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2019

Somatostatin analogs regulate tumor corticotrophs growth by reducing ERK1/2 activity

Treppiedi, D., Giardino, E., Catalano, R., Mangili, F., Vercesi, P., Sala, E., Locatelli, M., Arosio, M., Spada, A., Mantovani, G. & Peverelli, E., Mar 1 2019, In : Molecular and Cellular Endocrinology. 483, p. 31-38 8 p.

Research output: Contribution to journalArticle

2018

A novel pathway activated by somatostatin receptor type 2 (SST2): Inhibition of pituitary tumor cell migration and invasion through cytoskeleton protein recruitment

Peverelli, E., Giardino, E., Treppiedi, D., Catalano, R., Mangili, F., Locatelli, M., Lania, A. G., Arosio, M., Spada, A. & Mantovani, G., May 1 2018, In : International Journal of Cancer. 142, 9, p. 1842-1852 11 p.

Research output: Contribution to journalArticle

cAMP/PKA-induced filamin A (FLNA) phosphorylation inhibits SST2 signal transduction in GH-secreting pituitary tumor cells

Peverelli, E., Giardino, E., Mangili, F., Treppiedi, D., Catalano, R., Ferrante, E., Sala, E., Locatelli, M., Lania, A. G., Arosio, M., Spada, A. & Mantovani, G., Oct 28 2018, In : Cancer Letters. 435, p. 101-109 9 p.

Research output: Contribution to journalArticle

cAMP/PKA-induced filamin A (FLNA) phosphorylation inhibits SST2 signal transduction in GH-secreting pituitary tumor cells

Peverelli, E., Giardino, E., Mangili, F., Treppiedi, D., Catalano, R., Ferrante, E., Sala, E., Locatelli, M., Lania, A. G., Arosio, M., Spada, A. & Mantovani, G., Oct 28 2018, In : Cancer Letters. 435, p. 101-109 9 p.

Research output: Contribution to journalArticle

Single-molecule microscopy reveals dynamic FLNA interactions governing SSTR2 clustering and internalization

Treppiedi, D., Jobin, M. L., Peverelli, E., Giardino, E., Sungkaworn, T., Zabel, U., Arosio, M., Spada, A., Mantovani, G. & Calebiro, D., Aug 1 2018, In : Endocrinology. 159, 8, p. 2953-2965 13 p.

Research output: Contribution to journalArticle

2017

Cofilin is a cAMP effector in mediating actin cytoskeleton reorganization and steroidogenesis in mouse and human adrenocortical tumor cells

Peverelli, E., Catalano, R., Giardino, E., Treppiedi, D., Morelli, V., Ronchi, C. L., Vaczlavik, A., Fusco, N., Ferrero, S., Bertherat, J., Beuschlein, F., Chiodini, I., Arosio, M., Spada, A. & Mantovani, G., Oct 10 2017, In : Cancer Letters. 406, p. 54-63 10 p.

Research output: Contribution to journalArticle

Dopamine receptor type 2 (DRD2) and somatostatin receptor type 2 (SSTR2) agonists are effective in inhibiting proliferation of progenitor/stem-like cells isolated from nonfunctioning pituitary tumors

Peverelli, E., Giardino, E., Treppiedi, D., Meregalli, M., Belicchi, M., Vaira, V., Corbetta, S., Verdelli, C., Verrua, E., Serban, A. L., Locatelli, M., Carrabba, G., Gaudenzi, G., Malchiodi, E., Cassinelli, L., Lania, A. G., Ferrero, S., Bosari, S., Vitale, G., Torrente, Y. & 2 others, Spada, A. & Mantovani, G., 2017, In : International Journal of Cancer. 140, 8, p. 1870-1880 11 p.

Research output: Contribution to journalArticle

Dopamine receptor type 2 (DRD2) and somatostatin receptor type 2 (SSTR2) agonists are effective in inhibiting proliferation of progenitor/stem-like cells isolated from nonfunctioning pituitary tumors

Peverelli, E., Giardino, E., Treppiedi, D., Meregalli, M., Belicchi, M., Vaira, V., Corbetta, S., Verdelli, C., Verrua, E., Serban, A. L., Locatelli, M., Carrabba, G., Gaudenzi, G., Malchiodi, E., Cassinelli, L., Lania, A. G., Ferrero, S., Bosari, S., Vitale, G., Torrente, Y. & 2 others, Spada, A. & Mantovani, G., 2017, In : International Journal of Cancer. 140, 8, p. 1870-1880 11 p.

