• 470 Citations
  • 4 h-Index
20142015
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Fingerprint Dive into the research topics where Francesca Cottino is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Colorectal Neoplasms Medicine & Life Sciences
Epidermal Growth Factor Receptor Medicine & Life Sciences
Mitogen-Activated Protein Kinase Kinases Medicine & Life Sciences
Somatomedins Medicine & Life Sciences
Therapeutics Medicine & Life Sciences
Colonic Neoplasms Medicine & Life Sciences
Lung Neoplasms Medicine & Life Sciences
Neoplasms Medicine & Life Sciences

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Research Output 2014 2015

  • 470 Citations
  • 4 h-Index
  • 4 Article
94 Citations (Scopus)

HER2 activating mutations are targets for colorectal cancer treatment

Kavuri, S. M., Jain, N., Galimi, F., Cottino, F., Leto, S. M., Migliardi, G., Searleman, A. C., Shen, W., Monsey, J., Trusolino, L., Jacobs, S. A., Bertotti, A. & Bose, R., Aug 1 2015, In : Cancer Discovery. 5, 8, p. 832-841 10 p.

Research output: Contribution to journalArticle

Colorectal Neoplasms
Mutation
Therapeutics
Protein-Tyrosine Kinases
erbB-2 Genes
52 Citations (Scopus)

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies

Zanella, E. R., Galimi, F., Sassi, F., Migliardi, G., Cottino, F., Leto, S. M., Lupo, B., Erriquez, J., Isella, C., Comoglio, P. M., Medico, E., Tejpar, S., Budinská, E., Trusolino, L. & Bertotti, A., Jan 28 2015, In : Science Translational Medicine. 7, 272, 272ra12.

Research output: Contribution to journalArticle

Somatomedins
Epidermal Growth Factor Receptor
Colorectal Neoplasms
Therapeutics
Tumor Biomarkers
188 Citations (Scopus)

The genomic landscape of response to EGFR blockade in colorectal cancer

Bertotti, A., Papp, E., Jones, S., Adleff, V., Anagnostou, V., Lupo, B., Sausen, M., Phallen, J., Hruban, C. A., Tokheim, C., Niknafs, N., Nesselbush, M., Lytle, K., Sassi, F., Cottino, F., Migliardi, G., Zanella, E. R., Ribero, D., Russolillo, N., Mellano, A. & 15 others, Muratore, A., Paraluppi, G., Salizzoni, M., Marsoni, S., Kragh, M., Lantto, J., Cassingena, A., Li, Q. K., Karchin, R., Scharpf, R., Sartore-Bianchi, A., Siena, S., Diaz, L. A., Trusolino, L. & Velculescu, V. E., Oct 8 2015, In : Nature. 526, 7572, p. 263-267 5 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Colorectal Neoplasms
Neoplasms
Therapeutics
Transplants
136 Citations (Scopus)

Intrinsic resistance to MEK inhibition in kras mutant lung and colon cancer through transcriptional induction of ERBB3

Sun, C., Hobor, S., Bertotti, A., Zecchin, D., Huang, S., Galimi, F., Cottino, F., Prahallad, A., Grernrum, W., Tzani, A., Schlicker, A., Wessels, L. F. A., Smit, E. F., Thunnissen, E., Halonen, P., Lieftink, C., Beijersbergen, R. L., DiNicolantonio, F., Bardelli, A., Trusolino, L. & 1 others, Bernards, R., Oct 4 2014, In : Cell Reports. 7, 1, p. 86-93 8 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase Kinases
Colonic Neoplasms
Lung Neoplasms
Phosphorylation
Receptor Protein-Tyrosine Kinases