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Research Output 2000 2020

2020

Modulation of Pro-Oxidant and Pro-Inflammatory Activities of M1 Macrophages by the Natural Dipeptide Carnosine

Fresta, C. G., Fidilio, A., Lazzarino, G., Musso, N., Grasso, M., Merlo, S., Amorini, A. M., Bucolo, C., Tavazzi, B., Lazzarino, G., Lunte, S. M., Caraci, F. & Caruso, G., Jan 25 2020, In : International Journal of Molecular Sciences. 21, 3

Research output: Contribution to journalArticle

Open Access
Carnosine
macrophages
Dipeptides
Macrophages
Oxidants
2019

Adherence to the Mediterranean Diet is Associated with Better Sleep Quality in Italian Adults

Godos, J., Ferri, R., Caraci, F., Cosentino, F. I. I., Castellano, S., Galvano, F. & Grosso, G., Apr 28 2019, In : Nutrients. 11, 5

Research output: Contribution to journalArticle

Open Access
Mediterranean Diet
Mediterranean diet
sleep
Sleep
Weights and Measures

Blood-based systems biology biomarkers for next-generation clinical trials in Alzheimer's disease


Hampel, H., Vergallo, A., Afshar, M., Akman-Anderson, L., Arenas, J., Benda, N., Batrla, R., Broich, K., Caraci, F., Cuello, A. C., Emanuele, E., Haberkamp, M., Kiddle, S. J., Lucía, A., Mapstone, M., Verdooner, S. R., Woodcock, J. & Lista, S., Jan 1 2019, In : Dialogues in Clinical Neuroscience. 21, 2, p. 177-191 15 p.

Research output: Contribution to journalArticle

Systems Biology
Alzheimer Disease
Biomarkers
Clinical Trials
Nonlinear Dynamics

Brain Aβ load association and sexual dimorphism of plasma BACE1 concentrations in cognitively normal individuals at risk for AD

the INSIGHT-preAD study group & Alzheimer Precision Medicine Initiative (APMI), Oct 1 2019, In : Alzheimer's and Dementia. 15, 10, p. 1274-1285 12 p.

Research output: Contribution to journalArticle

Open Access
Sex Characteristics
Brain
Alzheimer Disease
Biomarkers
Apolipoprotein E4

Carnosine decreases PMA-induced oxidative stress and inflammation in murine macrophages

Caruso, G., Fresta, C. G., Fidilio, A., O'donnell, F., Musso, N., Lazzarino, G., Grasso, M., Amorini, A. M., Tascedda, F., Bucolo, C., Drago, F., Tavazzi, B., Lazzarino, G., Lunte, S. M. & Caraci, F., Aug 1 2019, In : Antioxidants. 8, 8, 281.

Research output: Contribution to journalArticle

Open Access
Carnosine
Oxidative stress
Macrophages
Acetates
Oxidative Stress

Carnosine Prevents Aβ-Induced Oxidative Stress and Inflammation in Microglial Cells: A Key Role of TGF-β1

Caruso, G., Fresta, C. G., Musso, N., Giambirtone, M., Grasso, M., Spampinato, S. F., Merlo, S., Drago, F., Lazzarino, G., Sortino, M. A., Lunte, S. M. & Caraci, F., Jan 17 2019, In : Cells. 8, 1

Research output: Contribution to journalArticle

Carnosine
Oxidative stress
Oxidative Stress
Inflammation
Oligomers

Dietary Inflammatory Index and Sleep Quality in Southern Italian Adults

Godos, J., Ferri, R., Caraci, F., Cosentino, F. I. I., Castellano, S., Shivappa, N., Hebert, J. R., Galvano, F. & Grosso, G., Jun 13 2019, In : Nutrients. 11, 6

Research output: Contribution to journalArticle

Open Access
sleep
Sleep
Diet
odds ratio
inflammation

Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease

INSIGHT-preAD study group & Alzheimer Precision Medicine Initiative (APMI), Jul 1 2019, In : Alzheimer's and Dementia. 15, 7, p. 940-950 11 p.

