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Research Output 1984 2019

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2019

Dopamine-beta-hydroxylase 19-bp insertion/deletion polymorphism affects medication overuse in patients with chronic migraine

Barbanti, P., Guadagni, F., De Marchis, M. L., Ialongo, C., Egeo, G., Fofi, L., Aurilia, C., Lovero, D., Della-Morte, D., Ferroni, P. & Palmirotta, R., Aug 1 2019, In : Neurological Sciences. 40, 8, p. 1717-1724 8 p.

Research output: Contribution to journalArticle

Dopamine beta-Hydroxylase
Migraine Disorders
Endophenotypes
Prescription Drug Overuse
Genetic Association Studies
2018

Artificial intelligence for cancer-associated thrombosis risk assessment

Ferroni, P., Roselli, M., Zanzotto, F. M. & Guadagni, F., 2018, In : The Lancet Haematology. 5, 9, p. e391

Research output: Contribution to journalArticle

Precision Medicine
Biomarkers
Migraine Disorders
Medicine
Therapeutics

Genetic bases of the nutritional approach to migraine

De Marchis, M. L., Guadagni, F., Silvestris, E., Lovero, D., Della-Morte, D., Ferroni, P., Barbanti, P. & Palmirotta, R., Mar 8 2018, In : Critical Reviews in Food Science and Nutrition. p. 1-13 13 p.

Research output: Contribution to journalArticle

Nutrigenomics
migraine
Migraine Disorders
genetic background
Food

Shorter telomere length in schizophrenia: Evidence from a real-world population and meta-analysis of most recent literature

Russo, P., Prinzi, G., Proietti, S., Lamonaca, P., Frustaci, A., Boccia, S., Amore, R., Lorenzi, M., Onder, G., Marzetti, E., Valdiglesias, V., Guadagni, F., Valente, M. G., Cascio, G. L., Fraietta, S., Ducci, G. & Bonassi, S., 2018, In : Schizophrenia Research. 202, p. 37-45 9 p.

Research output: Contribution to journalArticle

Standard PREanalytical Code version 3.0

Betsou, F., Bilbao, R., Case, J., Chuaqui, R., Clements, J. A., De Souza, Y., De Wilde, A., Geiger, J., Grizzle, W., Guadagni, F., Gunter, E., Heil, S., Kiehntopf, M., Koppandi, I., Lehmann, S., Linsen, L., Mackenzie-Dodds, J., Aguilar Quesada, R., Tebbakha, R., Selander, T. & 8 others, Shea, K., Sobel, M., Somiari, S., Spyropoulos, D., Stone, M., Tybring, G., Valyi-Nagy, K. & Wadhwa, L., Jan 29 2018, In : Biopreservation and Biobanking.

Research output: Contribution to journalArticle

2017

Clinical significance of glycemic parameters on venous thromboembolism risk preDiction in gastrointestinal cancer

Guadagni, F., RionDino, S., Formica, V., Del Monte, G., Morelli, A. M., Lucchetti, J., Spila, A., D'Alessandro, R., Della-Morte, D., Ferroni, P. & Roselli, M., Jul 28 2017, In : World Journal of Gastroenterology. 23, 28, p. 5187-5195 9 p.

Research output: Contribution to journalArticle

Gastrointestinal Neoplasms
Venous Thromboembolism
Type 2 Diabetes Mellitus
Drug Therapy
Obesity

Gender Differences in Cancer-Associated Venous Thromboembolism

Riondino, S., Guadagni, F., Formica, V., Ferroni, P. & Roselli, M., 2017, In : Current Medicinal Chemistry. 24, 24, p. 2589-2601

Research output: Contribution to journalArticle

Venous Thromboembolism
Anticoagulants
Catheters
Hemostatics
Platelets

Procoagulant imbalance in premenopausal women with chronic migraine

Ferroni, P., Barbanti, P., Aurilia, C., Egeo, G., Fofi, L., La Farina, F., Valente, M. G., De Marchis, M. L., Spila, A., Palmirotta, R., Della-Morte, D. & Guadagni, F., Oct 3 2017, In : Neurology. 89, 14, p. 1525-1527 3 p.

