20082020

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Article
2020

Prevalence of cardiac amyloidosis among adult patients referred to tertiary centres with an initial diagnosis of hypertrophic cardiomyopathy

Maurizi, N., Rella, V., Fumagalli, C., Salerno, S., Castelletti, S., Dagradi, F., Torchio, M., Marceca, A., Meda, M., Gasparini, M., Boschi, B., Girolami, F., Parati, G., Olivotto, I., Crotti, L. & Cecchi, F., Feb 1 2020, In : International Journal of Cardiology. 300, p. 191-195 5 p.

Research output: Contribution to journalArticle

2019

Calmodulin mutations and life-threatening cardiac arrhythmias: Insights from the International Calmodulinopathy Registry

Crotti, L., Spazzolini, C., Tester, D. J., Ghidoni, A., Baruteau, A. E., Beckmann, B. M., Behr, E. R., Bennett, J. S., Bezzina, C. R., Bhuiyan, Z. A., Celiker, A., Cerrone, M., Dagradi, F., De Ferrari, G. M., Etheridge, S. P., Fatah, M., Garcia-Pavia, P., Al-Ghamdi, S., Hamilton, R. M., Al-Hassnan, Z. N. & 21 others, Horie, M., Jimenez-Jaimez, J., Kanter, R. J., Kaski, J. P., Kotta, M. C., Lahrouchi, N., Makita, N., Norrish, G., Odland, H. H., Ohno, S., Papagiannis, J., Parati, G., Sekarski, N., Tveten, K., Vatta, M., Webster, G., Wilde, A. A. M., Wojciak, J., George, A. L., Ackerman, M. J. & Schwartz, P. J., Sep 14 2019, In : European Heart Journal. 40, 35, p. 2964-2975A

Research output: Contribution to journalArticle

Mexiletine Shortens the QT Interval in Patients with Potassium Channel-Mediated Type 2 Long QT Syndrome

Bos, J. M., Crotti, L., Rohatgi, R. K., Castelletti, S., Dagradi, F., Schwartz, P. J. & Ackerman, M. J., May 1 2019, In : Circulation: Arrhythmia and Electrophysiology. 12, 5, e007280.

Research output: Contribution to journalArticle

Open Access
2018

Cardiac arrest and Brugada syndrome: Is drug-induced type 1 ECG pattern always a marker of low risk?

Delise, P., Allocca, G., Sitta, N., Migliore, F., Dagradi, F., Spazzolini, C., Sciarra, L., Carinci, V., Corrado, D., Calò, L. & Schwartz, P. J., Mar 1 2018, In : International Journal of Cardiology. 254, p. 142-145 4 p.

Research output: Contribution to journalArticle

For neonatal ECG screening there is no reason to relinquish old Bazett's correction

Stramba-Badiale, M., Karnad, D. R., Goulene, K. M., Panicker, G. K., Dagradi, F., Spazzolini, C., Kothari, S., Lokhandwala, Y. Y. & Schwartz, P. J., Aug 1 2018, In : European Heart Journal. 39, 31, p. 2888-2895 8 p.

Research output: Contribution to journalArticle

SCN5A mutations in 442 neonates and children: Genotype-phenotype correlation and identification of higher-risk subgroups

Baruteau, A. E., Kyndt, F., Behr, E. R., Vink, A. S., Lachaud, M., Joong, A., Schott, J. J., Horie, M., Denjoy, I., Crotti, L., Shimizu, W., Bos, J. M., Stephenson, E. A., Wong, L., Abrams, D. J., Davis, A. M., Winbo, A., Dubin, A. M., Sanatani, S., Liberman, L. & 30 others, Kaski, J. P., Rudic, B., Kwok, S. Y., Rieubland, C., Tfelt-Hansen, J., Van Hare, G. F., Guyomarc'h-Delasalle, B., Blom, N. A., Wijeyeratne, Y. D., Gourraud, J. B., Marec, H. L., Ozawa, J., Fressart, V., Lupoglazoff, J. M., Dagradi, F., Spazzolini, C., Aiba, T., Tester, D. J., Zahavich, L. A., Beauséjour-Ladouceur, V., Jadhav, M., Skinner, J. R., Franciosi, S., Krahn, A. D., Abdelsayed, M., Ruben, P. C., Yung, T. C., Ackerman, M. J., Wilde, A. A. & Schwartz, P. J., Aug 1 2018, In : European Heart Journal. 39, 31, p. 2879-2887 9 p.

Research output: Contribution to journalArticle

The genetics underlying idiopathic ventricular fibrillation: A special role for catecholaminergic polymorphic ventricular tachycardia?

