1993 …2019

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2019

Axitinib exposure triggers endothelial cells senescence through ROS accumulation and ATM activation

Mongiardi, M. P., Radice, G., Piras, M., Stagni, V., Pacioni, S., Re, A., Putti, S., Ferrè, F., Farsetti, A., Pallini, R., Barilà, D., Levi, A. & Falchetti, M. L., Jan 1 2019, In : Oncogene.

Research output: Contribution to journalArticle

2017

ATM kinase sustains breast cancer stem-like cells by promoting ATG4C expression and autophagy

Antonelli, M., Strappazzon, F., Arisi, I., Brandi, R., D'Onofrio, M., Sambucci, M., Manic, G., Vitale, I., Barilà, D. & Stagni, V., Jan 1 2017, In : Oncotarget. 8, 13, p. 21692-21709 18 p.

Research output: Contribution to journalArticle

Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma

Fianco, G., Mongiardi, M. P., Levi, A., Luca, T. D., Desideri, M., Trisciuoglio, D., Bufalo, D. D., Cinà, I., Benedetto, A. D., Mottolese, M., Gentile, A., Centonze, D., Ferrè, F. & Barilà, D., Jun 8 2017, In : eLife. 6, e22593.

Research output: Contribution to journalArticle

Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma

Fianco, G., Mongiardi, M. P., Levi, A., De Luca, T., Desideri, M., Trisciuoglio, D., Del Bufalo, D., Cinà, I., Di Benedetto, A., Mottolese, M., Gentile, A., Centonze, D., Ferrè, F. & Barilà, D., Jun 8 2017, In : eLife. 6

Research output: Contribution to journalArticle

2016

ATM: An unexpected tumor-promoting factor in HER2-expressing tumors

Stagni, V., Oropallo, V. & Barilà, D., Mar 2016, In : Molecular & cellular oncology. 3, 2, p. e1054551

Research output: Contribution to journalArticle

Caspase-8 expression and its Src-dependent phosphorylation on Tyr380 promote cancer cell neoplastic transformation and resistance to anoikis

Fianco, G., Cenci, C. & Barilà, D., Sep 10 2016, In : Experimental Cell Research. 347, 1, p. 114-22 9 p.

Research output: Contribution to journalArticle

2015

ATM kinase sustains HER2 tumorigenicity in breast cancer

Stagni, V., Manni, I., Oropallo, V., Mottolese, M., Di Benedetto, A., Piaggio, G., Falcioni, R., Giaccari, D., Di Carlo, S., Sperati, F., Cencioni, M. T. & Barilà, D., Apr 16 2015, In : Nature Communications. 6, 6886.

Research output: Contribution to journalArticle

2014

ATM kinase activity modulates ITCH E3-ubiquitin ligase activity

Santini, S., Stagni, V., Giambruno, R., Fianco, G., Di Benedetto, A., Mottolese, M., Pellegrini, M. & Barilà, D., Feb 27 2014, In : Oncogene. 33, 9, p. 1113-1123 11 p.

Research output: Contribution to journalArticle

ITCH E3 ligase in ATM network

Stagni, V., Santini, S. & Barilà, D., 2014, In : Oncoscience. 1, 6, p. 394-395 2 p.

Research output: Contribution to journalArticle

Tug of war between survival and death: Exploring ATM function in cancer

Stagni, V., Oropallo, V., Fianco, G., Antonelli, M., Cinà, I. & Barilà, D., Mar 27 2014, In : International Journal of Molecular Sciences. 15, 4, p. 5388-5409 22 p.

Research output: Contribution to journalArticle

2013

ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition

Gilardini Montani, M. S., Prodosmo, A., Stagni, V., Merli, D., Monteonofrio, L., Gatti, V., Gentileschi, M. P., Barilà, D. & Soddu, S., Nov 19 2013, In : Journal of Experimental and Clinical Cancer Research. 32, 1, 95.

Research output: Contribution to journalArticle

2012

A new player in the development of TRAIL based therapies for hepatocarcinoma treatment: ATM kinase

Stagni, V., Santini, S. & Barilà, D., Jun 2012, In : Cancers. 4, 2, p. 354-378 25 p.