Research output: Contribution to journalArticle

Dopamine receptor type 2 (DRD2) and somatostatin receptor type 2 (SSTR2) agonists are effective in inhibiting proliferation of progenitor/stem-like cells isolated from nonfunctioning pituitary tumors

Peverelli, E., Giardino, E., Treppiedi, D., Meregalli, M., Belicchi, M., Vaira, V., Corbetta, S., Verdelli, C., Verrua, E., Serban, A. L., Locatelli, M., Carrabba, G., Gaudenzi, G., Malchiodi, E., Cassinelli, L., Lania, A. G., Ferrero, S., Bosari, S., Vitale, G., Torrente, Y. & 2 others, Spada, A. & Mantovani, G., Apr 15 2017, In : International Journal of Cancer. 140, 8, p. 1870-1880 11 p.

Research output: Contribution to journalArticle

Dopamine receptor type 2 (DRD2) and somatostatin receptor type 2 (SSTR2) agonists are effective in inhibiting proliferation of progenitor/stem-like cells isolated from nonfunctioning pituitary tumors

Peverelli, E., Giardino, E., Treppiedi, D., Meregalli, M., Belicchi, M., Vaira, V., Corbetta, S., Verdelli, C., Verrua, E., Serban, A. L., Locatelli, M., Carrabba, G., Gaudenzi, G., Malchiodi, E., Cassinelli, L., Lania, A. G., Ferrero, S., Bosari, S., Vitale, G., Torrente, Y. & 2 others, Spada, A. & Mantovani, G., Apr 15 2017, In : International Journal of Cancer. 140, 8, p. 1870-1880 11 p.

Research output: Contribution to journalArticle

2016

Dopamine receptor type 2 (DRD2) inhibits migration and invasion of human tumorous pituitary cells through ROCK-mediated cofilin inactivation

Peverelli, E., Giardino, E., Treppiedi, D., Locatelli, M., Vaira, V., Ferrero, S., Bosari, S., Lania, A. G., Spada, A. & Mantovani, G., Oct 28 2016, In : Cancer Letters. 381, 2, p. 279-286 8 p.

Research output: Contribution to journalArticle

Dopamine receptor type 2 (DRD2) inhibits migration and invasion of human tumorous pituitary cells through ROCK-mediated cofilin inactivation

Peverelli, E. M., Giardino, E., Treppiedi, D., Locatelli, M., Vaira, V., Ferrero, S., Bosari, S., Lania, A. G. A., Spada, A. M. & Mantovani, G., Oct 28 2016, In : Cancer Letters. 381, 2, p. 279-286 8 p.

Research output: Contribution to journalArticle

Expression of protein kinase A regulatory subunits in benign and malignant human thyroid tissues: A systematic review

Del Gobbo, A., Peverelli, E. M., Treppiedi, D., Lania, A. G. A., Mantovani, G. & Ferrero, S., Mar 18 2016, (Accepted/In press) In : Experimental Cell Research.

Research output: Contribution to journalArticle

Expression of protein kinase A regulatory subunits in benign and malignant human thyroid tissues: A systematic review

Del Gobbo, A., Peverelli, E., Treppiedi, D., Lania, A., Mantovani, G. & Ferrero, S., 2016, In : Experimental Cell Research. 346, 1, p. 85-90 6 p.

Research output: Contribution to journalArticle

Filamin-a is required to mediate SST2 effects in pancreatic neuroendocrine tumours

Vitali, E., Cambiaghi, V., Zerbi, A., Carnaghi, C., Colombo, P., Peverelli, E., Spada, A., Mantovani, G. & Lania, A. G., Mar 1 2016, In : Endocrine-Related Cancer. 23, 3, p. 181-190 10 p.

Research output: Contribution to journalArticle

Filamin-a is required to mediate SST2 effects in pancreatic neuroendocrine tumours

Vitali, E., Cambiaghi, V., Zerbi, A., Carnaghi, C., Colombo, P., Peverelli, E. M., Spada, A. M., Mantovani, G. & Lania, A. G. A., Mar 1 2016, In : Endocrine-Related Cancer. 23, 3, p. 181-190 10 p.

Research output: Contribution to journalArticle

Identification of human somatostatin receptor 2 domains involved in internalization and signaling in QGP-1 pancreatic neuroendocrine tumor cell line

Cambiaghi, V., Vitali, E., Morone, D., Peverelli, E., Spada, A., Mantovani, G. & Lania, A. G., Jul 12 2016, (Accepted/In press) In : Endocrine. p. 1-12 12 p.

Research output: Contribution to journalArticle

Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas

Ronchi, C. L., Peverelli, E. M., Herterich, S., Weigand, I., Mantovani, G., Schwarzmayr, T., Sbiera, S., Allolio, B., Honegger, J., Appenzeller, S., Lania, A. G. A., Reincke, M., Calebiro, D., Spada, A. M., Buchfelder, M., Flitsch, J., Strom, T. M. & Fassnacht, M., Mar 1 2016, In : European Journal of Endocrinology. 174, 3, p. 363-372 10 p.