Research output: Contribution to journalArticle

Redox Mechanisms in Migraine: Novel Therapeutics and Dietary Interventions

Ferroni, P., Barbanti, P., Della-Morte, D., Palmirotta, R., Jirillo, E. & Guadagni, F., Nov 21 2017, In : Antioxidants and Redox Signaling.

Research output: Contribution to journalArticle

Oxidative stress
Migraine Disorders
Oxidation-Reduction
Brain
Antioxidants

Risk Assessment for Venous Thromboembolism in Chemotherapy-Treated Ambulatory Cancer Patients: A Machine Learning Approach

Ferroni, P., Zanzotto, F. M., Scarpato, N., Riondino, S., Nanni, U., Roselli, M. & Guadagni, F., Feb 2017, In : Medical Decision Making. 37, 2, p. 234-242

Research output: Contribution to journalArticle

Venous Thromboembolism
Drug Therapy
Neoplasms
Machine Learning
Learning

Validation of a machine learning approach for venous thromboembolism risk prediction in oncology

Ferroni, P., Zanzotto, F. M., Scarpato, N., Riondino, S., Guadagni, F. & Roselli, M., Jan 1 2017, In : Disease Markers. 2017, 8781379.

Research output: Contribution to journalArticle

Oncology
Venous Thromboembolism
Learning systems
Chemotherapy
Neoplasms
2016

A Biospecimen Proficiency Testing Program for Biobank Accreditation: Four Years of Experience

Gaignaux, A., Ashton, G., Coppola, D., De Souza, Y., De Wilde, A., Eliason, J., Grizzle, W., Guadagni, F., Gunter, E., Koppandi, I., Shea, K., Shi, T., Stein, J. A., Sobel, M. E., Tybring, G., Van Den Eynden, G., Betsou, F. & ISBER Proficiency Testing Advisory Group, Oct 1 2016, In : Biopreservation and Biobanking. 14, 5, p. 429-439 11 p.

Research output: Contribution to journalArticle

Accreditation
Testing
Certification
Quality assurance
Processing

Assays for Qualification and Quality Stratification of Clinical Biospecimens Used in Research: A Technical Report from the ISBER Biospecimen Science Working Group

Betsou, F., Bulla, A., Cho, S. Y., Clements, J., Chuaqui, R., Coppola, D., De Souza, Y., De Wilde, A., Grizzle, W., Guadagni, F., Gunter, E., Heil, S., Hodgkinson, V., Kessler, J., Kiehntopf, M., Kim, H. S., Koppandi, I., Shea, K., Singh, R., Sobel, M. & 7 others, Somiari, S., Spyropoulos, D., Stone, M., Tybring, G., Valyi-Nagy, K., Van Den Eynden, G. & Wadhwa, L., Oct 1 2016, In : Biopreservation and Biobanking. 14, 5, p. 398-409 12 p.

Research output: Contribution to journalArticle

Quality Control
Quality control
Assays
Research

Brachyury, a vaccine target, is overexpressed in triple-negative breast cancer

Hamilton, D. H., Roselli, M., Ferroni, P., Costarelli, L., Cavaliere, F., Taffuri, M., Palena, C. & Guadagni, F., Oct 1 2016, In : Endocrine-Related Cancer. 23, 10, p. 783-796 14 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Vaccines
Neoplasms
Cancer Vaccines
Breast Neoplasms

Enhanced expression of LINE-1-encoded ORF2 protein in early stages of colon and prostate transformation

De Luca, C., Guadagni, F., Sinibaldi-Vallebona, P., Sentinelli, S., Gallucci, M., Hoffmann, A., Schumann, G. G., Spadafora, C. & Sciamanna, I., 2016, In : Oncotarget. 7, 4, p. 4048-4061 14 p.

Research output: Contribution to journalArticle

Prostate
Colon
RNA-Directed DNA Polymerase
Neoplasms
Proteins

Functional impairment of activated protein C in breast cancer - relationship to survival outcomes

Roselli, M., Ferroni, P., Riondino, S., Mariotti, S., Portarena, I., Alessandroni, J., Ialongo, C., Massoud, R., Costarelli, L., Cavaliere, F., Bernardini, S. & Guadagni, F., 2016, In : American Journal of Cancer Research. 6, 6, p. 1450-1457 8 p.

