If you made any changes in Pure these will be visible here soon.

Research Output

2020

Thrombin activatable fibrinolysis inhibitor pathway alterations correlate with bleeding phenotype in patients with severe hemophilia A

Semeraro, F., Mancuso, M. E., Ammollo, C. T., Dirienzo, L., Vitulli, A., Santagostino, E., Tripodi, A. & Colucci, M., 2020, In : Journal of Thrombosis and Haemostasis. 18, 2, p. 381-389

Research output: Contribution to journalArticle

2019

Bleeding and safety outcomes in persons with haemophilia A without inhibitors: Results from a prospective non-interventional study in a real-world setting

Kruse-Jarres, R., Oldenburg, J., Santagostino, E., Shima, M., Kempton, C. L., Kessler, C. M., Lehle, M., Chebon, S., Selak Bienz, N., Asikanius, E. & Mahlangu, J., Mar 1 2019, In : Haemophilia. 25, 2, p. 213-220 8 p.

Research output: Contribution to journalArticle

Consensus statements on vaccination in patients with haemophilia—results from the italian haemophilia and vaccinations (Heva) project

HEVA Study Group, Santagostino, E., Riva, A., Cesaro, S., Esposito, S., Matino, D., Mazzucchelli, R. I., Molinari, A. C., Mura, R., Notarangelo, L. D., Tagliaferri, A., Di Minno, G. & Clerici, M., Jan 1 2019, In : Haemophilia. 25, 4, p. 656-667

Research output: Contribution to journalArticle

Open Access

Consensus statements on vaccination in patients with haemophilia—results from the italian haemophilia and vaccinations (Heva) project

Santagostino, E., Riva, A., Cesaro, S., Esposito, S., Matino, D., Mazzucchelli, R. I., Molinari, A. C., Mura, R., Notarangelo, L. D., Tagliaferri, A., Di Minno, G. & Clerici, M., Apr 1 2019, In : Haemophilia.

Research output: Contribution to journalArticle

Factor VIII: Long-established role in haemophilia A and emerging evidence beyond haemostasis

Samuelson Bannow, B., Recht, M., Négrier, C., Hermans, C., Berntorp, E., Eichler, H., Mancuso, M. E., Klamroth, R., O'Hara, J., Santagostino, E., Matsushita, T. & Kessler, C., May 1 2019, In : Blood Reviews. 35, p. 43-50 8 p.

Research output: Contribution to journalReview article

Open Access

Fixed doses of N8-GP prophylaxis maintain moderate-to-mild factor VIII levels in the majority of patients with severe hemophilia A

Chowdary, P., Carcao, M., Holme, P. A., Jiménez-Yuste, V., Lentz, S. R., Møss, J., Poulsen, L. H., Shen, C., Tosetto, A., Wheeler, A. & Santagostino, E., Jul 2019, In : Research and practice in thrombosis and haemostasis. 3, 3, p. 542-554 13 p.

Research output: Contribution to journalArticle

Immune tolerance induction with moroctocog-alpha (Refacto/Refacto AF) in a population of Italian haemophilia A patients with high-titre inhibitors: Data from REF.IT Registry

Zanon, E., Pasca, S., Pollio, B., Santagostino, E., Linari, S., Tagliaferri, A., Santoro, C., Rocino, A., Marino, R., Aru, B., Borchiellini, A., Siragusa, S. & Coppola, A., 2019, In : Haemophilia. 25, 6, p. 1003-1010

Research output: Contribution to journalArticle

Inhibitors: A Need for Eradication?

Santagostino, E., Young, G., Escuriola Ettingshausen, C., Jimenez-Yuste, V. & Carcao, M., Apr 1 2019, In : Acta Haematologica. 141, 3, p. 151-155 5 p.

