• 674 Citations
  • 15 h-Index
20062018
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Research Output 2006 2018

  • 674 Citations
  • 15 h-Index
  • 29 Article
  • 1 Short survey
  • 1 Review article
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Article
2018

Staphylococcus aureus impacts Pseudomonas aeruginosa chronic respiratory disease in murine models

Cigana, C., Bianconi, I., Baldan, R., De Simone, M., Riva, C., Sipione, B., Rossi, G., Cirillo, DM. & Bragonzi, A., 2018, In : The Journal of infectious diseases. 217, 6, p. 933-942 10 p.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa
Staphylococcus aureus
Chronic Disease
Cystic Fibrosis
Pseudomonas Infections

Synthesized Heparan Sulfate Competitors Attenuate Pseudomonas aeruginosa Lung Infection

Lorè, NI., Veraldi, N., Riva, C., Sipione, B., Spagnuolo, L., De Fino, I., Melessike, M., Calzi, E., Bragonzi, A., Naggi, A. & Cigana, C., 2018, In : International Journal of Molecular Sciences. 19, 1, 207.

Research output: Contribution to journalArticle

pseudomonas
Heparitin Sulfate
infectious diseases
lungs
Pseudomonas aeruginosa

The impact of host genetic background in the Pseudomonas aeruginosa respiratory infections

Loré, NI., Cigana, C., Sipione, B. & Bragonzi, A., 2018, In : Mammalian Genome. 29, 7–8, p. 550-557 8 p.

Research output: Contribution to journalArticle

Respiratory Tract Infections
Pseudomonas aeruginosa
Opportunistic Infections
Medical Genetics
Inbred Strains Mice
2017
3 Citations (Scopus)

The PAPI-1 pathogenicity island-encoded small RNA PesA influences Pseudomonas aeruginosa virulence and modulates pyocin S3 production

Ferrara, S., Falcone, M., Macchi, R., Bragonzi, A., Girelli, D., Cariani, L., Cigana, C. & Bertoni, G., Jun 1 2017, In : PLoS One. 12, 6, e0180386.

Research output: Contribution to journalArticle

Pyocins
pathogenicity islands
Genomic Islands
Pseudomonas aeruginosa
Virulence
3 Citations (Scopus)

The PAPI-1 pathogenicity island-encoded small RNA PesA influences Pseudomonas aeruginosa virulence and modulates pyocin S3 production

Ferrara, S., Falcone, M., Macchi, R., Bragonzi, A., Girelli, D., Cariani, L., Cigana, C. & Bertoni, G., 2017, In : PLoS One. 12, 6, e0180386.

Research output: Contribution to journalArticle

Pyocins
pathogenicity islands
Genomic Islands
Pseudomonas aeruginosa
Virulence
2016
8 Citations (Scopus)

Efficacy of the novel antibiotic POL7001 in preclinical models of Pseudomonas aeruginosa pneumonia

Cigana, C., Bernardini, F., Facchini, M., Alcalá-Franco, B., Riva, C., De Fino, I., Rossi, A., Ranucci, S., Misson, P., Chevalier, E., Brodmann, M., Schmitt, M., Wach, A., Dale, G. E., Obrecht, D. & Bragonzi, A., Aug 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 8, p. 4991-5000 10 p.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa
Pneumonia
Anti-Bacterial Agents
Lung
Cystic Fibrosis
5 Citations (Scopus)

Genotypic and phenotypic relatedness of Pseudomonas aeruginosa isolates among the major cystic fibrosis patient cohort in Italy

Cigana, C., Melotti, P., Baldan, R., Pedretti, E., Pintani, E., Iansa, P., De Fino, I., Favari, F., Bergamini, G., Tridello, G., Cirillo, D. M., Assael, B. M. & Bragonzi, A., Jul 11 2016, In : BMC Microbiology. 16, 1, 142.