Research output: Contribution to journalArticle

Protein C
Breast Neoplasms
Survival
Disease Progression
Cohort Studies

Gender Differences in Cancer-Associated Venous Thromboembolism

Riondino, S., Guadagni, F., Formica, V., Ferroni, P. & Roselli, M., Oct 18 2016, In : Current Medicinal Chemistry.

Research output: Contribution to journalArticle

Venous Thromboembolism
Anticoagulants
Catheters
Hemostatics
Platelets

Insulin resistance as a predictor of venous thromboembolism in breast cancer

Ferroni, P., Roselli, M., Riondino, S., Cavaliere, F. & Guadagni, F., Jun 1 2016, In : Endocrine-Related Cancer. 23, 6, p. L25-L28

Research output: Contribution to journalArticle

Malignant mesothelioma effusions are infiltrated by CD3+ T cells highly expressing PD-L1 and the PD-L1+ tumor cells within these effusions are susceptible to ADCC by the anti-PD-L1 antibody avelumab

Khanna, S., Thomas, A., Abate-Daga, D., Zhang, J., Morrow, B., Steinberg, S. M., Orlandi, A., Ferroni, P., Schlom, J., Guadagni, F. & Hassan, R., Nov 13 2016, In : Journal of Thoracic Oncology. 11, 11, p. 1993-2005 13 p.

Research output: Contribution to journalArticle

Mesothelioma
Ligands
T-Lymphocytes
Antibodies
Neoplasms

Neutrophil/lymphocyte ratio helps select metastatic pancreatic cancer patients benefitting from oxaliplatin

Formica, V., Morelli, C., Ferroni, P., Nardecchia, A., Tesauro, M., Pellicori, S., Cereda, V., Russo, A., Riondino, S., Guadagni, F. & Roselli, M., 2016, In : Cancer Biomarkers. 17, 3, p. 335-345 11 p.

Research output: Contribution to journalArticle

oxaliplatin
gemcitabine
Pancreatic Neoplasms
Neutrophils
Lymphocytes

Pretreatment insulin levels as a prognostic factor for breast cancer progression

Ferroni, P., Riondino, S., Laudisi, A., Portarena, I., Formica, V., Alessandroni, J., D’Alessandro, R., Orlandi, A., Costarelli, L., Cavaliere, F., Guadagni, F. & Roselli, M., Sep 1 2016, In : Oncologist. 21, 9, p. 1041-1049 9 p.

Research output: Contribution to journalArticle

Insulin
Breast Neoplasms
Blood Glucose
Homeostasis
Survival

Prognostic value of glycated hemoglobin in colorectal cancer

Ferroni, P., Formica, V., Della-Morte, D., Lucchetti, J., Spila, A., D'Alessandro, R., Riondino, S., Guadagni, F. & Roselli, M., Dec 7 2016, In : World Journal of Gastroenterology. 22, 45, p. 9984-9993 10 p.

Research output: Contribution to journalArticle

Glycosylated Hemoglobin A
Colorectal Neoplasms
Survival
Blood Glucose
Fasting

Risk Assessment for Venous Thromboembolism in Chemotherapy-Treated Ambulatory Cancer Patients: A Machine Learning Approach

Ferroni, P., Zanzotto, F. M., Scarpato, N., Riondino, S., Nanni, U., Roselli, M. & Guadagni, F., Aug 4 2016, In : Medical Decision Making.

Research output: Contribution to journalArticle

Venous Thromboembolism
Drug Therapy
Neoplasms
Machine Learning
Learning

The association of clinical outcome and peripheral T-cell subsets in metastatic colorectal cancer patients receiving first-line FOLFIRI plus bevacizumab therapy

Roselli, M., Formica, V., Cereda, V., Jochems, C., Richards, J., Grenga, I., Orlandi, A., Ferroni, P., Guadagni, F. & Schlom, J., Jul 12 2016, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

T-Lymphocyte Subsets
Colorectal Neoplasms
irinotecan
Therapeutics
Levoleucovorin

VEGF and VTE risk in cancer patients-letter

Ferroni, P., Riondino, S., Guadagni, F. & Roselli, M., Mar 1 2016, In : Clinical Cancer Research. 22, 5, p. 1295 1 p.

