 Citations (Scopus)
Insulin Resistance
Interleukin-6
Type 2 Diabetes Mellitus
Homeostasis
Genotype
1 Citation (Scopus)

Interleukin-6 is a determinant of PAI-1 levels in diabetic subjects with the 4G allele at position -675 of the PAI-1 gene [3]

Bonfigli, A. R., Marra, M., Sirolla, C., Boemi, M., Mari, D., Sacchi, E., Procopio, A., Recchioni, R., Franceschi, C., Giovagnetti, S. & Testa, R., Mar 2006, In : Thrombosis and Haemostasis. 95, 3, p. 587-588 2 p.

Research output: Contribution to journalArticle

34 Citations (Scopus)

Markers of inflammation, Vitamin E and peripheral nervous system function. The InCHIANTI study

Di Iorio, A., Cherubini, A., Volpato, S., Sparvieri, E., Lauretani, F., Franceschi, C., Senin, U., Abate, G., Paganelli, R., Martin, A., Andres-Lacueva, C. & Ferrucci, L., Sep 2006, In : Neurobiology of Aging. 27, 9, p. 1280-1288 9 p.

Research output: Contribution to journalArticle

Neural Conduction
Peripheral Nervous System
Vitamin E
Inflammation
Peroneal Nerve
61 Citations (Scopus)

Mitochondrial DNA involvement in human longevity

Santoro, A., Salvioli, S., Raule, N., Capri, M., Sevini, F., Valensin, S., Monti, D., Bellizzi, D., Passarino, G., Rose, G., De Benedictis, G. & Franceschi, C., Sep 2006, In : Biochimica et Biophysica Acta - Bioenergetics. 1757, 9-10, p. 1388-1399 12 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
Aging of materials
Genes
Polymorphism
Parkinson Disease
28 Citations (Scopus)

Opposite role of pro-inflammatory alleles in acute myocardial infarction and longevity: Results of studies performed in a Sicilian population

Candore, G., Balistreri, C. R., Grimaldi, M. P., Listì, F., Vasto, S., Caruso, M., Caimi, G., Hoffmann, E., Colonna-Romano, G., Lio, D., Paolisso, G., Franceschi, C. & Caruso, C., May 2006, In : Annals of the New York Academy of Sciences. 1067, 1, p. 270-275 6 p.

Research output: Contribution to journalArticle

Alleles
Myocardial Infarction
Population
Cardiovascular Diseases
Genotype
14 Citations (Scopus)

p66Shc gene has a pro-apoptotic role in human cell lines and it is activated by a p53-independent pathway

Tiberi, L., Faisal, A., Rossi, M., Tella, L. D., Franceschi, C. & Salvioli, S., Apr 7 2006, In : Biochemical and Biophysical Research Communications. 342, 2, p. 503-508 6 p.

Research output: Contribution to journalArticle

Serine
Genes
Cells
Cell Line
Phosphorylation
35 Citations (Scopus)
Aryldialkylphosphatase
Genotype
Codon
Logistic Models
Alleles
10 Citations (Scopus)

Reduced expression levels of the senescence biomarker clusterin/ apolipoprotein J in lymphocytes from healthy centenarians

Trougakos, I. P., Petropoulou, C., Franceschi, C. & Gonos, E. S., May 2006, In : Annals of the New York Academy of Sciences. 1067, 1, p. 294-300 7 p.

Research output: Contribution to journalArticle

Clusterin
Lymphocytes
Biomarkers
Aging of materials
Tissue Donors
40 Citations (Scopus)

Resistance to apoptosis of HCW-2 cells can be overcome by curcumin- or vincristine-induced mitotic catastrophe

Magalska, A., Sliwinska, M., Szczepanowska, J., Salvioli, S., Franceschi, C. & Sikora, E., Oct 15 2006, In : International Journal of Cancer. 119, 8, p. 1811-1818 8 p.

Research output: Contribution to journalArticle

Curcumin
Vincristine
Apoptosis
Cell Division
G2 Phase
45 Citations (Scopus)

Role of the pyrin M694V (A2080G) allele in acute myocardial infarction and longevity: A study in the Sicilian population

Grimaldi, M. P., Candore, G., Vasto, S., Caruso, M., Caimi, G., Hoffmann, E., Colonna-Romano, G., Lio, D., Shinar, Y., Franceschi, C. & Caruso, C., Mar 2006, In : Journal of Leukocyte Biology. 79, 3, p. 611-615 5 p.

