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2019

Met inhibition revokes IFNγ-induction of PD-1 ligands in MET-amplified tumours

Martin, V., Chiriaco, C., Modica, C., Acquadro, A., Cortese, M., Galimi, F., Perera, T., Gammaitoni, L., Aglietta, M., Comoglio, P. M., Vigna, E. & Sangiolo, D., Mar 2019, In : British Journal of Cancer. 120, 5, p. 527-536 10 p.

Research output: Contribution to journalArticle

Veliparib: a new therapeutic option in ovarian cancer?

Ghisoni, E., Giannone, G., Tuninetti, V., Genta, S., Scotto, G., Aglietta, M., Sangiolo, D., Mittica, G. & Valabrega, G., Jun 1 2019, In : Future Oncology. 15, p. 1975-1987 13 p.

Research output: Contribution to journalArticle

2018

BRAF and MEK inhibitors increase PD-1-positive melanoma cells leading to a potential lymphocyte-independent synergism with anti–PD-1 antibody

Sanlorenzo, M., Vujic, I., Floris, A., Novelli, M., Gammaitoni, L., Giraudo, L., Macagno, M., Leuci, V., Rotolo, R., Donini, C., Basirico, M., Quaglino, P., Fierro, M. T., Giordano, S., Sibilia, M., Carnevale-Schianca, F., Aglietta, M. & Sangiolo, D., Jul 15 2018, In : Clinical Cancer Research. 24, 14, p. 3377-3385 9 p.

Research output: Contribution to journalArticle

CD44v6 as innovative sarcoma target for CAR-redirected CIK cells

Leuci, V., Casucci, G. M., Grignani, G., Rotolo, R., Rossotti, U., Vigna, E., Gammaitoni, L., Mesiano, G., Fiorino, E., Donini, C., Pisacane, A., ambrosio, L. D., Pignochino, Y., Aglietta, M., Bondanza, A. & Sangiolo, D., May 4 2018, In : OncoImmunology. 7, 5, e1423167.

Research output: Contribution to journalArticle

Cytokine Induced Killer cells are effective against sarcoma cancer stem cells spared by chemotherapy and target therapy.

Mesiano, G., Grignani, G., Fiorino, E., Leuci, V., Rotolo, R., D’Ambrosio, L., Salfi, C., Gammaitoni, L., Giraudo, L., Pisacane, A., Butera, S., Pignochino, Y., Basiricó, M., Capozzi, F., Sapino, A., Aglietta, M. & Sangiolo, D., Nov 2 2018, In : OncoImmunology. 7, 11, e1465161.

Research output: Contribution to journalArticle

Survivin-peptide vaccination elicits immune response after allogeneic nonmyeloablative transplantation: A safe strategy to enhance the graft versus tumor effect

Circosta, P., Vitaggio, K., Elia, A. R., Todorovic, M., Sangiolo, D., Carnevale-Schianca, F., Vallario, A., Geuna, M., Aglietta, M. & Cignetti, A., Jul 1 2018, In : Immunotherapy. 10, 9, p. 753-767 15 p.

Research output: Contribution to journalArticle

Trabectedin and olaparib in patients with advanced and non-resectable bone and soft-tissue sarcomas (TOMAS): an open-label, phase 1b study from the Italian Sarcoma Group

Grignani, G., D'Ambrosio, L., Pignochino, Y., Palmerini, E., Zucchetti, M., Boccone, P., Aliberti, S., Stacchiotti, S., Bertulli, R., Piana, R., Miano, S., Tolomeo, F., Chiabotto, G., Sangiolo, D., Pisacane, A., Dei Tos, A. P., Novara, L., Bartolini, A., Marchesi, E., D'Incalci, M. & 4 others, Bardelli, A., Picci, P., Ferrari, S. & Aglietta, M., Oct 2018, In : The Lancet Oncology. 19, 10, p. 1360-1371 12 p.

