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Research Output 1995 2020

2020

Scaffolds for Knee Chondral and Osteochondral Defects: Indications for Different Clinical Scenarios. A Consensus Statement

Filardo, G., Andriolo, L., Angele, P., Berruto, M., Brittberg, M., Condello, V., Chubinskaya, S., de Girolamo, L., Di Martino, A., Di Matteo, B., Gille, J., Gobbi, A., Lattermann, C., Nakamura, N., Nehrer, S., Peretti, G. M., Shabshin, N., Verdonk, P., Zaslav, K. & Kon, E., Jan 15 2020, In : Cartilage. p. 1947603519894729

Research output: Contribution to journalArticle

Scaffolds
Osteoarthritis
Cartilage
Knee
Consensus

Vegetable hierarchical structures as template for bone regeneration: New bio-ceramization process for the development of a bone scaffold applied to an experimental sheep model

Filardo, G., Roffi, A., Fey, T., Fini, M., Giavaresi, G., Marcacci, M., Martínez-Fernández, J., Martini, L., Ramírez-Rico, J., Salamanna, F., Sandri, M., Sprio, S., Tampieri, A. & Kon, E., 2020, In : Journal of Biomedical Materials Research - Part B Applied Biomaterials. p. 1-12 12 p.

Research output: Contribution to journalArticle

Vegetables
Scaffolds
Bone
Defects
Bearings (structural)
2019

A Composite Chitosan-Reinforced Scaffold Fails to Provide Osteochondral Regeneration

Roffi, A., Kon, E., Perdisa, F., Fini, M., Di Martino, A., Parrilli, A., Salamanna, F., Sandri, M., Sartori, M., Sprio, S., Tampieri, A., Marcacci, M. & Filardo, G., May 7 2019, In : International Journal of Molecular Sciences. 20, 9, p. 1-14 14 p.

Research output: Contribution to journalArticle

Chitosan
regeneration
Scaffolds
bones
Regeneration
adipose tissues
rabbits
Osteoarthritis
Blood Vessels
Adipose Tissue
2018
Osteochondritis Dissecans
Cartilage
Biomarkers
Scaffolds
Knee

Clinical and Biological Signature of Osteochondritis Dissecans in a Cross-Sectional Study

Gabusi, E., Manferdini, C., Paolella, F., Gambari, L., Kon, E., Filardo, G., Mariani, E. & Lisignoli, G., May 2018, In : BioMed Research International. 2018, p. 1-9 9 p.

Research output: Contribution to journalArticle

Osteochondritis Dissecans
Bone
Cartilage
Cross-Sectional Studies
Biomarkers

Clinical Outcomes of Knee Osteoarthritis Treated With an Autologous Protein Solution Injection: A 1-Year Pilot Double-Blinded Randomized Controlled Trial

Kon, E., Engebretsen, L., Verdonk, P., Nehrer, S. & Filardo, G., Jan 1 2018, In : American Journal of Sports Medicine. 46, 1, p. 171-180 10 p.

Research output: Contribution to journalArticle

Knee Osteoarthritis
Randomized Controlled Trials
Injections
Proteins
Pain

Cultures of a human synovial cell line to evaluate platelet-rich plasma and hyaluronic acid effects

Olivotto, E., Merli, G., Assirelli, E., Cavallo, C., Belluzzi, E., Ramonda, R., Favero, M., Filardo, G., Roffi, A., Kon, E. & Grigolo, B., Aug 2018, In : Journal of Tissue Engineering and Regenerative Medicine. 12, 8, p. 1835-1842 8 p.

Research output: Contribution to journalArticle

Hyaluronic acid
Platelet-Rich Plasma
Hyaluronic Acid
Platelets
Cell culture

Effect of microfragmented adipose tissue on osteoarthritic synovial macrophage factors

Paolella, F., Manferdini, C., Gabusi, E., Gambari, L., Filardo, G., Kon, E., Mariani, E. & Lisignoli, G., Sep 6 2018, In : Journal of Cellular Physiology. 234, 4, p. 5044-5055 12 p.