Research output: Contribution to journalArticle

Familial Mediterranean Fever
Coronary Disease
Alleles
Myocardial Infarction
Mutation
113 Citations (Scopus)

The genetics of human longevity

Capri, M., Salvioli, S., Sevini, F., Valensin, S., Celani, L., Monti, D., Pawelec, G., De Benedictis, G., Gonos, E. S. & Franceschi, C., May 2006, In : Annals of the New York Academy of Sciences. 1067, 1, p. 252-263 12 p.

Research output: Contribution to journalArticle

Medical Genetics
Genes
Association reactions
Polymorphism
Aging of materials
15 Citations (Scopus)

The PON1192RR genotype is associated with a higher prevalence of arterial hypertension

Marra, M., Marchegiani, F., Antonicelli, R., Sirolla, C., Spazzafumo, L., Olivieri, F., Franceschi, C., Testa, R., Paolisso, G., James, R. W., Boemi, M. & Parati, G., Jun 2006, In : Journal of Hypertension. 24, 7, p. 1293-1298 6 p.

Research output: Contribution to journalArticle

Genotype
Hypertension
Cardiovascular Diseases
Aryldialkylphosphatase
Genetic Polymorphisms
47 Citations (Scopus)

The unusual genetics of human longevity.

De Benedictis, G. & Franceschi, C., May 25 2006, In : Science of aging knowledge environment : SAGE KE. 2006, 10

Research output: Contribution to journalArticle

Medical Genetics
Phenotype
Geography
Mitochondrial Genome
Biological Factors
67 Citations (Scopus)

Thymic output and functionality of the IL-7/IL-7 receptor system in centenarians: Implications for the neolymphogenesis at the limit of human life

Nasi, M., Troiano, L., Lugli, E., Pinti, M., Ferraresi, R., Monterastelli, E., Mussi, C., Salvioli, G., Franceschi, C. & Cossarizza, A., Apr 2006, In : Aging Cell. 5, 2, p. 167-175 9 p.

Research output: Contribution to journalArticle

Interleukin-7 Receptors
Interleukin-7
T-Lymphocytes
T-Cell Antigen Receptor
Thymus Gland
2005
5 Citations (Scopus)

Age-related changes on platelet membrane: A study on elderly and centenarian monozygotic twins

Laura, N., Cinzia, M., Arianna, V., Patrizia, V., Claudio, F. & Laura, M., Jun 2005, In : Experimental Gerontology. 40, 6, p. 519-525 7 p.

Research output: Contribution to journalArticle

Monozygotic Twins
Platelets
Blood Platelets
Membranes
Aging of materials
43 Citations (Scopus)

Age-related modifications in circulating IL-15 levels in humans

Gangemi, S., Basile, G., Monti, D., Merendino, R. A., Di Pasquale, G., Bisignano, U., Nicita-Mauro, V. & Franceschi, C., Aug 31 2005, In : Mediators of Inflammation. 2005, 4, p. 245-247 3 p.

Research output: Contribution to journalArticle

Interleukin-15
T-Lymphocytes
Young Adult
Immune System
Antigens
249 Citations (Scopus)

A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages

Bellizzi, D., Rose, G., Cavalcante, P., Covello, G., Dato, S., De Rango, F., Greco, V., Maggiolini, M., Feraco, E., Mari, V., Franceschi, C., Passarino, G. & De Benedictis, G., Feb 2005, In : Genomics. 85, 2, p. 258-263 6 p.

Research output: Contribution to journalArticle

Sirtuin 3
Alleles
Survival
Genes
Minisatellite Repeats
54 Citations (Scopus)

Cholesteryl ester transfer protein (CETP) I405V polymorphism and longevity in Italian centenarians

Cellini, E., Nacmias, B., Olivieri, F., Ortenzi, L., Tedde, A., Bagnoli, S., Petruzzi, C., Franceschi, C. & Sorbi, S., Jun 2005, In : Mechanisms of Ageing and Development. 126, 6-7, p. 826-828 3 p.

Research output: Contribution to journalArticle

Cholesterol Ester Transfer Proteins
Polymorphism
Genes
Aging of materials
Gene-Environment Interaction
48 Citations (Scopus)

Chronic antigenic load and apoptosis in immunosenescence

Ginaldi, L., De Martinis, M., Monti, D. & Franceschi, C., Feb 2005, In : Trends in Immunology. 26, 2, p. 79-84 6 p.

