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Research Output 1994 2019

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2019

Exploring by whole exome sequencing patients with initial diagnosis of Rubinstein–Taybi syndrome: the interconnections of epigenetic machinery disorders

Negri, G., Magini, P., Milani, D., Crippa, M., Biamino, E., Piccione, M., Sotgiu, S., Perrìa, C., Vitiello, G., Frontali, M., Boni, A., Di Fede, E., Gandini, M. C., Colombo, E. A., Bamshad, M. J., Nickerson, D. A., Smith, J. D., Loddo, I., Finelli, P., Seri, M. & 3 others, Pippucci, T., Larizza, L. & Gervasini, C., 2019, In : Human Genetics. 138, 3, p. 257-269 13 p.

Research output: Contribution to journalArticle

Phenotypic overlap of Roberts and Baller-Gerold syndromes in two patients with craniosynostosis, limb reductions, and ESCO2 mutations

Colombo, E. A., Mutlu-Albayrak, H., Shafeghati, Y., Balasar, M., Piard, J., Gentilini, D., Di Blasio, A. M., Gervasini, C., Van Maldergem, L. & Larizza, L., 2019, In : Frontiers in Pediatrics. 7, MAY

Research output: Contribution to journalArticle

2018

Evaluation of the performance of Dutch Lipid Clinic Network score in an Italian FH population: The LIPIGEN study

LIPIGEN Group, Oct 1 2018, In : Atherosclerosis. 277, p. 413-418 6 p.

Research output: Contribution to journalArticle

Hyperlipoproteinemia Type II
Lipids
Population
Premature Birth
Dyslipidemias

Evaluation of the performance of Dutch Lipid Clinic Network score in an Italian FH population: The LIPIGEN study

Casula, M., Olmastroni, E., Pirillo, A., Catapano, A. L., Group, LIPIGEN., Averna, M., Bertolini, S., Calandra, S., Tarugi, P., Pellegatta, F., Angelico, F., Bartuli, A., Biasucci, G., Biolo, G., Bonanni, L., Bonomo, K., Borghi, C., Bossi, A. C., Branchi, A., Carubbi, F. & 86 others, Cipollone, F., Citroni, N., Federici, M., Ferri, C., Fiorenza, A. M., Giaccari, A., Giorgino, F., Guardamagna, O., Iannuzzi, A., Iughetti, L., Lupattelli, G., Lupi, A., Mandraffino, G., Marcucci, R., Maroni, L., Miccoli, R., Mombelli, G., Muntoni, S., Pecchioli, V., Pederiva, C., Pipolo, A., Pisciotta, L., Pujia, A., Purrello, F., Repetti, E., Rubba, P., Sabbà, C., Sampietro, T., Sarzani, R., Tagliabue, M. P., Trenti, C., Vigna, G. B., Werba, J. P., Zambon, S., Zenti, M. G., Minicocci, I., Noto, D., Fortunato, G., Banderali, G., Benso, A., Bigolin, P., Bonora, E., Bruzzi, P., Bucci, M., Buonuomo, P. S., Capra, M. E., Cardolini, I., Cefalù, B., Cervelli, N., Chiariello, G., Cocci, G., Colombo, E., Cremonini, A. L., D'addato, S., D'erasmo, L., Dal Pino, B., De Sanctis, L., De Vita, E., Del Ben, M., Di Costanzo, A., Di Taranto, M. D., Fasano, T., Gentile, L., Gentile, M., Ghirardello, O., Grigore, L., Lussu, M., Meregalli, G., Moffa, S., Montalcini, T., Morgia, V., Nascimbeni, F., Pasta, A., Pavanello, C., Saitta, A., Scicali, R., Siepi, D., Spagnolli, W., Spina, R., Sticchi, E., Suppressa, P., Vigo, L., Vinci, P., Manzato, E., Tragni, E. & Zampoleri, V., Oct 2018, In : Atherosclerosis. 277, p. 413-418 6 p.