Research output: Contribution to journalArticle

Apolipoprotein E4
Amyloid
Alzheimer Disease
Brain
Frontal Lobe

Fluoxetine and vortioxetine reverse depressive-like phenotype and memory deficits induced by Aβ1-42 oligomers in mice: A key role of transforming growth factor-β1

Torrisi, S. A., Geraci, F., Tropea, M. R., Grasso, M., Caruso, G., Fidilio, A., Musso, N., Sanfilippo, G., Tascedda, F., Palmeri, A., Salomone, S., Drago, F., Puzzo, D., Leggio, G. M. & Caraci, F., Jan 1 2019, In : Frontiers in Pharmacology. 10, JUN, 693.

Research output: Contribution to journalArticle

Open Access
Fluoxetine
Memory Disorders
Transforming Growth Factors
Amyloid
Antidepressive Agents

Impairment of quality of life associated with lifetime diagnosis of posttraumatic stress disorder in women-a national survey in italy

Sancassiani, F., Carmassi, C., Romano, F., Balestrieri, M., Caraci, F., Sciascio, G. D., Drago, F., Faravelli, C., Hardoy, M. C., Moro, M. F., Roncone, R., Preti, A. & Dell’osso, L., Jan 1 2019, In : Clinical Practice and Epidemiology in Mental Health. 15, 1, p. 38-43 6 p.

Research output: Contribution to journalArticle

Open Access
Post-Traumatic Stress Disorders
Italy
Quality of Life
Major Depressive Disorder
Mood Disorders

Inflammation as the common biological link between depression and cardiovascular diseases: Can carnosine exert a protective role?

Caruso, G., Fresta, C. G., Grasso, M., Santangelo, R., Lazzarino, G., Lunte, S. M. & Caraci, F., Jul 11 2019, In : Current Medicinal Chemistry.

Research output: Contribution to journalArticle

Carnosine
Cardiovascular Diseases
Inflammation
Macrophages
Dipeptides

Rescue of noradrenergic system as a novel pharmacological strategy in the treatment of chronic pain: Focus on microglia activation

Caraci, F., Merlo, S., Drago, F., Caruso, G., Parenti, C. & Sortino, M. A., Jan 1 2019, In : Frontiers in Pharmacology. 10, SEP, 1024.

Research output: Contribution to journalReview article

Open Access
Microglia
Chronic Pain
Hyperalgesia
Pharmacology
Analgesia

Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain

Vicario, N., Pasquinucci, L., Spitale, F. M., Chiechio, S., Turnaturi, R., Caraci, F., Tibullo, D., Avola, R., Gulino, R., Parenti, R. & Parenti, C., Jan 1 2019, In : Molecular Neurobiology.

Research output: Contribution to journalArticle

Connexin 43
delta Opioid Receptor
mu Opioid Receptor
Hyperalgesia
Neuralgia

Simultaneous targeting of MOR/DOR: A useful strategy for inflammatory pain modulation

Pasquinucci, L., Turnaturi, R., Montenegro, L., Caraci, F., Chiechio, S. & Parenti, C., Mar 15 2019, In : European Journal of Pharmacology. 847, p. 97-102 6 p.

Research output: Contribution to journalArticle

Analgesics
Pain
Narcotic Antagonists
Pain Measurement
Central Nervous System Sensitization

Targeting mGlu receptors for optimization of antipsychotic activity and disease-modifying effect in schizophrenia

Nicoletti, F., Orlando, R., Menna, L. D., Cannella, M., Notartomaso, S., Mascio, G., Iacovelli, L., Matrisciano, F., Fazio, F., Caraci, F., Copani, A., Battaglia, G. & Bruno, V., Jan 1 2019, In : Frontiers in Psychiatry. 10, FEB, 49.

Research output: Contribution to journalArticle

Open Access
Metabotropic Glutamate Receptors
Antipsychotic Agents
Schizophrenia
Animal Models
Pharmaceutical Preparations

The many faces of mitochondrial dysfunction in depression: From pathology to treatment

Caruso, G., Benatti, C., Blom, J. M. C., Caraci, F. & Tascedda, F., Jan 1 2019, In : Frontiers in Pharmacology. 10, SEP, 995.