Research output: Contribution to journalArticle

Trabectedin and olaparib in patients with advanced and non-resectable bone and soft-tissue sarcomas (TOMAS): an open-label, phase 1b study from the Italian Sarcoma Group

Grignani, G., D'Ambrosio, L., Pignochino, Y., Palmerini, E., Zucchetti, M., Boccone, P., Aliberti, S., Stacchiotti, S., Bertulli, R., Piana, R., Miano, S., Tolomeo, F., Chiabotto, G., Sangiolo, D., Pisacane, A., Dei Tos, A. P., Novara, L., Bartolini, A., Marchesi, E., D'Incalci, M. & 4 others, Bardelli, A., Picci, P., Ferrari, S. & Aglietta, M., Oct 2018, In : The Lancet Oncology. 19, 10, p. 1360-1371 12 p.

Research output: Contribution to journalArticle

Trabectedin and olaparib in patients with advanced and non-resectable bone and soft-tissue sarcomas (TOMAS): an open-label, phase 1b study from the Italian Sarcoma Group

Grignani, G., D'Ambrosio, L., Pignochino, Y., Palmerini, E., Zucchetti, M., Boccone, P., Aliberti, S., Stacchiotti, S., Bertulli, R., Piana, R., Miano, S., Tolomeo, F., Chiabotto, G., Sangiolo, D., Pisacane, A., Dei Tos, A. P., Novara, L., Bartolini, A., Marchesi, E., D'Incalci, M. & 4 others, Bardelli, A., Picci, P., Ferrari, S. & Aglietta, M., 2018, In : The Lancet Oncology. 19, 10, p. 1360-1371 12 p.

Research output: Contribution to journalArticle

Trabectedin and olaparib in patients with advanced and non-resectable bone and soft-tissue sarcomas (TOMAS): an open-label, phase 1b study from the Italian Sarcoma Group.

Grignani, G., D'Ambrosio, L., Pignochino, Y., Palmerini, E., Zucchetti, M., Boccone, P., Aliberti, S., Stacchiotti, S., Bertulli, R., Piana, R., Miano, S., Tolomeo, F., Chiabotto, G., Sangiolo, D., Pisacane, A., Dei Tos, A. P., Novara, L., Bartolini, A., Marchesi, E., D'Incalci, M. & 4 others, Bardelli, A., Picci, P., Ferrari, S. & Aglietta, M., Oct 1 2018, In : The Lancet. Oncology. 19, p. 1360-1371 12 p.

Research output: Contribution to journalArticle

Transcriptomic analysis and mutational status of IDH1 in paired primary-recurrent intrahepatic cholangiocarcinoma

Peraldo-Neia, C., Ostano, P., Cavalloni, G., Pignochino, Y., Sangiolo, D., De Cecco, L., Marchesi, E., Ribero, D., Scarpa, A., De Rose, A. M., Giuliani, A., Calise, F., Raggi, C., Invernizzi, P., Aglietta, M., Chiorino, G. & Leone, F., Jun 5 2018, In : BMC Genomics. 19, 1, 440.

Research output: Contribution to journalArticle

Transcriptomic analysis and mutational status of IDH1 in paired primary-recurrent intrahepatic cholangiocarcinoma

Peraldo-Neia, C., Ostano, P., Cavalloni, G., Pignochino, Y., Sangiolo, D., De Cecco, L., Marchesi, E., Ribero, D., Scarpa, A., De Rose, A. M., Giuliani, A., Calise, F., Raggi, C., Invernizzi, P., Aglietta, M., Chiorino, G. & Leone, F., Jun 5 2018, In : BMC Genomics. 19, 1

Research output: Contribution to journalArticle

Transcriptomic analysis and mutational status of IDH1 in paired primary-recurrent intrahepatic cholangiocarcinoma

Peraldo-Neia, C., Ostano, P., Cavalloni, G., Pignochino, Y., Sangiolo, D., De Cecco, L., Marchesi, E., Ribero, D., Scarpa, A., De Rose, A. M., Giuliani, A., Calise, F., Raggi, C., Invernizzi, P., Aglietta, M., Chiorino, G. & Leone, F., 2018, In : BMC Genomics. 19, 1

Research output: Contribution to journalArticle

2017

Analytic and dynamic secretory profile of patient-derived cytokine-induced killer cells

Mesiano, G., Zini, R., Montagner, G., Bianchi, N., Manfredini, R., Chillemi, A., Aglietta, M., Grignani, G., Lampronti, I., Fiorino, E., Malavasi, F., Sangiolo, D., Gambari, R. & Ferrari, D., Jan 1 2017, In : Molecular Medicine. 23, p. 235-246 12 p.

