• 87 Citations
  • 3 h-Index
20182019
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Research Output 2018 2019

  • 87 Citations
  • 3 h-Index
  • 19 Article
  • 5 Review article
2019
2 Citations (Scopus)

A multicenter REtrospective observational study of first-line treatment with PERtuzumab, trastuzumab and taxanes for advanced HER2 positive breast cancer patients. RePer Study

Gamucci, T., Pizzuti, L., Natoli, C., Mentuccia, L., Sperduti, I., Barba, M., Sergi, D., Iezzi, L., Maugeri-Saccà, M., Vaccaro, A., Magnolfi, E., Gelibter, A., Barchiesi, G., Magri, V., D’Onofrio, L., Cassano, A., Rossi, E., Botticelli, A., Moscetti, L., Omarini, C. & 29 others, Fabbri, M. A., Scinto, A. F., Corsi, D., Carbognin, L., Mazzotta, M., Bria, E., Foglietta, J., Samaritani, R., Garufi, C., Mariani, L., Barni, S., Mirabelli, R., Sarmiento, R., Graziano, V., Santini, D., Marchetti, P., Tonini, G., Di Lauro, L., Sanguineti, G., Paoletti, G., Tomao, S., De Maria, R., Veltri, E., Paris, I., Giotta, F., Latorre, A., Giordano, A., Ciliberto, G. & Vici, P., Feb 1 2019, In : Cancer Biology and Therapy. 20, 2, p. 192-200 9 p.

Research output: Contribution to journalArticle

Taxoids
Observational Studies
Retrospective Studies
Breast Neoplasms
Maintenance

Gene Expression Profiling of Lung Atypical Carcinoids and Large Cell Neuroendocrine Carcinomas Identifies Three Transcriptomic Subtypes with Specific Genomic Alterations

Simbolo, M., Barbi, S., Fassan, M., Mafficini, A., Ali, G., Vicentini, C., Sperandio, N., Corbo, V., Rusev, B., Mastracci, L., Grillo, F., Pilotto, S., Pelosi, G., Pelliccioni, S., Lawlor, R. T., Tortora, G., Fontanini, G., Volante, M., Scarpa, A. & Bria, E., Jan 1 2019, In : Journal of Thoracic Oncology.

Research output: Contribution to journalArticle

Open Access
Neuroendocrine Carcinoma
Large Cell Carcinoma
Carcinoid Tumor
Gene Expression Profiling
Lung
3 Citations (Scopus)

Lymph-node ratio predicts survival among the different stages of non-small-cell lung cancer: A multicentre analysis

Chiappetta, M., Leuzzi, G., Sperduti, I., Bria, E., Mucilli, F., Lococo, F., Spaggiari, L., Ratto, G. B., Filosso, P. L. & Facciolo, F., Mar 1 2019, In : European Journal of Cardio-thoracic Surgery. 55, 3, p. 405-412 8 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Disease-Free Survival
Lymph Nodes
Survival
Survival Rate

Maintenance with lanreotide in small-cell lung cancer expressing somatostatine receptors: A multicenter, randomized, phase 3 trial

On behalf of the Italian association FONICAP (Operative National Interdisciplinary Force against Lung Cancer), Aug 1 2019, In : Lung Cancer. 134, p. 121-126 6 p.

Research output: Contribution to journalArticle

Small Cell Lung Carcinoma
Maintenance
Disease-Free Survival
Observation
Survival

PD-L1 for selecting non-small-cell lung cancer patients for first-line immuno-chemotherapy combination: A systematic review and meta-analysis

Rossi, A., Noia, V. D., Gkountakos, A., D'Argento, E., Sartori, G., Vita, E., Monteverdi, S., Lombardo, F., Iacovelli, R., Carbognin, L., Sperduti, I., Milella, M., Tortora, G., Bria, E. & Pilotto, S., Jan 1 2019, In : Immunotherapy. 11, 10, p. 921-930 10 p.

