Elena Geuna &ndash; Research Output

2018

Self-evaluation of duration of adjuvant chemotherapy side effects in breast cancer patients: A prospective study

Galizia, D., Milani, A., Geuna, E., Martinello, R., Cagnazzo, C., Foresto, M., Longo, V., Berchialla, P., Solinas, G., Calori, A., Grasso, B., Volpone, C., Bertola, G., Parola, G., Tealdi, G., Giuliano, P. L., Ballari, A. M., Aglietta, M. & Montemurro, F., Sep 1 2018, In : Cancer Medicine. 7, 9, p. 4339-4344 6 p.

Research output: Contribution to journal › Article

Diagnostic Self Evaluation

Adjuvant Chemotherapy

Prospective Studies

Breast Neoplasms

Terminology

What is the best pharmacotherapeutic strategy for HER-2 positive breast cancer?

Giannone, G., Milani, A., Geuna, E., Galizia, D., Biello, F. & Montemurro, F., Nov 6 2018, In : Expert Opinion on Pharmacotherapy. p. 1-5 5 p.

Research output: Contribution to journal › Article

2017

22 Citations (Scopus)

A first-in-human, Phase I, dose-escalation study of TAK-117, A selective PI3Ka isoform inhibitor, in patients with advanced solid malignancies

Juric, D., De Bono, J. S., LoRusso, P. M., Nemunaitis, J., Heath, E. I., Kwak, E. L., Mercade, T. M., Geuna, E., De Miguel-Luken, M. J., Patel, C., Kuida, K., Sankoh, S., Westin, E. H., Zohren, F., Shou, Y. & Tabernero, J., Sep 1 2017, In : Clinical Cancer Research. 23, 17, p. 5015-5023 9 p.

Research output: Contribution to journal › Article

Protein Isoforms

Neoplasms

Safety

Aspartate Aminotransferases

Alanine Transaminase

Genotyping tumour DNA in cerebrospinal fluid and plasma of a HER2-positive breast cancer patient with brain metastases.

Siravegna, G., Geuna, E., Mussolin, B., Crisafulli, G., Bartolini, A., Galizia, D., Casorzo, L., Sarotto, I., Scaltriti, M., Sapino, A., Bardelli, A. & Montemurro, F., 2017, In : ESMO Open. 2, p. e000253

Research output: Contribution to journal › Article

Cerebrospinal Fluid

Breast Neoplasms

Neoplasm Metastasis

DNA

Brain

2016

3 Citations (Scopus)

Investigational ErbB-2 tyrosine kinase inhibitors for the treatment of breast cancer

Martinello, R., Milani, A., Geuna, E., Zucchini, G., Aversa, C., Nuzzo, A. & Montemurro, F., Apr 2 2016, In : Expert Opinion on Investigational Drugs. 25, 4, p. 393-403 11 p.

Research output: Contribution to journal › Article

TYK2 Kinase

Breast Neoplasms

Investigational Drugs

Neoplasms

Gene Amplification

2015

Adjuvant ovarian suppression in premenopausal breast cancer

Montemurro, F., Perrone, F. & Geuna, E., Apr 23 2015, In : New England Journal of Medicine. 372, 17, p. 1672-1673 2 p.

Research output: Contribution to journal › Article

Adjuvant ovarian suppression in premenopausal breast cancer

Montemurro, F., Perrone, F. & Geuna, E., Apr 23 2015, In : New England Journal of Medicine. 372, 17, p. 1672-1673 2 p.

Research output: Contribution to journal › Article

25 Citations (Scopus)

Buparlisib, an oral pan-PI3K inhibitor for the treatment of breast cancer

Geuna, E., Milani, A., Martinello, R., Aversa, C., Valabrega, G., Scaltriti, M. & Montemurro, F., 2015, In : Expert Opinion on Investigational Drugs. 24, 3, p. 421-431 11 p.

Research output: Contribution to journal › Article

Phosphatidylinositol 3-Kinase

Breast Neoplasms

Sirolimus

Class I Phosphatidylinositol 3-Kinases

Therapeutics

7 Citations (Scopus)

Clinical utility of exemestane in the treatment of breast cancer

Zucchini, G., Geuna, E., Milani, A., Aversa, C., Martinello, R. & Montemurro, F., May 27 2015, In : International Journal of Women's Health. 7, p. 551-563 13 p.

Research output: Contribution to journal › Article

exemestane

Breast Neoplasms

Aromatase Inhibitors

Therapeutics

Estrogen Receptor Modulators

15 Citations (Scopus)

Complications of hyperglycaemia with PI3K-AKT-mTOR inhibitors in patients with advanced solid tumours on Phase I clinical trials

Geuna, E., Roda, D., Rafii, S., Jimenez, B., Capelan, M., Rihawi, K., Montemurro, F., Yap, T. A., Kaye, S. B., De Bono, J. S., Molife, L. R. & Banerji, U., Dec 1 2015, In : British Journal of Cancer. 113, 11, p. 1541-1547 7 p.

Research output: Contribution to journal › Article

Clinical Trials, Phase I

Phosphatidylinositol 3-Kinases

Hyperglycemia

Neoplasms

Incidence

22 Citations (Scopus)

Higher risk of infections with PI3K-AKT-mTOR pathway inhibitors in patients with advanced solid tumors on phase I clinical trials

Rafii, S., Roda, D., Geuna, E., Jimenez, B., Rihawi, K., Capelan, M., Yap, T. A., Molife, L. R., Kaye, S. B., De Bono, J. S. & Banerji, U., Apr 15 2015, In : Clinical Cancer Research. 21, 8, p. 1869-1876 8 p.