Research output: Contribution to journalReview article

Open Access

The prevalence of specific phobia by age in an italian nationwide survey: How much does it affect the quality of life?

Sancassiani, F., Romano, F., Balestrieri, M., Caraci, F., Di Sciascio, G., Drago, F., Hardoy, M. C., Moro, M. F., Roncone, R., Piras, M., Preti, A., Dell’osso, L., Faravelli, C. & Carta, M. G., Jan 1 2019, In : Clinical Practice and Epidemiology in Mental Health. 15, 1, p. 30-37 8 p.

Research output: Contribution to journalArticle

Open Access
Quality of Life
Interviews
Anxiety Disorders
Psychiatry
Surveys and Questionnaires

β-amyloid and oxidative stress: Perspectives in drug development

Caruso, G., Spampinato, S. F., Cardaci, V., Caraci, F., Sortino, M. A. & Merlo, S., Jan 1 2019, In : Current Pharmaceutical Design. 25, 45, p. 4771-4781 11 p.

Research output: Contribution to journalReview article

Amyloid
Oxidative Stress
Serum Amyloid A Protein
Aptitude
Neuroglia
2018

Clinically Relevant Drug Interactions with Anti-Alzheimer's Drugs

Caraci, F., Sultana, J., Drago, F. & Spina, E., 2018, In : CNS and Neurological Disorders - Drug Targets. 16, 4, p. 501-513 13 p.

Research output: Contribution to journalArticle

Drug Interactions
Pharmaceutical Preparations
Galantamine
Memantine
Alzheimer Disease

International union of basic and clinical pharmacology CIV: The neurobiology of treatment-resistant depression: From antidepressant classifications to novel pharmacological targets

Caraci, F., Calabrese, F., Molteni, R., Bartova, L., Dold, M., Leggio, G. M., Fabbri, C., Mendlewicz, J., Racagni, G., Kasper, S., Riva, M. A. & Drago, F., Jul 1 2018, In : Pharmacological Reviews. 70, 3, p. 475-504 30 p.

Research output: Contribution to journalReview article

Treatment-Resistant Depressive Disorder
Neurobiology
Clinical Pharmacology
Antidepressive Agents
Pharmacology

Metabotropic glutamate receptors in glial cells: A new potential target for neuroprotection?

Spampinato, S. F., Copani, A., Nicoletti, F., Sortino, M. A. & Caraci, F., Nov 13 2018, In : Frontiers in Molecular Neuroscience. 11, 414.

Research output: Contribution to journalReview article

Metabotropic Glutamate Receptors
Neuroglia
Neurodegenerative Diseases
Oligodendroglia
Microglia

Neurobiological links between depression and AD: The role of TGF-β1 signaling as a new pharmacological target

Caraci, F., Spampinato, S. F., Morgese, M. G., Tascedda, F., Salluzzo, M. G., Giambirtone, M. C., Caruso, G., Munafò, A., Torrisi, S. A., Leggio, G. M., Trabace, L., Nicoletti, F., Drago, F., Sortino, M. A. & Copani, A., Jan 1 2018, (Accepted/In press) In : Pharmacological Research.

Research output: Contribution to journalArticle

Transforming Growth Factors
Alzheimer Disease
Pharmacology
Depression
Serotonin Uptake Inhibitors

Non-toxic engineered carbon nanodiamond concentrations induce oxidative/nitrosative stress, imbalance of energy metabolism, and mitochondrial dysfunction in microglial and alveolar basal epithelial cells article

Fresta, C. G., Chakraborty, A., Wijesinghe, M. B., Amorini, A. M., Lazzarino, G., Tavazzi, B., Lunte, S. M., Caraci, F., Dhar, P. & Caruso, G., 2018, In : Cell Death and Disease. 9, 2

Research output: Contribution to journalArticle

Carnosine
Neurodegenerative Diseases
Action Potentials
Brain
Therapeutics

Sub-Toxic Human Amylin Fragment Concentrations Promote the Survival and Proliferation of SH-SY5Y Cells via the Release of VEGF and HspB5 from Endothelial RBE4 Cells

