• 7591 Citations
  • 20 h-Index
20002019
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Research Output 2000 2019

  • 7591 Citations
  • 20 h-Index
  • 26 Article
  • 2 Chapter
  • 1 Review article
2019
Open Access
Amyloidosis
Tissue
Inflammation
Cell death
Cell Death
2016
20 Citations (Scopus)

HMGB1 Inhibits Apoptosis Following MI and Induces Autophagy via mTORC1 Inhibition

Foglio, E., Puddighinu, G., Germani, A., Russo, M. A. & Limana, F., 2016, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

HMGB1 Protein
Autophagy
Myocardial Infarction
Apoptosis
Cardiac Myocytes

HMGB1 Inhibits Apoptosis Following MI and Induces Autophagy via mTORC1 Inhibition

Foglio, E., Puddighinu, G., Germani, A., Russo, M. A. & Limana, F., 2016, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

HMGB1 Protein
Autophagy
Myocardial Infarction
Apoptosis
Cardiac Myocytes
90 Citations (Scopus)

The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression

Tafani, M., Sansone, L., Limana, F., Arcangeli, T., De Santis, E., Polese, M., Fini, M. & Russo, M. A., 2016, In : Oxidative Medicine and Cellular Longevity. 2016, 3907147.

Research output: Contribution to journalArticle

Sirtuins
Tumors
Reactive Oxygen Species
Inflammation
Neoplasms
2015
33 Citations (Scopus)

Exosomal clusterin, identified in the pericardial fluid, improves myocardial performance following MI through epicardial activation, enhanced arteriogenesis and reduced apoptosis

Foglio, E., Puddighinu, G., Fasanaro, P., D'Arcangelo, D., Perrone, G. A., Mocini, D., Campanella, C., Coppola, L., Logozzi, M., Azzarito, T., Marzoli, F., Fais, S., Pieroni, L., Marzano, V., Germani, A., Capogrossi, M. C., Russo, M. A. & Limana, F., Aug 5 2015, In : International Journal of Cardiology. 197, p. 333-347 15 p., 20664.

Research output: Contribution to journalArticle

Clusterin
Exosomes
Myocardial Infarction
Apoptosis
Epithelial-Mesenchymal Transition
14 Citations (Scopus)

Generation of cardiac progenitor cells through epicardial to mesenchymal transition

Germani, A., Foglio, E., Capogrossi, M. C., Russo, M. A. & Limana, F., Jul 22 2015, In : Journal of Molecular Medicine. 93, 7, p. 735-748 14 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Stem Cells
Biological Phenomena
Cardiac Myocytes
Smooth Muscle Myocytes
11 Citations (Scopus)

One special question to start with: Can HIF/NFkB be a target in inflammation?

Russo, M. A., Sansone, L., Carnevale, I., Limana, F., Runci, A., Polletta, L., Perrone, G. A., De Santis, E. D. & Tafani, M., Sep 1 2015, In : Endocrine, Metabolic and Immune Disorders - Drug Targets. 15, 3, p. 171-185 15 p.

Research output: Contribution to journalArticle

Inflammation
Cell Hypoxia
Innate Immunity
Neurodegenerative Diseases
Genes
2013
21 Citations (Scopus)

Transcriptional profiling of Hmgb1-induced myocardial repair identifies a key role for notch signaling

Limana, F., Esposito, G., Fasanaro, P., Foglio, E., Arcelli, D., Voellenkle, C., Di Carlo, A., Avitabile, D., Martelli, F., Antonio Russo, M., Pompilio, G., Germani, A. & Capogrossi, M. C., Oct 2013, In : Molecular Therapy. 21, 10, p. 1841-1851 11 p.

Research output: Contribution to journalArticle

HMGB1 Protein
Regeneration
Software
Myocardial Infarction
Notch Receptors
2011
84 Citations (Scopus)

HMGB1 attenuates cardiac remodelling in the failing heart via enhanced cardiac regeneration and miR-206-mediated inhibition of TIMP-3

Limana, F., Esposito, G., D'Arcangelo, D., Di Carlo, A., Romani, S., Melillo, G., Mangoni, A., Bertolami, C., Pompilio, G., Germani, A. & Capogrossi, M. C., 2011, In : PLoS One. 6, 6, e19845.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-3
HMGB1 Protein
Regeneration
heart
mice
59 Citations (Scopus)

The epicardium in cardiac repair: From the stem cell view

Limana, F., Capogrossi, M. C. & Germani, A., Jan 2011, In : Pharmacology and Therapeutics. 129, 1, p. 82-96 15 p.

Research output: Contribution to journalArticle

Pericardium
Stem Cells
Cardiac Myocytes
Blood Vessels
Cell Biology
2010
505 Citations (Scopus)

Circulating microRNAs are new and sensitive biomarkers of myocardial infarction

D'Alessandra, Y., Devanna, P., Limana, F., Straino, S., Di Carlo, A., Brambilla, P. G., Rubino, M., Carena, M. C., Spazzafumo, L., De Simone, M., Micheli, B., Biglioli, P., Achilli, F., Martelli, F., Maggiolini, S., Marenzi, G., Pompilio, G. & Capogrossi, M. C., Nov 2010, In : European Heart Journal. 31, 22, p. 2765-2773 9 p.