Research output: Contribution to journalArticle

Cystic Fibrosis
Pseudomonas aeruginosa
Italy
Clone Cells
Pyocyanine

IL-17A impairs host tolerance during airway chronic infection by Pseudomonas aeruginosa

Lorè, N. I., Cigana, C., Riva, C., De Fino, I., Nonis, A., Spagnuolo, L., Sipione, B., Cariani, L., Girelli, D., Rossi, G., Basso, V., Colombo, C., Mondino, A. & Bragonzi, A., May 18 2016, In : Scientific Reports. 6, 25937.

Research output: Contribution to journalArticle

Interleukin-17
Pseudomonas aeruginosa
Infection
Elastin
Matrix Metalloproteinases
17 Citations (Scopus)

IL-17A impairs host tolerance during airway chronic infection by Pseudomonas aeruginosa

Lorè, N. I., Cigana, C., Riva, C., De Fino, I., Nonis, A., Spagnuolo, L., Sipione, B., Cariani, L., Girelli, D., Rossi, G., Basso, V., Colombo, C., Mondino, A. & Bragonzi, A., May 18 2016, In : Scientific Reports. 6, 25937.

Research output: Contribution to journalArticle

Interleukin-17
Pseudomonas aeruginosa
Infection
Elastin
Matrix Metalloproteinases
3 Citations (Scopus)

Mapping genetic determinants of host susceptibility to Pseudomonas aeruginosa lung infection in mice

De Simone, M., Spagnuolo, L., Lorè, N. I., Cigana, C., De Fino, I., Broman, K. W., Iraqi, F. A. & Bragonzi, A., 2016, In : BMC Genomics. 17, 1, 351.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa
Pseudomonas Infections
Lung
Infection
Quantitative Trait Loci
3 Citations (Scopus)

The host genetic background defines diverse immune-reactivity and susceptibility to chronic Pseudomonas aeruginosa respiratory infection

Spagnuolo, L., Simone, M. D., Lorè, N. I., De Fino, I., Basso, V., Mondino, A., Cigana, C. & Bragonzi, A., Nov 16 2016, In : Scientific Reports. 6, 36924.

Research output: Contribution to journalArticle

Respiratory Tract Infections
Pseudomonas aeruginosa
Infection
Lung
Inbred Strains Mice
27 Citations (Scopus)

Tracking the immunopathological response to Pseudomonas aeruginosa during respiratory infections

Cigana, C., Lorè, N. I., Riva, C., De Fino, I., Spagnuolo, L., Sipione, B., Rossi, G., Nonis, A., Cabrini, G. & Bragonzi, A., Feb 17 2016, In : Scientific Reports. 6, 21465.

Research output: Contribution to journalArticle

Respiratory Tract Infections
Pseudomonas aeruginosa
Cystic Fibrosis
Inbred CFTR Mouse
Infection
2015
20 Citations (Scopus)

Activation of Human Toll-like receptor 4 (TLR4)·myeloid differentiation factor 2 (MD-2) by hypoacylated lipopolysaccharide from a clinical isolate of Burkholderia cenocepacia

Di Lorenzo, F., Kubik, Ł., Oblak, A., Lorè, N. I., Cigana, C., Lanzetta, R., Parrilli, M., Hamad, M. A., De Soyza, A., Silipo, A., Jerala, R., Bragonzi, A., Valvano, M. A., Martín-Santamaría, S. & Molinaro, A., Aug 28 2015, In : Journal of Biological Chemistry. 290, 35, p. 21305-21319 15 p.

Research output: Contribution to journalArticle

Burkholderia cenocepacia
Lipid A
Lipopolysaccharides
Chemical activation
Toll-Like Receptor 4
26 Citations (Scopus)

Host-pathogen interplay in the respiratory environment of cystic fibrosis

Yonker, L. M., Cigana, C., Hurley, B. P. & Bragonzi, A., Jul 1 2015, In : Journal of Cystic Fibrosis. 14, 4, p. 431-439 9 p.

Research output: Contribution to journalArticle

Cystic Fibrosis
Lung
Microbiota
Adaptive Immunity
Infection
21 Citations (Scopus)

Integrated whole-genome screening for Pseudomonas aeruginosa virulence genes using multiple disease models reveals that pathogenicity is host specific

Dubern, J. F., Cigana, C., De Simone, M., Lazenby, J., Juhas, M., Schwager, S., Bianconi, I., Döring, G., Eberl, L., Williams, P., Bragonzi, A. & Cámara, M., Nov 1 2015, In : Environmental Microbiology. 17, 11, p. 4379-4393 15 p.