Leinonen, J. T., Crotti, L., Djupsjöbacka, A., Castelletti, S., Junna, N., Ghidoni, A., Tuiskula, A. M., Spazzolini, C., Dagradi, F., Viitasalo, M., Kontula, K., Kotta, M. C., Widén, E., Swan, H. & Schwartz, P. J., Jan 1 2018, In : International Journal of Cardiology. 250, p. 139-145 7 p.

Research output: Contribution to journalArticle

2016

Impact of clinical and genetic findings on the management of young patients with Brugada syndrome

Andorin, A., Behr, E. R., Denjoy, I., Crotti, L., Dagradi, F., Jesel, L., Sacher, F., Petit, B., Mabo, P., Maltret, A., Wong, L. C. H., Degand, B., Bertaux, G., Maury, P., Dulac, Y., Delasalle, B., Gourraud, J. B., Babuty, D., Blom, N. A., Schwartz, P. J. & 2 others, Wilde, A. A. & Probst, V., Jun 1 2016, In : Heart Rhythm. 13, 6, p. 1274-1282 9 p.

Research output: Contribution to journalArticle

Management of survivors of cardiac arrest — the importance of genetic investigation

Schwartz, P. J. & Dagradi, F., Jul 7 2016, (Accepted/In press) In : Nature Reviews Cardiology.

Research output: Contribution to journalArticle

The genetics underlying acquired long QT syndrome: Impact for genetic screening

Itoh, H., Crotti, L., Aiba, T., Spazzolini, C., Denjoy, I., Fressart, V., Hayashi, K., Nakajima, T., Ohno, S., Makiyama, T., Wu, J., Hasegawa, K., Mastantuono, E., Dagradi, F., Pedrazzini, M., Yamagishi, M., Berthet, M., Murakami, Y., Shimizu, W., Guicheney, P. & 2 others, Schwartz, P. J. & Horie, M., May 7 2016, In : European Heart Journal. 37, 18, p. 1456-1464 9 p.

Research output: Contribution to journalArticle

The genetics underlying acquired long QT syndrome: Impact for genetic screening

Itoh, H., Crotti, L., Aiba, T., Spazzolini, C., Denjoy, I., Fressart, V., Hayashi, K., Nakajima, T., Ohno, S., Makiyama, T., Wu, J., Hasegawa, K., Mastantuono, E., Dagradi, F., Pedrazzini, M., Yamagishi, M., Berthet, M., Murakami, Y., Shimizu, W., Guicheney, P. & 2 others, Schwartz, P. J. & Horie, M., May 7 2016, In : European Heart Journal. 37, 18, p. 1456-1464 9 p.

Research output: Contribution to journalArticle

2015

Role of common and rare variants in SCN10A: Results from the Brugada syndrome QRS locus gene discovery collaborative study

Behr, E. R., Savio-Galimberti, E., Barc, J., Holst, A. G., Petropoulou, E., Prins, B. P., Jabbari, J., Torchio, M., Berthet, M., Mizusawa, Y., Yang, T., Nannenberg, E. A., Dagradi, F., Weeke, P., Bastiaenan, R., Ackerman, M. J., Haunso, S., Leenhardt, A., Kääb, S., Probst, V. & 12 others, Redon, R., Sharma, S., Wilde, A., Tfelt-Hansen, J., Schwartz, P., Roden, D. M., Bezzina, C. R., Olesen, M., Darbar, D., Guicheney, P., Crotti, L. & Jamshidi, Y., Jun 1 2015, In : Cardiovascular Research. 106, 3, p. 520-529 10 p.

Research output: Contribution to journalArticle

2014

A comprehensive electrocardiographic, molecular, and echocardiographic study of Brugada syndrome: Validation of the 2013 diagnostic criteria

Savastano, S., Rordorf, R., Vicentini, A., Petracci, B., Taravelli, E., Castelletti, S., D'Errico, A., Torchio, M., Dossena, C., Novara, P., Dagradi, F., Landolina, M., Spazzolini, C., Crotti, L. & Schwartz, P. J., 2014, In : Heart Rhythm. 11, 7, p. 1176-1183 8 p.

Research output: Contribution to journalArticle

Characterization of SEMA3A-encoded semaphorin as a naturally occurring Kv4.3 protein inhibitor and its contribution to Brugada syndrome

Boczek, N. J., Ye, D., Johnson, E. K., Wang, W., Crotti, L., Tester, D. J., Dagradi, F., Mizusawa, Y., Torchio, M., Alders, M., Giudicessi, J. R., Wilde, A. A. M., Schwartz, P. J., Nerbonne, J. M. & Ackerman, M. J., Aug 1 2014, In : Circulation Research. 115, 4, p. 460-469 10 p.