Research output: Contribution to journalArticle

Cytokine-induced killer cells kill chemo-surviving melanoma cancer stem cells

Gammaitoni, L., Giraudo, L., MacAgno, M., Leuci, V., Mesiano, G., Rotolo, R., Sassi, F., Sanlorenzo, M., Zaccagna, A., Pisacane, A., Senetta, R., Cangemi, M., Cattaneo, G., Martin, V., Coha, V., Gallo, S., Pignochino, Y., Sapino, A., Grignani, G., Carnevale-Schianca, F. & 2 others, Aglietta, M. & Sangiolo, D., May 1 2017, In : Clinical Cancer Research. 23, 9, p. 2277-2288 12 p.

Research output: Contribution to journalArticle

Impact of a risk-based follow-up in patients affected by gastrointestinal stromal tumour

D'Ambrosio, L., Palesandro, E., Boccone, P., Tolomeo, F., Miano, S., Galizia, D., Manca, A., Chiara, G., Bertotto, I., Russo, F., Campanella, D., Venesio, T., Sangiolo, D., Pignochino, Y., Siatis, D., De Simone, M., Ferrero, A., Pisacane, A., Dei Tos, A. P., Aliberti, S. & 2 others, Aglietta, M. & Grignani, G., Jun 1 2017, In : European Journal of Cancer. 78, p. 122-132 11 p.

Research output: Contribution to journalArticle

PARP1 expression drives the synergistic antitumor activity of trabectedin and PARP1 inhibitors in sarcoma preclinical models

Pignochino, Y., Capozzi, F., D'Ambrosio, L., Dell'Aglio, C., Basiricò, M., Canta, M., Lorenzato, A., Vignolo Lutati, F., Aliberti, S., Palesandro, E., Boccone, P., Galizia, D., Miano, S., Chiabotto, G., Napione, L., Gammaitoni, L., Sangiolo, D., Benassi, M. S., Pasini, B., Chiorino, G. & 2 others, Aglietta, M. & Grignani, G., Apr 28 2017, In : Molecular Cancer. 16, 1, 86.

Research output: Contribution to journalArticle

VEGF blockade enhances the antitumor effect of BRAFV600E inhibition

Comunanza, V., Corà, D., Orso, F., Consonni, F. M., Middonti, E., Di Nicolantonio, F., Buzdin, A., Sica, A., Medico, E., Sangiolo, D., Taverna, D. & Bussolino, F., 2017, In : EMBO Molecular Medicine. 9, 2, p. 219-237 19 p.

Research output: Contribution to journalArticle

VEGF blockade enhances the antitumor effect of BRAFV600E inhibition.

Comunanza, V., Cora, D., Orso, F., Consonni, F. M., Middonti, E., Di Nicolantonio, F., Buzdin, A., Sica, A., Medico, E., Sangiolo, D., Taverna, D. & Bussolino, F., Feb 1 2017, In : EMBO Molecular Medicine. 9, p. 219-237 19 p.

Research output: Contribution to journalArticle

2016

Adoptive immunotherapy against ovarian cancer

Mittica, G., Capellero, S., Genta, S., Cagnazzo, C., Aglietta, M., Sangiolo, D. & Valabrega, G., May 17 2016, In : Journal of Ovarian Research. 9, 1, 30.

Research output: Contribution to journalArticle

Cytokine-Induced Killer Cells Kill Chemosurviving Melanoma Cancer Stem Cells

Gammaitoni, L., Giraudo Diego, L., Macagno, M., Leuci, V., Mesiano, G., Rotolo, R., Sassi, F., Sanlorenzo, M., Zaccagna, A., Pisacane, A., Senetta, R., Cangemi, M., Cattaneo, G., Martin, V., Coha, V., Gallo, S., Pignochino, Y., Sapino, A., Grignani, G., Carnevale Schianca, F. & 2 others, Aglietta, M. & Sangiolo, D., 2016, In : Clinical Cancer Research.