Caruso, G., Fresta, C. G., Lazzarino, G., Distefano, D. A., Parlascino, P., Lunte, S. M., Lazzarino, G. & Caraci, F., Nov 20 2018, In : International Journal of Molecular Sciences. 19, 11

Research output: Contribution to journalArticle

Islet Amyloid Polypeptide
Poisons
Endothelial cells
Heat-Shock Proteins
Vascular Endothelial Growth Factor A
2017

A new nomenclature for classifying psychotropic drugs

Caraci, F., Enna, S. J., Zohar, J., Racagni, G., Zalsman, G., van den Brink, W., Kasper, S., Koob, G. F., Pariante, C. M., Piazza, P. V., Yamada, K., Spedding, M. & Drago, F., Aug 2017, In : British Journal of Clinical Pharmacology. 83, 8, p. 1614-1616 3 p.

Research output: Contribution to journalArticle

Psychotropic Drugs
Terminology
Neurosciences
Pharmacology
Pharmaceutical Preparations

Buspirone counteracts MK-801-induced schizophrenia-like phenotypes through dopamine D3 receptor blockade

Torrisi, S. A., Salomone, S., Geraci, F., Caraci, F., Bucolo, C., Drago, F. & Leggio, G. M., Oct 4 2017, In : Frontiers in Pharmacology. 8, OCT, 710.

Research output: Contribution to journalArticle

Dopamine D3 Receptors
Buspirone
Dizocilpine Maleate
Schizophrenia
Phenotype

Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system

Di Menna, L., Joffe, M. E., Iacovelli, L., Orlando, R., Lindsley, C. W., Mairesse, J., Gressèns, P., Cannella, M., Caraci, F., Copani, A., Bruno, V., Battaglia, G., Conn, P. J. & Nicoletti, F., Oct 25 2017, In : Neuropharmacology. 128, p. 301-313 13 p.

Research output: Contribution to journalArticle

Phosphatidylinositol Phosphates
Metabotropic Glutamate Receptors
Neuronal Plasticity
Pyramidal Cells
Prefrontal Cortex

Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease

Caraci, F. & Copani, A., Dec 23 2017, In : Current Opinion in Pharmacology. 38, p. 1-7 7 p.

Research output: Contribution to journalReview article

Metabotropic Glutamate Receptors
Alzheimer Disease
Therapeutics
Glutamic Acid
Central Nervous System

New drugs in psychiatry: focus on new pharmacological targets

Caraci, F., Leggio, G. M., Salomone, S. & Drago, F., 2017, In : F1000Research. 6, p. 397

Research output: Contribution to journalReview article

Psychiatry
Pharmacology
Depression
Alzheimer Disease
Pharmaceutical Preparations

Preface Drug discovery in neurodegenerative disorders: a defeat for pharmacology?

Caraci, F., Kraneveld, A., Krzan, M. & Luca, M. D., Dec 15 2017, In : European Journal of Pharmacology. 817, p. 1

Research output: Contribution to journalArticle

Searching for new pharmacological targets for the treatment of Alzheimer's disease in Down syndrome

Caraci, F., Iulita, M. F., Pentz, R., Flores Aguilar, L., Orciani, C., Barone, C., Romano, C., Drago, F. & Cuello, A. C., 2017, (Accepted/In press) In : European Journal of Pharmacology.

Research output: Contribution to journalArticle

Down Syndrome
Alzheimer Disease
Pharmacology
Dementia
Biomarkers

Silybin supplementation during HCV therapy with pegylated interferon-a plus ribavirin reduces depression and anxiety and increases work ability

Malaguarnera, G., Bertino, G., Chisari, G., Motta, M., Vecchio, M., Vacante, M., Caraci, F., Greco, C., Drago, F., Nunnari, G. & Malaguarnera, M., 2017, In : BMC Psychiatry. 16, 1, 398.

Research output: Contribution to journalReview article

Aptitude
Ribavirin
Interferons
Anxiety
Depression
Metabotropic Glutamate Receptors
Nervous System Diseases
Psychiatry
Major Depressive Disorder
Parkinson Disease
8 Downloads (Pure)

Topical ocular delivery of TGF-β1 to the back of the eye: Implications in age-related neurodegenerative diseases

Platania, C. B. M., Fisichella, V., Fidilio, A., Geraci, F., Lazzara, F., Leggio, G. M., Salomone, S., Drago, F., Pignatello, R., Caraci, F. & Bucolo, C., Oct 1 2017, In : International Journal of Molecular Sciences. 18, 10, 2076.