Research output: Contribution to journalArticle

Adipose Tissue
Macrophages
CC Chemokines
Ligands
Mesenchymal Stromal Cells

Evaluation of different crosslinking agents on hybrid biomimetic collagen-hydroxyapatite composites for regenerative medicine

Krishnakumar, G. S., Gostynska, N., Dapporto, M., Campodoni, E., Montesi, M., Panseri, S., Tampieri, A., Kon, E., Marcacci, M., Sprio, S. & Sandri, M., Jan 1 2018, In : International Journal of Biological Macromolecules. 106, p. 739-748 10 p.

Research output: Contribution to journalArticle

Biomimetics
Regenerative Medicine
Durapatite
Crosslinking
Collagen

Novel alginate biphasic scaffold for osteochondral regeneration: an in vivo evaluation in rabbit and sheep models

Filardo, G., Perdisa, F., Gelinsky, M., Despang, F., Fini, M., Marcacci, M., Parrilli, A. P., Roffi, A., Salamanna, F., Sartori, M., Schütz, K. & Kon, E., May 26 2018, In : Journal of Materials Science: Materials in Medicine. 29, 6, p. 1-13 13 p.

Research output: Contribution to journalArticle

Alginate
Scaffolds
Regeneration
Sheep
Biocompatible Materials

Platelet-Rich Plasma Versus Hyaluronic Acid Injections for the Treatment of Knee Osteoarthritis: Results at 5 Years of a Double-Blind, Randomized Controlled Trial

Di Martino, A., Di Matteo, B., Papio, T., Tentoni, F., Selleri, F., Cenacchi, A., Kon, E. & Filardo, G., Dec 13 2018, In : American Journal of Sports Medicine. p. 1-8 8 p.

Research output: Contribution to journalArticle

Platelet-Rich Plasma
Knee Osteoarthritis
Hyaluronic Acid
Randomized Controlled Trials
Knee

Treatment of Knee Osteochondritis Dissecans With a Cell-Free Biomimetic Osteochondral Scaffold: Clinical and Imaging Findings at Midterm Follow-up

Perdisa, F., Kon, E., Sessa, A., Andriolo, L., Busacca, M., Marcacci, M. & Filardo, G., Feb 1 2018, In : American Journal of Sports Medicine. 46, 2, p. 314-321 8 p.

Research output: Contribution to journalArticle

Osteochondritis Dissecans
Biomimetics
Cartilage
Knee
Bone and Bones
2017

3D porous collagen scaffolds reinforced by glycation with ribose for tissue engineering application

Gostynska, N., Shankar Krishnakumar, G., Campodoni, E., Panseri, S., Montesi, M., Sprio, S., Kon, E., Marcacci, M., Tampieri, A. & Sandri, M., Aug 21 2017, In : Biomedical Materials (Bristol). 12, 5, 055002.

Research output: Contribution to journalArticle

Ribose
Scaffolds (biology)
Tissue engineering
Collagen
Scaffolds

3D porous collagen scaffolds reinforced by glycation with ribose for tissue engineering application

Gostynska, N., Shankar Krishnakumar, G., Campodoni, E., Panseri, S., Montesi, M., Sprio, S., Kon, E., Tampieri, A., Sandri, M. & Marcacci, M., Aug 21 2017, In : Biomedical Materials. 12, 5, p. 055002

Research output: Contribution to journalArticle

Ribose
Scaffolds (biology)
Tissue engineering
Collagen
Scaffolds

Age Is Not a Contraindication for Cartilage Surgery: A Critical Analysis of Standardized Outcomes at Long-term Follow-up

Filardo, G., Andriolo, L., Sessa, A., Vannini, F., Ferruzzi, A., Marcacci, M. & Kon, E., Mar 1 2017, In : American Journal of Sports Medicine. 45, 8, p. 1822-1828 7 p.