Research output: Contribution to journalReview article

Combination Drug Therapy
Non-Small Cell Lung Carcinoma
Immunotherapy
Meta-Analysis
Disease-Free Survival
2018
1 Citation (Scopus)

Avoiding chemotherapy for advanced nononcogene addicted NSCLC overexpressing PD-L1: Rule or option?

Pilotto, S., Carbognin, L., Rossi, A., Tortora, G. & Bria, E., Jun 1 2018, In : Seminars in Oncology. 45, 3, p. 176-180 5 p.

Research output: Contribution to journalArticle

Drug Therapy
Non-Small Cell Lung Carcinoma
Survival
Combination Drug Therapy
Immunotherapy
2 Citations (Scopus)

Clinical implication of changes in body composition and weight in patients with early-stage and metastatic breast cancer

Trestini, I., Carbognin, L., Monteverdi, S., Zanelli, S., De Toma, A., Bonaiuto, C., Nortilli, R., Fiorio, E., Pilotto, S., Di Maio, M., Gasbarrini, A., Scambia, G., Tortora, G. & Bria, E., Sep 1 2018, In : Critical Reviews in Oncology/Hematology. 129, p. 54-66 13 p.

Research output: Contribution to journalReview article

Body Composition
Body Weight
Breast Neoplasms
Weights and Measures
Precision Medicine
2 Citations (Scopus)

Comparison Between Prognostic Classifications in De Novo Metastatic Hormone Sensitive Prostate Cancer

Iacovelli, R., Ciccarese, C., Mosillo, C., Bimbatti, D., Fantinel, E., Stefani, L., Simbolo, M., Romano, M., Mazzarotto, R., Brunelli, M., Bria, E., Scarpa, A., Lawlor, R. T., Artibani, W. & Tortora, G., Oct 1 2018, In : Targeted Oncology. 13, 5, p. 649-655 7 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Hormones
docetaxel
Proportional Hazards Models
Population
5 Citations (Scopus)

Genetic alterations analysis in prognostic stratified groups identified TP53 and ARID1A as poor clinical performance markers in intrahepatic cholangiocarcinoma

Simbolo, M., Vicentini, C., Ruzzenente, A., Brunelli, M., Conci, S., Fassan, M., Mafficini, A., Rusev, B., Corbo, V., Capelli, P., Bria, E., Pedron, S., Turri, G., Lawlor, R. T., Tortora, G., Bassi, C., Guglielmi, A. & Scarpa, A., Dec 1 2018, In : Scientific Reports. 8, 1, 7119.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Biomarkers
Recurrence
Gene Amplification
p53 Genes
56 Citations (Scopus)

Hyperprogressive Disease in Patients with Advanced Non-Small Cell Lung Cancer Treated with PD-1/PD-L1 Inhibitors or with Single-Agent Chemotherapy

Ferrara, R., Mezquita, L., Texier, M., Lahmar, J., Audigier-Valette, C., Tessonnier, L., Mazieres, J., Zalcman, G., Brosseau, S., Le Moulec, S., Leroy, L., Duchemann, B., Lefebvre, C., Veillon, R., Westeel, V., Koscielny, S., Champiat, S., Ferté, C., Planchard, D., Remon, J. & 8 others, Boucher, M. E., Gazzah, A., Adam, J., Bria, E., Tortora, G., Soria, J. C., Besse, B. & Caramella, C., Jan 1 2018, (Accepted/In press) In : JAMA oncology. p. E1-E10

Research output: Contribution to journalArticle

CD274 Antigen
Non-Small Cell Lung Carcinoma
Cell Death
Drug Therapy
Survival

Immunotherapy versus standard of care in metastatic renal cell carcinoma. A systematic review and meta-analysis

Iacovelli, R., Ciccarese, C., Bria, E., Bimbatti, D., Fantinel, E., Mosillo, C., Bisogno, I., Brunelli, M., Tortora, G. & Porta, C., Nov 2018, In : Cancer Treatment Reviews. 70, p. 112-117 6 p.