Research output: Contribution to journalArticle

2017

The GENDER ATTENTION Observational Study: Gender and Hormonal Status Differences in the Incidence of Adverse Events During Cyclosporine Treatment in Psoriatic Patients

Colombo, D., Banfi, G., Cassano, N., Graziottin, A., Vena, G. A., Fiori, G. G., Zagni, E., Stingeni, L., Chimenti, S., Berardesca, E., Micali, G., Albertini, G., De Simone, C., Bellia, G., Amato, S., Ayala, F., Bardazzi, F., Bernengo, M. G., Bongiorno, M. R., Borroni, G. & 46 others, Calvieri, S., Pinton, P. C., Cannarozzo, C., Cannavò, S. P., Cattaneo, A., Ceschini, R., Colombo, E., Congedo, M., Cusano, F., De Pità, O., Di Nuzzo, S., Donadio, D., Donelli, S., Filotico, R., Flori, M. L., Germino, M., Girolomoni, G., Kokelj, F., Lanzoni, A., Lembo, G., Locatelli, A., Magnoni, C., Marconi, M., Motolese, A., Papini, M., Parodi, A., Pau, M., Peris, K., Piaserico, S., Piccirillo, A., Potenza, C., Ricotti, G., Sedona, P., Stinco, G., Valenti, G., Fornasa, C. V., Zichichi, L., Ori, A., Amici, C., Zullo, A., Simoni, L., Lanci, N., Longagnani, C., Sala, S., Trevisan, F. & Magri, G., 2017, In : Advances in Therapy. 34, 6, p. 1349-1363 15 p.

Research output: Contribution to journalArticle

2016

CDKN2A and BAP1 germline mutations predispose to melanoma and mesothelioma

Betti, M., Aspesi, A., Biasi, A., Casalone, E., Ferrante, D., Ogliara, P., Gironi, L. C., Giorgione, R., Farinelli, P., Grosso, F., Libener, R., Rosato, S., Turchetti, D., Maffè, A., Casadio, C., Ascoli, V., Dianzani, C., Colombo, E., Piccolini, E., Pavesi, M. & 10 others, Miccoli, S., Mirabelli, D., Bracco, C., Righi, L., Boldorini, R., Papotti, M., Matullo, G., Magnani, C., Pasini, B. & Dianzani, I., Aug 10 2016, In : Cancer Letters. 378, 2, p. 120-130 11 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Mesothelioma
Melanoma
Neoplasms
p16 Genes

Lumbar plexus nervous distortion in XLIF

Mandelli, C., Colombo, E. V., Sicuri, G. M. & Mortini, P., Dec 1 2016, In : European Spine Journal. 25, 12, p. 4155 - 4163 9 p.

Research output: Contribution to journalArticle

Lumbosacral Plexus
Femoral Nerve
Psoas Muscles
Paralysis
Dissection
2015

Eratum: Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: Impact on tumor biology (Oncogene) (2014) 33 (2876-2887) DOI: 10.1038/onc.2013.251)

Vascotto, C., Lirussi, L., Poletto, M., Tiribelli, M., Damiani, D., Fabbro, D., Damante, G., Demple, B., Colombo, E. & Tell, G., Jun 27 2015, In : Oncogene. 34, 26, p. 3482 1 p.

Research output: Contribution to journalArticle

2014
Cytoplasm
Nuclear Export Signals
Antigens
Nuclear Localization Signals
Protein Sorting Signals

Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: Impact on tumor biology

Vascotto, C., Lirussi, L., Poletto, M., Tiribelli, M., Damiani, D., Fabbro, D., Damante, G., Demple, B., Colombo, E. & Tell, G., May 29 2014, In : Oncogene. 33, 22, p. 2876-2887 12 p.

Research output: Contribution to journalArticle

DNA-(Apurinic or Apyrimidinic Site) Lyase
DNA Repair
Endonucleases
Acute Myeloid Leukemia
Neoplasms
2013

Hepatocyte odd protein shuttling (HOPS) is a bridging protein in the nucleophosmin-p19Arf network

Castelli, M., Pieroni, S., Brunacci, C., Piobbico, D., Bartoli, D., Bellet, M. M., Colombo, E., Pelicci, P. G., Della Fazia, M. A. & Servillo, G., Jul 11 2013, In : Oncogene. 32, 28, p. 3350-3358 9 p.

