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2019

USP1 links platinum resistance to cancer cell dissemination by regulating Snail stability

Sonego, M., Pellarin, I., Costa, A., Vinciguerra, G. L. R., Coan, M., Kraut, A., D'Andrea, S., Dall'Acqua, A., Castillo-Tong, D. C., Califano, D., Losito, S., Spizzo, R., Couté, Y., Vecchione, A., Belletti, B., Schiappacassi, M. & Baldassarre, G., Jan 1 2019, In : Science Advances. 5, 5, eaav3235.

Research output: Contribution to journalArticle

Open Access

USP1 links platinum resistance to cancer cell dissemination by regulating Snail stability

Sonego, M., Pellarin, I., Costa, A., Vinciguerra, G. L. R., Coan, M., Kraut, A., D'Andrea, S., Dall'Acqua, A., Castillo-Tong, D. C., Califano, D., Losito, S., Spizzo, R., Couté, Y., Vecchione, A., Belletti, B., Schiappacassi, M. & Baldassarre, G., May 8 2019, In : Science advances. 5, 5, p. eaav3235-eaav3235 16 p.

Research output: Contribution to journalArticle

2018

Trabectedin in Ovarian Cancer: Is it now a Standard of Care?

Ventriglia, J., Paciolla, I., Cecere, S. C., Pisano, C., Di Napoli, M., Arenare, L., Setola, S. V., Losito, N. S., Califano, D., Orditura, M. & Pignata, S., 2018, In : Clinical Oncology.

Research output: Contribution to journalArticle

2017

CDK6 protects epithelial ovarian cancer from platinum-induced death via FOXO3 regulation

Dall'Acqua, A., Sonego, M., Pellizzari, I., Pellarin, I., Canzonieri, V., D'Andrea, S., Benevol, S., Sorio, R., Giorda, G., Califano, D., Bagnoli, M., Militello, L., Mezzanzanica, D., Chiappetta, G., Armenia, J., Belletti, B., Schiappacassi, M. & Baldassarre, G., 2017, In : EMBO Molecular Medicine. 9, 10, p. 1415-1433 19 p.

Research output: Contribution to journalArticle

CDK6 protects epithelial ovarian cancer from platinum-induced death via FOXO3 regulation

Dall'Acqua, A., Sonego, M., Pellizzari, I., Pellarin, I., Canzonieri, V., D'Andrea, S., Benevol, S., Sorio, R., Giorda, G., Califano, D., Bagnoli, M., Militello, L., Mezzanzanica, D., Chiappetta, G., Armenia, J., Belletti, B., Schiappacassi, M. & Baldassarre, G., Oct 2017, In : EMBO Molecular Medicine. 9, 10, p. 1415-1433 19 p.

Research output: Contribution to journalArticle

CDK6 protects epithelial ovarian cancer from platinum-induced death via FOXO3 regulation

Dall'Acqua, A., Sonego, M., Pellizzari, I., Pellarin, I., Canzonieri, V., D'Andrea, S., Benevol, S., Sorio, R., Giorda, G., Califano, D., Bagnoli, M., Militello, L., Mezzanzanica, D., Chiappetta, G., Armenia, J., Belletti, B., Schiappacassi, M. & Baldassarre, G., Oct 2017, In : EMBO Molecular Medicine.

Research output: Contribution to journalArticle

2016

Biomarker analysis of the MITO2 phase III trial of first-line treatment in ovarian cancer: Predictive value of DNA-PK and phosphorylated ACC

Perrone, F., Baldassarre, G., Signoriello, S., Chiappetta, G., Esposito, F., Ferrandina, G., Sonego, M., Zannoni, G. F., Canzonieri, V., Scambia, G., Breda, E., Scollo, P., Ferro, A., Tamberi, S., Febbraro, A., Natale, D., Califano, D., Scognamiglio, G., Canevari, S., Losito, S. & 2 others, Gallo, C. & Pignata, S., 2016, In : Oncotarget. 7, 45, p. 72654-72661 8 p.

