Cristina Cigana &ndash; Research Output

2018

Staphylococcus aureus impacts Pseudomonas aeruginosa chronic respiratory disease in murine models

Cigana, C., Bianconi, I., Baldan, R., De Simone, M., Riva, C., Sipione, B., Rossi, G., Cirillo, DM. & Bragonzi, A., 2018, In : The Journal of infectious diseases. 217, 6, p. 933-942 10 p.

Research output: Contribution to journal › Article

Pseudomonas aeruginosa

Staphylococcus aureus

Chronic Disease

Cystic Fibrosis

Pseudomonas Infections

Synthesized Heparan Sulfate Competitors Attenuate Pseudomonas aeruginosa Lung Infection

Lorè, NI., Veraldi, N., Riva, C., Sipione, B., Spagnuolo, L., De Fino, I., Melessike, M., Calzi, E., Bragonzi, A., Naggi, A. & Cigana, C., 2018, In : International Journal of Molecular Sciences. 19, 1, 207.

Research output: Contribution to journal › Article

pseudomonas

Heparitin Sulfate

infectious diseases

lungs

Pseudomonas aeruginosa

The impact of host genetic background in the Pseudomonas aeruginosa respiratory infections

Loré, NI., Cigana, C., Sipione, B. & Bragonzi, A., 2018, In : Mammalian Genome. 29, 7–8, p. 550-557 8 p.

Research output: Contribution to journal › Article

Respiratory Tract Infections

Pseudomonas aeruginosa

Opportunistic Infections

Medical Genetics

Inbred Strains Mice

2017

3 Citations (Scopus)

The PAPI-1 pathogenicity island-encoded small RNA PesA influences Pseudomonas aeruginosa virulence and modulates pyocin S3 production

Ferrara, S., Falcone, M., Macchi, R., Bragonzi, A., Girelli, D., Cariani, L., Cigana, C. & Bertoni, G., Jun 1 2017, In : PLoS One. 12, 6, e0180386.

Research output: Contribution to journal › Article

Pyocins

pathogenicity islands

Genomic Islands

Pseudomonas aeruginosa

Virulence

3 Citations (Scopus)

The PAPI-1 pathogenicity island-encoded small RNA PesA influences Pseudomonas aeruginosa virulence and modulates pyocin S3 production

Ferrara, S., Falcone, M., Macchi, R., Bragonzi, A., Girelli, D., Cariani, L., Cigana, C. & Bertoni, G., 2017, In : PLoS One. 12, 6, e0180386.

Research output: Contribution to journal › Article

Pyocins

pathogenicity islands

Genomic Islands

Pseudomonas aeruginosa

Virulence

2016

8 Citations (Scopus)

Efficacy of the novel antibiotic POL7001 in preclinical models of Pseudomonas aeruginosa pneumonia

Cigana, C., Bernardini, F., Facchini, M., Alcalá-Franco, B., Riva, C., De Fino, I., Rossi, A., Ranucci, S., Misson, P., Chevalier, E., Brodmann, M., Schmitt, M., Wach, A., Dale, G. E., Obrecht, D. & Bragonzi, A., Aug 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 8, p. 4991-5000 10 p.

Research output: Contribution to journal › Article

Pseudomonas aeruginosa

Pneumonia

Anti-Bacterial Agents

Lung

Cystic Fibrosis

5 Citations (Scopus)

Genotypic and phenotypic relatedness of Pseudomonas aeruginosa isolates among the major cystic fibrosis patient cohort in Italy

Cigana, C., Melotti, P., Baldan, R., Pedretti, E., Pintani, E., Iansa, P., De Fino, I., Favari, F., Bergamini, G., Tridello, G., Cirillo, D. M., Assael, B. M. & Bragonzi, A., Jul 11 2016, In : BMC Microbiology. 16, 1, 142.

Research output: Contribution to journal › Article

Cystic Fibrosis

Pseudomonas aeruginosa

Italy

Clone Cells

Pyocyanine

IL-17A impairs host tolerance during airway chronic infection by Pseudomonas aeruginosa

Lorè, N. I., Cigana, C., Riva, C., De Fino, I., Nonis, A., Spagnuolo, L., Sipione, B., Cariani, L., Girelli, D., Rossi, G., Basso, V., Colombo, C., Mondino, A. & Bragonzi, A., May 18 2016, In : Scientific Reports. 6, 25937.