Research output: Contribution to journalArticle

Lenalidomide normalizes tumor vessels in colorectal cancer improving chemotherapy activity

Leuci, V., Maione, F., Rotolo, R., Giraudo, E., Sassi, F., Migliardi, G., Todorovic, M., Gammaitoni, L., Mesiano, G., Giraudo, L., Luraghi, P., Leone, F., Bussolino, F., Grignani, G., Aglietta, M., Trusolino, L., Bertotti, A. & Sangiolo, D., May 5 2016, In : Journal of Translational Medicine. 14, 1, 119.

Research output: Contribution to journalArticle

VEGF blockade enhances the antitumor effect of BRAFV 600E inhibition

Comunanza, V., Corà, D., Orso, F., Consonni, F. M., Middonti, E., Di Nicolantonio, F., Buzdin, A., Sica, A., Medico, E., Sangiolo, D., Taverna, D. & Bussolino, F., 2016, In : EMBO Molecular Medicine.

Research output: Contribution to journalArticle

2015

Adoptive immunotherapy against sarcomas

Mesiano, G., Leuci, V., Giraudo, L., Gammaitoni, L., Carnevale Schianca, F., Cangemi, M., Rotolo, R., Capellero, S., Pignochino, Y., Grignani, G., Aglietta, M. & Sangiolo, D., Apr 1 2015, In : Expert Opinion on Biological Therapy. 15, 4, p. 517-528 12 p.

Research output: Contribution to journalArticle

Cytokine-induced killer cells as immunotherapy for solid tumors: Current evidence and perspectives

Giraudo, L., Gammaitoni, L., Cangemi, M., Rotolo, R., Aglietta, M. & Sangiolo, D., Sep 1 2015, In : Immunotherapy. 7, 9, p. 999-1010 12 p.

Research output: Contribution to journalArticle

Cytokine Induced Killer cells effectively kill chemo-resistant melanoma cancer stem cells

Gammaitoni, L., Giraudo, L., Leuci, V., Mesiano, G., Cangemi, M., Zaccagna, A., Pisacane, A., Gallo, S., Carnevale-Schianca, F., Aglietta, M. & Sangiolo, D., Jan 15 2015, (Accepted/In press) In : Journal of Translational Medicine. p. 1-2 2 p.

Research output: Contribution to journalArticle

Cytokine-induced killer cells engineered with exogenous t-cell receptors directed against melanoma antigens: Enhanced efficacy of effector cells endowed with a double mechanism of tumor recognition

Elia, A. R., Circosta, P., Sangiolo, D., Bonini, C., Gammaitoni, L., Mastaglio, S., Genovese, P., Geuna, M., Avolio, F., Inghirami, G., Tarella, C. & Cignetti, A., Apr 1 2015, In : Human Gene Therapy. 26, 4, p. 220-231 12 p.

Research output: Contribution to journalArticle

Redirected T cells in cancer therapy

Sangiolo, D., Oct 29 2015, (Accepted/In press) In : Expert Opinion on Biological Therapy.

Research output: Contribution to journalArticle

Sorafenib and everolimus for patients with unresectable high-grade osteosarcoma progressing after standard treatment: A non-randomised phase 2 clinical trial

Grignani, G., Palmerini, E., Ferraresi, V., D'Ambrosio, L., Bertulli, R., Asaftei, S. D., Tamburini, A., Pignochino, Y., Sangiolo, D., Marchesi, E., Capozzi, F., Biagini, R., Gambarotti, M., Fagioli, F., Casali, P. G., Picci, P., Ferrari, S. & Aglietta, M., 2015, In : The Lancet Oncology. 16, 1, p. 98-107 10 p.

Research output: Contribution to journalArticle

Synergy of molecular targeted approaches and immunotherapy in melanoma: Preclinical basis and clinical perspectives

Sanlorenzo, M., Vujic, I., Moy, A., Quaglino, P., Fierro, M. T., Gammaitoni, L., Carnevale-Schianca, F., Aglietta, M. & Sangiolo, D., Oct 3 2015, In : Expert Opinion on Biological Therapy. 15, 10, p. 1491-1500 10 p.