Research output: Contribution to journalArticle

Development and validation of a microRNA-based signature (MiROvaR) to predict early relapse or progression of epithelial ovarian cancer: a cohort study

Bagnoli, M., Canevari, S., Califano, D., Losito, S., Maio, M. D., Carcangiu, M. L., Cecchin, E., Canzonieri, V., Russo, D., Scognamiglio, G., Chiappetta, G., Baldassarre, G., Scambia, G., Zannoni, G. F., Carosi, M., Scollo, P., Breda, E., Murgia, V., Perrone, F., Pignata, S. & 2 others, for the & Multicentre Italian Trials in Ovarian cancer (MITO) translational group, Aug 1 2016, In : The Lancet Oncology. 17, 8, p. 1137-1146 10 p.

Research output: Contribution to journalArticle

2015

Detection of high mobility group A2 specific mRNA in the plasma of patients affected by epithelial ovarian cancer

Galdiero, F., Romano, A., Pasquinelli, R., Pignata, S., Greggi, S., Vuttariello, E., Bello, A. M., Calise, C., Scaffa, C., Pisano, C., Losito, N. S., Fusco, A., Califano, D. & Chiappetta, G., 2015, In : Oncotarget. 6, 22, p. 19328-19335 8 p.

Research output: Contribution to journalArticle

2014

High HMGA2 Expression and High Body Mass Index Negatively Affect the Prognosis of Patients With Ovarian Cancer

Califano, D., Pignata, S., Losito, N. S., Ottaiano, A., Greggi, S., De Simone, V., Cecere, S., Aiello, C., Esposito, F., Fusco, A. & Chiappetta, G., Jan 1 2014, In : Journal of Cellular Physiology. 229, 1, p. 53-59 7 p.

Research output: Contribution to journalArticle

The anti-apoptotic BAG3 protein is expressed in lung carcinomas and regulates small cell lung carcinoma (SCLC) tumor growth

Chiappetta, G., Basile, A., Barbieri, A., Falco, A., Rosati, A., Festa, M., Pasquinelli, R., Califano, D., Palma, G., Costanzo, R., Barcaroli, D., Capunzo, M., Franco, R., Rocco, G., Pascale, M., Turco, M. C., De Laurenzi, V. & Arra, C., 2014, In : Oncotarget. 5, 16, p. 6846-6853 8 p.

Research output: Contribution to journalArticle

2013

A microRNA signature defines chemoresistance in ovarian cancer through modulation of angiogenesis

Vecchione, A., Belletti, B., Lovat, F., Volinia, S., Chiappetta, G., Giglio, S., Sonego, M., Cirombella, R., Onesti, E. C., Pellegrini, P., Califano, D., Pignata, S., Losito, S., Canzonieri, V., Sorio, R., Alder, H., Wernicke, D., Stoppacciaro, A., Baldassarre, G. & Croce, C. M., Jun 11 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 24, p. 9845-9850 6 p.

Research output: Contribution to journalArticle

2012

BAG3 down-modulation reduces anaplastic thyroid tumor growth by enhancing proteasome-mediated degradation of BRAF protein

Chiappetta, G., Basile, A., Arra, C., Califano, D., Pasquinelli, R., Barbieri, A., De Simone, V., Rea, D., Giudice, A., Pezzullo, L., De Laurenzi, V., Botti, G., Losito, S., Conforti, D. & Turco, M. C., Jan 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 1

Research output: Contribution to journalArticle

2011

MiR-191 down-regulation plays a role in thyroid follicular tumors through CDK6 targeting

Colamaio, M., Borbone, E., Russo, L., Bianco, M., Federico, A., Califano, D., Chiappetta, G., Pallante, P., Troncone, G., Battista, S. & Fusco, A., Dec 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 12

Research output: Contribution to journalArticle

2010

FEZ1/LZTS1 protein expression in ovarian cancer

Califano, D., Pignata, S., Pisano, C., Greggi, S., Laurelli, G., Losito, N. S., Ottaiano, A., Gallipoli, A., Pasquinelli, R., De Simone, V., Cirombella, R., Fusco, A. & Chiappetta, G., Feb 2010, In : Journal of Cellular Physiology. 222, 2, p. 382-386 5 p.