Research output: Contribution to journal › Article

Clinical Trials, Phase I

Phosphatidylinositol 3-Kinases

Infection

Neoplasms

Confidence Intervals

7 Citations (Scopus)

Linifanib: Current status and future potential in cancer therapy

Aversa, C., Leone, F., Zucchini, G., Serini, G., Geuna, E., Milani, A., Valdembri, D., Martinello, R. & Montemurro, F., Jun 1 2015, In : Expert Review of Anticancer Therapy. 15, 6, p. 677-687 11 p.

Research output: Contribution to journal › Article

N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N1-(2-fluoro-5-methylphenyl)urea

Neoplasms

Clinical Trials

Therapeutics

Angiogenesis Inducing Agents

39 Citations (Scopus)

The neutrophil-lymphocyte ratio and its utilisation for the management of cancer patients in early clinical trials

Kumar, R., Geuna, E., Michalarea, V., Guardascione, M., Naumann, U., Lorente, D., Kaye, S. B. & De Bono, J. S., Mar 31 2015, In : British Journal of Cancer. 112, 7, p. 1157-1165 9 p.

Research output: Contribution to journal › Article

Neutrophils

Clinical Trials

Lymphocytes

Neoplasms

Clinical Trials, Phase I

2014

FDG avidity at PET/CT during adjuvant hormonal therapy in patients with breast cancer

Evangelista, L., Redana, S., Racca, M., Geuna, E., Vinante, L., Zago, G., De Carolis, V., Ghiotto, C., Saladini, G. & Varetto, T., Feb 2014, In : Clinical Nuclear Medicine. 39, 2

Research output: Contribution to journal › Article

Breast Neoplasms

Chi-Square Distribution

Tumor Biomarkers

Hormones

Students

35 Citations (Scopus)

Metastatic breast cancer subtypes and central nervous system metastases

Aversa, C., Rossi, V., Geuna, E., Martinello, R., Milani, A., Redana, S., Valabrega, G., Aglietta, M. & Montemurro, F., Oct 1 2014, In : Breast. 23, 5, p. 623-628 6 p.

Research output: Contribution to journal › Article

Central Nervous System

Breast Neoplasms

Neoplasm Metastasis

Neoplasms

Survival

53 Citations (Scopus)

Overcoming endocrine resistance in metastatic breast cancer: Current evidence and future directions

Milani, A., Geuna, E., Mittica, G. & Valabrega, G., Dec 10 2014, In : World Journal of Clinical Oncology. 5, 5, p. 990-1001 12 p.

Research output: Contribution to journal › Article

Breast Neoplasms

exemestane

letrozole

Estrogen Receptors

Aromatase Inhibitors

2012

9 Citations (Scopus)

Current status and future perspectives in the endocrine treatment of postmenopausal, hormone receptor-positive metastatic breast cancer

Montemurro, F., Rossi, V., Geuna, E., Valabrega, G., Martinello, R., Milani, A. & Aglietta, M., Oct 2012, In : Expert Opinion on Pharmacotherapy. 13, 15, p. 2143-2156 14 p.

Research output: Contribution to journal › Article

Hormones

Breast Neoplasms

Therapeutics

Medical Oncology

Expert Testimony

16 Citations (Scopus)

Potential of afatinib in the treatment of patients with HER2-positive breast cancer

Geuna, E., Montemurro, F., Aglietta, M. & Valabrega, G., Aug 24 2012, In : Breast Cancer: Targets and Therapy. 4, p. 131-137 7 p.

Research output: Contribution to journal › Article

Breast Neoplasms

Protein-Tyrosine Kinases

Therapeutics

Clinical Trials, Phase I

Cytoprotection

2011

7 Citations (Scopus)

Hitting multiple targets in HER2-positive breast cancer: Proof of principle or therapeutic opportunity?

Geuna, E., Milani, A., Redana, S., Rossi, V., Valabrega, G., Aglietta, M. & Montemurro, F., Mar 2011, In : Expert Opinion on Pharmacotherapy. 12, 4, p. 549-565 17 p.

Research output: Contribution to journal › Article

Breast Neoplasms

Therapeutics

Expert Testimony

Biological Factors

Receptor Protein-Tyrosine Kinases

1 Citation (Scopus)

Trastuzumab beyond progression in retrospective analyses: An issue of equal opportunities

Montemurro, F., Redana, S., Geuna, E., Milani, A., Rossi, V., Martinello, R., Valabrega, G. & Aglietta, M., 2011, In : The oncologist. 16, 4, p. 534-536 3 p.

Research output: Contribution to journal › Article

1 Citation (Scopus)

Trastuzumab in the adjuvant setting: A practical review

Rossi, V., Redana, S., Milani, A., Geuna, E., Valabrega, G., Aglietta, M. & Montemurro, F., Mar 2011, In : Therapy. 8, 2, p. 161-177 17 p.

Research output: Contribution to journal › Article

Breast Neoplasms

Drug Therapy

Trastuzumab

Anthracyclines

Adjuvant Chemotherapy