Research output: Contribution to journalArticle

VEGF gene promoter polymorphisms and risk of VTE in chemotherapytreated cancer patients

Ferroni, P., Palmirotta, R., Riondino, S., De Marchis, M. L., Nardecchia, A., Formica, V., Guadagni, F. & Roselli, M., 2016, In : Thrombosis and Haemostasis. 115, 1, p. 143-151 9 p.

Research output: Contribution to journalArticle

Venous Thromboembolism
Vascular Endothelial Growth Factor A
Genes
Neoplasms
Confidence Intervals
2015

Comparison of therapy with Ticagrelor, Prasugrel or high Clopidogrel dose in PCI patients with high on treatment platelet reactivity and genotype variation. Triplete reset trial

Sardella, G., Calcagno, S., Mancone, M., Lucisano, L., Pennacchi, M., Stio, R. E., Placentino, F., Di Roma, A., Cavallo, E., Palmirotta, R., Guadagni, F. & Fedele, F., Jun 12 2015, In : International Journal of Cardiology. 194, p. 60-62 3 p.

Research output: Contribution to journalArticle

Ensuring sample quality for biomarker discovery studies - Use of ict tools to trace biosample life-cycle

Riondino, S., Ferroni, P., Spila, A., Alessandroni, J., D'Alessandro, R., Formica, V., Della-Morte, D., Palmirotta, R., Nanni, U., Roselli, M. & Guadagni, F., Nov 1 2015, In : Cancer Genomics and Proteomics. 12, 6, p. 291-300 10 p.

Research output: Contribution to journalArticle

Precision Medicine
Biomarkers
Life Cycle Stages
Medicine
Life cycle

Impact of VEGF gene polymorphisms in elderly cancer patients: Clinical outcome and toxicity

Della-Morte, D., Riondino, S., Ferroni, P., Palmirotta, R., Pastore, D., Lauro, D., Guadagni, F. & Roselli, M., Jan 1 2015, In : Pharmacogenomics. 16, 1, p. 61-78 18 p.

Research output: Contribution to journalArticle

Vascular Endothelial Growth Factors
Genes
Neoplasms
Pharmacology
Frail Elderly

Inflammation and thrombophilia in pregnancy complications: Implications for risk assessment and clinical management

La Farina, F., Raparelli, V., Napoleone, L., Guadagni, F., Basili, S. & Ferroni, P., Dec 1 2015, In : Cardiovascular and Hematological Disorders - Drug Targets. 15, 3, p. 187-203 17 p.

Research output: Contribution to journalArticle

Thrombophilia
Pregnancy Complications
Inflammation
Venous Thromboembolism
Pregnancy

Is SOD2 Ala16Val polymorphism associated with migraine with aura phenotype?

Palmirotta, R., Barbanti, P., De Marchis, M. L., Egeo, G., Aurilia, C., Fofi, L., Ialongo, C., Valente, M. G., Ferroni, P., Della-Morte, D. & Guadagni, F., Jan 20 2015, In : Antioxidants and Redox Signaling. 22, 3, p. 275-279 5 p.

Research output: Contribution to journalArticle

Migraine with Aura
Polymorphism
Migraine Disorders
Phenotype
Genes

Look beyond Catechol-O-Methyltransferase genotype for cathecolamines derangement in migraine: the BioBIM rs4818 and rs4680 polymorphisms study

De Marchis, M. L., Barbanti, P., Palmirotta, R., Egeo, G., Aurilia, C., Fofi, L., Piroso, S., Ialongo, C., Della-Morte, D., D’Andrea, G., Ferroni, P. & Guadagni, F., Dec 1 2015, In : Journal of Headache and Pain. 16, 1, p. 1-8 8 p., 37.

Research output: Contribution to journalArticle

Catechol O-Methyltransferase
Migraine Disorders
Genotype
Catecholamines
Tyrosine Decarboxylase

O039. Case-control genetic association studies in migraine: a 7-year experience at the Interinstitutional Multidisciplinary Biobank (BioBIM) of IRCCS San Raffaele Pisana

Barbanti, P., Palmirotta, R., De Marchis, M. L., Ialongo, C., Egeo, G., Aurilia, C., Fofi, L., Piroso, S., Fratangeli, F., Valente, M. G. & Guadagni, F., Dec 1 2015, In : Journal of Headache and Pain. 16, p. 1-2 2 p., A120.