Research output: Contribution to journalArticle

Cartilage
Osteoarthritis
Therapeutics
Autologous Transplantation
Chondrocytes

A multilayer biomaterial for osteochondral regeneration shows superiority vs microfractures for the treatment of osteochondral lesions in a multicentre randomized trial at 2 years

Kon, E., Filardo, G., Brittberg, M., Busacca, M., Condello, V., Engebretsen, L., Marlovits, S., Niemeyer, P., Platzer, P., Posthumus, M., Verdonk, P., Verdonk, R., Victor, J., van der Merwe, W., Widuchowski, W., Zorzi, C. & Marcacci, M., Sep 14 2017, (Accepted/In press) In : Knee Surgery, Sports Traumatology, Arthroscopy. p. 1-12 12 p.

Research output: Contribution to journalArticle

Stress Fractures
Biocompatible Materials
Multicenter Studies
Regeneration
Cartilage

A multilayer biomaterial for osteochondral regeneration shows superiority vs microfractures for the treatment of osteochondral lesions in a multicentre randomized trial at 2 years.

Kon, E., Filardo, G., Brittberg, M., Busacca, M., Condello, V., Engebretsen, L., Marlovits, S., Niemeyer, P., Platzer, P., Posthumus, M., Verdonk, P., Verdonk, R., Victor, J., van der Merwe, W., Widuchowski, W., Zorzi, C. & Marcacci, M., Sep 14 2017, In : Knee Surgery, Sports Traumatology, Arthroscopy. p. 1-12 12 p.

Research output: Contribution to journalArticle

Stress Fractures
Biocompatible Materials
Multicenter Studies
Cartilage
Regeneration

Art in Science: The Artist and The Disease: The Exemplary Cases of Renoir and Toulouse-Lautrec

Di Matteo, B., Tarabella, V., Filardo, G., Tanzi, P., Kon, E., Iacono, F. & Marcacci, M., Aug 7 2017, (Accepted/In press) In : Clinical Orthopaedics and Related Research. p. 1-6 6 p.

Research output: Contribution to journalArticle

Art in Science: The Artist and The Disease: The Exemplary Cases of Renoir and Toulouse-Lautrec

Di Matteo, B., Tarabella, V., Filardo, G., Tanzi, P., Kon, E., Iacono, F. & Marcacci, M., Oct 2017, In : Clinical Orthopaedics and Related Research. 475, 10, p. 2376-2381 6 p.

Research output: Contribution to journalArticle

"Bone Morphogenic Protein augmentation for long bone healing" response to "Clinical need for bone morphogenetic protein".

Krishnakumar, G. S., Roffi, A., Reale, D., Kon, E. & Filardo, G., Sep 3 2017, In : International Orthopaedics. 41, 11, p. 2417-2419 3 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Osteogenesis
Bone and Bones
Bone Matrix
Osteonecrosis

Clinical application of bone morphogenetic proteins for bone healing: a systematic review

Krishnakumar, G. S., Roffi, A., Reale, D., Kon, E. & Filardo, G., Jun 2017, In : International Orthopaedics. 41, 6, p. 1073-1083 11 p.

Research output: Contribution to journalReview article

Bone Morphogenetic Proteins
Bone and Bones
Osteonecrosis
Bone Regeneration
Bone Fractures

Clinical application of bone morphogenetic proteins for bone healing: a systematic review.

Krishnakumar, G. S., Roffi, A., Reale, D., Kon, E. & Filardo, G., Apr 19 2017, In : International Orthopaedics. 41, 6, p. 1073-1083 11 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Proteins
Bone and Bones
Osteonecrosis
Bone Regeneration
Bone Fractures

Clinical Outcomes of Knee Osteoarthritis Treated With an Autologous Protein Solution Injection: A 1-Year Pilot Double-Blinded Randomized Controlled Trial.