Research output: Contribution to journalArticle

disease models
pathogenicity
virulence
Pseudomonas aeruginosa
Virulence
2014
54 Citations (Scopus)

Adaptation of Pseudomonas aeruginosa in cystic fibrosis airways influences virulence of Staphylococcus aureus in vitro and murine models of co-infection

Baldan, R., Cigana, C., Testa, F., Bianconi, I., De Simone, M., Pellin, D., Di Serio, C., Bragonzi, A. & Cirillo, D. M., Mar 6 2014, In : PLoS One. 9, 3, e89614.

Research output: Contribution to journalArticle

cystic fibrosis
Pathogens
Coinfection
mixed infection
Pseudomonas aeruginosa
13 Citations (Scopus)

Assessing Pseudomonas aeruginosa virulence and the host response using Murine models of acute and chronic lung infection

Kukavica-Ibrulj, I., Facchini, M., Cigana, C., Levesque, R. C. & Bragonzi, A., 2014, In : Methods in molecular biology (Clifton, N.J.). 1149, p. 757-771 15 p.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa
Virulence
Lung
Infection
Maintenance
31 Citations (Scopus)

BIIL 284 reduces neutrophil numbers but increases P. aeruginosa bacteremia and inflammation in mouse lungs

Döring, G., Bragonzi, A., Paroni, M., Aktürk, F. F., Cigana, C., Schmidt, A., Gilpin, D., Heyder, S., Born, T., Smaczny, C., Kohlhäufl, M., Wagner, T. O. F., Loebinger, M. R., Bilton, D., Tunney, M. M., Elborn, J. S., Pier, G. B., Konstan, M. W. & Ulrich, M., Mar 2014, In : Journal of Cystic Fibrosis. 13, 2, p. 156-163 8 p.

Research output: Contribution to journalArticle

Bacteremia
Neutrophils
Inflammation
Lung
Pseudomonas aeruginosa
19 Citations (Scopus)

Host genetic background influences the response to the opportunistic pseudomonas aeruginosa infection altering cell-mediated immunity and bacterial replication

De Simone, M., Spagnuolo, L., Lorè, N. I., Rossi, G., Cigana, C., De Fino, I., Iraqi, F. A. & Bragonzi, A., Sep 30 2014, In : PLoS One. 9, 9, e106873.

Research output: Contribution to journalArticle

Pseudomonas Infections
Pseudomonas aeruginosa
Cellular Immunity
cell-mediated immunity
genetic background
2012
10 Citations (Scopus)

Antibiotic pressure compensates the biological cost associated with Pseudomonas aeruginosa hypermutable phenotypes in vitro and in a murine model of chronic airways infection

Alcalá-Franco, B., Montanari, S., Cigana, C., Bertoni, G., Oliver, A. & Bragonzi, A., Apr 2012, In : Journal of Antimicrobial Chemotherapy. 67, 4, p. 962-969 8 p., dkr587.

Research output: Contribution to journalArticle

Pseudomonas aeruginosa
Cystic Fibrosis
Anti-Bacterial Agents
Phenotype
Pressure
67 Citations (Scopus)

Cystic fibrosis-niche adaptation of Pseudomonas aeruginosa reduces virulence in multiple infection hosts.

Lorè, N. I., Cigana, C., De Fino, I., Riva, C., Juhas, M., Schwager, S., Eberl, L. & Bragonzi, A., 2012, In : PLoS One. 7, 4

Research output: Contribution to journalArticle

cystic fibrosis
Pseudomonas aeruginosa
Cystic Fibrosis
Virulence
niches
11 Citations (Scopus)

MudPIT analysis of released proteins in Pseudomonas aeruginosa laboratory and clinical strains in relation to pro-inflammatory effects.