Research output: Contribution to journalArticle

Hepatocytes
Proteins
Cytoplasm
Centrosome
nucleophosmin

NPMc+ and FLT3-ITD mutations cooperate in inducing acute leukaemia in a novel mouse model

Mallardo, M., Caronno, A., Pruneri, G., Raviele, P. R., Viale, A., Pelicci, P. G. & Colombo, E., Nov 2013, In : Leukemia. 27, 11, p. 2248-2251 4 p.

Research output: Contribution to journalArticle

Nucleophosmin/B26 regulates PTEN through interaction with HAUSP in acute myeloid leukemia

Noguera, N. I., Song, M. S., Divona, M., Catalano, G., Calvo, K. L., García, F., Ottone, T., Florenzano, F., Faraoni, I., Battistini, L., Colombo, E., Amadori, S., Pandolfi, P. P. & Lo-Coco, F., May 2013, In : Leukemia. 27, 5, p. 1037-1043 7 p.

Research output: Contribution to journalArticle

Ubiquitin-Specific Proteases
Acute Myeloid Leukemia
Viruses
Cytoplasm
PTEN Phosphohydrolase
2011

Nucleophosmin and its complex network: A possible therapeutic target in hematological diseases

Colombo, E., Alcalay, M. & Pelicci, P. G., Jun 9 2011, In : Oncogene. 30, 23, p. 2595-2609 15 p.

Research output: Contribution to journalArticle

Hematologic Diseases
Nucleoplasmins
Neoplasms
Centrosome
Proteins

The lymphoma-associated NPM-ALK oncogene elicits a p16INK4a/pRb-dependent tumor-suppressive pathway

Martinelli, P., Bonetti, P., Sironi, C., Pruneri, G., Fumagalli, C., Raviele, P. R., Volorio, S., Pileri, S., Chiarle, R., McDuff, F. K. E., Tusi, B. K., Turner, S. D., Inghirami, G., Pelicci, P. G. & Colombo, E., Jun 16 2011, In : Blood. 117, 24, p. 6617-6626 10 p.

Research output: Contribution to journalArticle

Oncogenes
Tumors
Lymphoma
Anaplastic Large-Cell Lymphoma
Neoplasms

The multifunctional protein nucleophosmin (NPM1) is a human linker histone H1 chaperone

Gadad, S. S., Senapati, P., Syed, S. H., Rajan, R. E., Shandilya, J., Swaminathan, V., Chatterjee, S., Colombo, E., Dimitrov, S., Pelicci, P. G., Ranga, U. & Kundu, T. K., Apr 12 2011, In : Biochemistry. 50, 14, p. 2780-2789 10 p.

Research output: Contribution to journalArticle

Histone Chaperones
Histones
Proteins
Chromatin
HIV Long Terminal Repeat
2008

A ribosomal protein L23-nucleophosmin circuit coordinates Miz1 function with cell growth

Wanzel, M., Russ, A. C., Kleine-Kohlbrecher, D., Colombo, E., Pelicci, P. G. & Eilers, M., 2008, In : Nature Cell Biology. 10, 9, p. 1051-1061 11 p.

Research output: Contribution to journalArticle

myc Genes
Cell Cycle Checkpoints
Ribosomal Proteins
Zinc Fingers
Regulator Genes

Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7γ

Bonetti, P., Davoli, T., Sironi, C., Amati, B., Pelicci, P. G. & Colombo, E., Jul 14 2008, In : Journal of Cell Biology. 182, 1, p. 19-26 8 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
F-Box Proteins
Neoplasms
Ubiquitin-Protein Ligases
Ubiquitination
2007

NPM/ALK binds and phosphorylates the RNA/DNA-binding protein PSF in anaplastic large-cell lymphoma

Galietta, A., Gunby, R. H., Redaelli, S., Stano, P., Carniti, C., Bachi, A., Tucker, P. W., Tartari, C. J., Huang, C. J., Colombo, E., Pulford, K., Puttini, M., Piazza, R. G., Ruchatz, H., Villa, A., Donella-Deana, A., Marin, O., Perrotti, D. & Gambacorti-Passerini, C., Oct 1 2007, In : Blood. 110, 7, p. 2600-2609 10 p.