Research output: Contribution to journal › Article

Interleukin-17

Pseudomonas aeruginosa

Infection

Elastin

Matrix Metalloproteinases

17 Citations (Scopus)

IL-17A impairs host tolerance during airway chronic infection by Pseudomonas aeruginosa

Lorè, N. I., Cigana, C., Riva, C., De Fino, I., Nonis, A., Spagnuolo, L., Sipione, B., Cariani, L., Girelli, D., Rossi, G., Basso, V., Colombo, C., Mondino, A. & Bragonzi, A., May 18 2016, In : Scientific Reports. 6, 25937.

Research output: Contribution to journal › Article

Interleukin-17

Pseudomonas aeruginosa

Infection

Elastin

Matrix Metalloproteinases

3 Citations (Scopus)

Mapping genetic determinants of host susceptibility to Pseudomonas aeruginosa lung infection in mice

De Simone, M., Spagnuolo, L., Lorè, N. I., Cigana, C., De Fino, I., Broman, K. W., Iraqi, F. A. & Bragonzi, A., 2016, In : BMC Genomics. 17, 1, 351.

Research output: Contribution to journal › Article

Pseudomonas aeruginosa

Pseudomonas Infections

Lung

Infection

Quantitative Trait Loci

3 Citations (Scopus)

The host genetic background defines diverse immune-reactivity and susceptibility to chronic Pseudomonas aeruginosa respiratory infection

Spagnuolo, L., Simone, M. D., Lorè, N. I., De Fino, I., Basso, V., Mondino, A., Cigana, C. & Bragonzi, A., Nov 16 2016, In : Scientific Reports. 6, 36924.

Research output: Contribution to journal › Article

Respiratory Tract Infections

Pseudomonas aeruginosa

Infection

Lung

Inbred Strains Mice

27 Citations (Scopus)

Tracking the immunopathological response to Pseudomonas aeruginosa during respiratory infections

Cigana, C., Lorè, N. I., Riva, C., De Fino, I., Spagnuolo, L., Sipione, B., Rossi, G., Nonis, A., Cabrini, G. & Bragonzi, A., Feb 17 2016, In : Scientific Reports. 6, 21465.

Research output: Contribution to journal › Article

Respiratory Tract Infections

Pseudomonas aeruginosa

Cystic Fibrosis

Inbred CFTR Mouse

Infection

2015

20 Citations (Scopus)

Activation of Human Toll-like receptor 4 (TLR4)·myeloid differentiation factor 2 (MD-2) by hypoacylated lipopolysaccharide from a clinical isolate of Burkholderia cenocepacia

Di Lorenzo, F., Kubik, Ł., Oblak, A., Lorè, N. I., Cigana, C., Lanzetta, R., Parrilli, M., Hamad, M. A., De Soyza, A., Silipo, A., Jerala, R., Bragonzi, A., Valvano, M. A., Martín-Santamaría, S. & Molinaro, A., Aug 28 2015, In : Journal of Biological Chemistry. 290, 35, p. 21305-21319 15 p.

Research output: Contribution to journal › Article

Burkholderia cenocepacia

Lipid A

Lipopolysaccharides

Chemical activation

Toll-Like Receptor 4

26 Citations (Scopus)

Host-pathogen interplay in the respiratory environment of cystic fibrosis

Yonker, L. M., Cigana, C., Hurley, B. P. & Bragonzi, A., Jul 1 2015, In : Journal of Cystic Fibrosis. 14, 4, p. 431-439 9 p.

Research output: Contribution to journal › Article

Cystic Fibrosis

Lung

Microbiota

Adaptive Immunity

Infection

21 Citations (Scopus)

Integrated whole-genome screening for Pseudomonas aeruginosa virulence genes using multiple disease models reveals that pathogenicity is host specific

Dubern, J. F., Cigana, C., De Simone, M., Lazenby, J., Juhas, M., Schwager, S., Bianconi, I., Döring, G., Eberl, L., Williams, P., Bragonzi, A. & Cámara, M., Nov 1 2015, In : Environmental Microbiology. 17, 11, p. 4379-4393 15 p.