Research output: Contribution to journalArticle

Cell Death
Apoptosis
Immune System
Lymphocytes
Immunosenescence
310 Citations (Scopus)

Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

Anisimov, V. N., Berstein, L. M., Egormin, P. A., Piskunova, T. S., Popovich, I. G., Zabezhinski, M. A., Kovalenko, I. G., Poroshina, T. E., Semenchenko, A. V., Provinciali, M., Re, F. & Franceschi, C., Aug 2005, In : Experimental Gerontology. 40, 8-9, p. 685-693 9 p.

Research output: Contribution to journalArticle

Metformin
Somatomedins
Transgenic Mice
Tumors
Mammals

Erratum: Age-related changes on platelet membrance: A study on elderly and centenarian monozygotic twins (Experimental Gerontology (2005) 40/16 (519-525) DOI: 10.1016/j.exger.2005.03.009)

Nanetti, L., Moroni, C., Vignini, A., Vannini, P., Franceschi, C. & Mazzanti, L., Oct 2005, In : Experimental Gerontology. 40, 10, p. 839 1 p.

Research output: Contribution to journalArticle

Erratum: What evidence is there for the existence of individual genes with antagonistic pleiotropic effects? (Mechanisms of Ageing and Development (2005) 126 (421-429) PII: S0047637404001897 and DOI: 10.1016/j.mad.2004.07.012)

Leroi, A. M., Bartke, A., De Benedictis, G., Franceschi, C., Gartner, A., Gonos, E. S., Fedei, M. E., Kivisild, T., Lee, S., Kartaf-Ozer, N., Schumacher, M., Sikora, E., Slagboom, E., Tatar, M., Yashin, A. I., Vijg, J. & Zwaan, B., Aug 2005, In : Mechanisms of Ageing and Development. 126, 8, p. 906 1 p.

Research output: Contribution to journalArticle

168 Citations (Scopus)

Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: The lesson of centenarians

Franceschi, C., Olivieri, F., Marchegiani, F., Cardelli, M., Cavallone, L., Capri, M., Salvioli, S., Valensin, S., De Benedictis, G., Di Iorio, A., Caruso, C., Paolisso, G. & Monti, D., Feb 2005, In : Mechanisms of Ageing and Development. 126, 2, p. 351-361 11 p.

Research output: Contribution to journalArticle

Oxidative stress
Medical Genetics
Oxidative Stress
Genes
Insulin
1 Citation (Scopus)

Genotype of inflammatory cytokines in limbal stem cell graft in Italian patients

Lescai, F., Conti, L., Bartolozzi, M., Ramazzotti, G., Mazzi, M., Sarnicola, V. & Franceschi, C., Jun 24 2005, In : Biochemical and Biophysical Research Communications. 332, 1, p. 95-100 6 p.

Research output: Contribution to journalArticle

Stem cells
Polymorphism
Grafts
Interleukin-6
Stem Cells
289 Citations (Scopus)

Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity

De Martinis, M., Franceschi, C., Monti, D. & Ginaldi, L., Apr 11 2005, In : FEBS Letters. 579, 10, p. 2035-2039 5 p.

Research output: Contribution to journalArticle

T-cells
Aging of materials
T-Lymphocytes
Immune system
Immune System
62 Citations (Scopus)

Inflammation and life-span [4] (multiple letters)

Caruso, C., Candore, G., Colonna-Romano, G., Lio, D., Franceschi, C., Payne, A. G., Finch, C. E. & Crimmins, E. M., Jan 14 2005, In : Science. 307, 5707, p. 208-209 2 p.

Research output: Contribution to journalArticle

308 Citations (Scopus)

Innate immunity and inflammation in ageing: A key for understanding age-related diseases

Licastro, F., Candore, G., Lio, D., Porcellini, E., Colonna-Romano, G., Franceschi, C. & Caruso, C., May 18 2005, In : Immunity and Ageing. 2, 8.

Research output: Contribution to journalArticle

Innate Immunity
Immune System
Inflammation
Genotype
Sarcopenia
30 Citations (Scopus)
Microsatellite Instability
DNA Mismatch Repair
Microsatellite Repeats
Blood Cells
DNA
43 Citations (Scopus)

p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1

Salvioli, S., Bonafé, M., Barbi, C., Storci, G., Trapassi, C., Tocco, F., Gravina, S., Rossi, M., Tiberi, L., Mondello, C., Monti, D. & Franceschi, C., Sep 2005, In : Cell Cycle. 4, 9, p. 1264-1271 8 p.