Research output: Contribution to journalArticle

Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas

Ronchi, C. L., Peverelli, E., Herterich, S., Weigand, I., Mantovani, G., Schwarzmayr, T., Sbiera, S., Allolio, B., Honegger, J., Appenzeller, S., Lania, A. G., Reincke, M., Calebiro, D., Spada, A., Buchfelder, M., Flitsch, J., Strom, T. M. & Fassnacht, M., Mar 1 2016, In : European Journal of Endocrinology. 174, 3, p. 363-372 10 p.

Research output: Contribution to journalArticle

2015

CAMP effects in neuroendocrine tumors: The role of Epac and PKA in cell proliferation and adhesion

Vitali, E., Cambiaghi, V., Spada, A., Tresoldi, A., Zerbi, A., Peverelli, E., Carnaghi, C., Mantovani, G. & Lania, A. G., Jun 19 2015, (Accepted/In press) In : Experimental Cell Research.

Research output: Contribution to journalArticle

2014

Correction to Specific roles of Gi protein family members revealed by dissecting SST5 coupling in human pituitary cells [J. Cell Sci., 126, 638-644]

Peverelli, E., Busnelli, M., Vitali, E., Giardino, E., Galés, C., Lania, A. G., Beck-Peccoz, P., Chini, B., Mantovani, G. & Spada, A., 2014, In : Journal of Cell Science. 127, 10, p. 2377 1 p.

Research output: Contribution to journalArticle

Quantitative analysis of methylation defects and correlation with clinical characteristics in patients with pseudohypoparathyroidism type I and GNAS epigenetic alterations

Elli, F. M., De Sanctis, L., Bollati, V., Tarantini, L., Filopanti, M., Barbieri, A. M., Peverelli, E., Beck-Peccoz, P., Spada, A. & Mantovani, G., 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 3

Research output: Contribution to journalArticle

2013

cAMP in the pituitary: An old messenger for multiple signals

Peverelli, E., Mantovani, G., Lania, A. G. & Spada, A., Sep 18 2013, In : Journal of Molecular Endocrinology. 52, 1

Research output: Contribution to journalArticle

Deciphering the specific role of Gαi/o isoforms: Functional selective oxytocin ligands and somatostatin SST5 receptor mutants

Busnelli, M., Peverelli, E., Mantovani, G., Spada, A. & Chini, B., Feb 2013, In : Biochemical Society Transactions. 41, 1, p. 166-171 6 p.

Research output: Contribution to journalArticle

Somatostatin analogues increase AIP expression in somatotropinomas, irrespective of Gsp mutations

Jaffrain-Rea, M. L., Rotondi, S., Turchi, A., Occhi, G., Barlier, A., Peverelli, E., Rostomyan, L., Defilles, C., Angelini, M., Oliva, M. A., Ceccato, F., Maiorani, O., Dal, A. F., Esposito, V., Buttarelli, F., Figarella-Branger, D., Giangaspero, F., Spada, A., Scaroni, C., Alesse, E. & 1 others, Beckers, A., Oct 2013, In : Endocrine-Related Cancer. 20, 5, p. 753-766 14 p.

Research output: Contribution to journalArticle

Specific roles of Gi protein family members revealed by dissecting SST5 coupling in human pituitary cells

Peverelli, E., Busnelli, M., Vitali, E., Giardino, E., Galés, C., Lania, A. G., Beck-Peccoz, P., Chini, B., Mantovani, G. & Spada, A., Jan 2013, In : Journal of Cell Science. 126, 2, p. 638-644 7 p.

Research output: Contribution to journalArticle

2012

Filamin-A is essential for dopamine D2 receptor expression and signaling in tumorous lactotrophs

Peverelli, E., Mantovani, G., Vitali, E., Elli, F. M., Olgiati, L., Ferrero, S., Laws, E. R., Della Mina, P., Villa, A., Beck-Peccoz, P., Spada, A. & Lania, A. G., Mar 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 3, p. 967-977 11 p.

Research output: Contribution to journalArticle

2011
2010

Evolution of an aggressive prolactinoma into a growth hormone secreting pituitary tumor coincident with GNAS gene mutation

Lania, A. G., Ferrero, S., Pivonello, R., Mantovani, G., Peverelli, E., Di Sarno, A., Beck-Peccoz, P., Spada, A. & Colao, A., Jan 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 1, p. 13-17 5 p.