Research output: Contribution to journalReview article

Open Access

Inhibitors in haemophilia A and B: Management of bleeds, inhibitor eradication and strategies for difficult-to-treat patients

Ljung, R., Auerswald, G., Benson, G., Dolan, G., Duffy, A., Hermans, C., Jiménez-Yuste, V., Lambert, T., Morfini, M., Zupančić-Šalek, S. & Santagostino, E., 2019, In : European Journal of Haematology. 102, 2, p. 111-122

Research output: Contribution to journalArticle

Once-weekly prophylaxis with glycoPEGylated recombinant factor VIII (N8-GP) in severe haemophilia A: Safety and efficacy results from pathfinder 2 (randomized phase III trial)

Curry, N., Albayrak, C., Escobar, M., Andre Holme, P., Kearney, S., Klamroth, R., Misgav, M., Négrier, C., Wheeler, A., Santagostino, E., Shima, M., Landorph, A., Tønder, S. M. & Lentz, S. R., Jan 1 2019, In : Haemophilia. 25, 3, p. 373-381

Research output: Contribution to journalArticle

Open Access

Patient satisfaction and acceptability of an on-demand and on-prophylaxis device for factor viii delivery in patients with hemophilia A

Italian FusENGO B1831081 Study Group, Di Minno, G., Santagostino, E., Morfini, M., Ettorre, C., Cultrera, D., Baldacci, E., Russo, E. & Gallucci, C., Jan 1 2019, In : Patient Preference and Adherence. 13, p. 233-240 8 p.

Research output: Contribution to journalArticle

Open Access

Pharmacokinetics of a new human plasma-derived double virus inactivated and nanofiltered factor IX concentrate in previously treated severe or moderately severe haemophilia B patients

Castaman, G., Borchiellini, A., Santagostino, E., Tagariello, G., Serban, M., Uscatescu, M., Truica, C., Albert, F. & Morfini, M., 2019, In : Haemophilia. 25, 6, p. e364-e367

Research output: Contribution to journalLetter

Position paper on laboratory testing for patients with haemophilia. A consensus document from SISET, AICE, SIBioC and SIPMeL

Tripodi, A., Santoro, R. C., Testa, S., Molinari, A. C., Bernardini, S., Golato, M., Lippi, G., Ageno, W. & Santagostino, E., Jan 1 2019, In : Blood Transfusion. 17, 3, p. 229-236 8 p.

Research output: Contribution to journalArticle

Rapid and sustained immune tolerance to inhibitors induced by a plasma-derived, VWF-containing FVIII concentrate

Santagostino, E., Rangarajan, S., Oldenburg, J., Peiró-Jordan, R. & Jiménez-Yuste, V., Mar 1 2019, In : Haemophilia. 25, 2, p. e110-e113

Research output: Contribution to journalLetter

Recombinant factor VIII products and inhibitor development in previously untreated patients with severe haemophilia A: Combined analysis of three studies

Volkers, P., Hanschmann, K. M., Calvez, T., Chambost, H., Collins, P. W., Demiguel, V., Hart, D. P., Hay, C. R. M., Goudemand, J., Ljung, R., Palmer, B. P., Santagostino, E., van Hardeveld, E. M., van den Berg, M. & Keller-Stanislawski, B., Jan 1 2019, In : Haemophilia. 25, 3, p. 398-407

Research output: Contribution to journalArticle

Safety and efficacy of BAY 94-9027, an extended-half-life factor VIII, during surgery in patients with severe hemophilia A: Results of the PROTECT VIII clinical trial

Santagostino, E., Lalezari, S., Reding, M. T., Ducore, J., Ng, H. J., Poulsen, L. H., Michaels, L. A. & Linardi, C. C. G., Nov 1 2019, In : Thrombosis Research. 183, p. 13-19 7 p.

Research output: Contribution to journalArticle

Open Access

Switching patients in the age of long-acting recombinant products?

Escobar, M., Santagostino, E., Mancuso, M. E., Coppens, M., Balasa, V., Taylor, J. A., Iorio, A. & Negrier, C., Jan 14 2019, In : Expert Review of Hematology. 12, sup1, p. 1-13 13 p.

Research output: Contribution to journalArticle

Open Access

Systematic review and analysis of efficacy of recombinant factor IX products for prophylactic treatment of hemophilia B in comparison with rIX-FP

Davis, J., Yan, S., Matsushita, T., Alberio, L., Bassett, P. & Santagostino, E., Jan 1 2019, In : Journal of Medical Economics. 22, 10, p. 1014-1021

Research output: Contribution to journalArticle

The changing face of immune tolerance induction in haemophilia A with the advent of emicizumab

Future of Immunotolerance Treatment Group, Jul 1 2019, In : Haemophilia. 25, 4, p. 676-684 9 p.