Kon, E., Engebretsen, L., Verdonk, P., Nehrer, S. & Filardo, G., Oct 1 2017, In : American Journal of Sports Medicine. 46, 1, p. 171-180 10 p.

Research output: Contribution to journalArticle

Knee Osteoarthritis
Randomized Controlled Trials
Injections
Proteins
Pain

Evaluation of different crosslinking agents on hybrid biomimetic collagen-hydroxyapatite composites for regenerative medicine.

Shankar Krishnakumar, G., Gostyńska, N., Dapporto, M., Campodoni, E., Montesi, M., Panseri, S., Tampieri, A., Kon, E., Marcacci, M., Sprio, S. & Sandri, M., 2017, In : International Journal of Biological Macromolecules. 106, p. 739-748 10 p.

Research output: Contribution to journalArticle

Biomimetics
Regenerative Medicine
Durapatite
Crosslinking
Collagen

Failure of Autologous Chondrocyte implantation

Andriolo, L., Merli, G., Filardo, G., Marcacci, M. & Kon, E., 2017, In : Sports Medicine and Arthroscopy Review. 25, 1, p. 10-18 9 p.

Research output: Contribution to journalReview article

Chondrocytes
Autologous Transplantation
Treatment Failure
Cartilage
Knee
Osteochondritis Dissecans
Knee
Bone
Joints
Cartilage
Osteochondritis Dissecans
Knee
Bone
Joints
Cartilage

Implant strategy affects scaffold stability and integrity in cartilage treatment.

Drobnič, M., Perdisa, F., Kon, E., Cefalì, F., Marcacci, M. & Filardo, G., Oct 11 2017, In : Knee Surgery, Sports Traumatology, Arthroscopy. p. 1-10 10 p.

Research output: Contribution to journalArticle

Fibrin Tissue Adhesive
Cartilage
Weight-Bearing
Bone and Bones
Sutures

International Meniscus Reconstruction Experts Forum (IMREF) 2015 Consensus Statement on the Practice of Meniscal Allograft Transplantation

Getgood, A., LaPrade, R. F., Verdonk, P., Gersoff, B., Cole, B., Spalding, T., Amis, A., Bin, S. I., Bugbee, W., Caborn, D., Carter, T., Chan, K. M., Cohen, C., Cohen, M., Condello, V., DeBerardino, T., Dirisamer, F., Engebretsen, L., Farr, J. ., Gomoll, A. & 29 others, Harner, C., Heard, M., Hiemstra, L., Kim, J. M., Kon, E., Laggae, K., Lee, B. S., Litchfild, R., Marcacci, M., McCormack, R., McDermott, I., Monlau, J. C., Myers, P., Noyes, F., Patsch, C., Robinson, J., Rodeo, S. R., Seo, S. S., Sherman, S., Siebold, R., Snow, M., Stone, K., Tashman, S., Thompson, P., van Arkel, E., Van Der Merwe, W., Verdonk, R., Williams, A. & Zaffagnini, S., 2017, In : American Journal of Sports Medicine. 45, 5, p. 1195-1205 11 p.

Research output: Contribution to journalArticle

Allografts
Transplantation
Sports Medicine
Postoperative Care
Knee

Investigation of different cross-linking approaches on 3D gelatin scaffolds for tissue engineering application: A comparative analysis

Shankar, K. G., Gostynska, N., Montesi, M., Panseri, S., Sprio, S., Kon, E., Marcacci, M., Tampieri, A. & Sandri, M., Feb 1 2017, In : International Journal of Biological Macromolecules. 95, p. 1199-1209 11 p.

Research output: Contribution to journalArticle

Gelatin
Tissue Engineering
Tissue engineering
Scaffolds
Cartilage

One-Step Treatment for Patellar Cartilage Defects With a Cell-Free Osteochondral Scaffold.

Perdisa, F., Filardo, G., Sessa, A., Busacca, M., Zaffagnini, S., Marcacci, M. & Kon, E., Mar 2017, In : American Journal of Sports Medicine. 45, 7, p. 1581-1588 8 p.