Research output: Contribution to journalArticle

2013

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

Bezzina, C. R., Barc, J., Mizusawa, Y., Remme, C. A., Gourraud, J. B., Simonet, F., Verkerk, A. O., Schwartz, P. J., Crotti, L., Dagradi, F., Guicheney, P., Fressart, V., Leenhardt, A., Antzelevitch, C., Bartkowiak, S., Schulze-Bahr, E., Zumhagen, S., Behr, E. R., Bastiaenen, R., Tfelt-Hansen, J. & 43 others, Olesen, M. S., Kääb, S., Beckmann, B. M., Weeke, P., Watanabe, H., Endo, N., Minamino, T., Horie, M., Ohno, S., Hasegawa, K., Makita, N., Nogami, A., Shimizu, W., Aiba, T., Froguel, P., Balkau, B., Lantieri, O., Torchio, M., Wiese, C., Weber, D., Wolswinkel, R., Coronel, R., Boukens, B. J., Bézieau, S., Charpentier, E., Chatel, S., Despres, A., Gros, F., Kyndt, F., Lecointe, S., Lindenbaum, P., Portero, V., Violleau, J., Gessler, M., Tan, H. L., Roden, D. M., Christoffels, V. M., Le Marec, H., Wilde, A. A., Probst, V., Schott, J. J., Dina, C. & Redon, R., Sep 2013, In : Nature Genetics. 45, 9, p. 1044-1049 6 p.

Research output: Contribution to journalArticle

Condizioni cliniche associate ad anomalie dell'intervallo QT: Implicazioni cliniche

Translated title of the contribution: Clinical conditions associated with abnormalities of the QT interval: Clinical implicationsCrotti, L., Dossena, C., Mastantuono, E., Dagradi, F. & Schwartz, P. J., Jan 2013, In : Giornale Italiano di Cardiologia. 14, 1, p. 55-65 11 p.

Research output: Contribution to journalArticle

Erratum: Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death (Nature Genetics (2013) 45 (1044-1049))

Bezzina, C. R., Barc, J., Mizusawa, Y., Remme, C. A., Gourraud, J. B., Simonet, F., Verkerk, A. O., Schwartz, P. J., Crotti, L., Dagradi, F., Guicheney, P., Fressart, V., Leenhardt, A., Antzelevitch, C., Bartkowiak, S., Schulze-Bahr, E., Zumhagen, S., Behr, E. R., Bastiaenen, R., Tfelt-Hansen, J. & 43 others, Olesen, M. S., Kääb, S., Beckmann, B. M., Weeke, P., Watanabe, H., Endo, N., Minamino, T., Horie, M., Ohno, S., Hasegawa, K., Makita, N., Nogami, A., Shimizu, W., Aiba, T., Froguel, P., Balkau, B., Lantieri, O., Torchio, M., Wiese, C., Weber, D., Wolswinkel, R., Coronel, R., Boukens, B. J., Bézieau, S., Charpentier, E., Chatel, S., Despres, A., Gros, F., Kyndt, F., Lecointe, S., Lindenbaum, P., Portero, V., Violleau, J., Gessler, M., Tan, H. L., Roden, D. M., Christoffels, V. M., Le Marec, H., Wilde, A. A., Probst, V., Schott, J. J., Dina, C. & Redon, R., Nov 2013, In : Nature Genetics. 45, 11, p. 1409 1 p.

Research output: Contribution to journalArticle

FGF12 is a candidate Brugada syndrome locus

Hennessey, J. A., Marcou, C. A., Wang, C., Wei, E. Q., Wang, C., Tester, D. J., Torchio, M., Dagradi, F., Crotti, L., Schwartz, P. J., Ackerman, M. J. & Pitt, G. S., Dec 2013, In : Heart Rhythm. 10, 12, p. 1886-1894 9 p.

Research output: Contribution to journalArticle

Identification of a KCNQ1 polymorphism acting as a protective modifier against arrhythmic risk in long-QT syndrome

Duchatelet, S., Crotti, L., Peat, R. A., Denjoy, I., Itoh, H., Berthet, M., Ohno, S., Fressart, V., Monti, M. C., Crocamo, C., Pedrazzini, M., Dagradi, F., Vicentini, A., Klug, D., Brink, P. A., Goosen, A., Swan, H., Toivonen, L., Lahtinen, A. M., Kontula, K. & 6 others, Shimizu, W., Horie, M., George, A. L., Trégouët, D. A., Guicheney, P. & Schwartz, P. J., Aug 2013, In : Circulation: Cardiovascular Genetics. 6, 4, p. 354-361 8 p.