Research output: Contribution to journalArticle

Protein Splicing
Anaplastic Large-Cell Lymphoma
RNA-Binding Proteins
DNA-Binding Proteins
RNA
2006

Aberrant subcellular expression of nucleophosmin and NPM-MLF1 fusion protein in acute myeloid leukaemia carrying t(3;5): A comparison with NPMc+ AML [9]

Falini, B., Bigerna, B., Pucciarini, A., Tiacci, E., Mecucci, C., Morris, S. W., Bolli, N., Rosati, R., Hanissian, S., Ma, Z., Sun, Y., Colombo, E., Arber, D. A., Pacini, R., La Starza, R., Galletti, B. V., Liso, A., Martelli, M. P., Diverio, D., Pelicci, P. G. & 2 others, Coco, F. L. & Martelli, M. F., Feb 2006, In : Leukemia. 20, 2, p. 368-371 4 p.

Research output: Contribution to journalArticle

Cytoplasmic localization of NPM in myeloid leukemias is dictated by gain-of-function mutations that create a functional nuclear export signal

Mariano, A. R., Colombo, E., Luzi, L., Martinelli, P., Volorio, S., Bernard, L., Meani, N., Bergomas, R., Alcalay, M. & Pelicci, P. G., Jul 20 2006, In : Oncogene. 25, 31, p. 4376-4380 5 p.

Research output: Contribution to journalArticle

Nuclear Export Signals
Myeloid Leukemia
Mutation
Exons
Acute Myeloid Leukemia

Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant

Colombo, E., Martinelli, P., Zamponi, R., Shing, D. C., Bonetti, P., Luzi, L., Volorio, S., Bernard, L., Pruneri, G., Alcalay, M. & Pelicci, P. G., Mar 15 2006, In : Cancer Research. 66, 6, p. 3044-3050 7 p.

Research output: Contribution to journalArticle

Leukemia
Acute Myeloid Leukemia
Neoplasms
Centrosome
Mutation

Erratum: Aberrant subcellular expression of nucleophosmin and NPM-MLF1 fusion protein in acute myeloid leukaemia carrying t(3;5): A comparison with NPMc + AML (Leukemia (2006) vol. 20 (368-371) 10.1038/sj.leu.2404068)

Falini, B., Bigerna, B., Pucciarini, A., Tiacci, E., Mecucci, C., Morris, S. W., Bolli, N., Rosati, R., Hanissian, S., Ma, Z., Sun, Y., Colombo, E., Arber, D. A., Pacini, R., La Starza, R., Galletti, B. V., Liso, A., Martelli, M. P., Diverio, D., Pelicci, P. G. & 2 others, Coco, F. L. & Martelli, M. F., Jul 2006, In : Leukemia. 20, 7, p. 1330 1 p.

Research output: Contribution to journalArticle

2005

Activation of α-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase

Bacchiocchi, R., Baldanzi, G., Carbonari, D., Capomagi, C., Colombo, E., Van Blitterswijk, W. J., Graziani, A. & Fazioli, F., Sep 15 2005, In : Blood. 106, 6, p. 2175-2182 8 p.

Research output: Contribution to journalArticle

Diacylglycerol Kinase
Chemical activation
Anaplastic Large-Cell Lymphoma
Cells
R 59949

Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance

Alcalay, M., Tiacci, E., Bergomas, R., Bigerna, B., Venturini, E., Minardi, S. P., Meani, N., Diverio, D., Bernard, L., Tizzoni, L., Volorio, S., Luzi, L., Colombo, E., Lo Coco, F., Mecucci, C., Falini, B. & Pelicci, P. G., Aug 1 2005, In : Blood. 106, 3, p. 899-902 4 p.