Research output: Contribution to journalArticle

2008

HMGA2 mRNA expression correlates with the malignant phenotype in human thyroid neoplasias

Chiappetta, G., Ferraro, A., Vuttariello, E., Monaco, M., Galdiero, F., De Simone, V., Califano, D., Pallante, P., Botti, G., Pezzullo, L., Pierantoni, G. M., Santoro, M. & Fusco, A., May 2008, In : European Journal of Cancer. 44, 7, p. 1015-1021 7 p.

Research output: Contribution to journalArticle

2007

Design, synthesis, and cytotoxic evaluation of a new series of 3-substituted spiro[(dihydropyrazine-2,5-dione)-6,3′-(2′,3′- dihydrothieno[2,3-b]naphtho-4′,9′-dione)] derivatives

Gomez-Monterrey, I., Campiglia, P., Carotenuto, A., Califano, D., Pisano, C., Vesci, L., Lama, T., Bertamino, A., Sala, M., Di Bosco, A. M., Grieco, P. & Novellino, E., Apr 19 2007, In : Journal of Medicinal Chemistry. 50, 8, p. 1787-1798 12 p.

Research output: Contribution to journalArticle

Loss of p27 expression through RAS→BRAF→MAP kinase-dependent pathway in human thyroid carcinomas

Motti, M. L., De Marco, C., Califano, D., De Gisi, S., Malanga, D., Troncone, G., Persico, A., Losito, S., Fabiani, F., Santoro, M., Chiappetta, G., Fusco, A. & Viglietto, G., Nov 15 2007, In : Cell Cycle. 6, 22, p. 2817-2825 9 p.

Research output: Contribution to journalArticle

Overexpression of the S-phase kinase-associated protein 2 in thyroid cancer

Chiappetta, G., De Marco, C., Quintiero, A., Califano, D., Gherardi, S., Malanga, D., Scrima, M., Montero-Conde, C., Cito, L., Monaco, M., Motti, M. L., Pasquinelli, R., Agosti, V., Robledo, M., Fusco, A. & Viglietto, G., Jun 2007, In : Endocrine-Related Cancer. 14, 2, p. 405-420 16 p.

Research output: Contribution to journalArticle

2006

Significance of erb-B2 immunoreactivity in cervical cancer

Califano, D., Losito, S., Pisano, C., Santelli, G., Greggi, S., Iodice, F., DiVagno, G., Silvestro, G., Tambaro, R., Formato, R., Iaffaioli, V. R., Di Maio, M. & Pignata, S., 2006, In : Frontiers in Bioscience. 11, SUPPL. 1, p. 2071-2076 6 p.

Research output: Contribution to journalArticle

Synthesis, pharmacological evaluation, and molecular modeling studies of novel peptidic CAAX analogues as farnesyl-protein-transferase inhibitors

Santagada, V., Caliendo, G., Severino, B., Lavecchia, A., Perissutti, E., Fiorino, F., Zampella, A., Sepe, V., Califano, D., Santelli, G. & Novellino, E., Mar 23 2006, In : Journal of Medicinal Chemistry. 49, 6, p. 1882-1890 9 p.

Research output: Contribution to journalArticle

2005

Complex regulation of the cyclin-dependent kinase inhibitor p27 kip1 in thyroid cancer cells by the PI3K/AKT pathway: Regulation of p27kip1 expression and localization

Motti, M. L., Califano, D., Troncone, G., De Marco, C., Migliaccio, I., Palmieri, E., Pezzullo, L., Palombini, L., Fusco, A. & Viglietto, G., Mar 2005, In : American Journal of Pathology. 166, 3, p. 737-749 13 p.