Research output: Contribution to journalArticle

Cartilage
Magnetic Resonance Imaging
Patella
Durapatite
Knee

Patients control preferences and results in knee arthroplasty

Filardo, G., Roffi, A., Merli, G., Marcacci, T., Berti Ceroni, F., Raboni, D., Kon, E. & Marcacci, M., Feb 1 2017, In : Knee Surgery, Sports Traumatology, Arthroscopy. 25, 2, p. 552-558 7 p.

Research output: Contribution to journalArticle

Knee Replacement Arthroplasties
Patient Preference
Patient Participation
Pain
Decision Making

Reviews, reviewers and reviewing

Zazgyva, A., Kon, E., Mauffrey, C., Mavrogenis, A. F. & Scarlat, M. M., Jan 1 2017, In : International Orthopaedics. 41, 1, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Ribose mediated crosslinking of collagen-hydroxyapatite hybrid scaffolds for bone tissue regeneration using biomimetic strategies

Krishnakumar, G. S., Gostynska, N., Campodoni, E., Dapporto, M., Montesi, M., Panseri, S., Tampieri, A., Kon, E., Marcacci, M., Sprio, S. & Sandri, S., Aug 1 2017, In : Materials Science and Engineering C. 77, p. 594-605 12 p.

Research output: Contribution to journalArticle

ribose
Tissue regeneration
Ribose
biomimetics
Biomimetics

Ribose mediated crosslinking of collagen-hydroxyapatite hybrid scaffolds for bone tissue regeneration using biomimetic strategies

Krishnakumar, G. S., Gostynska, N., Campodoni, E., Dapporto, M., Montesi, M., Panseri, S., Tampieri, A., Kon, E., Marcacci, M., Sprio, S. & Sandri, M., 2017, In : Materials Science and Engineering C. 77, p. 594-605 12 p.

Research output: Contribution to journalArticle

ribose
Tissue regeneration
Ribose
biomimetics
Biomimetics

Short-Term Homing of Hyaluronan-Primed Cells: Therapeutic Implications for Osteoarthritis Treatment.

Desando, G., Bartolotti, I., Cavallo, C., Schiavinato, A., Secchieri, C., Kon, E., Filardo, G., Paro, M. & Grigolo, B., Dec 22 2017, In : Tissue Engineering - Part C: Methods. p. 1-13 13 p.

Research output: Contribution to journalArticle

Cartilage
Hyaluronic Acid
Osteoarthritis
Synovial Membrane
Macrophages

The Role of Three-Dimensional Scaffolds in Treating Long Bone Defects: Evidence from Preclinical and Clinical Literature - A Systematic Review

Roffi, A., Krishnakumar, G. S., Gostynska, N., Kon, E., Candrian, C. & Filardo, G., Jan 1 2017, In : BioMed Research International. 2017, 8074178.

Research output: Contribution to journalReview article

Scaffolds
Bone
Bone and Bones
Defects
Tissue Engineering

The Role of Three-Dimensional Scaffolds in Treating Long Bone Defects: Evidence from Preclinical and Clinical Literature-A Systematic Review.

Roffi, A., Krishnakumar, G. S., Gostyńska, N., Kon, E., Candrian, C. & Filardo, G., 2017, In : BioMed Research International. p. 1-13 13 p.

Research output: Contribution to journalArticle

Scaffolds
Bone
Bone and Bones
Defects
Tissue Engineering

Treatment of Knee Osteochondritis Dissecans With a Cell-Free Biomimetic Osteochondral Scaffold: Clinical and Imaging Findings at Midterm Follow-up.

Perdisa, F., Kon, E., Sessa, A., Andriolo, L., Busacca, M., Marcacci, M. & Filardo, G., Nov 1 2017, In : American Journal of Sports Medicine. p. 1-8 8 p.