Research output: Contribution to journalArticle

Pseudohypoparathyroidism and GNAS epigenetic defects: Clinical evaluation of Albright hereditary osteodystrophy and molecular analysis in 40 patients

Mantovani, G., De Sanctis, L., Barbieri, A. M., Elli, F. M., Bollati, V., Vaira, V., Labarile, P., Bondioni, S., Peverelli, E., Lania, A. G., Beck-Peccoz, P. & Spada, A., Feb 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 2, p. 651-658 8 p.

Research output: Contribution to journalArticle

2009

Analysis of genetic variants of phosphodiesterase 11A in acromegalic patients

Peverelli, E., Ermetici, F., Filopanti, M., Elli, F. M., Ronchi, C. L., Mantovani, G., Ferrero, S., Bosari, S., Beck-Peccoz, P., Lania, A. & Spada, A., 2009, In : European Journal of Endocrinology. 161, 5, p. 687-694 8 p.

Research output: Contribution to journalArticle

Analysis of GNAS1 and PRKAR1A gene mutations in human cardiac myxomas not associated with multiple endocrine disorders.

Mantovani, G., Bondioni, S., Corbetta, S., Menicanti, L., Rubino, B., Peverelli, E., Labarile, P., Dall'Asta, C., Ambrosi, B., Beck-Peccoz, P., Lania, A. G. & Spada, A., Jun 2009, In : Journal of Endocrinological Investigation. 32, 6, p. 501-504 4 p.

Research output: Contribution to journalArticle

Peripheral insulin-like factor 3 concentrations are reduced in men with type 2 diabetes mellitus: Effect of glycemic control and visceral adiposity on Leydig cell function

Ermetici, F., Donadio, F., Iorio, L., Malavazos, A. E., Dolci, A., Peverelli, E., Barbieri, A. M., Morricone, L., Chiodini, I., Arosio, M., Lania, A., Beck-Peccoz, P., Ambrosi, B. & Corbetta, S., 2009, In : European Journal of Endocrinology. 161, 6, p. 853-859 7 p.

Research output: Contribution to journalArticle

2008

Different expression of protein kinase A (PKA) regulatory subunits in cortisol-secreting adrenocortical tumors: Relationship with cell proliferation

Mantovani, G., Lania, A. G., Bondioni, S., Peverelli, E., Pedroni, C., Ferrero, S., Pellegrini, C., Vicentini, L., Arnaldi, G., Bosari, S., Beck-Peccoz, P. & Spada, A., Jan 1 2008, In : Experimental Cell Research. 314, 1, p. 123-130 8 p.

Research output: Contribution to journalArticle

High expression of PKA regulatory subunit 1A protein is related to proliferation of human melanoma cells

Mantovani, G., Bondioni, S., Lania, A. G., Rodolfo, M., Peverelli, E., Polentarutti, N., Veliz Rodriguez, T., Ferrero, S., Bosari, S., Beck-Peccoz, P. & Spada, A., Mar 20 2008, In : Oncogene. 27, 13, p. 1834-1843 10 p.

Research output: Contribution to journalArticle

The third intracellular loop of the human somatostatin receptor 5 is crucial for arrestin binding and receptor internalization after somatostatin stimulation

Peverelli, E., Mantovani, G., Calebiro, D., Doni, A., Bondioni, S., Lania, A., Beck-Peccoz, P. & Spada, A., Mar 2008, In : Molecular Endocrinology. 22, 3, p. 676-688 13 p.

Research output: Contribution to journalArticle

2007

Evaluation of proopiomelanocortin mRNA in the peripheral blood from patients with Cushing's syndrome of different origin

Bondioni, S., Mantovani, G., Polentarutti, N., Ambrosi, B., Loli, P., Peverelli, E., Lania, A. G., Beck-Peccoz, P. & Spada, A., Nov 2007, In : Journal of Endocrinological Investigation. 30, 10, p. 828-832 5 p.

Research output: Contribution to journalArticle

2006

HESX1 expression in human normal pituitaries and pituitary adenomas

Mantovani, G., Asteria, C., Pellegrini, C., Bosari, S., Alberti, L., Bondioni, S., Peverelli, E., Spada, A. & Beck-Peccoz, P., Mar 9 2006, In : Molecular and Cellular Endocrinology. 247, 1-2, p. 135-139 5 p.

Research output: Contribution to journalArticle

Octreotide promotes apoptosis in human somatotroph tumor cells by activating somatostatin receptor type 2

Ferrante, E., Pellegrini, C., Bondioni, S., Peverelli, E., Locatelli, M., Gelmini, P., Luciani, P., Peri, A., Mantovani, G., Bosari, S., Beck-Peccoz, P., Spada, A. & Lania, A., Sep 2006, In : Endocrine-Related Cancer. 13, 3, p. 955-962 8 p.

Research output: Contribution to journalArticle