Research output: Contribution to journalArticle

p27Kip1 is expressed in proliferating cells in its form phosphorylated on threonine 187

Troncone, G., Martinez, J. C., Iaccarino, A., Zeppa, P., Caleo, A., Russo, M., Migliaccio, I., Motti, M. L., Califano, D., Palmieri, E. A. & Palombini, L., Feb 23 2005, In : BMC Clinical Pathology. 5

Research output: Contribution to journalArticle

Reduced E-cadherin expression contributes to the loss of p27 kip1-mediated mechanism of contact inhibition in thyroid anaplastic carcinomas

Motti, M. L., Califano, D., Baldassarre, G., Celetti, A., Merolla, F., Forzati, F., Napolitano, M., Tavernise, B., Fusco, A. & Viglietto, G., 2005, In : Carcinogenesis. 26, 6, p. 1021-1034 14 p.

Research output: Contribution to journalArticle

Synthesis and cytotoxic evaluation of novel spirohydantoin derivatives of the dihydrothieno[2,3-b]naphtho-4,9-dione system

Gomez-Monterrey, I., Santelli, G., Campiglia, P., Califano, D., Falasconi, F., Pisano, C., Vesci, L., Lama, T., Grieco, P. & Novellino, E., Feb 24 2005, In : Journal of Medicinal Chemistry. 48, 4, p. 1152-1157 6 p.

Research output: Contribution to journalArticle

2004

Akt-dependent T198 phosphorylation of cyclin-dependent kinase inhibitor p27kip1 in breast cancer

Motti, M. L., De Marco, C., Califano, D., Fusco, A. & Viglietto, G., Aug 2004, In : Cell Cycle. 3, 8, p. 1074-1080 7 p.

Research output: Contribution to journalArticle

Thymosin β-10 gene expression as a possible tool in diagnosis of thyroid neoplasias

Chiappetta, G., Pentimalli, F., Monaco, M., Fedele, M., Pasquinelli, R., Pierantoni, G. M., Ribecco, M. T., Santelli, G., Califano, D., Pezzullo, L. & Fusco, A., Aug 2004, In : Oncology Reports. 12, 2, p. 239-243 5 p.

Research output: Contribution to journalArticle

2003

The tyrosine phosphatase Shp-2 mediates intracellular signaling initiated by Ret mutants

D'Alessio, A., Califano, D., Incoronato, M., Santelli, G., Florio, T., Schettini, G., Carlomagno, M. S., Cerchia, L. & De Franciscis, V., Oct 1 2003, In : Endocrinology. 144, 10, p. 4298-4305 8 p.

Research output: Contribution to journalArticle

2002

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27kip1 by PKB/Akt-mediated phosphorylation in breast cancer

Viglietto, G., Motti, M. L., Bruni, P., Melillo, R. M., D'Alessio, A., Califano, D., Vinci, F., Chiappetta, G., Tsichliss, P., Bellacosa, A., Fusco, A. & Santoro, M., Oct 1 2002, In : Nature Medicine. 8, 10, p. 1136-1144 9 p.

Research output: Contribution to journalArticle

Erratum: Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues (British Journal of Cancer (2002) 86 (917-923))

De Nigris, F., Cerutti, J., Morelli, C., Califano, D., Chiariotti, L., Viglietto, G., Santelli, G. & Fusco, A., Dec 2 2002, In : British Journal of Cancer. 87, 12, p. 1479 1 p.

Research output: Contribution to journalArticle

Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues

De Nigris, F., Cerutti, J., Morelli, C., Califano, D., Chiariotti, L., Viglietto, G., Santelli, G. & Fusco, A., Mar 18 2002, In : British Journal of Cancer. 86, 6, p. 917-923 7 p.

Research output: Contribution to journalArticle

Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues.

De Nigris, F., Cerutti, J., Morelli, C., Califano, D., Chiariotti, L., Viglietto, G., Santelli, G. & Fusco, A., Dec 2 2002, In : British Journal of Cancer. 87, 12, p. 1479 1 p.