Research output: Contribution to journalArticle

Osteochondritis Dissecans
Biomimetics
Cartilage
Knee
Bone and Bones
2016

Aetiology and pathogenesis of bone marrow lesions and osteonecrosis of the knee

Marcacci, M., Andriolo, L., Kon, E., Shabshin, N. & Filardo, G., 2016, In : EFORT Open Reviews.

Research output: Contribution to journalArticle

Osteonecrosis
Knee
Bone Marrow
Stress Fractures
Pathology

A novel aragonite-based scaffold for osteochondral regeneration: early experience on human implants and technical developments

Kon, E., Robinson, D., Verdonk, P., Drobnic, M., Patrascu, J. M., Dulic, O., Gavrilovic, G. & Filardo, G., Dec 1 2016, In : Injury. 47, p. S27-S32 6 p.

Research output: Contribution to journalArticle

Calcium Carbonate
Regeneration
Cartilage
Safety
Reoperation

Anterior cruciate ligament injury: post-traumatic bone marrow oedema correlates with long-term prognosis

Filardo, G., Kon, E., Tentoni, F., Andriolo, L., Di Martino, A., Busacca, M., Di Matteo, B. & Marcacci, M., Jan 1 2016, In : International Orthopaedics. 40, 1, p. 183-190 8 p.

Research output: Contribution to journalArticle

Edema
Bone Marrow
Sports
Knee
Anterior Cruciate Ligament Reconstruction

Biomimetic Materials in Regenerative Medicine: A Clinical Perspective

Marcacci, M., Filardo, G., Venieri, G., Milani, L. & Kon, E., 2016, Bio-Inspired Regenerative Medicine. Materials, Processes, and Clinical Applications. Pan Stanford Publishing Pte. Ltd.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Bone marrow lesions and subchondral bone pathology of the knee

Kon, E., Ronga, M., Filardo, G., Farr, J., Madry, H., Milano, G., Andriolo, L. & Shabshin, N., Apr 13 2016, (Accepted/In press) In : Knee Surgery, Sports Traumatology, Arthroscopy. p. 1-18 18 p.

Research output: Contribution to journalArticle

Knee
Bone Marrow
Pathology
Bone and Bones
Differential Diagnosis

Cartilage Repair: Scaffolding

Kon, E., Filardo, G., Andriolo, L., Perdisa, F., Tentoni, F. & Marcacci, M., 2016, Arthroscopy. Basic and Advanced. Springer, p. 197-207 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Cell-free osteochondral scaffolds

Kon, E. & Filardo, G., 2016, Let’s Discuss Series. Joint preservation of the Knee. p. 91-103 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Chondral and osteochondral operative treatment in early osteoarthritis

Angele, P., Niemeyer, P., Steinwachs, M., Filardo, G., Gomoll, A. H., Kon, E., Zellner, J. & Madry, H., Feb 27 2016, (Accepted/In press) In : Knee Surgery, Sports Traumatology, Arthroscopy. p. 1-10 10 p.

Research output: Contribution to journalArticle

Osteoarthritis
Cartilage
Therapeutics
Joints
Stress Fractures

Clinical Aspects in Regeneration of Articular Regions: New Biologically Inspired Multifunctional Scaffolds.

Kon, E., Filardo, G., Tentoni, F., Sessa, A. & Marcacci, M., 2016, Bio-Inspired Regenerative Medicine. Materials, Processes, and Clinical Applications. Springer Berlin Heidelberg, p. 321-330 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

Do cartilage lesions affect the clinical outcome of anterior cruciate ligament reconstruction? A systematic review

Filardo, G., de Caro, F., Andriolo, L., Kon, E., Zaffagnini, S. & Marcacci, M., Apr 4 2016, (Accepted/In press) In : Knee Surgery, Sports Traumatology, Arthroscopy. p. 1-15 15 p.

Research output: Contribution to journalArticle

Anterior Cruciate Ligament Reconstruction
Cartilage
Manuscripts
Anterior Cruciate Ligament
Therapeutics