Research output: Contribution to journalArticle

Fibroblasts
Proline
Codon
Arginine
Cell Cycle
45 Citations (Scopus)

p66shc is highly expressed in fibroblasts from centenarians

Pandolfi, S., Bonafè, M., Di Tella, L., Tiberi, L., Salvioli, S., Monti, D., Sorbi, S. & Franceschi, C., Aug 2005, In : Mechanisms of Ageing and Development. 126, 8, p. 839-844 6 p.

Research output: Contribution to journalArticle

Fibroblasts
Methylation
Oxidative stress
Polymorphism
Oxidative Stress
1 Citation (Scopus)

Pathological relevance of the natural immune system

Salvioli, S., Capri, M., Fumelli, C., Lescai, F., Monti, D. & Franceschi, C., 2005, In : NeuroImmune Biology. 5, C, p. 331-350 20 p.

Research output: Contribution to journalArticle

Innate Immunity
Immune System
Immunologic Monitoring
Autoimmunity
Sepsis
26 Citations (Scopus)

Postoperative Delirium after elective and emergency surgery: Analysis and checking of risk factors. A study protocol

Agnoletti, V., Ansaloni, L., Catena, F., Chattat, R., De Cataldis, A., Di Nino, G., Franceschi, C., Gagliardi, S., Melotti, R. M., Potalivo, A. & Taffurelli, M., May 28 2005, In : BMC Surgery. 5

Research output: Contribution to journalArticle

Delirium
Emergencies
Cognition Disorders
Erythrocyte Transfusion
Confusion
31 Citations (Scopus)

Quantifying the relevance of different mediators in the human immune cell network

Tieri, P., Valensin, S., Latora, V., Castellani, G. C., Marchiori, M., Remondini, D. & Franceschi, C., Apr 15 2005, In : Bioinformatics. 21, 8, p. 1639-1643 5 p.

Research output: Contribution to journalArticle

Mediator
Immune system
Immune System
Cell
Cytokines
36 Citations (Scopus)

Role of interaction between variants in the PPARG and interleukin-6 genes on obesity related metabolic risk factors

Barbieri, M., Rizzo, M. R., Papa, M., Acampora, R., De Angelis, L., Olivieri, F., Marchegiani, F., Franceschi, C. & Paolisso, G., Jul 2005, In : Experimental Gerontology. 40, 7, p. 599-604 6 p.

Research output: Contribution to journalArticle

Interleukin-6
Obesity
Genes
Peroxisome Proliferator-Activated Receptors
Polymorphism
26 Citations (Scopus)

Role of TLR4 receptor polymorphisms in Boutonneuse fever.

Balistreri, C. R., Candore, G., Lio, D., Colonna-Romano, G., Di Lorenzo, G., Mansueto, P., Rini, G., Mansueto, S., Cillari, E., Franceschi, C. & Caruso, C., Oct 2005, In : International Journal of Immunopathology and Pharmacology. 18, 4, p. 655-660 6 p.

Research output: Contribution to journalArticle

Boutonneuse Fever
Toll-Like Receptor 4
Alleles
Sicily
Infection
15 Citations (Scopus)

Study of the association with - 330T/G IL-2 in a population of centenarians from Centre and South Italy

Scola, L., Candore, G., Colonna-Romano, G., Crivello, A., Forte, G. I., Paolisso, G., Franceschi, C., Lio, D. & Caruso, C., Dec 2005, In : Biogerontology. 6, 6, p. 425-429 5 p.

Research output: Contribution to journalArticle

Italy
Interleukin-2
Population
Genotype
T-Lymphocytes
43 Citations (Scopus)

The -308G/A polymorphism of TNF-α influences immunological parameters in old subjects affected by infectious diseases

Cipriano, C., Caruso, C., Lio, D., Giacconi, R., Malavolta, M., Muti, E., Gasparini, N., Franceschi, C. & Mocchegiani, E., Feb 2005, In : International Journal of Immunogenetics. 32, 1, p. 13-18 6 p.

Research output: Contribution to journalArticle

Communicable Diseases
Interleukin-10
Cytokines
Zinc
Interleukin-6