Research output: Contribution to journalArticle

Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver

Furlan, A., Lamballe, F., Stagni, V., Hussain, A., Richelme, S., Prodosmo, A., Moumen, A., Brun, C., Del Barco Barrantes, I., Arthur, J. S. C., Koleske, A. J., Nebreda, A. R., Barilà, D. & Maina, F., Dec 2012, In : Journal of Hepatology. 57, 6, p. 1292-1298 7 p.

Research output: Contribution to journalArticle

Proteomic profiling of ATM kinase proficient and deficient cell lines upon blockage of proteasome activity

Marzano, V., Santini, S., Rossi, C., Zucchelli, M., D'Alessandro, A., Marchetti, C., Mingardi, M., Stagni, V., Barilà, D. & Urbani, A., Aug 3 2012, In : Journal of Proteomics. 75, 15, p. 4632-4646 15 p.

Research output: Contribution to journalArticle

2011

Abl interconnects oncogenic Met and p53 core pathways in cancer cells

Furlan, A., Stagni, V., Hussain, A., Richelme, S., Conti, F., Prodosmo, A., Destro, A., Roncalli, M., Barilà, D. & Mainá, F., Oct 2011, In : Cell Death and Differentiation. 18, 10, p. 1608-1616 9 p.

Research output: Contribution to journalArticle

Oxygen sensing is impaired in ATM defective cells

Mongiardi, M. P., Stagni, V., Natoli, M., Giaccari, D., D'Agnano, I., Falchetti, M. L., Barilà, D. & Levi, A., Dec 15 2011, In : Cell Cycle. 10, 24, p. 4311-4320 10 p.

Research output: Contribution to journalArticle

2010

ATM kinase activity modulates cFLIP protein levels: Potential interplay between DNA damage signalling and TRAIL-induced apoptosis

Stagni, V., Mingardi, M., Santini, S., Giaccari, D. & Barilà, D., Nov 2010, In : Carcinogenesis. 31, 11, p. 1956-1963 8 p.

Research output: Contribution to journalArticle

2009

Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis

Barbero, S., Mielgo, A., Torres, V., Teitz, T., Shields, D. J., Mikolon, D., Bogyo, M., Barilà, D., Lahti, J. M., Schlaepfer, D. & Stupack, D. G., May 1 2009, In : Cancer Research. 69, 9, p. 3755-3763 9 p.

Research output: Contribution to journalArticle

2008

ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells

Stagni, V., Di Bari, M. G., Cursi, S., Condò, I., Cencioni, M. T., Testi, R., Lerenthal, Y., Cundari, E. & Barilà, D., Jan 15 2008, In : Blood. 111, 2, p. 829-837 9 p.

Research output: Contribution to journalArticle

Caspase 8 promotes peripheral localization and activation of Rab5

Torres, V. A., Mielgo, A., Barilà, D., Anderson, D. H. & Stupack, D., Dec 26 2008, In : Journal of Biological Chemistry. 283, 52, p. 36280-36289 10 p.

Research output: Contribution to journalArticle

Identification of a critical tyrosine residue in caspase 8 that promotes cell migration

Barbero, S., Barilà, D., Mielgo, A., Stagni, V., Clair, K. & Stupack, D., May 9 2008, In : Journal of Biological Chemistry. 283, 19, p. 13031-13034 4 p.

Research output: Contribution to journalArticle

2007

Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma

Podar, K., Raab, M. S., Tonon, G., Sattler, M., Barilà, D., Zhang, J., Tai, Y. T., Yasui, H., Raje, N., DePinho, R. A., Hideshima, T., Chauhan, D. & Anderson, K. C., Feb 15 2007, In : Cancer Research. 67, 4, p. 1680-1688 9 p.

Research output: Contribution to journalArticle

2006

c-Abl acetylation by histone acetyltransferases regulates its nuclear-cytoplasmic localization

di Bari, M. G., Ciuffini, L., Mingardi, M., Testi, R., Soddu, S. & Barilà, D., Jul 2006, In : EMBO Reports. 7, 7, p. 727-733 7 p.

Research output: Contribution to journalArticle

Deregulation of proteasome function induces Abl-mediated cell death by uncoupling p130CAS and c-CrkII

Holcomb, M., Rufini, A., Barilà, D. & Klemke, R. L., Feb 3 2006, In : Journal of Biological Chemistry. 281, 5, p. 2430-2440 11 p.

