• 56 Citations
  • 5 h-Index
20152019
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Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 1 Similar Profiles
Early Detection of Cancer Medicine & Life Sciences
Italy Medicine & Life Sciences
Molecular Chaperones Medicine & Life Sciences
Colorectal Neoplasms Medicine & Life Sciences
Benzazepines Chemical Compounds
Scaffolds Chemical Compounds
Allosteric Regulation Medicine & Life Sciences
Lead compounds Chemical Compounds

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Research Output 2015 2019

  • 56 Citations
  • 5 h-Index
  • 7 Article
  • 2 Review article
2 Citations (Scopus)

Allosteric Modulators of HSP90 and HSP70: Dynamics Meets Function through Structure-Based Drug Design

Ferraro, M., D'Annessa, I., Moroni, E., Morra, G., Paladino, A., Rinaldi, S., Compostella, F. & Colombo, G., Oct 1 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 60-87 28 p.

Research output: Contribution to journalArticle

Drug Design
Adenosine Triphosphate
Multiprotein Complexes
Molecular Chaperones
Pharmaceutical Preparations

Expedient Access to 2-Benzazepines by Palladium-Catalyzed C−H Activation: Identification of a Unique Hsp90 Inhibitor Scaffold

Virelli, M., Moroni, E., Colombo, G., Fiengo, L., Porta, A., Ackermann, L. & Zanoni, G., Nov 7 2018, In : Chemistry - A European Journal. 24, 62, p. 16516-16520 5 p.

Research output: Contribution to journalArticle

Benzazepines
Lead compounds
HSP90 Heat-Shock Proteins
Palladium
Scaffolds (biology)

The calcium-binding type III repeats domain of thrombospondin-2 binds to fibroblast growth factor 2 (FGF2)

Rusnati, M., Borsotti, P., Moroni, E., Foglieni, C., Chiodelli, P., Carminati, L., Pinessi, D., Annis, D. S., Paiardi, G., Bugatti, A., Gori, A., Longhi, R., Belotti, D., Mosher, D. F., Colombo, G. & Taraboletti, G., Jan 1 2018, (Accepted/In press) In : Angiogenesis.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 2
Thrombospondin 1
Calcium
Intercellular Signaling Peptides and Proteins
thrombospondin 2
3 Citations (Scopus)

The Structural Asymmetry of Mitochondrial Hsp90 (Trap1) Determines Fine Tuning of Functional Dynamics

Moroni, E., Agard, D. A. & Colombo, G., Feb 13 2018, In : Journal of Chemical Theory and Computation. 14, 2, p. 1033-1044 12 p.

Research output: Contribution to journalArticle

hydrolysis
Hydrolysis
nucleotides
Protein Subunits
Nucleotides
8 Citations (Scopus)

Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads

D'Annessa, I., Sattin, S., Tao, J., Pennati, M., Sànchez-Martìn, C., Moroni, E., Rasola, A., Zaffaroni, N., Agard, D. A., Bernardi, A. & Colombo, G., Jan 1 2017, In : Chemistry - A European Journal. 23, 22, p. 5188-5192 5 p.

Research output: Contribution to journalArticle

Adenosine Triphosphatases