Research output: Contribution to journalArticle

Open Access

The effect of emicizumab prophylaxis on health-related outcomes in persons with haemophilia A with inhibitors: HAVEN 1 Study

Oldenburg, J., Mahlangu, J. N., Bujan, W., Trask, P., Callaghan, M. U., Young, G., Asikanius, E., Peyvandi, F., Santagostino, E., Kruse-Jarres, R., Negrier, C., Kessler, C., Xu, J., Windyga, J., Shima, M. & von Mackensen, S., 2019, In : Haemophilia. 25, 1, p. 33-44

Research output: Contribution to journalArticle

Timing of inhibitor development in more than 1000 previously untreated patients with severe hemophilia A

PedNet Study Group, van den Berg, H. M., Fischer, K., Carcao, M., Chambost, H., Kenet, G., Kurnik, K., Königs, C., Male, C., Santagostino, E. & Ljung, R., Jul 18 2019, In : Blood. 134, 3, p. 317-320 4 p.

Research output: Contribution to journalLetter

2018

A contemporary look at FVIII inhibitor development: still a great influence on the evolution of hemophilia therapies

Santagostino, E., Young, G., Carcao, M., Mannucci, P. M., Halimeh, S. & Austin, S., Feb 1 2018, In : Expert Review of Hematology. 11, 2, p. 87-97 11 p.

Research output: Contribution to journalReview article

Ageing successfully with haemophilia: A multidisciplinary programme

Boccalandro, E., Mancuso, M. E., Riva, S., Pisaniello, D. M., Ronchetti, F., Santagostino, E., Peyvandi, F., Solimeno, L. P., Mannucci, P. M. & Pasta, G., 2018, In : Haemophilia. 24, 1, p. 57-62

Research output: Contribution to journalArticle

Bleeding events and safety outcomes in persons with haemophilia A with inhibitors: A prospective, multi-centre, non-interventional study

Mahlangu, J., Oldenburg, J., Callaghan, M. U., Shima, M., Santagostino, E., Moore, M., Recht, M., Garcia, C., Yang, R., Lehle, M., Macharia, H., Asikanius, E., Levy, G. G. & Kruse-Jarres, R., 2018, In : Haemophilia. 24, 6, p. 921-929

Research output: Contribution to journalArticle

Comorbidities in persons with haemophilia aged 60 years or more compared with age-matched people from the general population

Marchesini, E., Oliovecchio, E., Coppola, A., Santagostino, E., Radossi, P., Castaman, G., Valdrè, L., Santoro, C., Tagliaferri, A., Ettorre, C., Zanon, E., Barillari, G., Cantori, I., Caimi, T. M., Sottilotta, G., Iorio, A. & Mannucci, P. M., 2018, In : Haemophilia. 24, 1, p. e6-e10

Research output: Contribution to journalArticle

Defining extended half-life rFVIII-A critical review of the evidence

Mahlangu, J., Young, G., Hermans, C., Blanchette, V., Berntorp, E. & Santagostino, E., 2018, In : Haemophilia. 24, 3, p. 348-358

Research output: Contribution to journalArticle

Desmopressin in moderate hemophilia a patients: A treatment worth considering

Rise Consortium, Feb 28 2018, In : Haematologica. 103, 3, p. 550-557 8 p.

Research output: Contribution to journalArticle

GlycoPEGylated recombinant factor IX for hemophilia B in context

Santagostino, E. & Mancuso, M. E., Jan 1 2018, In : Drug Design, Development and Therapy. 12, p. 2933-2943 11 p.