Research output: Contribution to journalArticle

The combination of sorafenib and everolimus shows antitumor activity in preclinical models of malignant pleural mesothelioma

Pignochino, Y., Dell'Aglio, C., Inghilleri, S., Zorzetto, M., Basiricò, M., Capozzi, F., Canta, M., Piloni, D., Cemmi, F., Sangiolo, D., Gammaitoni, L., Soster, M., Marchiò, S., Pozzi, E., Morbini, P., Luisetti, M., Aglietta, M., Grignani, G. & Stella, G. M., May 8 2015, In : BMC Cancer. 15, 1, 374.

Research output: Contribution to journalArticle

2014

Activity of cytokine-induced killer cells against bone and soft tissue sarcoma

Sangiolo, D., Mesiano, G., Gammaitoni, L., Aglietta, M. & Grignani, G., 2014, In : OncoImmunology. 3, 3, e28269.

Research output: Contribution to journalArticle

Cytokine-induced killer cells eradicate bone and soft-tissue sarcomas

Sangiolo, D., Mesiano, G., Gammaitoni, L., Leuci, V., Todorovic, M., Giraudo, L., Cammarata, C., Dell'Aglio, C., D'Ambrosio, L., Pisacane, A., Sarotto, I., Miano, S., Ferrero, I., Carnevale-Schianca, F., Pignochino, Y., Sassi, F., Bertotti, A., Piacibello, W., Fagioli, F., Aglietta, M. & 1 others, Grignani, G., Jan 1 2014, In : Cancer Research. 74, 1, p. 119-129 11 p.

Research output: Contribution to journalArticle

Ex vivo-activated MHC-unrestricted immune effectors for cancer adoptive immunotherapy

Leuci, V., Mesiano, G., Gammaitoni, L., Todorovic, M., Giraudo, L., Carnevale-Schianca, F., Aglietta, M. & Sangiolo, D., 2014, In : Anti-Cancer Agents in Medicinal Chemistry. 14, 2, p. 211-222 12 p.

Research output: Contribution to journalArticle

Genetically redirected T lymphocytes for adoptive immunotherapy of solid tumors

Leuci, V., Mesiano, G., Gammaitoni, L., Aglietta, M. & Sangiolo, D., 2014, In : Current Gene Therapy. 14, 1, p. 52-62 11 p.

Research output: Contribution to journalArticle

Immunotherapy of cancer stem cells in solid tumors: Initial findings and future prospective

Gammaitoni, L., Leuci, V., Mesiano, G., Giraudo, L., Todorovic, M., Carnevale-Schianca, F., Aglietta, M. & Sangiolo, D., 2014, In : Expert Opinion on Biological Therapy. 14, 9, p. 1259-1270 12 p.

Research output: Contribution to journalArticle

Recent advances in the development of breast cancer vaccines

Milani, A., Sangiolo, D., Aglietta, M. & Valabrega, G., Oct 14 2014, In : Breast Cancer: Targets and Therapy. 6, p. 159-168 10 p.

Research output: Contribution to journalArticle

2013

Active immunotherapy in HER2 overexpressing breast cancer: Current status and future perspectives

Milani, A., Sangiolo, D., Montemurro, F., Aglietta, M. & Valabrega, G., Jul 2013, In : Annals of Oncology. 24, 7, p. 1740-1748 9 p., mdt133.

Research output: Contribution to journalArticle

Effective activity of cytokine-induced killer cells against autologous metastatic melanoma including cells with stemness features

Gammaitoni, L., Giraudo, L., Leuci, V., Todorovic, M., Mesiano, G., Picciotto, F., Pisacane, A., Zaccagna, A., Volpe, M. G., Gallo, S., Caravelli, D., Giacone, E., Venesio, T., Balsamo, A., Pignochino, Y., Grignani, G., Carnevale-Schianca, F., Aglietta, M. & Sangiolo, D., Aug 15 2013, In : Clinical Cancer Research. 19, 16, p. 4347-4358 12 p.

Research output: Contribution to journalArticle

The combination of sorafenib and everolimus abrogates mTORC1 and mTORC2 upregulation in osteosarcoma preclinical models

Pignochino, Y., Dell'Aglio, C., Basiricò, M., Capozzi, F., Soster, M., Marchiò, S., Bruno, S., Gammaitoni, L., Sangiolo, D., Torchiaro, E., D'Ambrosio, L., Fagioli, F., Ferrari, S., Alberghini, M., Picci, P., Aglietta, M. & Grignani, G., Apr 15 2013, In : Clinical Cancer Research. 19, 8, p. 2117-2131 15 p.