Research output: Contribution to journalArticle

Bearings (structural)
Stem cells
Transcriptome
Acute Myeloid Leukemia
Gene expression

Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype

Falini, B., Mecucci, C., Tiacci, E., Alcalay, M., Rosati, R., Pasqualucci, L., La Starza, R., Diverio, D., Colombo, E., Santucci, A., Bigerna, B., Pacini, R., Pucciarini, A., Liso, A., Vignetti, M., Fazi, P., Meani, N., Pettirossi, V., Saglio, G., Mandelli, F. & 3 others, Lo-Coco, F., Pelicci, P. G. & Martelli, M. F., Jan 20 2005, In : New England Journal of Medicine. 352, 3, p. 254-266 13 p.

Research output: Contribution to journalArticle

Karyotype
Acute Myeloid Leukemia
Induction Chemotherapy
Genes
nucleophosmin

G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv

Doumont, G., Martoriati, A., Beekman, C., Bogaerts, S., Mee, P. J., Bureau, F., Colombo, E., Alcalay, M., Bellefroid, E., Marchesi, F., Scanziani, E., Pelicci, P. G. & Marine, J. C., Sep 2005, In : EMBO Journal. 24, 17, p. 3093-3103 11 p.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Tumors
Cells
Cyclin-Dependent Kinase Inhibitor p21
Apoptosis

Nucleophosmin is required for DNA integrity and p19Arf protein stability

Colombo, E., Bonetti, P., Denchi, E. L., Martinelli, P., Zamponi, R., Marine, J. C., Helin, K., Falini, B. & Pelicci, P. G., Oct 2005, In : Molecular and Cellular Biology. 25, 20, p. 8874-8886 13 p.

Research output: Contribution to journalArticle

Protein Stability
DNA
DNA Damage
Fibroblasts
Cell Proliferation
2002

Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation

Migliorini, D., Danovi, D., Colombo, E., Carbone, R., Pelicci, P. G. & Marine, J. C., Mar 1 2002, In : Journal of Biological Chemistry. 277, 9, p. 7318-7323 6 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Transcriptional Activation
Ubiquitination
Oncogene Proteins
Transcription

Nucleophosmin regulates the stability and transcriptional activity of p53

Colombo, E., Marine, J. C., Danovi, D., Falini, B. & Pelicci, P. G., 2002, In : Nature Cell Biology. 4, 7, p. 529-533 5 p.

Research output: Contribution to journalArticle

nucleophosmin
Neoplasms
Proteins
Molecular Chaperones
Ribosomal Proteins

PML-RAR induces promyelocytic leukemias with high efficiency following retroviral gene transfer into purified murine hematopoietic progenitors

Minucci, S., Monestiroli, S., Giavara, S., Ronzoni, S., Marchesi, F., Insinga, A., Diverio, D., Gasparini, P., Capillo, M., Colombo, E., Matteucci, C., Contegno, F., Lo-Coco, F., Scanziani, E., Gobbi, A. & Pelicci, P. G., Oct 15 2002, In : Blood. 100, 8, p. 2989-2995 7 p.

Research output: Contribution to journalArticle

Gene transfer
Leukemia
Retinoic Acid Receptors
Acute Promyelocytic Leukemia
Fusion reactions
2000

Human transaldolase-associated repetitive elements are transcribed by RNA polymerase III

Perl, A., Colombo, E., Samoilova, E., Butler, M. C. & Banki, K., Mar 10 2000, In : Journal of Biological Chemistry. 275, 10, p. 7261-7272 12 p.

Research output: Contribution to journalArticle

Transaldolase
RNA Polymerase III
Transcription
Genes
Amanitins

Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation

Minucci, S., Maccarana, M., Cioce, M., De Luca, P., Gelmetti, V., Segalla, S., Di Croce, L., Giavara, S., Matteucci, C., Gobbi, A., Bianchini, A., Colombo, E., Schiavoni, I., Badaracco, G., Hu, X., Lazar, M. A., Landsberger, N., Nervi, C. & Pelicci, P. G., 2000, In : Molecular Cell. 5, 5, p. 811-820 10 p.