Research output: Contribution to journal › Article

disease models

pathogenicity

virulence

Pseudomonas aeruginosa

Virulence

2014

54 Citations (Scopus)

Adaptation of Pseudomonas aeruginosa in cystic fibrosis airways influences virulence of Staphylococcus aureus in vitro and murine models of co-infection

Baldan, R., Cigana, C., Testa, F., Bianconi, I., De Simone, M., Pellin, D., Di Serio, C., Bragonzi, A. & Cirillo, D. M., Mar 6 2014, In : PLoS One. 9, 3, e89614.

Research output: Contribution to journal › Article

cystic fibrosis

Pathogens

Coinfection

mixed infection

Pseudomonas aeruginosa

13 Citations (Scopus)

Assessing Pseudomonas aeruginosa virulence and the host response using Murine models of acute and chronic lung infection

Kukavica-Ibrulj, I., Facchini, M., Cigana, C., Levesque, R. C. & Bragonzi, A., 2014, In : Methods in molecular biology (Clifton, N.J.). 1149, p. 757-771 15 p.

Research output: Contribution to journal › Article

Pseudomonas aeruginosa

Virulence

Lung

Infection

Maintenance

31 Citations (Scopus)

BIIL 284 reduces neutrophil numbers but increases P. aeruginosa bacteremia and inflammation in mouse lungs

Döring, G., Bragonzi, A., Paroni, M., Aktürk, F. F., Cigana, C., Schmidt, A., Gilpin, D., Heyder, S., Born, T., Smaczny, C., Kohlhäufl, M., Wagner, T. O. F., Loebinger, M. R., Bilton, D., Tunney, M. M., Elborn, J. S., Pier, G. B., Konstan, M. W. & Ulrich, M., Mar 2014, In : Journal of Cystic Fibrosis. 13, 2, p. 156-163 8 p.

Research output: Contribution to journal › Article

Bacteremia

Neutrophils

Inflammation

Lung

Pseudomonas aeruginosa

19 Citations (Scopus)

Host genetic background influences the response to the opportunistic pseudomonas aeruginosa infection altering cell-mediated immunity and bacterial replication

De Simone, M., Spagnuolo, L., Lorè, N. I., Rossi, G., Cigana, C., De Fino, I., Iraqi, F. A. & Bragonzi, A., Sep 30 2014, In : PLoS One. 9, 9, e106873.

Research output: Contribution to journal › Article

Pseudomonas Infections

Pseudomonas aeruginosa

Cellular Immunity

cell-mediated immunity

genetic background

2012

10 Citations (Scopus)

Antibiotic pressure compensates the biological cost associated with Pseudomonas aeruginosa hypermutable phenotypes in vitro and in a murine model of chronic airways infection

Alcalá-Franco, B., Montanari, S., Cigana, C., Bertoni, G., Oliver, A. & Bragonzi, A., Apr 2012, In : Journal of Antimicrobial Chemotherapy. 67, 4, p. 962-969 8 p., dkr587.

Research output: Contribution to journal › Article

Pseudomonas aeruginosa

Cystic Fibrosis

Anti-Bacterial Agents

Phenotype

Pressure

67 Citations (Scopus)

Cystic fibrosis-niche adaptation of Pseudomonas aeruginosa reduces virulence in multiple infection hosts.

Lorè, N. I., Cigana, C., De Fino, I., Riva, C., Juhas, M., Schwager, S., Eberl, L. & Bragonzi, A., 2012, In : PLoS One. 7, 4

Research output: Contribution to journal › Article

cystic fibrosis

Pseudomonas aeruginosa

Cystic Fibrosis

Virulence

niches

11 Citations (Scopus)

MudPIT analysis of released proteins in Pseudomonas aeruginosa laboratory and clinical strains in relation to pro-inflammatory effects.