Research output: Contribution to journalArticle

2012

Cytokine-induced killer (CIK) cells as feasible and effective adoptive immunotherapy for the treatment of solid tumors

Mesiano, G., Todorovic, M., Gammaitoni, L., Leuci, V., Giraudo Diego, L., Carnevale-Schianca, F., Fagioli, F., Piacibello, W., Aglietta, M. & Sangiolo, D., Jun 2012, In : Expert Opinion on Biological Therapy. 12, 6, p. 673-684 12 p.

Research output: Contribution to journalArticle

Ex vivo allogeneic stimulation significantly improves expansion of cytokine-Induced killer cells without increasing their alloreactivity across HLA barriers

Todorovic, M., Mesiano, G., Gammaitoni, L., Leuci, V., Giraudo Diego, L., Cammarata, C., Jordaney, N., Carnevale-Schianca, F., Gallo, S., Fagioli, F., Piacibello, W., Elia, A. R., Pignochino, Y., Dell'Aglio, C., Grignani, G., Cignetti, A., Aglietta, M. & Sangiolo, D., Sep 2012, In : Journal of Immunotherapy. 35, 7, p. 579-586 8 p.

Research output: Contribution to journalArticle

Cytokine induced killer cells as promising immunotherapy for solid tumors

Sangiolo, D., 2011, In : Journal of Cancer. 2, 1, p. 363-368 6 p.

Research output: Contribution to journalArticle

Gene-modified T lymphocytes in the setting of hematopoietic cell transplantation: Potential benefits and possible risks

Sangiolo, D., Leuci, V., Gallo, S., Aglietta, M. & Piacibello, W., May 2011, In : Expert Opinion on Biological Therapy. 11, 5, p. 655-666 12 p.

Research output: Contribution to journalArticle

Transient proteasome inhibition as a strategy to enhance lentiviral transduction of hematopoietic CD34 + cells and T lymphocytes: Implications for the use of low viral doses and large-size vectors

Leuci, V., Mesiano, G., Gammaitoni, L., Cammarata, C., Capellero, S., Todorovic, M., Jordaney, N., Circosta, P., Elia, A., Lesnikova, M., Georges, G. E., Piacibello, W., Fagioli, F., Cignetti, A., Aglietta, M. & Sangiolo, D., Dec 10 2011, In : Journal of Biotechnology. 156, 3, p. 218-226 9 p.

Research output: Contribution to journalArticle

2010

Outcome of allogeneic hematopoietic cell transplantation from HLA-identical siblings for severe aplastic anemia in patients over 40 years of age

Sangiolo, D., Storb, R., Deeg, H. J., Flowers, M. E. D., Martin, P. J., Sandmaier, B. M., Kiem, H. P., Nash, R. A., Doney, K., Leisenring, W. M. & Georges, G. E., Oct 2010, In : Biology of Blood and Marrow Transplantation. 16, 10, p. 1411-1418 8 p.

Research output: Contribution to journalArticle

Seventh annual meeting of the Italian Network for Tumor Biotherapy (NIBIT), Siena, 1-3 October 2009

Maio, M., Nicolay, H. J. M., Ascierto, P. A., Belardelli, F., Camerini, R., Colombo, M. P., Queirolo, P., Ridolfi, R., Russo, V., Fonsatti, E., Parmiani, G., Allavena, P., Anichini, A., Bellone, M., Bronte, V., Calabrò, L., Camisaschi, C., Castelli, C., Corti, A., Danova, M. & 18 others, Dellabona, P., Di Giacomo, A. M., Di Nicola, M., Ferlazzo, G., Gentilcore, G., Giovannoni, L., Hwu, P., Lehmann, F., Maccalli, C., Melero, I., Monsurrò, V., Montagna, D., Moschella, F., Ponzoni, M., Protti, M. P., Puccetti, P., Sangiolo, D. & Schuler, G., Dec 2010, In : Cancer Immunology, Immunotherapy. 59, 12, p. 1895-1901 7 p.

Research output: Contribution to journalArticle

2009