Research output: Contribution to journalArticle

MicroRNAs
Biomarkers
Myocardial Infarction
Troponin I
Percutaneous Coronary Intervention
101 Citations (Scopus)

Myocardial infarction induces embryonic reprogramming of epicardial c-kit+ cells: Role of the pericardial fluid

Limana, F., Bertolami, C., Mangoni, A., Di Carlo, A., Avitabile, D., Mocini, D., Iannelli, P., De Mori, R., Marchetti, C., Pozzoli, O., Gentili, C., Zacheo, A., Germani, A. & Capogrossi, M. C., Apr 2010, In : Journal of Molecular and Cellular Cardiology. 48, 4, p. 609-618 10 p.

Research output: Contribution to journalArticle

Pericardium
Myocardial Infarction
Cell Proliferation
Embryonic Development
Stem Cells
2007
3 Citations (Scopus)

Activation of the Local Regenerative System of the Heart

Germani, A., Limana, F. & Capogrossi, M. C., Nov 12 2007, Cardiovascular Regeneration and Stem Cell Therapy. Blackwell Publishing Ltd, p. 95-102 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

176 Citations (Scopus)

Identification of myocardial and vascular precursor cells in human and mouse epicardium

Limana, F., Zacheo, A., Mocini, D., Mangoni, A., Borsellino, G., Diamantini, A., De Mori, R., Battistini, L., Vigna, E., Santini, M., Loiaconi, V., Pompilio, G., Germani, A. & Capogrossi, M. C., Dec 2007, In : Circulation Research. 101, 12, p. 1255-1265 11 p.

Research output: Contribution to journalArticle

Pericardium
Blood Vessels
Myocardial Infarction
Smooth Muscle Myocytes
Stem Cells
13 Citations (Scopus)

Molecular mechanisms of cardiomyocyte regeneration and therapeutic outlook

Germani, A., Di Rocco, G., Limana, F., Martelli, F. & Capogrossi, M. C., Mar 2007, In : Trends in Molecular Medicine. 13, 3, p. 125-133 9 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Regeneration
Vertebrates
Stem Cells
Adult Stem Cells
48 Citations (Scopus)

Pivotal Advance: High-mobility group box 1 protein - A cytokine with a role in cardiac repair

Germani, A., Limana, F. & Capogrossi, M. C., Jan 2007, In : Journal of Leukocyte Biology. 81, 1, p. 41-45 5 p.

Research output: Contribution to journalArticle

Staphylococcal Protein A
Cytokines
Stem Cells
Myocardial Infarction
Nuclear Proteins
2006
16 Citations (Scopus)

Cyclo-oxygenase-2 (COX-2) inhibition reduces apoptosis in acute myocardial infarction

Abbate, A., Limana, F., Capogrossi, M. C., Santini, D., Biondi-Zoccai, G. G. L., Scarpa, S., Germani, A., Straino, S., Severino, A., Vasaturo, F., Campioni, M., Liuzzo, G., Crea, F., Vetrovec, G. W., Biasucci, L. M. & Baldi, A., Jun 2006, In : Apoptosis. 11, 6, p. 1061-1063 3 p.

Research output: Contribution to journalArticle

2005
433 Citations (Scopus)

Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival

Urbanek, K., Rota, M., Cascapera, S., Bearzi, C., Nascimbene, A., De Angelis, A., Hosoda, T., Chimenti, S., Baker, M., Limana, F., Nurzynska, D., Torella, D., Rotatori, F., Rastaldo, R., Musso, E., Quaini, F., Leri, A., Kajstura, J. & Anversa, P., Sep 30 2005, In : Circulation Research. 97, 7, p. 663-673 11 p.

Research output: Contribution to journalArticle

Ventricular Function
Growth Factor Receptors
Myocardium
Stem Cells
Hepatocyte Growth Factor
260 Citations (Scopus)

Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarction via enhanced cardiac C-kit+ cell proliferation and differentiation.

Limana, F., Germani, A., Zacheo, A., Kajstura, J., Di Carlo, A., Borsellino, G., Leoni, O., Palumbo, R., Battistini, L., Rastaldo, R., Müller, S., Pompilio, G., Anversa, P., Bianchi, M. E. & Capogrossi, M. C., Oct 14 2005, Circulation research.. 8 ed. Vol. 97.

Research output: Chapter in Book/Report/Conference proceedingChapter

HMGB1 Protein
Infarction
Regeneration
Cell Differentiation
Cell Proliferation
2003
207 Citations (Scopus)

Ablation of telomerase and telomere loss leads to cardiac dilatation and heart failure associated with p53 upregulation

Leri, A., Franco, S., Zacheo, A., Barlucchi, L., Chimenti, S., Limana, F., Nadal-Ginard, B., Kajstura, J., Anversa, P. & Blasco, M. A., Jan 2 2003, In : EMBO Journal. 22, 1, p. 131-139 9 p.