Research output: Contribution to journalArticle

Thymosin β-10 protein synthesis suppression reduces the growth of human thyroid carcinoma cells in semisolid medium

Santelli, G., Fusco, A., Bartoli, P. C., Giuliano, A., Porcellini, A., Mineo, A., Barone, M. V., Busiello, I., Trapasso, F. & Califano, D., Sep 2002, In : Thyroid. 12, 9, p. 765-772 8 p.

Research output: Contribution to journalArticle

2000

Abrogation of nerve growth factor-induced terminal differentiation by ret oncogene involves perturbation of nuclear translocation of ERK

Colucci-D'Amato, G. L., D'Alessio, A., Califano, D., Calì, G., Rizzo, C., Nitsch, L., Santelli, G. & De Franciscis, V., Jun 23 2000, In : Journal of Biological Chemistry. 275, 25, p. 19306-19314 9 p.

Research output: Contribution to journalArticle

Human dbl proto-oncogene in 85 kb of Xq26, and determination of the transcription initiation site

Palmieri, G., De Franciscis, V., Casamassimi, A., Romano, G., Torino, A., Pingitore, P., Califano, D., Santelli, G., Eva, A., Vecchio, G., D'Urso, M. & Ciccodicola, A., Jul 25 2000, In : Gene. 253, 1, p. 107-115 9 p.

Research output: Contribution to journalArticle

Signaling through Ras is essential for ret oncogene-induced cell differentiation in PC12 cells

Califano, D., Rizzo, C., D'Alessio, A., Colucci-D'Amato, G. L., Cali, G., Cannada Bartoli, P., Santelli, G., Vecchio, G. & De Franciscis, V., Jun 23 2000, In : Journal of Biological Chemistry. 275, 25, p. 19297-19305 9 p.

Research output: Contribution to journalArticle

1999

Regulation of thymosin β10 expression by TSH and other mitogenic signals in the thyroid gland and in cultured thyrocytes

Viglietto, G., Califano, D., Bruni, P., Baldassarre, G., Vento, M. T., Belletti, B., Fedele, M., Santelli, G., Boccia, A., Manzo, G., Santoro, M. & Fusco, A., Jun 1999, In : European Journal of Endocrinology. 140, 6, p. 597-607 11 p.

Research output: Contribution to journalArticle

Synthesis and biological activity of pseudopeptides inhibitors of Ras farnesyl transferase containing unconventional amino acids

Caliendo, G., Fiorino, F., Grieco, P., Perissutti, E., De Luca, S., Giuliano, A., Santelli, G., Califano, D., Severino, B. & Santagada, V., Nov 9 1999, In : Farmaco. 54, 11-12, p. 785-790 6 p.

Research output: Contribution to journalArticle

Thymosin β-10 gene overexpression is a general event in human carcinogenesis

Santelli, G., Califano, D., Chiappetta, G., Vento, M. T., Bartoli, P. C., Zullo, F., Trapasso, F., Viglietto, G. & Fusco, A., Sep 1999, In : American Journal of Pathology. 155, 3, p. 799-804 6 p.

Research output: Contribution to journalArticle

1998

Overexpression of the HIP gene coding for a heparin/heparan sulfate- binding protein in human thyroid carcinomas

De Nigris, F., Visconti, R., Cerutti, J., Califano, D., Mineo, A., Santoro, M., Santelli, G. & Fusco, A., Oct 15 1998, In : Cancer Research. 58, 20, p. 4745-4751 7 p.

Research output: Contribution to journalArticle

Phenol-derived CVFM analog inhibitors of Ras farnesyltransferase possessing cellular in vitro activity

Caliendo, G., Fiorino, F., Grieco, P., Perissutti, E., Ramunno, A., Santagada, V., Albrizio, S., Califano, D., Giuliano, A. & Santelli, G., 1998, In : European Journal of Medicinal Chemistry. 33, 9, p. 725-732 8 p.