Bergamini, G., Di Silvestre, D., Mauri, P., Cigana, C., Bragonzi, A., De Palma, A., Benazzi, L., Döring, G., Assael, B. M., Melotti, P. & Sorio, C., Mar 2012, In : Integrative biology : quantitative biosciences from nano to macro. 4, 3, p. 270-279 10 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinases
Pseudomonas aeruginosa
Pathogens
Conditioned Culture Medium
Cystic Fibrosis
2011
45 Citations (Scopus)

Positive signature-tagged mutagenesis in Pseudomonas aeruginosa: Tracking patho-adaptive mutations promoting airways chronic infection

Bianconi, I., Milani, A., Cigana, C., Paroni, M., Levesque, R. C., Bertoni, G. & Bragonzi, A., Feb 2011, In : PLoS Pathogens. 7, 2, e1001270.

Research output: Contribution to journalArticle

Mutagenesis
Pseudomonas aeruginosa
Mutation
Cystic Fibrosis
Infection
2009
16 Citations (Scopus)

Effects of azithromycin on glutathione S-transferases in cystic fibrosis airway cells

Bergamini, G., Cigana, C., Sorio, C., Della Peruta, M., Pompella, A., Corti, A., Huaux, F. A., Leal, T., Assael, B. M. & Melotti, P., Aug 1 2009, In : American Journal of Respiratory Cell and Molecular Biology. 41, 2, p. 199-206 8 p.

Research output: Contribution to journalArticle

Azithromycin
Glutathione Transferase
Cystic Fibrosis
Anti-Inflammatory Agents
Glutathione
78 Citations (Scopus)

Pseudomonas aeruginosa exploits lipid a and muropeptides modification as a strategy to lower innate immunity during cystic fibrosis lung infection

Cigana, C., Curcuru, L., Leone., M. R., Ierano, T., Lore, N. I., Bianconi, I., Silipo, A., Cozzolino, F., Lanzetta, R., Molinaro, A., Bernardini, M. L. & Bragonzi, A., 2009, In : PLoS One. 4, 12, e8439.

Research output: Contribution to journalArticle

cystic fibrosis
Pseudomonas aeruginosa
Innate Immunity
Cystic Fibrosis
lipopolysaccharides
2007
81 Citations (Scopus)

Azithromycin selectively reduces tumor necrosis factor alpha levels in cystic fibrosis airway epithelial cells

Cigana, C., Assael, B. M. & Melotti, P., Mar 2007, In : Antimicrobial Agents and Chemotherapy. 51, 3, p. 975-981 7 p.

Research output: Contribution to journalArticle

Azithromycin
Cystic Fibrosis
Tumor Necrosis Factor-alpha
Epithelial Cells
Macrolides
9 Citations (Scopus)

Effects of azithromycin on the expression of ATP binding cassette transporters in epithelial cells from the airways of cystic fibrosis patients

Cigana, C., Nicolis, E., Pasetto, M., Assael, B. M. & Melotti, P., Dec 2007, In : Journal of Chemotherapy. 19, 6, p. 643-649 7 p.

Research output: Contribution to journalArticle

Azithromycin
ATP-Binding Cassette Transporters
Cystic Fibrosis
Epithelial Cells
P-Glycoprotein
2006
74 Citations (Scopus)

Anti-inflammatory effects of azithromycin in cystic fibrosis airway epithelial cells

Cigana, C., Nicolis, E., Pasetto, M., Assael, B. M. & Melotti, P., Dec 1 2006, In : Biochemical and Biophysical Research Communications. 350, 4, p. 977-982 6 p.

Research output: Contribution to journalArticle

Azithromycin
Cystic Fibrosis
Transcription Factor AP-1
Anti-Inflammatory Agents
Epithelial Cells
6 Citations (Scopus)

The GCC repeat length in the 5′UTR of MRP1 gene is polymorphic: A functional characterization of its relevance for cystic fibrosis

Nicolis, E., Pasetto, M., Cigana, C., Pradal, U., Assael, B. M. & Melotti, P., Feb 7 2006, In : BMC Medical Genetics. 7

Research output: Contribution to journalArticle

Cystic Fibrosis
Alleles
Modifier Genes
MDR Genes
Trinucleotide Repeats