Research output: Contribution to journalArticle

2012

Spectrum and prevalence of mutations involving BrS1- Through BrS12-susceptibility genes in a cohort of unrelated patients referred for brugada syndrome genetic testing: Implications for genetic testing

Crotti, L., Marcou, C. A., Tester, D. J., Castelletti, S., Giudicessi, J. R., Torchio, M., Medeiros-Domingo, A., Simone, S., Will, M. L., Dagradi, F., Schwartz, P. J. & Ackerman, M. J., Oct 9 2012, In : Journal of the American College of Cardiology. 60, 15, p. 1410-1418 9 p.

Research output: Contribution to journalArticle

Torsades de pointes following acute myocardial infarction: Evidence for a deadly link with a common genetic variant

Crotti, L., Hu, D., Barajas-Martinez, H., De Ferrari, G. M., Oliva, A., Insolia, R., Pollevick, G. D., Dagradi, F., Guerchicoff, A., Greco, F., Schwartz, P. J., Viskin, S. & Antzelevitch, C., Jul 2012, In : Heart Rhythm. 9, 7, p. 1104-1112 9 p.

Research output: Contribution to journalArticle

Vagal reflexes following an exercise stress test: A simple clinical tool for gene-specific risk stratification in the long QT syndrome

Crotti, L., Spazzolini, C., Porretta, A. P., Dagradi, F., Taravelli, E., Petracci, B., Vicentini, A., Pedrazzini, M., La Rovere, M. T., Vanoli, E., Goosen, A., Heradien, M., George, A. L., Brink, P. A. & Schwartz, P. J., Dec 18 2012, In : Journal of the American College of Cardiology. 60, 24, p. 2515-2524 10 p.

Research output: Contribution to journalArticle

2009

A KCNH2 branch point mutation causing aberrant splicing contributes to an explanation of genotype-negative long QT syndrome

Crotti, L., Lewandowska, M. A., Schwartz, P. J., Insolia, R., Pedrazzini, M., Bussani, E., Dagradi, F., George, A. L. & Pagani, F., Feb 2009, In : Heart Rhythm. 6, 2, p. 212-218 7 p.

Research output: Contribution to journalArticle

Novel human pathological mutations. Gene symbol: SCN5A. Disease: Brugada Syndrome.

Crotti, L., Pedrazzini, M., Insolia, R., Cuoretti, A., Ghidoni, A., Dagradi, F., Taravelli, E., Chieffo, E., Vicentini, A. & Schwartz, P. J., Aug 2009, In : Human Genetics. 126, 2, p. 339 1 p.

Research output: Contribution to journalArticle

2008

Congenital long QT syndrome

Crotti, L., Celano, G., Dagradi, F. & Schwartz, P. J., 2008, In : Orphanet Journal of Rare Diseases. 3, 1, 18.

Research output: Contribution to journalArticle

Gene symbol: KCNQ1. Disease: Long QT syndrome.

Crotti, L., Ferrandi, C., Pedrazzini, M., Insolia, R., Cuoretti, A., Celano, G., Dagradi, F., Stramba-Badiale, M. & Schwartz, P. J., Jun 2008, In : Human Genetics. 123, 5, p. 543 1 p.

Research output: Contribution to journalArticle

Gene symbol: SCN5A. Disease: Brugada syndrome.

Crotti, L., Ferrandi, C., Pedrazzini, M., Insolia, R., Cuoretti, A., Sanzo, A., Dagradi, F., De Ferrari, G. M. & Schwartz, P. J., Jun 2008, In : Human Genetics. 123, 5, p. 542 1 p.

Research output: Contribution to journalArticle

Gene symbol: KCNH2. Disease: Long QT syndrome.

Crotti, L., Crotti, L., Pedrazzini, M., Insolia, R., Ferrandi, C., Cuoretti, A., Gandolfi, E., Celano, G., Dagradi, F. & Schwartz, P. J., Jun 2008, In : Human Genetics. 123, 5, p. 540 1 p.

Research output: Contribution to journalArticle

Gene symbol: KCNQ1. Disease: Long QT syndrome.

Crotti, L., Insolia, R., Ferrandi, C., Pedrazzini, M., Cuoretti, A., Gandolfi, E., Sanzo, A., Dagradi, F. & Schwartz, P. J., Jun 2008, In : Human Genetics. 123, 5, p. 541 1 p.

Research output: Contribution to journalArticle