Research output: Contribution to journalArticle

Thymosin β-10 gene overexpression correlated with the highly malignant neoplastic phenotype of transformed thyroid cells in vivo and in vitro

Califano, D., Monaco, C., Santelli, G., Giuliano, A., Veronese, M. L., Berlingieri, M. T., De Franciscis, V., Berger, N., Trapasso, F., Santoro, M., Viglietto, G. & Fusco, A., Feb 15 1998, In : Cancer Research. 58, 4, p. 823-828 6 p.

Research output: Contribution to journalArticle

1997

Upregulation of the angiogenic factors PlGF, VEGF and their receptors (Flt-1, Flk-1/KDR) by TSH in cultured thyrocytes and in the thyroid gland of thiouracil-fed rats suggest a TSH-dependent paracrine mechanism for goiter hypervascularization

Viglietto, G., Romano, A., Manzo, G., Chiappetta, G., Paoletti, I., Califano, D., Galati, M. G., Mauriello, V., Bruni, P., Lago, C. T., Fusco, A. & Persico, M. G., 1997, In : Oncogene. 15, 22, p. 2687-2698 12 p.

Research output: Contribution to journalArticle

1996

A potential pathogenetic mechanism for multiple endocrine neoplasia type 2 syndromes involves ret-induced impairment of terminal differentiation of neuroepithelial cells

Califano, D., D'Alessio, A., Colucci-D'Amato, G. L., De Vita, G., Monaco, C., Santelli, G., Di Fiore, P. P., Vecchio, G., Fusco, A., Santoro, M. & De Franciscis, V., Jul 23 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 15, p. 7933-7937 5 p.

Research output: Contribution to journalArticle

Ligand stimulation of a Ret chimeric receptor carrying the activating mutation responsible for the multiple endocrine neoplasia type 2B

Rizzo, C., Califano, D., Luca Colucci-D'Amato, G., De Vita, G., D'Alessio, A., Dathan, N. A., Fusco, A., Monaco, C., Santelli, G., Vecchio, G., Santoro, M. & De Franciscis, V., 1996, In : Journal of Biological Chemistry. 271, 46, p. 29497-29501 5 p.

Research output: Contribution to journalArticle

Low frequency of p53 mutations in human thyroid tumors; p53 and Ras mutation in two out of fifty-six thyroid tumours

Salvatore, D., Celetti, A., Fabien, N., Paulin, C., Martelli, M. L., Battaglia, C., Califano, D., Monaco, C., Viglietto, G., Santoro, M. & Fusco, A., Feb 1996, In : European Journal of Endocrinology. 134, 2, p. 177-183 7 p.

Research output: Contribution to journalArticle

Neovascularization in human germ cell tumors correlates with a marked increase in the expression of the vascular endothelial growth factor but not the placenta-derived growth factor

Viglietto, G., Romano, A., Maglione, D., Rambaldi, M., Paoletti, I., Lago, C. T., Califano, D., Monaco, C., Mineo, A., Santelli, G., Manzo, G., Botti, G., Chiappetta, G. & Persico, M. G., 1996, In : Oncogene. 13, 3, p. 577-587 11 p.

Research output: Contribution to journalArticle

Transgenic mice carrying the human KRAS oncogene under the control of a thyroglobulin promoter: KRAS expression in thyroids analyzed by in situ hybridization

Chiappetta, G., Fabien, N., Picone, A., Califano, D., Monaco, C., De Franciscis, V., Vecchio, G. & Santelli, G., 1996, In : Oncology Research. 8, 2, p. 85-93 9 p.

Research output: Contribution to journalArticle

1995

Activated RET/PTC oncogene elicits immediate early and delayed response genes in PC12 cells

Califano, D., Monaco, C., De Vita, G., D'Alessio, A., Dathan, N. A., Possenti, R., Vecchio, G., Fusco, A., Santoro, M. & De Franciscis, V., 1995, In : Oncogene. 11, 1, p. 107-112 6 p.

Research output: Contribution to journalArticle