Research output: Contribution to journalArticle

Open Access
File
Neurodegenerative diseases
Transforming Growth Factors
Neurodegenerative Diseases
delivery
degeneration
2016

A link between nerve growth factor metabolic deregulation and amyloid-β-driven inflammation in down syndrome

Iulita, M. F., Caraci, F. & Cuello, A. C., May 1 2016, In : CNS and Neurological Disorders - Drug Targets. 15, 4, p. 434-447 14 p.

Research output: Contribution to journalArticle

Nerve Growth Factor
Down Syndrome
Amyloid
Alzheimer Disease
Inflammation

An inflammatory and trophic disconnect biomarker profile revealed in Down syndrome plasma: Relation to cognitive decline and longitudinal evaluation

Iulita, M. F., Ower, A., Barone, C., Pentz, R., Gubert, P., Romano, C., Cantarella, R. A., Elia, F., Buono, S., Recupero, M., Castellano, S., Bosco, P., Di Nuovo, S., Drago, F., Caraci, F. & Cuello, A. C., Nov 1 2016, In : Alzheimer's and Dementia. 12, 11, p. 1132-1148 17 p.

Research output: Contribution to journalArticle

Down Syndrome
Biomarkers
Dementia
Matrix Metalloproteinases
Interleukin-10

Fluoxetine Prevents Aβ1-42-Induced Toxicity via a Paracrine Signaling Mediated by Transforming-Growth-Factor-β1

Caraci, F., Tascedda, F., Merlo, S., Benatti, C., Spampinato, S. F., Munafò, A., Leggio, G. M., Brunello, N., Drago, F., Sortino, M. A. & Copani, A., 2016, In : Frontiers in Pharmacology. 7, p. 389

Research output: Contribution to journalArticle

Paracrine Communication
Fluoxetine
Transforming Growth Factors
Sertraline
Astrocytes

Italian psychiatrists perception on cognitive symptoms in major depressive disorder

Albert, U. S., Brugnoli, R., Caraci, F., Dell'Osso, B., Di Sciascio, G., Tortorella, A., Vampini, C., Cataldo, N. & Pegoraro, V., 2016, In : International Journal of Psychiatry in Clinical Practice. 20, 1, p. 2-9 8 p.

Research output: Contribution to journalArticle

Italian psychiatrists perception on cognitive symptoms in major depressive disorder

Albert, U., Brugnoli, R., Caraci, F., Di Sciascio, G., Tortorella, A., Vampini, C., Cataldo, N. & Pegoraro, V., Jan 2 2016, In : International Journal of Psychiatry in Clinical Practice. 20, 1, p. 2-9 8 p.

Research output: Contribution to journalArticle

Neurobehavioral Manifestations
Major Depressive Disorder
Psychiatry
Antidepressive Agents
Recurrence

Linkage of CNS and immunology with psychology: Searching for new pharmacological targets

Caraci, F. & Kamal, M. A., May 1 2016, In : CNS and Neurological Disorders - Drug Targets. 15, 4, p. 378-380 3 p.

Research output: Contribution to journalArticle

Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease

Simoni, E., Caporaso, R., Bergamini, C., Fiori, J., Fato, R., Miszta, P., Filipek, S., Caraci, F., Giuffrida, M. L., Andrisano, V., Minarini, A., Bartolini, M. & Rosini, M., Dec 8 2016, In : ACS Medicinal Chemistry Letters. 7, 12, p. 1145-1150 6 p.

Research output: Contribution to journalArticle

Polyamines
Amyloid
Alzheimer Disease
Agglomeration
Neuroprotective Agents

Selective Serotonin Reuptake Inhibitors and Serotonin and Noradrenaline Reuptake Inhibitors Improve Cognitive Function in Partial Responders Depressed Patients: Results from a Prospective Observational Cohort Study

Castellano, S., Ventimiglia, A., Salomone, S., Ventimiglia, A., De Vivo, S., Signorelli, M. S., Bellelli, E., Santagati, M., Cantarella, R. A., Fazio, E., Aguglia, E., Drago, F., Di Nuovo, S. & Caraci, F., 2016, In : CNS and Neurological Disorders - Drug Targets. 15, 10, p. 1290-1298 9 p.