Research output: Contribution to journalArticle

Telomere Shortening
Telomerase
Telomere
Ablation
Cardiac Myocytes
2743 Citations (Scopus)

Adult cardiac stem cells are multipotent and support myocardial regeneration

Beltrami, A. P., Barlucchi, L., Torella, D., Baker, M., Limana, F., Chimenti, S., Kasahara, H., Rota, M., Musso, E., Urbanek, K., Leri, A., Kajstura, J., Nadal-Ginard, B. & Anversa, P., Sep 19 2003, In : Cell. 114, 6, p. 763-776 14 p.

Research output: Contribution to journalArticle

Adult Stem Cells
Stem cells
Regeneration
Muscle Cells
Endothelial cells
2002
80 Citations (Scopus)

Bcl-2 overexpression promotes myocyte proliferation

Limana, F., Urbanek, K., Chimenti, S., Quaini, F., Leri, A., Kajstura, J., Nadal-Ginard, B., Izumo, S. & Anversa, P., Apr 30 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 9, p. 6257-6262 6 p.

Research output: Contribution to journalArticle

Muscle Cells
Transgenic Mice
Cell Nucleus Division
Developmental Biology
Spindle Apparatus
121 Citations (Scopus)

Cardiac-specific IGF-1 expression attenuates dilated cardiomyopathy in tropomodulin-overexpressing transgenic mice

Welch, S., Plank, D., Witt, S., Glascock, B., Schaefer, E., Chimenti, S., Andreoli, A. M., Limana, F., Leri, A., Kajstura, J., Anversa, P. & Sussman, M. A., Apr 5 2002, In : Circulation Research. 90, 6, p. 641-648 8 p.

Research output: Contribution to journalArticle

Tropomodulin
Dilated Cardiomyopathy
Somatomedins
Transgenic Mice
Heart Failure
2001
15 Citations (Scopus)

CHF-1024, a DA 22 agonist, blunts norepinephrine excretion and cardiac fibrosis in pressure overload

Masson, S., Chimenti, S., Salio, M., Torri, M., Limana, F., Bernasconi, R., Calvillo, L., Santambrogio, D., Gagliano, N., Arosio, B., Annoni, G., Razzetti, R., Bongrani, S. & Latini, R., 2001, In : Cardiovascular Drugs and Therapy. 15, 2, p. 131-138 8 p.

Research output: Contribution to journalArticle

Norepinephrine
Fibrosis
Pressure
Captopril
Adrenergic Agonists
231 Citations (Scopus)

Hyperglycemia Activates p53 and p53-Regulated Genes Leading to Myocyte Cell Death

Fiordaliso, F., Leri, A., Cesselli, D., Limana, F., Safai, B., Nadal-Ginard, B., Anversa, P. & Kajstura, J., Oct 2001, In : Diabetes. 50, 10, p. 2363-2375 13 p.

Research output: Contribution to journalArticle

p53 Genes
Angiotensin II
Hyperglycemia
Muscle Cells
Cell Death
303 Citations (Scopus)

IGF-1 0verexpression inhibits the development of diabetic cardiomyopathy and angiotensin II-mediated oxidative stress

Kajstura, J., Fiordaliso, F., Andreoli, A. M., Li, B., Chimenti, S., Medow, M. S., Limana, F., Nadal-Ginard, B., Leri, A. & Anversa, P., 2001, In : Diabetes. 50, 6, p. 1414-1424 11 p.

Research output: Contribution to journalArticle

Diabetic Cardiomyopathies
Insulin-Like Growth Factor I
Angiotensin II
Muscle Cells
Oxidative Stress
1858 Citations (Scopus)

Mobilized bone marrow cells repair the infarcted heart, improving function and survival

Orlic, D., Kajstura, J., Chimenti, S., Limana, F., Jakoniuk, I., Quaini, F., Nadal-Ginard, B., Bodine, D. M., Leri, A. & Anversa, P., Aug 28 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 18, p. 10344-10349 6 p.

Research output: Contribution to journalArticle

Bone Marrow Cells
Cytokines
Muscle Cells
Regeneration
Myocardium
85 Citations (Scopus)

Telomerase expression and activity are coupled with myocyte proliferation and preservation of telomeric length in the failing heart

Leri, A., Barlucchi, L., Limana, F., Deptala, A., Darzynkiewicz, Z., Hintze, T. H., Kajstura, J., Nadal-Ginard, B. & Anversa, P., Jul 17 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 15, p. 8626-8631 6 p.

Research output: Contribution to journalArticle

Telomerase
Muscle Cells
Ventricular Dysfunction
Dilated Cardiomyopathy
Cardiomegaly
2000
61 Citations (Scopus)

Inhibition of p53 function prevents renin-angiotensin system activation and stretch-mediated myocyte apoptosis

Leri, A., Fiordaliso, F., Setoguchi, M., Limana, F., Bishopric, N. H., Kajstura, J., Webster, K. & Anversa, P., 2000, In : American Journal of Pathology. 157, 3, p. 843-857 15 p.

Research output: Contribution to journalArticle

Renin-Angiotensin System
Muscle Cells
Apoptosis
Angiotensin II
Angiotensinogen