Research output: Contribution to journalReview article

Standard of Care
Renal Cell Carcinoma
Immunotherapy
Meta-Analysis
PubMed
Non-Small Cell Lung Carcinoma
Disease-Free Survival
Lymph Nodes
Survival
Survival Rate

Lymph-node ratio predicts survival among the different stages of non-small-cell lung cancer: a multicentre analysis

Chiappetta, M., Leuzzi, G., Sperduti, I., Bria, E., Mucilli, F., Lococo, F., Spaggiari, L., Ratto, G. B., Filosso, P. L. & Facciolo, F., Sep 6 2018, In : European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Lymph Nodes
Disease-Free Survival
Survival
Confidence Intervals

Metformin Enhances Cisplatin-Induced Apoptosis and Prevents Resistance to Cisplatin in Co-mutated KRAS/LKB1 NSCLC

Moro, M., Caiola, E., Ganzinelli, M., Zulato, E., Rulli, E., Marabese, M., Centonze, G., Busico, A., Pastorino, U., de Braud, F. G., Vernieri, C., Simbolo, M., Bria, E., Scarpa, A., Indraccolo, S., Broggini, M., Sozzi, G. & Garassino, M. C., Nov 2018, In : Journal of Thoracic Oncology. 13, 11, p. 1692-1704 13 p.

Research output: Contribution to journalArticle

Metformin
Cisplatin
Phosphotransferases
Apoptosis
Liver

Metformin Enhances Cisplatin-Induced Apoptosis and Prevents Resistance to Cisplatin in Co-mutated KRAS/LKB1 NSCLC

Moro, M., Caiola, E., Ganzinelli, M., Zulato, E., Rulli, E., Marabese, M., Centonze, G., Busico, A., Pastorino, U., de Braud, F. G., Vernieri, C., Simbolo, M., Bria, E., Scarpa, A., Indraccolo, S., Broggini, M., Sozzi, G. & Garassino, M. C., 2018, In : Journal of Thoracic Oncology. 13, 11, p. 1692-1704 13 p.

Research output: Contribution to journalArticle

Metformin
Cisplatin
Phosphotransferases
Apoptosis
Liver

Metformin Enhances Cisplatin-Induced Apoptosis and Prevents Resistance to Cisplatin in Co-mutated KRAS/LKB1 NSCLC

Moro, M., Caiola, E., Ganzinelli, M., Zulato, E., Rulli, E., Marabese, M., Centonze, G., Busico, A., Pastorino, U., de Braud, F. G., Vernieri, C., Simbolo, M., Bria, E., Scarpa, A., Indraccolo, S., Broggini, M., Sozzi, G. & Garassino, M. C., 2018, In : Journal of Thoracic Oncology. 13, 11, p. 1692-1704 13 p.

Research output: Contribution to journalArticle

Most high-grade neuroendocrine tumours of the lung are likely to secondarily develop from pre-existing carcinoids: innovative findings skipping the current pathogenesis paradigm

Pelosi, G., Bianchi, F., Dama, E., Simbolo, M., Mafficini, A., Sonzogni, A., Pilotto, S., Harari, S., Papotti, M., Volante, M., Fontanini, G., Mastracci, L., Albini, A., Bria, E., Calabrese, F. & Scarpa, A., 2018, In : Virchows Archiv. 472, 4, p. 567-577 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Necitumumab in the treatment of non-small-cell lung cancer: clinical controversies

di Noia, V., D'Argento, E., Pilotto, S., Grizzi, G., Caccese, M., Iacovelli, R., Tortora, G. & Bria, E., Sep 2 2018, In : Expert Opinion on Biological Therapy. 18, 9, p. 937-945 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Cells
Chemotherapy
Epidermal Growth Factor Receptor
Therapeutics

Outcomes of First-Generation EGFR-TKIs Against Non-Small-Cell Lung Cancer Harboring Uncommon EGFR Mutations: A Post Hoc Analysis of the BE-POSITIVE Study