Research output: Contribution to journalArticle

Serotonin Uptake Inhibitors
Affective Symptoms
Cognition
Observational Studies
Neurobehavioral Manifestations

TGF-β1 prevents rat retinal insult induced by amyloid-β (1–42) oligomers

Fisichella, V., Giurdanella, G., Platania, C. B. M., Romano, G. L., Leggio, G. M., Salomone, S., Drago, F., Caraci, F. & Bucolo, C., 2016, In : European Journal of Pharmacology. 787, p. 72-77 6 p.

Research output: Contribution to journalArticle

Macular Degeneration
Amyloid
bcl-2-Associated X Protein
Gene Regulatory Networks
Computational Biology

The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ß1-42 oligomers in mice

Leggio, G. M., Catania, M. V., Puzzo, D., Spatuzza, M., Pellitteri, R., Gulisano, W., Torrisi, S. A., Giurdanella, G., Piazza, C., Impellizzeri, A. R., Gozzo, L., Navarria, A., Bucolo, C., Palmeri, A., Salomone, S., Copani, A., Caraci, F. & Drago, F., Apr 1 2016, In : Pharmacological Research. 106, p. 10-20 11 p.

Research output: Contribution to journalArticle

alvocidib
Memory Disorders
Amyloid
Antineoplastic Agents
Cell Cycle

The antineoplastic drug flavopiridol reverses memory impairment induced by Amyloid-ß1-42 oligomers in mice

Leggio, G. M., Catania, M. V., Puzzo, D., Spatuzza, M., Pellitteri, R., Gulisano, W., Torrisi, S. A., Giurdanella, G., Piazza, C., Impellizzeri, A. R., Gozzo, L., Navarria, A., Bucolo, C., Nicoletti, F., Palmeri, A., Salomone, S., Copani, A., Caraci, F. & Drago, F., Apr 1 2016, In : Pharmacological Research. 106, p. 10-20 11 p.

Research output: Contribution to journalArticle

alvocidib
Memory Disorders
Amyloid
Antineoplastic Agents
Cell Cycle
Metabotropic Glutamate Receptors
Nervous System Diseases
Psychiatry
Major Depressive Disorder
Parkinson Disease
2015

A key role for TGF-β1 in hippocampal synaptic plasticity and memory

Caraci, F., Gulisano, W., Guida, C. A., Impellizzeri, A. A. R., Drago, F., Puzzo, D. & Palmeri, A., Jun 10 2015, In : Scientific Reports. 5, 11252.

Research output: Contribution to journalArticle

Neuronal Plasticity
Transforming Growth Factors
Long-Term Potentiation
Long-Term Memory
Nerve Growth Factors

Central serotonin2B receptor blockade inhibits cocaine-induced hyperlocomotion independently of changes of subcortical dopamine outflow

Devroye, C., Cathala, A., Di Marco, B., Caraci, F., Drago, F., Piazza, P. V. & Spampinato, U., Oct 1 2015, In : Neuropharmacology. 97, p. 329-337 9 p.

Research output: Contribution to journalArticle

Cocaine
Dopamine
Nucleus Accumbens
Substance-Related Disorders
Pharmacology

Does Mood Disorder Questionnaire identify sub-threshold bipolarity? Evidence studying worsening of quality of life

Carta, M. G., Norcini-Pala, A., Moro, M. F., Balestrieri, M., Caraci, F., Dell'Osso, L., Sciascio, G. D., Faravelli, C., Hardoy, M. C., Aguglia, E., Roncone, R., Nardi, A. E. & Drago, F., Sep 1 2015, In : Journal of Affective Disorders. 183, p. 173-178 6 p., 7435.

Research output: Contribution to journalArticle

Mood Disorders
Quality of Life
Health Surveys
Bipolar Disorder
Mental Disorders