Research output: Contribution to journalArticle

Src kinase phosphorylates Caspase-8 on Tyr380: A novel mechanism of apoptosis suppression

Cursi, S., Rufini, A., Stagni, V., Condò, I., Matafora, V., Bachi, A., Bonifazi, A. P., Coppola, L., Superti-Furga, G., Testi, R. & Barilà, D., May 3 2006, In : EMBO Journal. 25, 9, p. 1895-1905 11 p.

Research output: Contribution to journalArticle

2003

Caspase-dependent cleavage of c-Abl contributes to apoptosis

Barilà, D., Rufini, A., Condò, I., Ventura, N., Dorey, K., Superti-Furga, G. & Testi, R., Apr 2003, In : Molecular and Cellular Biology. 23, 8, p. 2790-2799 10 p.

Research output: Contribution to journalArticle

2002

c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis

Furstoss, O., Dorey, K., Simon, V., Barilà, D., Superti-Furga, G. & Roche, S., Feb 15 2002, In : EMBO Journal. 21, 4, p. 514-524 11 p.

Research output: Contribution to journalArticle

2000

A nuclear tyrosine phosphorylation circuit: c-Jun as an activator and substrate of c-Abl and JNK

Barilá, D., Mangano, R., Gonfloni, S., Kretzschmar, J., Moro, M., Bohmann, D. & Superti-Furga, G., Jan 17 2000, In : EMBO Journal. 19, 2, p. 273-281 9 p.

Research output: Contribution to journalArticle

Nuclear tyrosine phosphorylation: The beginning of a map

Cans, C., Mangano, R., Barilá, D., Neubauer, G. & Superti-Furga, G., Oct 15 2000, In : Biochemical Pharmacology. 60, 8, p. 1203-1215 13 p.

Research output: Contribution to journalArticle

1999

Regulation of human c-Abl tyrosine kinase activity in Xenopus oocytes and acceleration of progesterone-induce G2/M transition by oncogenic forms

Dorey, K., Barilá, D., Gavin, A. C., Nebreda, A. R. & Superti-Furga, G., Feb 1999, In : Biological Chemistry. 380, 2, p. 223-230 8 p.

Research output: Contribution to journalArticle

1998

An intramolecular SH3-domain interaction regulates c-Abl activity

Barila, D. & Superti-Furga, G., 1998, In : Nature Genetics. 18, 3, p. 280-282 3 p.

Research output: Contribution to journalArticle

Effects of retinoids on gene expression in different epithelial models in vivo and in vitro

Perozzi, G., Barilà, D., Plateroti, M., Sambuy, Y., Nobili, F. & Gaetani, S., 1998, In : Zeitschrift fur Ernahrungswissenschaft. 37, SUPPL. 1, p. 29-34 6 p.

Research output: Contribution to journalArticle

Regulation of the SRC and ABU protein tyrosine kinases

Superti-Furga, G., Barilâ, D., Dorey, K. & Gonfloni, S., 1998, In : FASEB Journal. 12, 8

Research output: Contribution to journalArticle

1996

The Dri 42 gene, whose expression is up-regulated during epithelial differentiation, encodes a novel endoplasmic reticulum resident transmembrane protein

Barilà, D., Plateroti, M., Nobili, F., Muda, A. O., Xie, Y., Morimoto, T. & Perozzi, G., 1996, In : Journal of Biological Chemistry. 271, 47, p. 29928-29936 9 p.

Research output: Contribution to journalArticle

1995

Transcriptional regulation of the ezrin gene during rat intestinal development and epithelial differentiation

Barilá, D., Murgia, C., Nobili, F. & Perozzi, G., Aug 22 1995, In : BBA - Gene Structure and Expression. 1263, 2, p. 133-140 8 p.

Research output: Contribution to journalArticle

1994

Subtractive hybridization cloning of novel genes differentially expressed during intestinal development

Barila, D., Murgia, C., Nobili, F., Gaetani, S. & Perozzi, G., 1994, In : European Journal of Biochemistry. 223, 2, p. 701-709 9 p.

Research output: Contribution to journalArticle

1993

Expression of differentiated functions in the developing porcine small intestine

Perozzi, G., Barilà, D., Murgia, C., Kelly, D., Begbie, R. & King, T. P., 1993, In : Journal of Nutritional Biochemistry. 4, 12, p. 699-705 7 p.

Research output: Contribution to journalArticle