Research output: Contribution to journalArticle

Progesterone receptor gene (PROGINS) polymorphism correlates with late onset of migraine

Palmirotta, R., Barbanti, P., Ialongo, C., De Marchis, M. L., Alessandroni, J., Egeo, G., Aurilia, C., Fofi, L., Valente, M. G., Ferroni, P., Della-Morte, D. & Guadagni, F., Mar 1 2015, In : DNA and Cell Biology. 34, 3, p. 208-212 5 p.

Research output: Contribution to journalArticle

Progesterone Receptors
Migraine Disorders
Genes
Age of Onset
Genotype

Role of Serum and Glucocorticoid-Inducible Kinase (SGK)-1 in senescence: A novel molecular target against age-related diseases

Lauro, D., Pastore, D., Capuani, B., Pacifici, F., Palmirotta, R., Abete, P., Roselli, M., Bellia, A., Federici, M., Di Daniele, N., Sbraccia, P., Guadagni, F., Lauro, R. & Della-Morte, D., Dec 1 2015, In : Current Medicinal Chemistry. 22, 33, p. 3765-3788 24 p.

Research output: Contribution to journalArticle

Glucocorticoids
Phosphotransferases
Aging of materials
Oxidative stress
Hyperglycemia

Type 2 diabetes and breast cancer: The interplay between impaired glucose metabolism and oxidant stress

Ferroni, P., Riondino, S., Buonomo, O., Palmirotta, R., Guadagni, F. & Roselli, M., 2015, In : Oxidative Medicine and Cellular Longevity. 2015, 183928.

Research output: Contribution to journalArticle

Medical problems
Oxidants
Metabolism
Type 2 Diabetes Mellitus
Breast Neoplasms

Venous thromboembolism risk prediction in ambulatory cancer patients: Clinical significance of neutrophil/lymphocyte ratio and platelet/lymphocyte ratio

Ferroni, P., Riondino, S., Formica, V., Cereda, V., Tosetto, L., La Farina, F., Valente, M. G., Vergati, M., Guadagni, F. & Roselli, M., Mar 1 2015, In : International Journal of Cancer. 136, 5, p. 1234-1240 7 p.

Research output: Contribution to journalArticle

Venous Thromboembolism
Neutrophils
Blood Platelets
Lymphocytes
Neoplasms
2014

Association between migraine and ACE gene (insertion/deletion) polymorphism: The BioBIM study

Palmirotta, R., Barbanti, P., Ludovici, G., De Marchis, M. L., Ialongo, C., Egeo, G., Aurilia, C., Fofi, L., Abete, P., Spila, A., Ferroni, P., Della-Morte, D. & Guadagni, F., Feb 2014, In : Pharmacogenomics. 15, 2, p. 147-155 9 p.

Research output: Contribution to journalArticle

Insertional Mutagenesis
Gene Deletion
Migraine Disorders
Migraine with Aura
Migraine without Aura

Clinical models and biochemical predictors of VTE in lung cancer

Roselli, M., Riondino, S., Mariotti, S., La Farina, F., Ferroni, P. & Guadagni, F., 2014, In : CANCER AND METASTASIS REVIEW. 33, 2-3, p. 771-789 19 p.

Research output: Contribution to journalArticle

Venous Thromboembolism
Lung Neoplasms
Coagulants
Hemostasis
Heparin

Diagnostic procedures for paraffi n-embedded tissues analysis in pharmacogenomic studies

Palmirotta, R., De Marchis, M. L., Ludovici, G., Ferroni, P., Abete, P., Guadagni, F. & Della-Morte, D., 2014, In : Methods in molecular biology (Clifton, N.J.). 1175, p. 45-65 21 p.

Research output: Contribution to journalArticle

Neoplasms
Molecular Pathology
Biotechnology
Italy
Genes

Estimated glomerular filtration rate is an easy predictor of venous thromboembolism in cancer patients undergoing platinum-based chemotherapy

Ferroni, P., Guadagni, F., Laudisi, A., Vergati, M., Riondino, S., Russo, A., Davi, G. & Roselli, M., 2014, In : The oncologist. 19, 5, p. 562-567 6 p.