Pilotto, S., Rossi, A., Vavalà, T., Follador, A., Tiseo, M., Galetta, D., Morabito, A., Di Maio, M., Martelli, O., Caffo, O., Piovano, P. L., Cortinovis, D., Zilembo, N., Casartelli, C., Banna, G. L., Ardizzoia, A., Barzelloni, M. L., Bearz, A., Genestreti, G., Mucciarini, C. & 9 others, Filipazzi, V., Menis, J., Rizzo, E., Barbieri, F., Rijavec, E., Cecere, F., Spitaleri, G., Bria, E. & Novello, S., Jan 2018, In : Clinical Lung Cancer. 19, 1, p. 93-104 12 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Mutation
Disease-Free Survival

Outcomes of First-Generation EGFR-TKIs Against Non-Small-Cell Lung Cancer Harboring Uncommon EGFR Mutations: A Post Hoc Analysis of the BE-POSITIVE Study

Pilotto, S., Rossi, A., Vavalà, T., Follador, A., Tiseo, M., Galetta, D., Morabito, A., Di Maio, M., Martelli, O., Caffo, O., Piovano, P. L., Cortinovis, D., Zilembo, N., Casartelli, C., Banna, G. L., Ardizzoia, A., Barzelloni, M. L., Bearz, A., Genestreti, G., Mucciarini, C. & 9 others, Filipazzi, V., Menis, J., Rizzo, E., Barbieri, F., Rijavec, E., Cecere, F., Spitaleri, G., Bria, E. & Novello, S., Jan 2018, In : Clinical Lung Cancer. 19, 1, p. 93-104 12 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Mutation
Disease-Free Survival

Outcomes of First-Generation EGFR-TKIs Against Non-Small-Cell Lung Cancer Harboring Uncommon EGFR Mutations: A Post Hoc Analysis of the BE-POSITIVE Study

Pilotto, S., Rossi, A., Vavalà, T., Follador, A., Tiseo, M., Galetta, D., Morabito, A., Di Maio, M., Martelli, O., Caffo, O., Piovano, P. L., Cortinovis, D., Zilembo, N., Casartelli, C., Banna, G. L., Ardizzoia, A., Barzelloni, M. L., Bearz, A., Genestreti, G., Mucciarini, C. & 9 others, Filipazzi, V., Menis, J., Rizzo, E., Barbieri, F., Rijavec, E., Cecere, F., Spitaleri, G., Bria, E. & Novello, S., 2018, In : Clinical Lung Cancer. 19, 1, p. 93-104 12 p.

Research output: Contribution to journalArticle

Prognostic Model for Resected Squamous Cell Lung Cancer: External Multicenter Validation and Propensity Score Analysis exploring the Impact of Adjuvant and Neoadjuvant Treatment

Pilotto, S., Sperduti, I., Leuzzi, G., Chiappetta, M., Mucilli, F., Ratto, G. B., Lococo, F., Filosso, P. L., Spaggiari, L., Novello, S., Milella, M., Santo, A., Scarpa, A., Infante, M., Tortora, G., Facciolo, F. & Bria, E., 2018, In : Journal of Thoracic Oncology. 13, 4, p. 568-575 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Role of mTOR signaling in tumor microenvironment: An overview

Conciatori, F., Bazzichetto, C., Falcone, I., Pilotto, S., Bria, E., Cognetti, F., Milella, M. & Ciuffreda, L., Aug 19 2018, In : International Journal of Molecular Sciences. 19, 8, 2453.

Research output: Contribution to journalReview article

Tumor Microenvironment
Sirolimus
Tumors
tumors
Neoplasms
3 Citations (Scopus)

Unmasking the impact of Rictor in cancer: Novel insights of mTORC2 complex

Gkountakos, A., Pilotto, S., Mafficini, A., Vicentini, C., Simbolo, M., Milella, M., Tortora, G., Scarpa, A., Bria, E. & Corbo, V., Jul 30 2018, In : Carcinogenesis. 39, 8, p. 971-980 10 p.

Research output: Contribution to journalReview article

Sirolimus
Carcinogenesis
Neoplasms
Gene Amplification
MicroRNAs