Research output: Contribution to journalArticle

Co-Repressor Proteins
Transcription Factors
Histone Deacetylases
Leukemia
Molecular Weight
1999

Detection of normal and chimeric nucleophosmin in human cells

Cordell, J. L., Pulford, K. A. F., Bigerna, B., Roncador, G., Banham, A., Colombo, E., Pelicci, P. G., Mason, D. Y. & Falini, B., Jan 15 1999, In : Blood. 93, 2, p. 632-642 11 p.

Research output: Contribution to journalArticle

Cells
Antibodies
Anaplastic Large-Cell Lymphoma
Fusion reactions
Cell Nucleus
Endocytosis
Proteins
rev Gene Products
Protein Interaction Domains and Motifs
Transfer RNA
1998

The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein

Alcalay, M., Tomassoni, L., Colombo, E., Stoldt, S., Grignani, F., Fagioli, M., Szekely, L., Helin, K. & Pelicci, P. G., Feb 1998, In : Molecular and Cellular Biology. 18, 2, p. 1084-1093 10 p.

Research output: Contribution to journalArticle

Retinoblastoma Protein
Retinoic Acid Receptors
Leukemia
Genes
Acute Promyelocytic Leukemia
1997

Comparative analysis of antibody and cell-mediated autoimmunity to transaldolase and myelin basic protein in patients with multiple sclerosis

Colombo, E., Banki, K., Tatum, A. H., Daucher, J., Ferrante, P., Murray, R. S., Phillips, P. E. & Perl, A., Mar 15 1997, In : Journal of Clinical Investigation. 99, 6, p. 1238-1250 13 p.

Research output: Contribution to journalArticle

Transaldolase
Myelin Basic Protein
Autoimmunity
Multiple Sclerosis
Antibodies
1996

Glutathione levels and sensitivity to apoptosis are regulated by changes in transaldolase expression

Banki, K., Hutter, E., Colombo, E., Gonchoroff, N. J. & Perl, A., 1996, In : Journal of Biological Chemistry. 271, 51, p. 32994-33001 8 p.

Research output: Contribution to journalArticle

Transaldolase
Glutathione
Apoptosis
Pentoses
Pentose Phosphate Pathway
1995

Antibody reactivity to the HRES-1 endogenous retroviral element identifies a subset of patients with systemic lupus erythematosus and overlap syndromes: Correlation with antinuclear antibodies and HLA class II alleles

Perl, A., Colombo, E., Dai, H., Agarwal, R., Mark, K. A., Banki, K., Poiesz, B. J., Phillips, P. E., Hoch, S. O., Reveille, J. D. & Arnett, F. C., Nov 1995, In : Arthritis and Rheumatism. 38, 11, p. 1660-1671 12 p.

Research output: Contribution to journalArticle

Immunoglobulin Isotypes
Antinuclear Antibodies
Systemic Lupus Erythematosus
Alleles
Antibodies

HTLV infection among Italian intravenous drug users and North African subjects detected by the polymerase chain reaction and serological methods

Colombo, E., Magistrem, I., Mendozzi, E., Cattaneo, E., Achilli, G. & Ferrante, P., 1995, In : Journal of Medical Virology. 47, 1, p. 10-15 6 p.

Research output: Contribution to journalArticle

Deltaretrovirus
Human T-lymphotropic virus 2
Virus Diseases
Drug Users
Human T-lymphotropic virus 1
1994

Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis

Banki, K., Colombo, E., Sia, F., Halladay, D., Mattson, D. H., Tatum, A. H., Massa, P. T., Phillips, P. E. & Perl, A., Nov 1 1994, In : Journal of Experimental Medicine. 180, 5, p. 1649-1663 15 p.

Research output: Contribution to journalArticle

Transaldolase
Oligodendroglia
Multiple Sclerosis
Molecular Mimicry
Pentose Phosphate Pathway