Research output: Contribution to journalArticle

Venous Thromboembolism
Platinum
Glomerular Filtration Rate
Drug Therapy
Neoplasms

Evaluation of mean platelet volume as a predictive marker for cancer-associated venous thromboembolism during chemotherapy

Ferroni, P., Guadagni, F., Riondino, S., Portarena, I., Mariotti, S., La Farina, F., Davì, G. & Roselli, M., Oct 1 2014, In : Haematologica. 99, 10, p. 1638-1644 7 p.

Research output: Contribution to journalArticle

Mean Platelet Volume
Venous Thromboembolism
Drug Therapy
Neoplasms
Survival Analysis

Obesity and colorectal cancer: Role of adipokines in tumor initiation and progression

Riondino, S., Roselli, M., Palmirotta, R., Della-Morte, D., Ferroni, P. & Guadagni, F., May 14 2014, In : World Journal of Gastroenterology. 20, 18, p. 5177-5190 14 p.

Research output: Contribution to journalArticle

Adipokines
Adipocytes
Colorectal Neoplasms
Obesity
Adipose Tissue

Overexpression of the EMT driver brachyury in breast carcinomas: Association with poor prognosis

Palena, C., Roselli, M., Litzinger, M. T., Ferroni, P., Costarelli, L., Spila, A., Cavaliere, F., Huang, B., Fernando, R. I., Hamilton, D. H., Jochems, C., Tsang, K. Y., Cheng, Q., Lyerly, H. K., Schlom, J. & Guadagni, F., May 14 2014, In : Journal of the National Cancer Institute. 106, 5, dju054.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Breast Neoplasms
docetaxel
Drug Resistance
Brachyury protein

Pharmacogenomics and pharmacogenetics of thiazolidinediones: Role in diabetes and cardiovascular risk factors

Della-Morte, D., Palmirotta, R., Rehni, A. K., Pastore, D., Capuani, B., Pacifici, F., De Marchis, M. L., Dave, K. R., Bellia, A., Fogliame, G., Ferroni, P., Donadel, G., Cacciatore, F., Abete, P., Dong, C., Pileggi, A., Roselli, M., Ricordi, C., Sbraccia, P., Guadagni, F. & 2 others, Rundek, T. & Lauro, D., Dec 1 2014, In : Pharmacogenomics. 15, 16, p. 2063-2082 20 p.

Research output: Contribution to journalArticle

Thiazolidinediones
rosiglitazone
pioglitazone
Pharmacogenetics
troglitazone

Plasma plasminogen activator inhibitor-1 (PAI-1) levels in breast cancer - Relationship with clinical outcome

Ferroni, P., Roselli, M., Portarena, I., Formica, V., Riondino, S., La Farina, F., Costarelli, L., Melino, A., Massimiani, G., Cavaliere, F., Palmirotta, R. & Guadagni, F., Mar 1 2014, In : Anticancer Research. 34, 3, p. 1153-1161 9 p.

Research output: Contribution to journalArticle

Plasminogen Activator Inhibitor 1
Breast Neoplasms
Tumor Microenvironment
Thrombin
Survival
Venous Thromboembolism
HDL Cholesterol
Drug Therapy
Neoplasms
Survival Analysis

Systemic inflammation, as measured by the neutrophil/lymphocyte ratio, may have differential prognostic impact before and during treatment with fluorouracil, irinotecan and bevacizumab in metastatic colorectal cancer patients

Formica, V., Luccchetti, J., Cunningham, D., Smyth, E. C., Ferroni, P., Nardecchia, A., Tesauro, M., Cereda, V., Guadagni, F. & Roselli, M., Sep 1 2014, In : Medical Oncology. 31, 9, p. 166 1 p.

Research output: Contribution to journalArticle

irinotecan
Fluorouracil
Colorectal Neoplasms
Neutrophils
Lymphocytes
2013

Age-related reduction of cerebral ischemic preconditioning: Myth or reality?

Della-Morte, D., Cacciatore, F., Salsano, E., Pirozzi, G., del Genio, M. T., D'Antonio, I., Gaetano, G., Palmirotta, R., Guadagni, F., Rundek, T. & Abete, P., Aug 7 2013, In : Clinical Interventions in Aging. 8, p. 1055-1061 7 p.

Research output: Contribution to journalArticle

Ischemic Preconditioning
Brain Ischemia
Stroke
Developed Countries
Cause of Death