Research output: Contribution to journalReview article

Long-term safety and efficacy of turoctocog alfa in prophylaxis and treatment of bleeding episodes in severe haemophilia A: Final results from the guardian 2 extension trial

Lentz, S. R., Janic, D., Kavakli, K., Miljic, P., Oldenburg, J., C. Ozelo, M., Santagostino, E., Suzuki, T., Zupancic Šalek, S., Korsholm, L., Matytsina, I. & Tiede, A., 2018, In : Haemophilia. 24, 6, p. e391-e394

Research output: Contribution to journalArticle

Pharmacokinetic modelling and validation of the half-life extension needed to reduce the burden of infusions compared with standard factor VIII

Hermans, C., Mahlangu, J., Booth, J., Schütz, H., Santagostino, E., Young, G., Lee, H. Y., Steinitz-Trost, K. N., Blanchette, V. & Berntorp, E., 2018, In : Haemophilia. 24, 3, p. 376-384

Research output: Contribution to journalArticle

Polypharmacy in older adults with severe haemophilia

Riva, S., Mancuso, M. E., Cortesi, L., Nobili, A., Santagostino, E., Peyvandi, F. & Mannucci, P. M., Jan 1 2018, In : Haemophilia. 24, 1, p. e1-e3

Research output: Contribution to journalLetter

Prophylaxis re-visited: The potential impact of novel factor and non-factor therapies on prophylaxis

Carcao, M., Lambert, T., Leissinger, C., Escuriola-Ettingshausen, C., Santagostino, E. & Aledort, L., 2018, In : Haemophilia. 24, 6, p. 845-848

Research output: Contribution to journalArticle

Rate and appropriateness of polypharmacy in older patients with hemophilia compared with age-matched controls

Mannucci, P. M., Nobili, A., Marchesini, E., Oliovecchio, E., Cortesi, L., Coppola, A., Santagostino, E., Radossi, P., Castaman, G., Valdrè, L., Santoro, C., Tagliaferri, A., Ettorre, C., Zanon, E., Barillari, G., Cantori, I., Caimi, T. M., Sottilotta, G., Peyvandi, F. & Iorio, A., 2018, In : Haemophilia. 24, 5, p. 726-732

Research output: Contribution to journalArticle

The importance of inhibitor eradication in clinically complicated hemophilia A patients

Oldenburg, J., Young, G., Santagostino, E. & Escuriola Ettingshausen, C., Nov 2 2018, In : Expert Review of Hematology. 11, 11, p. 857-862 6 p.

Research output: Contribution to journalReview article

Treatment Regimens with Bypassing Agents in Patients with Hemophilia A and Inhibitors: A Survey from the Italian Association of Hemophilia Centers (AICE)

Coppola, A., Franchini, M., Castaman, G., Santagostino, E., Santoro, C., Santoro, R. C., Morfini, M., Di Minno, G. & Rocino, A., 2018, In : Seminars in Thrombosis and Hemostasis. 44, 6, p. 551-560

Research output: Contribution to journalArticle

Usefulness of bone microarchitectural and geometric DXA-derived parameters in haemophilic patients

Ulivieri, F. M., Rebagliati, G. A. A., Piodi, L. P., Solimeno, L. P., Pasta, G., Boccalandro, E., Fasulo, M. R., Mancuso, M. E. & Santagostino, E., 2018, In : Haemophilia. 24, 6, p. 980-987 8 p.

Research output: Contribution to journalArticle

2017

Beyond stopping the bleed: Short-term episodic prophylaxis with recombinant activated factor FVII in haemophilia patients with inhibitors

Šalek, S. Z., Auerswald, G., Benson, G., Dolan, G., Duffy, A., Hermans, C., Jiménez-Yuste, V., Ljung, R., Morfini, M., Santagostino, E. & Lambert, T., Jan 1 2017, In : Blood Transfusion. 15, 1, p. 77-84 8 p.

Research output: Contribution to journalArticle

Clinical evaluation of glycoPEGylated recombinant FVIII: Efficacy and safety in severe haemophilia A