Bergamini, G., Di Silvestre, D., Mauri, P., Cigana, C., Bragonzi, A., De Palma, A., Benazzi, L., Döring, G., Assael, B. M., Melotti, P. & Sorio, C., Mar 2012, In : Integrative biology : quantitative biosciences from nano to macro. 4, 3, p. 270-279 10 p.

Research output: Contribution to journal › Article

Matrix Metalloproteinases

Pseudomonas aeruginosa

Pathogens

Conditioned Culture Medium

Cystic Fibrosis

2011

45 Citations (Scopus)

Positive signature-tagged mutagenesis in Pseudomonas aeruginosa: Tracking patho-adaptive mutations promoting airways chronic infection

Bianconi, I., Milani, A., Cigana, C., Paroni, M., Levesque, R. C., Bertoni, G. & Bragonzi, A., Feb 2011, In : PLoS Pathogens. 7, 2, e1001270.

Research output: Contribution to journal › Article

Mutagenesis

Pseudomonas aeruginosa

Mutation

Cystic Fibrosis

Infection

2009

16 Citations (Scopus)

Effects of azithromycin on glutathione S-transferases in cystic fibrosis airway cells

Bergamini, G., Cigana, C., Sorio, C., Della Peruta, M., Pompella, A., Corti, A., Huaux, F. A., Leal, T., Assael, B. M. & Melotti, P., Aug 1 2009, In : American Journal of Respiratory Cell and Molecular Biology. 41, 2, p. 199-206 8 p.

Research output: Contribution to journal › Article

Azithromycin

Glutathione Transferase

Cystic Fibrosis

Anti-Inflammatory Agents

Glutathione

78 Citations (Scopus)

Pseudomonas aeruginosa exploits lipid a and muropeptides modification as a strategy to lower innate immunity during cystic fibrosis lung infection

Cigana, C., Curcuru, L., Leone., M. R., Ierano, T., Lore, N. I., Bianconi, I., Silipo, A., Cozzolino, F., Lanzetta, R., Molinaro, A., Bernardini, M. L. & Bragonzi, A., 2009, In : PLoS One. 4, 12, e8439.

Research output: Contribution to journal › Article

cystic fibrosis

Pseudomonas aeruginosa

Innate Immunity

Cystic Fibrosis

lipopolysaccharides

2007

81 Citations (Scopus)

Azithromycin selectively reduces tumor necrosis factor alpha levels in cystic fibrosis airway epithelial cells

Cigana, C., Assael, B. M. & Melotti, P., Mar 2007, In : Antimicrobial Agents and Chemotherapy. 51, 3, p. 975-981 7 p.

Research output: Contribution to journal › Article

Azithromycin

Cystic Fibrosis

Tumor Necrosis Factor-alpha

Epithelial Cells

Macrolides

9 Citations (Scopus)

Effects of azithromycin on the expression of ATP binding cassette transporters in epithelial cells from the airways of cystic fibrosis patients

Cigana, C., Nicolis, E., Pasetto, M., Assael, B. M. & Melotti, P., Dec 2007, In : Journal of Chemotherapy. 19, 6, p. 643-649 7 p.

Research output: Contribution to journal › Article

Azithromycin

ATP-Binding Cassette Transporters

Cystic Fibrosis

Epithelial Cells

P-Glycoprotein

2006

74 Citations (Scopus)

Anti-inflammatory effects of azithromycin in cystic fibrosis airway epithelial cells

Cigana, C., Nicolis, E., Pasetto, M., Assael, B. M. & Melotti, P., Dec 1 2006, In : Biochemical and Biophysical Research Communications. 350, 4, p. 977-982 6 p.

Research output: Contribution to journal › Article

Azithromycin

Cystic Fibrosis

Transcription Factor AP-1

Anti-Inflammatory Agents

Epithelial Cells

6 Citations (Scopus)

The GCC repeat length in the 5′UTR of MRP1 gene is polymorphic: A functional characterization of its relevance for cystic fibrosis

Nicolis, E., Pasetto, M., Cigana, C., Pradal, U., Assael, B. M. & Melotti, P., Feb 7 2006, In : BMC Medical Genetics. 7

Research output: Contribution to journal › Article

Cystic Fibrosis

Alleles

Modifier Genes

MDR Genes

Trinucleotide Repeats