Giangrande, P., Andreeva, T., Chowdary, P., Ehrenforth, S., Hanabusa, H., Leebeek, F. W. G., Lentz, S. R., Nemes, L., Poulsen, L. H., Santagostino, E., You, C. W., Clausen, W. H. O., Jönsson, P. G., Oldenburg, J., Rothschild, C., Lambert, T., Trossaert, M., Negrier, C., Miesbach, W., Tiede, A. & 73 others, Oldenburg, J., Klamroth, R., Eichler, H., Santagostino, E., Tosetto, A., Dunsmore, K., Escobar, M., Wright, J., Gruppo, R., Guron, G. K., Kearney, S., Lasky, J., Lentz, S., Kutlar, A., Paroskie-Wheeler, A., Powell, J. S., Recht, M., Takemoto, C., Cockrell, E., Yee, D., Felgenhauer, J., Apollonsky, N., Lazarchick, J., Kulkarni, R., Knoll, C., Morales, J., Kavasch, P., Nagasubramanian, G. R., Guerrera, M., Chitlur, M., Lowe, E., Tsay, W., Shen, M. C., Zupancic-Salek, S., Kampmann, P., Poulsen, L. H., Boda, Z., Nemes, L., Leebeek, F. W. G., Meijer, K., Holme, P. A., Jiménez Yuste, V., Mingot, E. M., Zetterberg, E., Brand, B., Alberio, L., Boehlen, F., Thomson, G., Chowdary, P., Collins, P. W., Curry, N., Hampton, K., Rangarajan, S., Barnes, C., Brown, S., Dunkley, S., Castro Ozelo, M., Misgav, M., Karim, F. A., Sathar, J., Andreeva, T. A., Kavakli, K., Sasmaz, I., Albayrak, C., Fukutake, K., Matsushita, T., Hanabusa, H., Madoiwa, S., Shima, M., Fujii, T., Sato, T., Takedani, H. & Shibuya, A., 2017, In : Thrombosis and Haemostasis. 117, 2, p. 252-261 10 p.

Research output: Contribution to journalArticle

Cost-effectiveness analysis of late prophylaxis vs. on-demand treatment for severe haemophilia A in Italy

Coppola, A., D'Ausilio, A., Aiello, A., Amoresano, S., Toumi, M., Mathew, P., Tagliaferri, A., Group, T. P. S., Feola, G., Molinari, A. C., Santoro, C., Rivolta, G. F., Cultrera, D. B., Gagliano, F., Zanon, E., Mancuso, M. E., Valdrè, L., Mameli, L., Banov, L., Di Minno, G. & 4 others, Quintavalle, G., Mazzucconi, M. G., Negri, N. & Santagostino, E., 2017, In : Haemophilia. 23, 3, p. 422-429 8 p.

Research output: Contribution to journalArticle

Emicizumab prophylaxis in hemophilia A with inhibitors

Oldenburg, J., Mahlangu, J. N., Kim, B., Schmitt, C., Callaghan, M. U., Young, G., Santagostino, E., Krusejarres, R., Negrier, C., Kessler, C., Valente, N., Asikanius, E., Levy, G. G., Windyga, J. & Shima, M., Aug 31 2017, In : New England Journal of Medicine. 377, 9, p. 809-818 10 p.

Research output: Contribution to journalArticle

European retrospective study of real-life haemophilia treatment

Berntorp, E., Dolan, G., Hay, C., Linari, S., Santagostino, E., Tosetto, A., Castaman, G., Álvarez-Román, M., Parra Lopez, R., Oldenburg, J., Albert, T., Scholz, U., Holmström, M., Schved, J. F., Trossaërt, M., Hermans, C., Boban, A., Ludlam, C. & Lethagen, S., 2017, In : Haemophilia. 23, 1, p. 105-114

Research output: Contribution to journalArticle

First report on the safety and efficacy of an extended half-life glycoPEGylated recombinant FVIII for major surgery in severe haemophilia A

Hampton, K., Chowdary, P., Dunkley, S., Ehrenforth, S., Jacobsen, L., Neff, A., Santagostino, E., Sathar, J., Takedani, H., Takemoto, C. M. & Négrier, C., 2017, In : Haemophilia. 23, 5, p. 689-696

Research output: Contribution to journalArticle

Insight into health-related quality of life of young children with haemophilia B treated with long-acting nonacog beta pegol recombinant factor IX

Carcao, M., Kearney, S., Santagostino, E., Oyesiku, J. O. O., Young, N. L., Meunier, J., Hoxer, C. S., Zhang, C. & Blanchette, V. S., May 1 2017, In : Haemophilia. 23, 3, p. e222-e224

Research output: Contribution to journalLetter

New findings on inhibitor development: from registries to clinical studies

Peyvandi, F., Ettingshausen, C. E., Goudemand, J., Jiménez-Yuste, V., Santagostino, E. & Makris, M., Jan 1 2017, In : Haemophilia. 23, p. 4-13 10 p.

Research output: Contribution to journalReview article